Clinical trials: Depressed
Depression, Treatment Resistant
rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression
The goal of this clinical trial is to learn if Transcranial Magnetic Stimulation (TMS) to part of the brain called the ventromedial prefrontal cortex (VMPFC) can treat a symptom called rumination in adults with major depression…
- Trial name
- NCT06511544
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Depression, Anxiety
Consultation-Liaison Intervention for Patients with Depression and Anxiety in Primary Care
The CoLiPri study is a cluster randomized controlled trial funded by the Swiss National Science Foundation to evaluate the clinical and cost effectiveness as well as the implementation of a complex consultation-liaison…
- Trial name
- CoLiPri (NCT04233853)
- Testing
- CoLiPri intervention, Usual primary care enhanced
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- University of Zurich
PTSD - Post Traumatic Stress Disorder, Depression
Effects of EMDR on Psychological Symptoms and EEG Findings in Trauma-Exposed Individuals
This study will examine the effects of Eye Movement Desensitization and Reprocessing (EMDR) group therapy on adults who experienced the April 2025 Silivri earthquake in Turkey.
- Conditions
- PTSD - Post Traumatic Stress Disorder, Depression, Anxiety Disorders and Symptoms, Sleep Quality
- Trial name
- NCT07206381
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR) Group Therapy
- Volunteers
- 40 people
- Sponsor
- Istanbul Galata University
Diabetes Mellitus, Type 1
Telemedicine Program in Type 1 Diabetes and CSII
Diabetes mellitus is a chronic disease of high socio-health relevance for their clinical and economic implications (risk of complications, disability ...) (healthcare costs).
- Trial name
- NCT02790645
- Testing
- Group 2a. Telemedicine program, Group 1a. Control, Group 1b.Telemedicine program
- Volunteers
- 51 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Diabetes Mellitus, Type 2
Perceived Stress and Negative Thoughts With Biomarkers in People With Type 2 Diabetes Mellitus and Healthy Subjects
The purpose of this study is to determine the effect of measured and induced negative feelings on glucose, tumor necrosis factor alpha, and cortisol levels in healthy participants and participants with type 2 diabetes mellitus.
- Trial name
- NCT04387045
- Testing
- Guilty feelings
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Francisco Carlos López Marquez
Major Depressive Disorder (MDD)
A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major Depression
The goal of this clinical trial is to explore if the treatment with ketamine tablets in addition to standard antidepressant therapy can reduce depressive symptoms in adults with Major Depressive Disorder.
- Trial name
- KET01-IIT03 (NCT07396272)
- Testing
- Treatment with Ketamine Hydrochloride Prolonged-Release Tablets
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Daniel Lindqvist
Pregnant Women
The Effect of Self-Compassion Based Birth Preparation Program
The pregnancy period, during which physiological, psychological and social changes occur, can negatively affect women mentally. It is stated that women's concerns about their own and their baby's health, anxiety and fear…
- Trial name
- NCT07187557
- Testing
- A self-compassion based birth preparation program
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ordu University
Unipolar Depression
Effect of Tao Calligraphy Meditation and Energized Water on Depression
The goal of this controlled randomized clinical study is to learn if a Tao Calligraphy Mindfulness and Energized water Practice works to improve Unipolar Depression.
- Trial name
- NCT06934330
- Testing
- Mindfulness practice with Tao Art (Calligraphy and Song Greatest Love), Drinking Energized water
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sha Research Foundation
Treatment Resistant Depression
Exercise in Treatment Resistant Depression (TRD): A Feasibility Study
The objective of this study is to determine the effects of adjunct exercise in treatment resistant depression. The central hypothesis for the research is that adjunct exercise with usual care in Treatment Resistant Depression…
- Trial name
- NCT01383811
- Testing
- Moderate Intensity Aerobic Exercise, Wait-list
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Milton S. Hershey Medical Center
Human Immunodeficiency Virus, Neurocognitive Impairment
Brain Imaging for HIV-Associated Thinking and Mood Disorders
Background: Human immunodeficiency virus (HIV) infection appears to cause problems with blood vessel function. These problems may add to some thinking and mood disorders found in people with HIV infection.
- Trial name
- NCT01692236
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Depressive Symptoms
Investigating the Effect of a Smartphone-based Serious Game on Depressive Symptoms.
The objective of the present project is to study the effect of a smartphone-based serious game intervention for depressive symptoms.
- Trial name
- NCT04988529
- Testing
- Smartphone-based serious game intervention
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universitat Jaume I
Angina, Stable
Effectiveness of Inspiratory Muscle Training in Patient With Stable Angina
Stable angina is a cardiac pathology that adversely affects the quality of life of the patient, which develops as a result of narrowing of the coronary vessels developing in atherosclerotic ground and / or impaired oxygen…
- Trial name
- NCT03923153
- Testing
- Inspiratory muscle training with PowerBreathe (IMT Technologies Ltd., Birmingham,England)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Mustafa Kemal University
Depression, Adolescent Behavior
Adolescent Depression Screening and Treatment in Mozambican Primary Care
This is a cluster-randomized pilot trial of depression screening and treatment implementation at four Youth-friendly Health Services (YFHS) in primary care clinics, two in Maputo City and two in Maputo Province.
- Trial name
- NCT05476237
- Testing
- Group Interpersonal Therapy for Adolescents (IPT-AG), Treatment as Usual (TAU)
- Where
- 4 sites in Mozambique
- Volunteers
- 95 people
- Sponsor
- Columbia University
Elderly Depression, Sleep Disturbance
Wearable-Based Study of Depression and Sleep in Older Adults
This 4-year study aims to develop a safe and effective management model for late-life depression using wearable technologies. The research will recruit older adults (aged 60 and above) with major depressive disorder, confirmed by…
- Trial name
- NCT07232472
- Testing
- Photobiomodulation
- Where
- United Kingdom
- Volunteers
- 162 people
- Sponsor
- China Medical University Hospital
Depressive Disorder, Major
Pharmacogenetics Informed Tricyclic Antidepressant Dosing (PITA)
Tricyclic Antidepressants (TCA's) are the cornerstone of treatment for patients with severe Major Depressive Disorder (sMDD). Current dosing is guided by repeated measurements of blood levels.
- Trial name
- PITA (NCT03548675)
- Testing
- TCA treatment
- Where
- Netherlands
- Volunteers
- 125 people
- Sponsor
- Radboud University Medical Center
Prader-Willi Syndrome
Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation
The goal of this study is to help teens with Prader-Willi Syndrome (PWS) and their families learn practical strategies for managing issues like irritability, meltdowns, and anxiety.
- Trial name
- RT-PWS (NCT07607730)
- Testing
- Regulating Together group therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Mercy Hospital Kansas City
Major Depressive Disorder
Group CBT and Exercise in Management of Depression
INTRODUCTION: There is strong evidence indicating the effectiveness of Cognitive-Behavior Therapy (CBT) in the management of Major Depressive Disorder (MDD) and some clinical trials indicating physical exercise (PE) as an…
- Trial name
- NCT03731728
- Testing
- Group CBT, Group exercise
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Depression
Short-term Existential Behavioural Therapy for Informal Caregivers of Palliative Patients: a Randomised Controlled Trial
The purpose of the study is to test the effectiveness of a short-term manualised individual psychotherapy, called Existential Behavioural Therapy (EBT), to prevent depression in informal caregivers of palliative patients.
- Trial name
- NCT02325167
- Testing
- EBT, treatment-as-usual
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Suicide, Suicide Threat
Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department
Current treatment for acutely suicidal patients are limited to hospitalization, psychotherapy, electro-convulsant therapy, or a combination of the aforementioned. However, this has added to the national boarding problem.
- Conditions
- Suicide, Suicide Threat, Depression Severe
- Trial name
- NCT04260607
- Testing
- Ketamine Hydrochloride, Normal saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Naval Medical Center Camp Lejeune
Depression, Adolescent Development
Thoughts and Health - Preventing Depression in Adolescents
This study aims to test the feasibility of implementing an Icelandic cognitive-behavioral program designed to prevent depression, called "Thoughts and Health" in a Swedish school setting.
- Conditions
- Depression, Adolescent Development, Mental Disorder, Child
- Trial name
- NCT04128644
- Testing
- Thoughts & health, Treatment as Usual
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
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