Clinical trials: Depression
Depressive Disorder, Major
Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function
The purpose of this study is to assess the low-intensity focused ultrasound pulsation (LIFUP) neuromodulation on emotion processing in healthy individuals, and to assess the overall safety of the LIFUP to stimulate or inhibit…
- Trial name
- NCT05194332
- Testing
- LIFUP sonication to the amygdala
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Depression, Anxiety
Shaping Neural Activity Through Parenting
The purpose of this study is to test causal links between dimensions of positive and harsh parenting and children's brain responses to rewards and errors, using a parenting intervention.
- Trial name
- SNAP (NCT02667522)
- Testing
- Parent Child Interaction Therapy (PCIT)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Premenstrual Syndrome
Altered Calcium and Vitamin D in PMDD or Severe PMS
Osteoporosis has become one of the most widely recognized disorders of our times affecting an estimated 25 million women in this country.
- Trial name
- NCT00005119
- Testing
- Measures of calcium and bone turnover
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Depression, Self-regulation
Building Regulation in Dual Generations
Families who experience maternal mental illness and a variety of chronic stressors are currently underserved by the parenting programs.
- Conditions
- Depression, Self-regulation, Child Development
- Trial name
- BRIDGE (NCT04347707)
- Testing
- BRIDGE Therapy Program
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Social Behaviour
Serotonin and Everyday Social Interaction
Rationale: Poor social functioning may contribute to major depressive disorder (MDD). Poor serotonin function may also contribute to MDD. Recent research suggests that serotonin plays a role in regulating human social behaviour.
- Trial name
- NCT02051569
- Testing
- Tryptophan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Groningen
Bipolar Depression
CoQ10 in Geriatric Bipolar Depression
We propose to study and compare measures of brain energy metabolism in geriatric bipolar individuals and healthy older adults. We would also like to investigate changes in brain energy metabolites and in vivo creatine kinase (CK)…
- Trial name
- CoQ10 (NCT00720369)
- Testing
- CoEnzyme Q10
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Trauma
Passport to Freedom (P2F): Adaptation and Implementation of a Wellness Program
Women currently residing at an emergency shelter for women and children will participate in group sessions that cover topics that promote physical and emotional well-being through a combination of mindfulness exercises and health…
- Trial name
- NCT04069754
- Testing
- Adapted Passport to Freedom
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Depressive Disorder
TAK-653 Escalating Single and Multiple Dose Study in Healthy Participants
The purpose of this study is to assess the safety, tolerability and pharmacokinetics (PK) of TAK-653 when administered as single and multiple oral doses at escalating dose levels in healthy participants.
- Trial name
- NCT02561156
- Testing
- TAK-653
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Neurocrine Biosciences
Anxiety, Depression
PARTNER II: Improving Patient and Family Centered Care in Advanced Critical Illness
This is a stepped wedged randomized controlled trial comparing the PARTNER intervention with usual care in 5 Intensive Care Units.
- Trial name
- NCT02445937
- Testing
- PARTNER II
- Where
- 2 sites in United States
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Aging, Physical Dependence
Intelligent Personal Assistant for Managing Depression in Homebound Older Adults
The purpose of this study is to design a companion booklet and pilot test it with a voice-controlled intelligent personal assistants (VIPA), like Google Home or Amazon Alexa, to provide homebound older adult patients with skills…
- Trial name
- NCT04900272
- Testing
- VIPA and companion booklet
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Depression, Anxiety
Income Volatility and Mental Health, Full Experiment
Income instability is a defining aspect of the lives of the poor, who also disproportionately suffer from poor mental and physical health.
- Conditions
- Depression, Anxiety, Blood Pressure
- Trial name
- NCT06988410
- Testing
- Work opportunities
- Where
- Ghana
- Volunteers
- 2,267 people, healthy volunteers welcome
- Sponsor
- Cornell University
Hydrocortisone, Depression
Exploring the Effects of Corticosteroids on the Human Hippocampus
Chronic corticosteroid (CS) exposure is associated with changes in memory and the hippocampus in both humans and in animal models.
- Conditions
- Hydrocortisone, Depression, Healthy Volunteers
- Trial name
- NCT03896659
- Testing
- Hydrocortisone Oral
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Burnout
Reducing Burnout Among Frontline Healthcare Workers During COVID-19
Physician burnout has a significant impact on the wellness and productivity of physicians as well as patient health outcomes. Managing burnout among frontline workers is critical to Canada's response to the COVID-19 pandemic, in…
- Trial name
- RESTORE (NCT04474080)
- Testing
- Virtual Peer Support Platform, Control Period
- Where
- Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Depression, Serotonin Deficiency
Human Cerebral Blood Flow and Serotonin
Breathing, blood pressure, and blood flow into the brain are controlled - in part - by small areas in the brainstem; the central chemoreceptors.
- Trial name
- NCT05957094
- Testing
- Pharmacological agent: Citalopram
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Late Life Depression
A Breathing-Based Meditation Intervention for Patients With Treatment Resistant Late Life Depression
Late-life depression affects 2-8% of seniors and causes high rates of caregiver distress and risk of suicide. To exacerbate the problem, antidepressants, the cornerstone of therapy, are resistant in 55-80% of this population.
- Trial name
- NCT03368560
- Testing
- Sudarshan Kriya Yoga
- Volunteers
- healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Social Behavior, Depression
Contemplative Well-being Apps for the Workplace
The study will examine the use and impact of a meditation app delivered to adult workforce populations facing extreme time demands.
- Conditions
- Social Behavior, Depression, Inflammation
- Trial name
- NCT03452670
- Testing
- Active Group, Waitlist Group
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Emory University
Total Knee Replacement, Post Operative Pain
Effect of Mindfulness on Pain After Total Knee Arthroplasty
This study will be a prospective randomized controlled trial evaluating the effectiveness of using Headspace before and after undergoing total knee replacement surgery.
- Conditions
- Total Knee Replacement, Post Operative Pain, Opioid Use
- Trial name
- NCT06118073
- Testing
- Headspace, Total Knee Replacement
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Depression, Anxiety
The Correlation Characteristics Between Mental Health and Gut Microbiota of College Students in Qingyuan Vocational Education City
The goal of this observational study is to learn about the mental health status and gut microbiota characteristics of college students in Qingyuan Vocational Education City.
- Trial name
- NCT06595095
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Depression
To Demonstrate the Relative Bioavailability of Bupropion HCI 300 mg Extended-Release Tablets Under Fasting Conditions
The purpose of this study is to demonstrate the relative bioequivalence of Bupropion HCI 300 mg ER Tablets under fasting conditions.
- Trial name
- NCT00861939
- Testing
- Bupropion HCI 300 mg Extended-Release Tablets EON, WELLBUTRIN XL 300 mg Extended-Release Tablets GlaxoSmithKline
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sandoz
Substance-Related Disorders, Depression
Wraparound for High-risk Families with Substance Use Disorders: Examining Family, Child, and Parent Outcomes
The investigators propose a Hybrid Type 1 effectiveness-implementation quasi-experimental trial. Participants are drawn from two different communities contemporaneously.
- Conditions
- Substance-Related Disorders, Depression, Stress Disorders, Post-Traumatic, Child Abuse
- Trial name
- NCT04637581
- Testing
- Wraparound
- Where
- 4 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.