Clinical trials: Depressed
Major Depressive Disorder
High Dose Accelerated iTBS for Depression
This trial will compare active intermittent theta burst stimulation (iTBS) rTMS in an accelerated treatment schedule (8 treatment sessions per day for 5 days) to a placebo control.
- Trial name
- NCT04255784
- Testing
- Active iTBS
- Where
- 2 sites in Canada
- Volunteers
- 228 people
- Sponsor
- Centre for Addiction and Mental Health
Dementia, Depression
Geriatric Psychiatry and Pharmacovigilance
The purpose of this observational multicenter-study is to investigate safety of psychopharmacological treatment and rates of adverse drug reactions in gerontopsychiatric inpatients.
- Conditions
- Dementia, Depression, Schizophrenia, Psychosomatic Disorders
- Trial name
- GAP (NCT01858857)
- Where
- 5 sites in Germany
- Volunteers
- 4,000 people
- Sponsor
- Hannover Medical School
Acute Coronary Syndrome, Heart Failure
International CR Registry
The ICRR is a health services registry to establish the quality of CR delivery, and the effectiveness in terms of patient outcomes, in low-resource settings.
- Conditions
- Acute Coronary Syndrome, Heart Failure, Coronary Artery Disease
- Trial name
- ICRR (NCT04676100)
- Testing
- Cardiac rehabilitation
- Where
- Qatar
- Volunteers
- 7,000 people
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder, Severe Depressive Episode Without Psychotic Symptoms
The Friendship Bench Plus Trial
The goal of this randomised controlled trial is to enhance the Friendship Bench intervention with antidepressants in adults with moderate to severe depression. The main questions it aims to answer are: 1.
- Trial name
- NCT06384209
- Testing
- Fluoxetine, Sertraline Pill, Friendship Bench Intervention- Problem Solving Therapy
- Where
- Zimbabwe
- Volunteers
- 296 people
- Sponsor
- University of Bern
Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive Perturbations, Perimenopause
Probiotic Intake and Perimenopausal Psychological Assessments
Recent evidence suggests multi-strain probiotics containing Lactobacillus rhamnosus and Bifidobacterium longum have been found to enhance emotional processing and reduce salience to negative cues in studies involving people with…
- Conditions
- Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive Perturbations, Perimenopause, Perimenopause-Related Depression, Perimenopausal Women
- Trial name
- PIPPA (NCT07590999)
- Testing
- Multi-strain probiotic
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- University of Oxford
Postpartum Depression, Postpartum Anxiety
Virtual Group Psychoeducational Discussions With Spanish-Speaking Mothers of Infants in Pediatric Primary Care
The goal of the proposed research is to test the feasibility and acceptability of a virtual group session which is intended to be offered universally to Spanish-speaking parents of newborns/infants attending pediatric primary…
- Trial name
- NCT05423093
- Testing
- Single-Session Virtual Group Psychoeducational Session about Postpartum Depression
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Major Depressive Disorder
A 6-Month Open-Label Extension Study to the B2061014 Study to Evaluate the Safety, Tolerability and Efficacy of DVS SR in the Treatment of Children and Adolescents With MDD
This is a 6-month, open-label, flexible-dose study evaluating desvenlafaxine succinate sustained release (DVS SR) in the treatment of child and adolescent outpatients with major depressive disorder (MDD).
- Trial name
- NCT01371721
- Testing
- DVS SR
- Where
- 35 sites in United States, Mexico
- Volunteers
- 269 people
- Sponsor
- Pfizer
Postpartum Depression
Evaluate SAGE-547 in Female Participants With Severe Postpartum Depression
This is an open-label proof-of-concept study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of SAGE-547 Injection in adult female participants diagnosed with severe postpartum depression (PPD).
- Trial name
- NCT02285504
- Testing
- SAGE-547
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Depression
Development of a Targeted Patient Portal Intervention to Improve Depression Treatment Adherence and Outcomes
The purpose of this research study is to learn how best to use patient portals to help improve the treatment of mood disorders.
- Trial name
- Patient Portal (NCT04646681)
- Testing
- ConnectCare
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Carolyn L Turvey
Major Depressive Disorder, Treatment-Resistant Depression
Adjuvant Accelerated piTBS for Reducing Suicidal Ideation in TRD Patients
In this double-blind, randomized, sham-controlled trial, the investigators aimed to examine the effect of accelerated piTBS on suicide risk in a group of treatment-resistant patients with MDD (i.e., TRD), using an extensive…
- Conditions
- Major Depressive Disorder, Treatment-Resistant Depression, Suicide Ideations
- Trial name
- NCT06372834
- Testing
- piTBS being delivered using the Magstim Rapid2 stimulator
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Depression, Depression/Anxiety
START NOW Adapted: Culturally Adapted Version of START NOW
The goal of this clinical trial is to test the effectiveness of the culturally adapted skills-training START NOW in youth migrant populations.
- Conditions
- Depression, Depression/Anxiety, Anxiety, Adolescent
- Trial name
- NCT06324864
- Testing
- START NOW Adapted
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Prof. Christina Stadler
Perinatal Depression, Stepped Care
A Randomized Controlled Trial of the "Psychological Training Camp & Obstetrician-Led Psychoprenatal Intervention (PICONI)" Stepwise Intervention Model for Depression and Anxiety During Pregnancy.
In this study, pregnant women were screened and managed for depression and anxiety in three time windows: early pregnancy, mid-pregnancy, and late pregnancy.
- Conditions
- Perinatal Depression, Stepped Care, Perinatal Anxiety
- Trial name
- NCT06383221
- Testing
- "Mental Fitness Boot Camp - Advanced Counseling" Step-by-Step Care
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Depression
PACEPro - Mood Management Pilot
Researchers at the University of California at San Diego (UCSD) are conducting a 12-week study to test the PACEPRO program. This program is designed to reduce depression by providing: Lexapro, an antidepressant medicine…Learn…
- Trial name
- NCT00416221
- Testing
- Lexapro, an antidepressant medicine, Physical Activity, Mood Management Skills
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Depression
Outreach to Reduce Depression Disparities
Previous research by Mental Health Research Network (MHRN) investigators and others demonstrates that online messaging and other telehealth technologies can effectively and efficiently address premature discontinuation of…
- Trial name
- NCT05580406
- Testing
- Outreach messaging
- Where
- 2 sites in United States
- Volunteers
- 309 people
- Sponsor
- Kaiser Permanente
Psychosis, Substance Abuse
Effect Evaluation of Individual Placement and Support (IPS)
Roughly one third of disability pensions issued in Norway are classified as mental and behavioral disorders. The proposed study aims to evaluate the effect of an innovative intervention for returning people with moderate to…
- Conditions
- Psychosis, Substance Abuse, Depression, Anxiety
- Trial name
- NCT01964092
- Testing
- Individual Placement and Support, Ordinary employment schemes
- Where
- Norway
- Volunteers
- 410 people
- Sponsor
- NORCE Norwegian Research Centre AS
Depression and Quality of Life
ICBT for Mental Health Problems Related to the Climate Crisis
The study seeks to investigate the effects of a guided internet-based cognitive behavioral therapy (ICBT) programme on adult mental health problems related to the climate crisis.
- Trial name
- NCT05169736
- Testing
- Cognitive Behavioural Therapy
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Linkoeping University
Depression
An 8-week, Open-label Study to Evaluate the Effect of Sertraline on Polysomnogram in Depressive Patients With Insomnia
Major depressive disorder is associated with several sleep Polysomnograph (PSG) findings: (1) impaired sleep continuity; (2) non-REM (NREM) changes; and (3) enhanced rapid eye movement (REM) sleep.
- Trial name
- NCT01032434
- Testing
- sertraline
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Guang Dong Provincial Mental Health Institute
Major Depressive Disorder, Unipolar Depression
RTMS Feasibility Study on Adolescent Depression Stimulation
This is an open-label study, in which all participants receives an active treatment with repetitive transcranial magnetic stimulation (rTMS) according to clinical protocol.
- Conditions
- Major Depressive Disorder, Unipolar Depression, Bipolar Depression
- Trial name
- NCT06126198
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Depression and Anxiety Symptoms
Remote Group Cognitive Behavioral Skills Training for Mexican University Students With Anxiety or Depression
The aim is to assess the effectiveness of remote group cognitive behavioral skills training for reducing symptoms of depression and anxiety among university students in Mexico.
- Trial name
- NCT07776236
- Testing
- Remote group cognitive behavioral skills training, Mood monitoring web application
- Volunteers
- 400 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Major Depressive Disorder, Healthy
Sleep Modulation to Treat Depression
Current first-line treatments for major depression (antidepressants and psychotherapy) show a long latency to response, and less than half of all patients experience full remission with optimized treatment, indicating the need…
- Trial name
- NCT06443216
- Testing
- Auditory closed-loop stimulation
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Christoph Nissen
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