Clinical trials: Depressed
Depression, Information Dissemination
Community Partners in Care is a Research Project Funded by the National Institutes of Health
CPIC is a community initiative and research study funded by the NIH. CPIC was developed and is being run by community and academic partners in Los Angeles underserved communities of color.
- Conditions
- Depression, Information Dissemination, Social Determinants of Health
- Trial name
- CPIC (NCT01699789)
- Testing
- Quality Improvement Program, Resources for Services Expert Team, Community Engagement and Planning Council
- Where
- United States
- Volunteers
- 1,246 people
- Sponsor
- RAND
Critical Illness, Chronic Disease
Improving Communication About Serious Illness
The purpose of this study is to improve care delivered to patients with serious illness by enhancing communication among patients, families, and clinicians in the outpatient setting.
- Conditions
- Critical Illness, Chronic Disease, Terminal Care, Palliative Care
- Trial name
- ICSI (NCT01933789)
- Testing
- Communication Feedback Form for Patients with Serious Illness
- Where
- 6 sites in United States
- Volunteers
- 817 people
- Sponsor
- University of Washington
Alcohol Use Disorder, Depression
Zambia Common Elements Treatment Approach Pilot Study
This is a randomized controlled trial (RCT) evaluating the effectiveness of an alcohol brief intervention alone compared to the brief intervention plus an evidence-based psychotherapy (CETA) in reducing alcohol misuse and…
- Conditions
- Alcohol Use Disorder, Depression, Post-traumatic Stress Disorder, HIV/AIDS
- Trial name
- ZCAP (NCT03966885)
- Testing
- Brief Intervention, Common Elements Treatment Approach (CETA)
- Where
- Zambia
- Volunteers
- 160 people
- Sponsor
- Columbia University
Depression
Imaging the Nucleus Accumbens in Major Depressed Patients 'Treated With Pramipexole
We hope to learn how a brain circuit that is important to the understanding of depression, anhedonia and positive affect responds to a novel pharmaceutical treatment for depression and related symptoms.
- Trial name
- NCT01066897
- Testing
- Pramipexole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depression
African American Knowledge Optimized for Mindfully Healthy Adolescents
The purpose of this study was to better understand how African American families identify and treat emotional and behavioral concerns associated with depression in their adolescent youth.
- Trial name
- AAKOMA (NCT00578318)
- Testing
- Motivational Interviewing Active
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Georgetown University
Depression, Anhedonia
DTA (Dopaminergic Therapy for Anhedonia) Study
The purpose of this 6-week, double-blind, placebo-controlled, crossover study is to explore new treatment options for people with depression who have high inflammation and anhedonia.
- Trial name
- NCT04723147
- Testing
- Carbidopa Levodopa
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Emory University
Anxiety Depression
Guided Group Telehealth to Deliver Evidence-based Therapeutic Care to Black College Students
The goal of this study is to address the mental health crisis among college students by creating a promising solution for group teletherapy, which is equivalent to individual teletherapy in terms of treatment outcomes.The main…
- Trial name
- NCT07237217
- Testing
- Cognitive Behavioral Therapy (CBT) Coping Skills Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. Veronica Tetterton
Major Depressive Disorder
Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females
The investigators propose to determine if 8 weeks of dietary augmentation with oral 5g creatine monohydrate daily and 100 mg of 5-hydroxytryptophan (5-HTP) twice daily reduces hypoxia-related depressive symptoms measured by the…
- Trial name
- NCT02922725
- Testing
- 5-hydroxytryptophan and Creatine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brent Michael Kious, MD, PhD
Pregnancy
The Effect of a Father Inclusive Psychoeducation Program on Postnatal Depression
Study hypothesis: Childbearing couples who receive the father inclusive psychoeducation program will have: (a) a lower level of depressive symptoms, (b) a higher level of marital relationship, and (c) a higher level of quality of…
- Trial name
- NCT02010840
- Testing
- Psychoeducation program
- Where
- Hong Kong
- Volunteers
- 388 people
- Sponsor
- The University of Hong Kong
Hot Flushes, Night Sweats
Progesterone for Perimenopausal Night Sweats
The purpose of this study is to test whether a oral micronized progesterone reduces the Vasomotor Symptom Score comprised of the number and severity of hot flushes and night sweats in perimenopausal women.
- Trial name
- NCT01464697
- Testing
- Oral micronized progesterone
- Where
- Canada
- Volunteers
- 249 people
- Sponsor
- University of British Columbia
Major Depressive Disorder (MDD), History of Childhood Sexual Abuse (CSA)
An Investigation of Early Life Stress and Depression
The purpose of this study is to investigate brain pathways within adult females (with a history of CSA that occurred between the ages of 5-14) with and without a current diagnosis of major depressive disorder (MDD).
- Trial name
- NCT01701258
- Testing
- Amisulpride
- Where
- 2 sites in United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Treatment Resistant Depression
A Study of Olanzapine and Fluoxetine for Treatment-resistant Depression
The purpose of this study is to assess the efficacy and safety of olanzapine and fluoxetine compared to placebo and fluoxetine as treatment for treatment-resistant depression (TRD) in Chinese participants.
- Trial name
- NCT01687478
- Testing
- Olanzapine, Fluoxetine
- Where
- 11 sites in China
- Volunteers
- 176 people
- Sponsor
- Eli Lilly and Company
Depression, Anxiety
Mental Health Assessment Project on the Thailand-Burma Border
The aim of the study is to determine the effectiveness of a transdiagnostic psychotherapy intervention - namely, Common Elements Treatment Approach (CETA) - in reducing the severity of mental health symptoms experienced by…
- Conditions
- Depression, Anxiety, Posttraumatic Stress
- Trial name
- MHAP (NCT01459068)
- Testing
- Common Elements Treatment Approach
- Where
- Thailand
- Volunteers
- 347 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Depressive Disorder
A Randomised, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder
This is a 6-week, randomised, multicenter, double-blind, placebo controlled, fixed dose parallel group study to assess the efficacy and safety of orvepitant (30 and 60 mg/day) versus placebo in subjects with a diagnosis of a…
- Trial name
- Orvepitant MDD (NCT00880048)
- Testing
- orvepitant
- Where
- 32 sites in United States, Canada
- Volunteers
- 343 people
- Sponsor
- GlaxoSmithKline
Bipolar Depression
Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar Depression
The investigators propose to study and compare measures of brain energy metabolism in geriatric bipolar individuals and healthy older adults.
- Trial name
- NCT01390389
- Testing
- Coenzyme Q10
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depressive Disorder, Insomnia
Combining Antidepressant Medication and Psychotherapy for Insomnia to Improve Depression Outcome
This study will examine the effectiveness of a combination of antidepressant medication and sleep-focused psychotherapy to simultaneously treat sleep difficulties and depression.
- Trial name
- NCT00149825
- Testing
- Escitalopram, CBTI, CTRL
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Depression
fMRI Studies of Emotional Brain Circuitry in People With Major Depression
This study will examine activation of a brain circuit that regulates emotion in depressed patients before and after treatment to see which areas of the brain are involved in chronic depression.
- Trial name
- NCT00749125
- Testing
- Lexapro
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder
The Safety and Efficacy of Escitalopram in Pediatric Patients With Major Depressive Disorder
Depression affects approximately 2.5% of children and 8% of adolescents. Escitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are selective serotonin reuptake inhibitors (SSRIs) and are used to treat…
- Trial name
- NCT00107120
- Testing
- Escitalopram
- Where
- 28 sites in United States
- Volunteers
- 312 people
- Sponsor
- Forest Laboratories
Depression, Problematic Alcohol Use
Scaling Up Science-based Mental Health Interventions in Latin America
Conduct systematic, multi-site mental health implementation research in both rural and urban primary care settings with a broad group of stakeholders in the US and Latin America.
- Trial name
- DIADA (NCT03392883)
- Testing
- Laddr
- Where
- 6 sites in Colombia
- Volunteers
- 1,348 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Bipolar Depression
Bipolar Depression Before and After Lamotrigine Treatment
This study compared glutamate and other neurometabolites measured by proton magnetic resonance spectroscopy (1H-MRS) in bipolar I and II patients currently depressed with age-matched healthy controls.
- Trial name
- 1HMRS-BP (NCT01042496)
- Testing
- Lamotrigine, 1H-MR
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.