Clinical trials: Depressed
Depressive Symptoms, Depression
Evaluation of a Mobile Therapy for Elevated Depressive Symptoms
The purpose of this research study is to evaluate a mobile application (app) for depression treatment. Participants will be randomly assigned to either receive the mobile app, "Moodivate", or not.
- Trial name
- NCT04463914
- Testing
- Behavioral Activation Therapy app, Behavioral Activation Therapy app + EHR, Treatment as Usual
- Where
- United States
- Volunteers
- 649 people
- Sponsor
- Medical University of South Carolina
Depression, Aortic Stenosis
Depression and Major Adverse Events in Older Patients Who Undergo a Transcatheter Aortic Valve Implantation
Depression, screened using the Geriatric Depression Scale (GDS) Short Form, has recently been found to be associated with a 3-fold increase in 1-year mortality after aortic valve replacement (AVR) in patients aged 70 or older.
- Trial name
- TAVIDEP (NCT03995914)
- Sponsor
- University Hospital, Montpellier
Hunger, Depression
Carbohydrate Rich Drink Reduces Pre-endoscopic Discomfort for Patients Going for Elective Endoscopic Procedures
The study is a randomised controlled trial that aims to evaluate whether carbohydrate loading pre-endoscopy can improve patients' overall satisfaction and is not associated with negative impact on endoscopic quality or increased…
- Conditions
- Hunger, Depression, Anxiety, Vomiting
- Trial name
- NCT05342116
- Testing
- Nestle Preload, Water
- Where
- Singapore
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Treatment Resistant Depression
Working Mechanisms and Effectiveness of IV Ketamine-assisted Psychotherapy on Depression in TRD Clients
Ketamine-Assisted Psychotherapy (KAP) is an innovative treatment that combines intravenous ketamine with psychotherapy in a carefully monitored clinical setting.
- Trial name
- NCT07706478
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Senz
Moderate Depression, Major Depressive Disorder
The Dosage Effect of pBFS Guided rTMS Treatment for MDD
The investigators aim to find the optimal dosage of the pBFS-guided rTMS treatment for patients with moderate to severe depression.
- Conditions
- Moderate Depression, Major Depressive Disorder, Severe Depression
- Trial name
- NCT05842278
- Testing
- 4 session rTMS, 6 session rTMS, 8 session rTMS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changping Laboratory
Depression, Suicidal Ideation
Social Connections and Late Life Suicide
With the long-term goal of improving interventions for late-life suicide, the purpose of this study is to examine whether a mechanism by which behavioral interventions reduce risk for late-life suicide is by increasing social…
- Trial name
- NCT02188485
- Testing
- ENGAGE
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Rochester
Substance-Related Disorders, Mood Disorders
Behavioral Activation for Heroin Use in China: A Randomized Controlled Trial
This was a single-site two-arm parallel-group trial conducted in a Methadone Maintenance Treatment (MMT) Clinic that provides medication service for 254 heroin users in Wuhan, China.
- Conditions
- Substance-Related Disorders, Mood Disorders, Behavioral Activation Treatment, Mental Disorders
- Trial name
- NCT03705143
- Testing
- Treatment as usual, Chinese translated LETS ACT
- Where
- China
- Volunteers
- 90 people
- Sponsor
- University of North Carolina, Chapel Hill
Bipolar Disorder
A Six-week Flexible Dose Study Evaluating the Efficacy and Safety of Geodon in Patients With Bipolar I Depression.
This is a 6-week trial that evaluates the efficacy and safety of Geodon (ziprasidone) in outpatient subjects ages 18 and older with Bipolar Disorder type I, depressed.
- Trial name
- NCT00282464
- Testing
- Geodon (Ziprasidone)
- Where
- 43 sites in United States
- Volunteers
- 392 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
HIV, Depressive Symptoms
Relaxation, Depressive Symptoms, Quality of Life in People Living With HIV: a Pilot Study
Progressive muscle relaxation (PMR) and autogenic training (AT) are effective relaxation techniques to reduce depressive symptoms.
- Trial name
- NCT01901016
- Testing
- Jacobson progressive muscular relaxation, Schultz's autogenic training
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Université de Montréal
Major Depressive Disorder (MDD)
Magnesium Supplementation With Fluoxetine for Cognitive Function in Depression
The goal of this clinical trial is to evaluate whether magnesium supplementation can improve cognitive function in patients with depression receiving fluoxetine therapy.
- Trial name
- MAG-DEP (NCT07521358)
- Testing
- Fluoxetine (drug), Magnesium
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Hasanuddin University
Cognitive/Functional Effects, Depression
Physical and Mental Assessment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia
RATIONALE: Learning about physical ability and mental function over time in older patients with acute myeloid leukemia may help doctors learn about the long-term effects of treatment and plan the best treatment.
- Conditions
- Cognitive/Functional Effects, Depression, Leukemia
- Trial name
- NCT00499785
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
Premature Birth, Obstetric Labor, Premature
Family Nurture Intervention in the NICU at The Valley Hospital
The purpose of this study is to compare neurodevelopment and activity in infants born preterm (25 to 34 1/7 weeks gestational age (GA)) receiving Standard Care (SC) or Family Nurture Intervention (FNI) in the neonatal intensive…
- Trial name
- NCT03267043
- Testing
- Family Nurture Intervention (FNI), Standard Care
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Chronic Obstructive Pulmonary Disease, Depression
Effectiveness and Cost-effectiveness of Digital Psychological Intervention (EmoEase) in Chinese COPD Patients
Background Mental health issues are common and often overlooked in COPD patients. Digital psychological interventions might help, but their effectiveness in Chinese COPD patients hasn't been studied.
- Conditions
- Chronic Obstructive Pulmonary Disease, Depression, Anxiety
- Trial name
- NCT06026709
- Testing
- EmoEase
- Volunteers
- 1,200 people
- Sponsor
- Peking Union Medical College
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Clinical Trial to Assess the Improvement of Fatigue, Sleep Problems, Anxiety / Depression, Neurovegetatives Alterations and Quality of Life After the Administration of ImmunoVita® in Chronic Fatigue Syndrome Patients
Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis (CFS / MS) is a medical entity characterized mainly by debilitating and prolonged fatigue lasting more than 6 months, post-exertion fatigue (physical and / or…
- Trial name
- NCT04301609
- Testing
- Active
- Where
- Spain
- Volunteers
- 67 people
- Sponsor
- Vitae Health Innovation
Mental Health
Educational Intervention for Optimizing Adolescent Mental Health Screening and Treatment in Pediatric Residency
The purpose of this study is: 1) to assess pediatric resident knowledge of adolescent mental health; 2) to assess pediatric resident comfort level for screening, assessing, and treating mental health disorders in adolescents…
- Trial name
- NCT00768352
- Testing
- Educational intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Emotion Regulation, Stress
Evaluation of a Transdiagnostic Mobile App Intervention Among University Students
This study is a two-armed randomized controlled trial (RCT) aimed at evaluating the effectiveness and adoption of a transdiagnostic mobile app intervention that focuses is on enhancing adaptive emotional regulation (ER) skills…
- Conditions
- Emotion Regulation, Stress, Resilience, Depressive Symptoms
- Trial name
- NCT06224647
- Testing
- Mobile Transdiagnostic Emotion Regulation Intervention
- Where
- Netherlands
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Erasmus University Rotterdam
Study Focus: 30-day Rehospitalizations Among At-risk Older Adults Randomized to a Social Work-driven Care Transitions Intervention, Heart Disease
Social Work Intervention Focused on Transitions
In response to Program Announcement (PA)-09-164, "NIH Exploratory/Developmental Research Grant Program (R21) a randomized pilot study testing the efficacy of SWIFT: Social Work Intervention Focused on Transitions among at-risk…
- Conditions
- Study Focus: 30-day Rehospitalizations Among At-risk Older Adults Randomized to a Social Work-driven Care Transitions Intervention, Heart Disease, Diabetes, Hypertension
- Trial name
- SWIFT (NCT02232126)
- Testing
- SWIFT home intervention
- Where
- 2 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Anxiety, Depression
Probiotics and the Microbiome: Clinical Intervention Trial for Anxiety and Depression
The proposed project will investigate the effects of probiotics on anxiety and associated psychological and physiological factors in humans.
- Trial name
- NCT02035878
- Testing
- Probiotics
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Acadia University
Caregiver Distress
Reducing Distress in Phase 1 Trial Caregivers: The P1-CaLL Study
This study seeks to decrease distress in the lives of the caregivers who are helping cancer patients who have entered a phase 1 clinical trial.
- Trial name
- NCT03557515
- Testing
- Stress Management and CBT, Stress Management and Metta-Meditation
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Bipolar Disorder Depression, Major Depression
AI-based Multi-center Research on Identification/Classification/Aided Diagnosis of Mood Disorder
At present, diagnosis and recognition of depression and bipolar disorder are mainly based on subjective evidence such as clinical interview and scale evaluation.
- Trial name
- NCT05608135
- Where
- China
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
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