Clinical trials: Depressed
Mild to Moderate Depressive Symptoms
Effectiveness of Internet-based Depression Treatment
Care for people suffering from depressive symptoms should be given in a step-wise approach. One first step can be the provision of self-help material. Online self-help is an innovative way of providing self-help.
- Trial name
- EVIDENT (NCT01636752)
- Testing
- Deprexis
- Where
- 4 sites in Germany
- Volunteers
- 1,013 people
- Sponsor
- University of Luebeck
Obesity, Depression
GLP-1 Medicines and Mental Health Changes
Key question: Is the use of GLP-1 weight loss medicines - semaglutide and tirzepatide - associated with improvements in mental health and health-related quality of life? Key finding: Across six- months of GLP-1 treatment…
- Conditions
- Obesity, Depression, GLP-1
- Trial name
- NCT07368855
- Testing
- GLP-1
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Diego
Preterm, Infant, Premature, Diseases
The Effect of Lullaby and Breastmilk Smell on Preterm Newborns
The goal of this clinical trial is to investigate the effect of live lullaby from mother voice, and breast milk smell on pyhsiological parameters, comfort and maternal attachment levels of preterm newborns who are between 35-37…
- Conditions
- Preterm, Infant, Premature, Diseases, Postpartum Depression, Mother-Infant Interaction
- Trial name
- NCT05830955
- Testing
- Lullaby group, Breast milk group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Postpartum Depression
Online Peer-Delivered Group CBT for PPD
Mothers and birthing parents (hereafter referred to as mothers) who have recovered from Postpartum Depression and are well now, receive training to teach a 9 week Cognitive Behavioural Therapy (CBT) treatment to mothers who are…
- Trial name
- NCT05044455
- Testing
- Cognitive Behavioural Therapy (CBT)
- Where
- Canada
- Volunteers
- 191 people
- Sponsor
- McMaster University
Functionally-Impaired Elderly, Caregivers
Impact on Family or Care-givers of Very Old ICU-survivors, Trajectories and 6 Months' Outcome in the Very Old.
It is known from extensive documentation that second victims in critical illness often are the care givers of the patients: family, friends or other persons.
- Conditions
- Functionally-Impaired Elderly, Caregivers, PTSD, Depression, Anxiety
- Trial name
- VIP2 (NCT03138278)
- Testing
- Telephone support on demand
- Sponsor
- University of Bergen
Anxiety Disorders, Depression
The Study of Internet-delivered, Transdiagnostic Treatments for Anxiety and Depression
Anxiety and depression are common psychiatric disorders, resulting in suffering and impaired functioning for the individual. Today, most psychological treatments are disorder specific, even tough comorbidity between depression…
- Trial name
- TRAbee (NCT05016843)
- Testing
- Treatment condition: Internet-administered Unified protocol, Treatment condition: Internet-administered Affect phobia treatment, Treatment condition: Waitlist control
- Where
- Sweden
- Volunteers
- 2,477 people
- Sponsor
- Stockholm University
Depression
An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment Alternatives
The purpose of this expanded access program (EAP) is to provide expanded access to esketamine treatment and collect additional safety data and quality of life until esketamine is commercially available for participants with…
- Trial name
- NCT04476446
- Testing
- Esketamine
- Where
- 8 sites in Mexico
- Volunteers
- 41 people
- Sponsor
- Janssen-Cilag, S.A.
Depression, Bipolar
Olanzapine Treatment of Patients With Bipolar I Disorder
The purpose of this study is to assess whether olanzapine is superior to placebo in patients with bipolar depression.
- Trial name
- NCT00510146
- Testing
- Olanzapine
- Where
- 16 sites in China, Japan and 1 more
- Volunteers
- 514 people
- Sponsor
- Eli Lilly and Company
Support, Postpartum Period
Association of Spousal Support With Parenting Self-Confidence and Depression in Primipar Mothers
The transition to motherhood, particularly for first-time (primiparous) women, is a critical life period requiring substantial psychological and social adjustment.
- Conditions
- Support, Postpartum Period, Parenting
- Trial name
- NCT07376369
- Where
- Turkey (Türkiye)
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Major Depressive Disorder, Psychotic Disorders
An International Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress…
- Trial name
- NCT00128505
- Testing
- Mifepristone
- Where
- 19 sites in Bulgaria, Croatia and 2 more
- Volunteers
- 104 people
- Sponsor
- Corcept Therapeutics
Bipolar Disorder, Bipolar Depression
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression
The protocol involves functional Magnetic Resonance Imaging acquisitions immediately before and after Low Field Magnetic Stimulation treatment on two separate days in a sham controlled, randomized trial, in order to assess the…
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- LFMSBioMGeri (NCT03484494)
- Testing
- Low Field Magnetic Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mclean Hospital
Sarcopenia, Pediatric Cancer
Determination of Sarcopenia Risk and Related Factors in Pediatric Oncological Patients
In children, both malnutrition and sarcopenia are associated with prolongation of hospital stay, increased morbidity, mortality, and health-related complications.
- Trial name
- NCT05294380
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Trakya University
Psychological Distress, Quality of Life
The Effectiveness of Culturally Adapted Cognitive Behavioral Intervention Among COVID-19 Survivors
The effectiveness study for Culturally-Adapted Cognitive Behavioral Intervention (CA-CBI) will be conducted with individuals infected with and recovered from Coronavirus disease (COVID-19) to measure if this intervention is…
- Conditions
- Psychological Distress, Quality of Life, Depressive Symptoms, Anxiety
- Trial name
- NCT04949061
- Testing
- Culturally Adapted Cognitive Behavioral Intervention (CA-CBI), Enhanced Treatment as Usual (ETA-U)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Koç University
Blood Cancers, Leukemia
A Manualised Post-Traumatic Growth Intervention For People With Hematological Cancers In Greece
This clinical trial aims to determine whether a manualised group intervention for people with blood cancers can help them experience positive psychological changes following their diagnosis, known as post-traumatic growth.
- Conditions
- Blood Cancers, Leukemia, Lymphoma, Bone Marrow Transplant
- Trial name
- NCT07814170
- Testing
- A manualised post-traumatic growth intervention for people with hematological cancers
- Where
- 2 sites in Greece
- Volunteers
- 80 people
- Sponsor
- University of West Attica
Major Depressive Disorder
Long-Term Follow Up Study
The LTFU study will conduct a naturalistic follow up of the well characterized CAN-BIND study population of patients every six months and continuing over a five-year period.
- Trial name
- CAN-BIND LTFU (NCT02998762)
- Where
- 5 sites in Canada
- Volunteers
- 96 people
- Sponsor
- Sidney Kennedy
Depression in Old Age
Can Life's Wisdom Help Counter Depression? Evaluating the CBT Timeline Approach for Older Adults With Depression
This study aims to evaluate a specific psychological technique to help older adults with depression improve their mood and develop or utilise their 'wisdom' for managing their current difficulties.
- Trial name
- NCT04015505
- Testing
- Cognitive Behavioural Therapy for older adults: wisdom enhancement 'timeline technique'
- Where
- 2 sites in United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of East Anglia
Sleep Phase Rhythm Disturbance, Sleep Deprivation
Are Bright Lights and Regulated Sleep Effective Treatment for Depression?
Previous data suggest some depressed patients act as if their internal biological clock is out of sync with the outside world and re-aligning their clock with the timing of sunlight lessens their depressed mood and accompanying…
- Trial name
- NCT03010488
- Testing
- Morning Light Therapy, Assigned Sleep Times, Goggles
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- New York State Psychiatric Institute
Major Depression
Discontinuation Study Of Citalopram (Antidepressant) in Depressed Adolescents
The purpose of the study is to evaluate whether it is advantageous for adolescents who have recovered from depression after a 6 to 12 week course of antidepressant treatment to stay on the treatment a further 6 months or is it…
- Trial name
- NCT00249886
- Testing
- Citalopram
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Major Depression
Evaluation of the H-Coil Transcranial Magnetic Stimulation(TMS) Device- Augmentation for Drug Resistant Depression
There is a general consensus of efficacy of TMS in treatment of major depression,yet results are not satisfying.A new coil ("H"-coil, recently invented in Weizmann Institute of Science, Neurobiology Department, Rehovot, Israel)…
- Trial name
- NCT00577070
- Testing
- TMS
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- BeerYaakov Mental Health Center
Perinatal Anxiety, Perinatal Depression
Pathways to Perinatal Mental Health Equity
Mental health conditions occurring during pregnancy and up to one year postpartum (the perinatal period) occur in 1 in 5 perinatal individuals.
- Conditions
- Perinatal Anxiety, Perinatal Depression, Social Determinants of Health (SDOH), Peer Support
- Trial name
- Pathways (NCT06790641)
- Testing
- Program in Support of Moms (PRISM), PSI Peer Support
- Where
- United States
- Volunteers
- 1,270 people
- Sponsor
- University of Massachusetts, Worcester
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