Clinical trials: Depression
Schizophrenia, Bipolar Disorder
Technology-Assisted Implementation of a Mobile Health Program for Serious Mental Illness
The goal of this clinical trial is to learn about how a digital training platform can enhance implementation and effectiveness of a validated mHealth system, called FOCUS, in people with serious mental illness.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Schizo Affective Disorder
- Trial name
- NCT05725785
- Testing
- FOCUS participants
- Where
- 3 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- University of Washington
Depression
Effects of Cognitive Behavioral Therapy on Brain Serotonin Activity in People With Depression
This study will examine changes in brain serotonin activity in people with depression before and after they receive cognitive behavioral therapy.
- Trial name
- NCT00641108
- Testing
- ADAM SPECT plus Cognitive Therapy, ADAM SPECT plus No Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Suicide, Depression
Adaptation of a French E-health Tool for Suicide Prevention in Young Populations
"France's suicide rate is among the highest in Europe, with the young among the more at risk. Several European projects have demonstrated the effectiveness of using e-tools in suicide prevention particularly for hard-to-reach…
- Conditions
- Suicide, Depression, Psychological Distress, Anxiety Disorders
- Trial name
- E-psYouth (NCT04946955)
- Testing
- Application and website with or without promotion
- Where
- France
- Volunteers
- 12,000,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Maternal Care Patterns
The Correlation Between Maternal Infant Bonding, Pain and Postpartum Depression
The delivery process can be associated with significant maternal pain. which has many long and short term affects. The aim of our study is to assess whether pain during and after childbirth negatively impacts a mother's…
- Trial name
- NCT05206552
- Testing
- Questionnaire
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Major Depressive Disorder, Bipolar Disorder
Transdiagnostic Markers of Cognitive Symptoms in Disorders Affective.
The objective of this project is to determine the concordance between the subjective and objective evaluation of cognitive functions in affective patients in partial remission through scales and cognitive tests that would be…
- Conditions
- Major Depressive Disorder, Bipolar Disorder, BDMF, GSH
- Trial name
- NCT05523076
- Where
- Spain
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Intervention, Waitlist Control
Qigong and Executive Attention in Older Adults with Depressive Symptoms
The goal of this randomized controlled trial is to test whether executive attention unpacks the antidepressant effect of Baduanjin (a form of health qigong) in older adults.
- Trial name
- NCT06852417
- Testing
- Health qigong training
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Respiratory Tract Infections (RTI), Mucosal Immunity
Fermented Milk Drink With Lacticaseibacillus Paracasei Strain Shirota Helps Triathletes With Cold-Like Symptoms Before and After a Race
This study aims to evaluate whether a fermented milk drink containing the probiotic strain Lacticaseibacillus paracasei strain Shirota (LCS), commonly found in Yakult®, can help reduce upper respiratory symptoms in triathletes…
- Conditions
- Respiratory Tract Infections (RTI), Mucosal Immunity, Systemic Inflammation, Depressive Disorder
- Trial name
- NCT06970964
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Depressive Disorder and Anxiety Disorders
To Investigate Effects GSK561679 on Part of the Body's System That Controls the Balance of Many of the Hormones.
A study to investigate the effects GSK561679 on part of the body's system that controls the balance of many of the hormones (including cortisol).
- Trial name
- NCT00426608
- Testing
- metyrapone, alprazolam, GSK561679
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cardiovascular Disease, Stress
Mindfulness, Yoga, and Cardiovascular Disease
In this study, we will conduct a preliminary, yet comprehensive evaluation of Mindfulness and Yoga, as compared to an exercise and education-based stress-reduction program.
- Conditions
- Cardiovascular Disease, Stress, Anxiety, Depression
- Trial name
- NCT00696852
- Testing
- Mindfulness Meditation, Yoga, Exercise, Relaxation, and Health Education
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Depression, Dual Diagnosis
Open-Label Creatine Study for Female Meth Users
Study Purposes and Objectives: The objectives should be stated in such a way that the reader can determine the appropriateness of the study design. If appropriate, state the specific hypotheses being tested and/or study aims.
- Conditions
- Depression, Dual Diagnosis, Substance Use
- Trial name
- NCT02189915
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Health College Students
Effects of VR Tai Chi Intervention on Physical Fitness, Anxiety, Depression and Stress Among College Students in Henan, China
Research indicates a substantial increase in the rates of anxiety, depression and stress among college students (Roy, Biswas, \& Sharma, 2025).
- Trial name
- NCT07854821
- Testing
- Virtual Reality-Assisted Tai Chi Training
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Xin Liu
Rumination, Depression
Adolescent Mindfulness Mobile App Study (RCT)
Rumination involves focusing on negative emotions repeatedly and is a risk factor for developing depression, anxiety, and self-injury. These negative outcomes increase in adolescence.
- Conditions
- Rumination, Depression, Anxiety, Self-Injurious Behavior
- Trial name
- AMMASRCT (NCT03900416)
- Testing
- Mindfulness App
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Lawrence University
Treatment Resistant Depression
Linear Asymmetric rTMS in Adolescent Treatment-Resistant Depression: Treatment Durations From Ten Days to One Day
This is a pilot interventional study to investigate the acceptability, tolerability, and side effect profile for varying numbers of treatment sessions/day of a new rTMS treatment in adolescents with treatment-resistant depression…
- Trial name
- NCT03986658
- Testing
- Linear Asymmetric rTMS System
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- NeuroQore Inc.
Depression
Remote Training in Evidence-based Practices for Clinicians Who Work With Migrant Workers
This study will compare training as usual to automated training using an intelligent tutoring system in training bachelors (BA) level social workers in cognitive behavioral therapy (CBT).
- Trial name
- NCT03515226
- Testing
- ITS based training, Traditional Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Washington
Postnatal Depression
Effect of the 'Mother and Baby' Program on Well-Being
The study investigates the effect of the 'Mother and Baby' (M\&B) program on the psychological health and well-being of new mothers 6-10 weeks following the birth of their baby.
- Trial name
- NCT00361478
- Testing
- Exercise and education, Education
- Where
- Australia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Depression, Postpartum
Multimodal Biomarkers and Precision TMS for Postpartum Depression
The purpose of this study is to identify multimodal biological markers associated with postpartum depression (PPD) and to evaluate the effectiveness of precision brain stimulation treatment.
- Trial name
- MOTHER-TMS (NCT07757815)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 2 sites in Macau
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Macau
Posttraumatic Stress Disorder, Depression
Yoga Breath Program and Client-Centered Exposure for Relief of PTSD in Tsunami Victims
Study hypothesis: that a standardized course of Eastern practices (Breath Water Sound Course -BWS) will significantly relieve PTSD and depression in tsunami victims.
- Trial name
- NCT00290225
- Testing
- Breath Water Sound Course and Traumatic Incident Reduction
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Victim Services Center, Miami
Depression
The Effects of ECT and/or iTBS on Olfaction and Cognition in Patients With Depression
The sense of smell and cognition are known to be closely associated with mood and emotional processes. However, despite the clear links between olfaction and cognitive processes with emotional states, research into the role of…
- Trial name
- NCT02804347
- Testing
- Cognitive Function Imaging and Battery, Sniffin Sticks, Cognitive Batteries
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen's University
Mental Depression
Using Group Interpersonal Psychotherapy to Improve the Well-Being of Adolescent Girls
Adolescent girls in developing countries face high rates of adversity and are at an elevated risk of depression and other forms of psychological distress.
- Trial name
- NCT03966833
- Testing
- IPT-G, Unconditional Cash Transfer
- Where
- Uganda
- Volunteers
- 1,914 people, healthy volunteers welcome
- Sponsor
- George Washington University
Major Depressive Disorder
Characterization of Microbial, Immune and Epigenetic Biomarkers for Major Depressive Disorder and ECT Treatment
The investigators aim to characterize fecal microbial biomarkers as well as blood cytokine levels in MDD patients vs. healthy controls.
- Trial name
- NCT03703414
- Testing
- Fecal microbiota composition analysis and blood cytokine level analysis
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
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