Clinical trials: Depressed
Major Depressive Disorder, Psychedelic Experiences
Antidepressant Response of DMT Masked With Propofol
The aim of this study is to elucidate if the anti-depressive effect of N,N-dimethyltryptamine (DMT) is based on a biological mechanisms including neuroplasticity and anti-inflammatory effect or due to the subjective psychedelic…
- Trial name
- DMT4D (NCT06927076)
- Testing
- N,N-Dimethyltryptamine, Propofol, no sedation
- Where
- Switzerland
- Volunteers
- 112 people
- Sponsor
- University Hospital, Basel, Switzerland
Sexual and Gender Minorities, Social Stigma
Examining the Health Effects of NPOWER365 Among Black Same Gender Loving Men
This research study aims to test the effectiveness, reach, and maintenance over time of the NPOWER365 HIV care intervention for Black men who have sex with men (BMSM) living with HIV.
- Conditions
- Sexual and Gender Minorities, Social Stigma, Medication Adherence, Depressive Symptoms
- Trial name
- NCT06315218
- Testing
- NPOWER365 HIV care intervention
- Volunteers
- 350 people
- Sponsor
- Rutgers, The State University of New Jersey
Depression
Nexalin Therapy for the Treatment of Depressive Symptoms
The primary objectives of this Phase II study are to demonstrate the safety of Nexalin Therapy and to investigate the efficacy of Nexalin Therapy.
- Trial name
- NCT00774813
- Testing
- Nexalin 1.3mA Device, Nexalin 15mA device
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- Kalaco Scientific, Inc.
Depressive Disorder, Major
Study Of The Effects Of A New Antidepressant Therapy In Patients With Major Depressive Disorder (MDD)
The purpose of this study is to assess the efficacy, safety and tolerability of GW679769 patients with Major depressive Disorder (MDD).
- Trial name
- NCT00413023
- Testing
- GW679769
- Where
- 39 sites in Argentina, Belgium and 9 more
- Volunteers
- 348 people
- Sponsor
- GlaxoSmithKline
Major Depressive Disorder
Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disorder
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Levomilnacipran ER versus placebo in the treatment of outpatients with major depressive disorder
- Trial name
- NCT01034462
- Testing
- Levomilnacipran ER
- Where
- 23 sites in United States
- Volunteers
- 442 people
- Sponsor
- Forest Laboratories
Substance Use Disorder
The Effectiveness of Mindfulness-based Relapse Prevention
This study developed a Mindfulness-based Relapse Prevention targeting craving. Based on the Randomized Controlled Trial design, 600 adult USD females and 600 adult USD males with methamphetamine, heroin, or ketamine in…
- Trial name
- NCT06739304
- Testing
- Mindfulness-based Relapse Prevention
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
COVID-19, Anxiety Syndrome
Prevalence and Risk Factors of Anxiety and Depression Among Policemen During the Health Crisis Linked to COVID-19
To date, there is little international data on depression and anxiety among police officers apart from studies carried out after an attack or natural disaster.
- Conditions
- COVID-19, Anxiety Syndrome, Depression Syndrome, Policemen
- Trial name
- Covid19-Police (NCT06076876)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Strasbourg, France
Menopause, Depression
Depression, Aging, Stress and Heart Health Study
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women.
- Conditions
- Menopause, Depression, Heart Disease in Women, Stress
- Trial name
- DASHH (NCT05570721)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression, Postpartum Depression
Cognitive-Behavioral Therapy (CBT) in Women Discontinuing Antidepressant for Pregnancy
The overarching goal of this study is to adapt a cognitive behavioral prevention of recurrence treatment (CBT-PR) for women with a history of recurrent major depressive disorder who decide to discontinue their maintenance…
- Conditions
- Depression, Postpartum Depression, Antenatal Depression
- Trial name
- NCT01453114
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Inflammatory Bowel Disease, Depression
Treatment of Depressed Adolescents With Physical Illness
The purpose of this study is a randomized trial of cognitive-behavioral intervention (CBI) for eligible adolescents who have Inflammatory Bowel Disease and subsyndromal depressive symptoms, but who did not meet diagnostic…
- Trial name
- NCT00446238
- Testing
- Cognitive Behavioral Therapy, Standard of Community Care Treatment
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Pittsburgh
Rheumatoid Arthritis, Depressive Symptoms
MBSR in Rheumatoid Arthritis Patients With Controlled Disease But Persistent Depressive Symptoms
Despite their efficacy at controlling joint inflammation, current treatments of rheumatoid arthritis (RA) leave up to 40% of patients into non-remission.
- Trial name
- PARIS-D (NCT03514355)
- Testing
- Mindfulness-Based Stress Reduction
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- Université de Sherbrooke
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) Activity: Serotonin Transporter (SERT), Cytokines and Depression (CASCADE Study)
The goal of the study is to look at how genes and certain chemicals in the body are related to depression and chronic obstructive pulmonary disease.
- Trial name
- CASCADE (NCT01074515)
- Where
- 4 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Washington
Resilience, Connectedness
This Study Explores the Mental Health Impact of Two Akashic Records Sessions.
The goal of this clinical study is to learn the impact of two Akashic Records sessions on mental health symptoms in adults. We want to see how sessions are linked to stress, anxiety, and depression, and to resilience (ability to…
- Conditions
- Resilience, Connectedness, Depression, Anxiety
- Trial name
- Akashic Record (NCT07219914)
- Testing
- Akashic Records Session
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Rasa Healing Inc
Major Depressive Disorder (MDD)
Study Of Bupropion SR (323U66) In Patients With Major Depressive Disorder In Japan
This is a study to obtain clinical experience of 323U66 SR for elderly patients with depression in repeat-dose of 323U66 SR up to 300mg/day, and to conduct exploratory investigation on safety, efficacy and pharmacokinetics…
- Trial name
- NCT00330616
- Testing
- 323U66 SR
- Where
- 9 sites in Japan
- Volunteers
- 35 people
- Sponsor
- GlaxoSmithKline
Depressive Symptoms, Anxiety
The Impact of PM+For Moms Intervention on Improving Mother's Mental Health in Zambia (PM+FM)
CMHD are particularly prevalent among women, posing a major threat to their own and their children's wellbeing. Despite the high prevalence of CMHD and the existence of effective treatments, interventions supporting women living…
- Conditions
- Depressive Symptoms, Anxiety, Trauma, Psychological
- Trial name
- PM+FM (NCT05627206)
- Testing
- Problem Management + For Moms
- Where
- Zambia
- Volunteers
- 270 people
- Sponsor
- Swiss Tropical & Public Health Institute
Psychological Distress
Well-Being Therapy by Personalized Mobile Technology Program for Psychological Distress and Promote Healthy Behaviors
The WELL-ME study is a three-arm randomized controlled clinical trial (RCT). The aim of this RCT is to compare the effectiveness of the Well Being Web Based Therapy (WBT-Web) with the gold standard CBT (Cognitive Behavior…
- Trial name
- WELL-ME (NCT01543815)
- Testing
- Well-Being Therapy based on Web Mobile Technology, Cognitive Behavior Therapy, Standardized Care Management
- Volunteers
- 400 people
- Sponsor
- University of Bergamo
Major Depressive Disorder
Study Evaluating DVS-233 in Adult Outpatients With Major Depressive Disorder
Primary: To compare the antidepressant efficacy and safety of subjects receiving DVS-233 SR versus subjects receiving placebo. Secondary: To assess the response of subjects receiving DVS-233 SR for the clinical global evaluation…
- Trial name
- NCT00063206
- Testing
- DVS-233 SR
- Volunteers
- 247 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Stress, Postpartum Depressive Disorder
Powerly - Science-based Digital Intervention Preventing Postpartum Depression and Anxiety
The goal of this clinical trial is to determine if the Powerly app can help prevent postpartum depression and anxiety in healthy pregnant women.
- Conditions
- Stress, Postpartum Depressive Disorder, Postpartum Anxiety
- Trial name
- POWERLY app (NCT06610552)
- Testing
- Powerly
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Marta Marciniak
Depression, Insomnia
Treatment of Insomnia and Depression in Elders (TIDE)
Insomnia and depression are two of the most prevalent mental health disorders and often co-occur. Health disparities in rural America and among African-Americans are well documented.
- Trial name
- TIDE (NCT01648049)
- Testing
- Integrated Cognitive Behavioral Therapy (CBT), Treatment as usual
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Alabama, Tuscaloosa
Self Harm, Suicidal Idealtion
Self Harm in Females of South Asian Family Origin
Aim of the study is to adapt and develop a culturally appropriate psychological intervention and to pilot test it's feasibility, and acceptability for the adult South Asian females presenting to general hospital emergency…
- Conditions
- Self Harm, Suicidal Idealtion, Hopelessness
- Trial name
- NCT00884078
- Testing
- Culturally adapted manualized problem solving training
- Where
- 3 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Lancashire Care NHS Foundation Trust
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