Clinical trials: Depressed
Major Depressive Disorder
Comparison of Anodal Transcranial Direct Current Stimulation (t-DCS) and Sham Stimulation in Patients With Treatment-resistant Depression
Major depressive disorder (MDD) is a significant public health problem. Existing treatment modalities are not always sufficient to alleviate this disorder. Treatment refractoriness is a common clinical problem.
- Trial name
- NCT02141776
- Testing
- Transcranial direct current stimulation (t-DCS)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Bipolar Depression
RU-486 in the Treatment of Bipolar Depression
Bipolar disorder is a chronic and recurrent illness which involves episodes of mania and depression. It is believed that disturbance of the stress hormone system (the hypothalamic-pituitary-adrenal or HPA axis) may cause thinking…
- Trial name
- NCT00359125
- Testing
- mifepristone (RU-486)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of British Columbia
Insomnia, Depression - Major Depressive Disorder
Enhancing Operational Readiness With Digital Self-Managed Cognitive Behavioral Therapy for Insomnia (CBTI)
The goal of this pilot clinical trial is to evaluate the effectiveness and delivery method of a CBTI self-managed digital mobile application in service members. The main questions it aims to answer are: RQ1.
- Conditions
- Insomnia, Depression - Major Depressive Disorder, PTSD
- Trial name
- NCT07335276
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Volunteers
- 144 people
- Sponsor
- Madigan Army Medical Center
Depression
The Impact of Disclosing Personalized Depression Risk Information on High-risk Individuals' Outcomes
Major depressive episode (MDE) is one of the most prevalent and disabling form of mental illness in the general population. Despite increased mental health services and antidepressants use in the past 10 years, there has been no…
- Trial name
- NCT02943876
- Testing
- personalized depression risk information
- Where
- 2 sites in Canada
- Volunteers
- 712 people
- Sponsor
- University of Calgary
Esketamine, ECT
Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study
The study design was a randomized, double blind, parallel controlled trial.The goal of this clinical trial is to learn if esketamine-assisted modified electroconvulsive therapy (ESK-MECT) works to treat severe depression in…
- Conditions
- Esketamine, ECT, Depression, Adolescent
- Trial name
- NCT07247968
- Testing
- Esketamine injection group (0.25 mg/kg), Saline injection group (Consistent with esketamine injection volume)
- Where
- 2 sites in China
- Volunteers
- 220 people
- Sponsor
- Min Su
HIV Infections, Depression
Cognitive Behavioral Therapy Combined With Antidepressants to Reduce HIV Risk and Drug Relapse Among Depressed Intravenous Drug Users
This study will evaluate the effectiveness of combining cognitive behavioral therapy (CBT) and antidepressants in reducing HIV risk behavior and drug relapse rates in depressed intravenous drug users.
- Conditions
- HIV Infections, Depression, Substance-Related Disorders
- Trial name
- NCT00183768
- Testing
- Cognitive Behavioral Therapy, Psychopharmacology
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Butler Hospital
Depression
Role of Self-focused Attention in Depression
Using a task measuring the tracking of eye movements, the aim of this study is to demonstrate that individuals suffering from depression focus their attention more on their reflection in the screen after recalling a failure (and…
- Trial name
- RFASD (NCT05464550)
- Testing
- Eye tracker
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Henri Laborit
Depression, Medication Adherence
Cognitive Behavioral Therapy on Adherence and Depression (CBT-AD) Among HIV/AIDS Patients
Depression is highly comorbid with HIV/ AIDS and is associated with worse poor adherence to antiretroviral therapy (ART), and potentially to long-term immune functioning. Cognitive behavioral therapy may solve these problem.
- Trial name
- NCT06109610
- Testing
- Cognitive Behavioral Therapy
- Where
- Ethiopia
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Mattu University
Depression, Anhedonia
Multimodal Differences in Effort-based Decision-Making in Depression
Major depressive disorder (MDD) is a serious condition that causes long-term symptoms such as feeling sad, losing interest in activities, and having thoughts of self-harm.
- Trial name
- BBQS (NCT06648460)
- Testing
- Effort-based Decision-Making Task
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Depression
Clinical Pharmacogenomics of Antidepressant Response
The purpose of this study is to understand how genetic polymorphisms influence the efficacy and side effect profiles of Paroxetine and Escitalopram for major depression treatment.
- Trial name
- NCT00384020
- Testing
- Paroxetine (Seroxat), Escitalopram (Lexapro)
- Where
- 4 sites in Taiwan
- Volunteers
- 402 people
- Sponsor
- National Health Research Institutes, Taiwan
Postnatal Depression
Behavioural Activation (BA) for Postnatal Depression in Blackpool
Is Behavioural Activation feasible, acceptable and potentially effective for mothers experiencing post natal depression in Blackpool? Phase 1: A series of single case studies which aim to examine and refine a) the appropriateness…
- Trial name
- BA (NCT04183582)
- Testing
- Behavioural Activation
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- National Society for the Prevention of Cruelty to Children
Stroke Sequelae, Cognitive Impairment
Remote Bimanual Virtual Rehabilitation Post CVD
The aim of the study is to develop the BrightBrainer G (grasp), a game-based upper-extremity motor and cognitive rehabilitation system using custom virtual reality simulations.
- Conditions
- Stroke Sequelae, Cognitive Impairment, Depression
- Trial name
- NCT04713384
- Testing
- Integrative tele-rehalitation of chronic stroke survivors using custom therapeutic games
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Grigore Burdea
Depressive Episode
Characterisation of Fundamental Decision Making in People Suffering From a Characterised Depressive Episode
The investigators will include patients suffering from Major Depressive Disorder (MDD), in episode. The patients will undertake neuropsychological tasks evaluating executive function and clinical assessment related to depressive…
- Trial name
- MINDDE (NCT05654948)
- Testing
- computerised cognitive performance test : MindPulse
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Tours
Apical Periodontitis, Anxiety
Apical Periodontitis and Mental Health
This study is investigating the relationship between anxiety, depression and apical periodontitis (AP), a common oral inflammatory condition.
- Conditions
- Apical Periodontitis, Anxiety, Depression
- Trial name
- NCT06589076
- Testing
- Clinical and Radiographic assessment + Questionnaires
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Siena
Fatigue, Sleep Deprivation
Effect and Utilization of Protected Time Among Interns on Extended Duty-Hour Call Shifts
This study will test the feasibility and effectiveness of protected time for physicians in training during 30 hour shifts in a medical intensive care unit. The primary outcome will be fatigue.
- Conditions
- Fatigue, Sleep Deprivation, Depression
- Trial name
- NCT00983008
- Testing
- Protected time and Dedicated time
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Providence Health & Services
Cancer, Depression
Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE
To test the efficacy of a web-based stepped collaborative care intervention to reduce symptoms of depression, pain, and fatigue and improve health-related quality of life (HRQL) in advanced cancer patients and to reduce stress…
- Conditions
- Cancer, Depression, Fatigue, Pain
- Trial name
- CARES-Lite (NCT05601206)
- Testing
- Stepped collaborative care intervention, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Inflammation, Psychosocial Functioning
Mindfulness Meditation Neuroimaging Study for Undergraduates
This study is designed to test the effectiveness of mindfulness meditation intervention classes on psychosocial health outcomes.
- Conditions
- Inflammation, Psychosocial Functioning, Depression, Anxiety
- Trial name
- NCT05304052
- Testing
- Mindfulness Meditation classes
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Respiratory Depression
Postoperative Respiratory Monitoring After Neuraxial Opioid Administration for Cesarean Delivery
Respiratory depression occurs in labor and delivery; noticeably when neuraxial opioids are given.Pathophysiological respiratory depression -failure to respond to hypercapnia or hypoxia - is challenging to measure…
- Trial name
- NCT02417038
- Testing
- Capnostream
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depression, Anxiety
Digital Cognitive Behavioral Therapy for Depressive Disorders
This study aims to explore the effectiveness of digital interventions combined with medication in the treatment of patients with depressive disorders.
- Trial name
- NCT06423443
- Testing
- Digital Cognitive Behavioral Therapy, Health Education, TAU
- Sponsor
- Adai Technology (Beijing) Co., Ltd.
Depression Anxiety Disorder, Geriatric Diseases
A Tripartite Biopsychosocial Intervention Program Enhances Mental Health and Quality of Life in Elderly Patients With Depression Secondary to Geriatric Diseases
The biopsychosocial integrated intervention program is an effective model for improving holistic health in elderly patients with geriatric disease-related secondary depression, significantly alleviating depressive symptoms…
- Conditions
- Depression Anxiety Disorder, Geriatric Diseases, Mental Health and Quality of Life in Elderly Patients
- Trial name
- NCT07002385
- Testing
- control group, Intervention group
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Wenzhou Seventh People's Hospital
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