Clinical trials: Depressed Mood
Major Depressive Disorder
Changes in Cerebral Glucose Metabolism After Electroconvulsive Therapy (ECT)
There exist already a few studies that have measured changes of brain metabolism pre and post Electroconvulsive Therapy (ECT) by Positron emission tomography (PET) but these were all performed in a small number of patients and…
- Trial name
- NCT01514435
- Testing
- Electroconvulsive therapy, 18-Fluoro-desoxy-glucose positron emission tomography
- Where
- Austria
- Volunteers
- 13 people
- Sponsor
- Medical University of Graz
Major Depressive Disorder
VR-Moodboost; an Innovative Virtual Reality Treatment for Adolescents With Depression
Major depressive disorder (MDD) is a prevalent and disabling mental health condition. A recent meta-analysis shows that across all forms of psychotherapy, only 43% of all depressive patients fully recover from MDD and relapse…
- Trial name
- VR-Moodboost (NCT05486676)
- Testing
- VR-Moodboost; a Virtual Reality intervention for depression to enhance positive affect and reduce depressive symptoms.
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Claudi Bockting
Major Depressive Disorder
Comparison of Tianeptine Versus Escitalopram Patients Major Depressive Disorder
The primary object of this study is to confirm the superiority of tianeptine compared to escitalopram on effects that improves subjective and objective cognitive impairments in patients suffering from major depressive disorder.
- Trial name
- CAMPION (NCT01309776)
- Testing
- Tianeptine, Escitalopram
- Where
- 6 sites in South Korea
- Volunteers
- 164 people
- Sponsor
- Samsung Medical Center
Epilepsy
Epilepsy and Mood Regulation Disorder in Children
Epilepsy is a multifaceted disorder and a major public health problem. In addition to recurrent and unpredictable seizures, abnormalities in psychiatric status, cognition and social-adaptive behaviors are potential major sources…
- Trial name
- EPILETRE (NCT02568813)
- Testing
- Multiscore Depression Inventory for Children scale
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Nicotine Dependence, Major Depressive Disorder
Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers
Persons who struggle with depression smoke at high rates and experience low quit rates in treatment. The best way to improve cessation treatment for this underserved population remains unknown.
- Trial name
- NCT02378714
- Testing
- Varenicline, BASC, Standard treatment
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Northwestern University
Depressive Disorder, Major, Suicide
Rapid Acting TMS for Suicide Ideation in Depression
This study evaluates the effects of an accelerated schedule of theta-burst stimulation, termed accelerated intermittent theta-burst stimulation (aiTBS), on the neural networks underlying explicit and implicit suicidal cognition…
- Trial name
- NCT05100004
- Testing
- Accelerated Theta Burst Stimulation
- Where
- United States
- Sponsor
- Stanford University
Major Depressive Disorder
Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Depression
The purpose of the study is to determine the efficacy, safety and pharmacokinetics of inhaled Esketamine in participants with treatment-resistant depression (TRD) in the course of Major Depressive Disorder (MDD).
- Trial name
- NCT03965858
- Testing
- Esketamine DPI - low dose, Esketamine DPI - medium dose, Esketamine DPI - high dose
- Where
- 12 sites in Poland
- Volunteers
- 88 people
- Sponsor
- Celon Pharma SA
Depression
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram
This study will compare levels of p11 protein in people with and without major depressive disorder (MDD) and examine if p11 levels in patients are affected by treatment with citalopram (Celexa).
- Trial name
- NCT00697268
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Resistant Depression, Moods Disorders
tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients
The aim is to investigate the effect of transcranial Direct Current Stimulation (tDCS) applied at the anodal left CDLPF of patients with resistant depression compared to patients treated with conventional therapy.
- Conditions
- Resistant Depression, Moods Disorders, Unipolar Depression, Bipolar Disorder
- Trial name
- STICODEP (NCT01644747)
- Testing
- transcranial Direct Current Stimulation (tDCS) (Eldith DC NeuroConn Stimulator)
- Where
- 6 sites in France
- Volunteers
- 87 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Insomnia, Major Depression
Cortical GABA Concentrations in Insomnia
Disturbances in the amino acid neurotransmitter (AANt), gamma-amino butyric acid (GABA) function are hypothesized to contribute to the neurobiology of Major Depressive Disorder (MDD) and insomnia.
- Trial name
- NCT00765752
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
Depression, Depressive Symptoms
VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,871 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids…
- Conditions
- Depression, Depressive Symptoms, Mood
- Trial name
- VITAL-DEP (NCT01696435)
- Testing
- vitamin D3, omega-3 fatty acids (fish oil)
- Where
- United States
- Volunteers
- 18,353 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Treatment Resistant Depression
TBS in Major Depression
Background Major depression is associated with morbidity and increased mortality. Along with the psychological strain depression represents a high socioeconomic burden costing Europe more than €113 billion/year.
- Trial name
- NCT03257397
- Testing
- theta-burst stimulation (TBS) using a MagPro X1000
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Rupert Lanzenberger
ASD, Autism Spectrum Disorder
Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder
Evaluate the efficacy of accelerated theta burst stimulation (aTBS) in reducing depressive symptoms in autism spectrum disorder (ASD)
- Conditions
- ASD, Autism Spectrum Disorder, Autism, Depression - Major Depressive Disorder
- Trial name
- RETSORE-RCT (NCT06670040)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bipolar Disorder
The Treatment of Children and Adolescents With Treatment-Resistant Depression
This study seeks to learn about brain function in adolescents with depression and to determine whether adding lithium carbonate to antidepressant medication can reduce depression in children and adolescents.
- Trial name
- NCT00029640
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Loneliness
Empower@Home:Connected - Feasibility and Preliminary Effect Study
This single-group trial will evaluate the feasibility and preliminary effect of a novel group-based cognitive behavioral therapy program for older adults with elevated depressive symptoms.
- Conditions
- Depression, Loneliness, Social Isolation, Depressive Disorder
- Trial name
- NCT05732740
- Testing
- Empower@Home:Connected
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Michigan
Psychological Stress, Sleep Disturbance
Sleep More, Stress Less: 90-Day Trial of Neuralli Mood
This decentralized, single-arm study evaluates the effects of 90 days of daily Neuralli Mood supplementation on perceived stress, sleep disturbance, mood, anxiety, depressive symptoms, happiness, and occupational burnout in…
- Conditions
- Psychological Stress, Sleep Disturbance, Anxiety Symptoms, Depressive Symptoms
- Trial name
- NM90 (NCT07717385)
- Testing
- Neuralli Mood
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Efforia, Inc
Depression; Bipolar Disorder
Comparing Different Patterns of rTMS in Major Depression
This trial will compare the trajectories of improvement for three different patterns of twice-daily rTMS in major depression: two daily sessions of dorsomedial prefrontal rTMS delivered at 0 min vs. 30 min vs. 60 min intervals.
- Trial name
- NCT02778035
- Testing
- Dorsomedial prefrontal rTMS
- Where
- 2 sites in Canada
- Volunteers
- 180 people
- Sponsor
- University Health Network, Toronto
Postpartum Hemorrhage, Postpartum Women
Prevalence of Psychological Disorders After Immediate Postpartum Hemorrhage
The objective of this cross-sectional study is to assess the prevalence of depression at 2 months, 6 months, and 1 year postpartum in women who had an immediate postpartum hemorrhage (immediate PPH defined as blood loss ≥ 500 mL…
- Conditions
- Postpartum Hemorrhage, Postpartum Women, Postpartum Depression, Postpartum Stress
- Trial name
- PSYCHE (NCT03120208)
- Testing
- • The Edinburgh postnatal depression scale (EPDS), validated in French, with a discrimination threshold ≥ 11., The GAD-7 with a discrimination threshold ≥10., • Spielberger's State-Trait anxiety inventory, Form Y (validated in French), with a STAI (form Y-A) discrimination threshold ≥ 46
- Where
- France
- Volunteers
- 1,298 people
- Sponsor
- University Hospital, Clermont-Ferrand
Bipolar Disorder
Acute Treatment of Bipolar II Depression
This study will compare the medications lithium and lamotrigine (Lamictal®) in treating depression in individuals with bipolar II disorder.
- Trial name
- NCT00074776
- Testing
- Lithium, Lamotrigine
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Stanford University
Opioid Use Disorder, Depressive Disorder
Ketamine for OUD and Comorbid Depression (OUDCD)
Methadone is a first-line, evidence-based treatment for opioid use disorder (OUD). Unfortunately, retention and adherence in methadone treatment is a major challenge.
- Trial name
- NCT05051449
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.