Clinical trials: Depression, Unipolar
Major Depressive Disorder
Light Therapy for Elderly Depression
The purpose of this study is to investigate the following two hypotheses: 1. Treatment with bright light improves their sleep, mood, concentration and self-sufficiency of elderly depressed subjects.
- Trial name
- NCT00332670
- Testing
- 10.000lux blue 1 hour every day during three weeks, 50lux dim red 1 hour every day during three weeks
- Where
- Netherlands
- Volunteers
- 89 people
- Sponsor
- GGZ Buitenamstel
Major Depressive Disorder
Gait, Depression, and Mind-body Therapy in Seniors
Falls are the leading cause of injury---related hospitalization and death in the elderly. As such, fear of falling (FOF) is common among senior populations and often leads to activity avoidance, social isolation, and reduced…
- Trial name
- NCT02283541
- Testing
- Automatic self-transcending meditation
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Major Depression, Diabetes Mellitus
Efficacy Study of Escitalopram for Depression in Patients With Diabetes
Patients with diabetes and major depression treated with Escitalopram might experience significant improvement in depression and anxiety scores; functional ability; diabetes-related self-care; and pain symptoms
- Trial name
- EFDID (NCT00650897)
- Testing
- Escitalopram
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Hyperthermia, Major Depressive Disorder
Peripheral Neuroimmune Mechanisms of Hyperthermia
The goal of this study is to examine how whole-body hyperthermia affects the thermoinflammatory profile, which includes the combined immune and heat shock response, in patients with depression and whether these changes correlate…
- Conditions
- Hyperthermia, Major Depressive Disorder, Inflammation
- Trial name
- NCT05366270
- Testing
- WBH
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder (MDD)
Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
This study will evaluate the efficacy and safety of SPN-821 in adults with major depressive disorder
- Trial name
- NCT07226661
- Testing
- SPN-821 2400 mg
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Major Depressive Disorder, Depression
rTMS for MDD: 5.5cm Rule vs. F3 Targeting
The purpose of this study is to examine the effects of different treatment locations using repetitive transcranial magnetic stimulation (rTMS) to treat major depressive disorder.
- Trial name
- NCT03378570
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Nicholas Trapp
Major Depressive Disorder, Healthy Controls
Effects of Treatment on Decision-making in Major Depression
In this trial, fifty participants with current major depressive disorder who are not receiving an antidepressant medication and fifty healthy controls will complete questionnaires and computerized tasks to assess their…
- Trial name
- NCT01916824
- Testing
- Any FDA Approved Antidepressant
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Emory University
Major Depression
Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression
This study investigates the hypothesis that pindolol can accelerate the response to antidepressants in patients with major depression treated with venlafaxine.
- Trial name
- NCT00159146
- Testing
- Pindolol and venlafaxin
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Hillerod Hospital, Denmark
Major Depressive Disorder (MDD)
Reward-specific Changes of the Chemical Messenger Dopamine in the Brain of Healthy and Depressed People
Major depressive disorder was shown to be associated with pathological alterations within neurotransmitter systems of the brain.
- Trial name
- NCT06675851
- Testing
- WELLBUTRIN SR (Bupropion HCI) Sustained-Release Tablets, 150 mg; GlaxoSmithKline, Cipralex (escitalopram)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Anxiety Disorders, Depressive Disorder, Major
Auricular Acupuncture vs. Progressive Muscle Relaxation in Patients With Anxiety Disorders or Major Depressive Disorder.
The purpose of this study is to determine whether auricular acupuncture (AA) according to the NADA protocol and progressive muscle relaxation (PMR) differ in their effectiveness of treating people with anxiety disorders or major…
- Trial name
- NCT02340351
- Testing
- Auricular acupuncture, Progressive muscle relaxation
- Volunteers
- 136 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Major Depressive Disorder
Effects of Psilocybin in Major Depressive Disorder
The proposed pilot study will assess whether people with major depressive disorder experience psychological and behavioral benefits and/or harms from psilocybin.
- Trial name
- NCT03181529
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Major Depressive Disorder, MDD
Xanamem® in Adults With Major Depressive Disorder and Impaired Cognition (XanaCIDD)
Xanamem is being developed as a potential treatment for symptomatic, early stages of Alzheimer's Disease (AD) and Major Depressive Disorder (MDD).
- Conditions
- Major Depressive Disorder, MDD, Cognitive Impairment
- Trial name
- NCT05657691
- Testing
- Xanamem™
- Where
- 12 sites in Australia, United Kingdom
- Volunteers
- 167 people
- Sponsor
- Actinogen Medical
Major Depressive Disorder, Insomnia
Efficacy and Safety of Low-dose Laser Acupuncture on Treating Insomnia Associated With Major Depressive Disorder
The goal of this randomized controlled trial is to assess the efficacy and safety of low-dose laser acupuncture (LLA) in alleviating insomnia symptoms among patients suffering from major depressive disorder.
- Trial name
- NCT06443242
- Testing
- Low-Dose Laser Acupuncture (LLA)
- Volunteers
- 120 people
- Sponsor
- Mohammad Farris Iman Leong Bin Abdullah
Major Depressive Disorder
Storytelling Video Intervention for Depressed Primary Care Patients - Open Trial
The overall aim of this program of research is to develop a collaborative narrative intervention for patients with depression being treated in primary care.
- Trial name
- sTVi-Open (NCT02309060)
- Testing
- Storytelling Video Intervention (sTVi)
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Butler Hospital
Major Depressive Disorder
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Sleep Deprivation
In the treatment of Major Depressive Disorder (MDD), total sleep deprivation can produce rapid but short-lasting improvements in mood.
- Trial name
- NCT05893173
- Testing
- Sleep Deprivation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Pennsylvania
Bipolar Disorder, Type 1
Evaluation of Theta-burst Stimulation Efficacy, Safety and Tolerability in Major Depressive Episodes of Bipolar I Disorder
INTRODUCTION: Pharmacological treatment of major depressive episodes in bipolar disorder (BD) is characterized by suboptimal efficacy rates, poor tolerability and adherence, delayed onset of action, and iatrogenic mood swings.
- Trial name
- NCT05501626
- Testing
- Active Theta Burst Stimulation (TBS)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Depression - Major Depressive Disorder, Adjustment Disorder
Health and Work Ability Following Inpatient Treatment for Stress-related Disorders - Follow-up Study of the HARMODI Cohort
When treating stress-related conditions, it is important to understand how health and work ability develop over the long term. In our research project, we aim, firstly, to investigate how health and work ability develop over the…
- Conditions
- Depression - Major Depressive Disorder, Adjustment Disorder, Burnout Syndrome
- Trial name
- NCT07757997
- Where
- 2 sites in Switzerland
- Volunteers
- 143 people
- Sponsor
- Clinica Holistica Engiadina
Anxiety Disorders, Depressive Disorder
Transdiagnostic Internet-delivered Intervention for Adolescents With Anxiety and Depression
The goal of this clinical trial is to test the efficacy of a transdiagnostic Internet-delivered interventions for Romanian adolescents with anxiety and/ or depression.
- Conditions
- Anxiety Disorders, Depressive Disorder, Social Anxiety Disorder, Major Depressive Disorder
- Trial name
- NEURO4C (NCT06724666)
- Testing
- Transdiagnostic Internet-delivered intervention
- Where
- 2 sites in Romania
- Volunteers
- 198 people
- Sponsor
- Babes-Bolyai University
Adjunct in the Treatment of Depressive Disorder
A Randomized, Open-Label, 52-Week Extension Study to Evaluate the Maintenance of Remission, Relapse Prevention, and Long-Term Safety of CreNeuroS™ in Patients With Major Depressive Disorder Who Achieved Remission Following an 8-Week Parent Study
This multicenter, randomized, open-label extension study will evaluate the maintenance of remission, relapse prevention, long-term clinical outcomes, and safety of CreNeuroS™ in participants with Major Depressive Disorder (MDD)…
- Trial name
- NCT07893002
- Testing
- No intervention, CreNeuroS™ CNS Fish Oil Plus Softgels, 1 capsule orally once daily, CreNeuroS™ CNS Fish Oil Plus Softgels, 2 capsule orally once daily
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Sichuan Credit Pharmaceutical Co., Ltd.
Major Depressive Disorder (MDD)
Genomics Used to Improve DEpression Decisions
Evaluate the impact of GeneSight Psychotropic on response to psychotropic treatment as judged by the mean change in the 17-item Hamilton Depression (HAM-D17) score from baseline to end of Week 8 of the study.
- Trial name
- GUIDED (NCT02109939)
- Testing
- GeneSight Psychotropic
- Where
- 61 sites in United States
- Volunteers
- 1,398 people
- Sponsor
- Assurex Health Inc.