Clinical trials: Depression, open to volunteers
Traumatic Brain Injury (TBI)
Allopregnanolone in Chronic Complex Traumatic Brain Injury
This study will determine if allopregnanolone (ALLO) improves depression and pain symptoms in patients who have a history of mild traumatic brain injury (TBI) [primary endpoints].
- Trial name
- ALLO (NCT04003285)
- Testing
- Allopregnanolone
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- VA Office of Research and Development
Depressive Symptoms, Anxiety Disorders and Symptoms
Family Spirit Strengths
This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities.
- Conditions
- Depressive Symptoms, Anxiety Disorders and Symptoms, Substance Use, Mental Health Issue
- Trial name
- FSS (NCT05836090)
- Testing
- Family Spirit Strengths (FSS), Family Spirit Nurture
- Where
- 3 sites in United States
- Volunteers
- 188 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Treatment Resistant Depression
Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)
Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects.
- Trial name
- SYNVEST (NCT06512220)
- Testing
- Psilocybin 25 mg, Risperidone 1 MG
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Centre for Addiction and Mental Health
Unipolar Depression
Transcranial Direct Current Stimulation for Depression
This study will test the efficacy of transcranial direct current stimulation (tDCS) combined with mindfulness, remotely-delivered using a telemedicine protocol in 25 adults with unipolar depression.
- Trial name
- NCT07042217
- Testing
- transcranial direct current stimulation (tDCS) and mindfulness instruction
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Soterix Medical
Post Traumatic Stress Disorder, Depression - Major Depressive Disorder
Mindfulness-based Psilocybin Therapy for PTSD
The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD).
- Trial name
- NCT07104916
- Testing
- Psilocybin + MBCT therapy, Active Comparator: Psilocybin with Support Only
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Anthony P King
Anxiety Symptoms, Post-traumatic Stress Symptoms
Improving Student Mental Health Through a Universal Trauma-Informed Intervention
The goal of this trial is to identify the most effective ways for schools to deliver RAP Club, a universal school-based mental health intervention.
- Conditions
- Anxiety Symptoms, Post-traumatic Stress Symptoms, Depressive Symptoms, Behavioral Problems
- Trial name
- PPP (NCT07842432)
- Testing
- RAP Club Delivered by a School Clinician, RAP Club Delivered by a Teacher, Standard Supervision
- Where
- 3 sites in United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Older Adults Institutionalized in Residential Homes
A Virtual Reality Program for Nursing Home Residents With Physical Disabilities
This project will evaluate how well the immersive virtual reality psychological program works in residential care homes and how it can be used in everyday practice.
- Trial name
- NCT07879677
- Testing
- Psychological intervention
- Volunteers
- 400 people
- Sponsor
- Tung Wah College
Anxiety, Depression
Weighted Blankets for Dental Anxiety
The objective of this project is to determine the effectiveness of weighted blankets as an anxiety-reducing intervention for neurotypical adult patients with dental anxiety undergoing routine dental procedures at the University…
- Trial name
- NCT07879846
- Testing
- Blanket at visit 1., No blanket at visit 1, Blanket at visit 2.
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Depression - Major Depressive Disorder
Dual Neuromodulation for Depression: Boosting TMS With tES
Major depressive disorder (MDD) is a common and disabling condition. Transcranial magnetic stimulation (TMS) is an established non-invasive neuromodulation treatment for depression, but clinical response varies considerably…
- Trial name
- DUAL MOD (NCT07879924)
- Testing
- Transcranial Magnetic Stimulation, Transcranial Alternating Current Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Mersey Care NHS Trust
Autism Spectrum Disorder (ASD), Anxiety
Adapted Group Therapy Compared With Usual Care for Anxiety and Depression in Adults With an Autism Diagnosis
The goal of this clinical trial is to learn whether an adapted group therapy works to treat anxiety and depression in adults with an autism diagnosis. The therapy is a form of cognitive behavioral therapy (CBT).
- Conditions
- Autism Spectrum Disorder (ASD), Anxiety, Depression
- Trial name
- CoMind (NCT07880028)
- Testing
- Autism-adapted group cognitive behavioral therapy
- Volunteers
- 154 people
- Sponsor
- Lovisenberg Diakonale Hospital
Perinatal Anxiety, Perinatal Depression
Improving Perinatal Mental Health Through a Collaborative, Community Health Worker and Social Worker Intervention
The goal of this clinical trial is to learn if an intervention can improve mental health outcomes among pregnant and postpartum Latinas.
- Trial name
- NCT07880457
- Testing
- Patient Navigation (PN), Problem Solving Therapy (PST)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- American University
Subthreshold Depression
Dietary Education Intervention for Subthreshold Depression (MIND-Trial)
This randomized controlled trial evaluates the efficacy of an 8-week dietary education intervention in adults with subthreshold depression.
- Trial name
- NCT07880652
- Testing
- Mediterranean-Style Dietary Education Program, Befriending
- Where
- Singapore
- Volunteers
- 64 people
- Sponsor
- Institute of Mental Health, Singapore
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Healthy Volunteers, Depression
Neurobiology of Suicide
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies.
- Trial name
- NCT02543983
- Testing
- Magnetic Resonance Imaging scanner, 3T, NeurOptics PLRTM-3000 Pupillometer, Experimental Anxiety Devices
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Treatment Resistant Depression
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic…
- Trial name
- TRANSCEND (NCT06423430)
- Testing
- Active-stimulation
- Where
- 26 sites in United States
- Volunteers
- 100 people
- Sponsor
- Abbott Medical Devices
Substance Abuse, Intimate Partner Violence (IPV)
SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Families
This study aims to prevent syndemic health conditions by decreasing acculturative stress and promoting resilience via SER Familia (Salud, Estrés y Resilencia en Familias/ Health, Stress, and Resilience in Families), a…
- Conditions
- Substance Abuse, Intimate Partner Violence (IPV), HIV Infections, Depression
- Trial name
- SER Familia (NCT06627764)
- Testing
- SER Familia
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Duke University
Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD)
Intravenous Ketamine for Treatment-Resistant Depression
The purpose of this study is to to evaluate the relationships between peak (% change from baseline) central GABA and Glu levels during a 40-min IV ketamine or normal saline infusion utilizing fMRS, and change in peripheral GABA…
- Trial name
- G2K (NCT06668571)
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Major Depressive Disorder (MDD), Depression in Adults
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD.
- Conditions
- Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder, Depression Disorders
- Trial name
- EMBRACE (NCT06793397)
- Testing
- CYB003, Psychological Support
- Where
- 79 sites in United States, Australia and 6 more
- Volunteers
- 330 people
- Sponsor
- Cybin IRL Limited
Positive Affect, Depression
Training Reward Responsiveness Through Virtual Reality
The purpose of this study is to compare the effects of Virtual Reality-Reward Training (VR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms.
- Trial name
- NCT07219875
- Testing
- Virtual Reality-Reward Training (VR-RT), Virtual Reality-Memory Training (VR-MT)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Depression - Major Depressive Disorder
Effects of Concurrent and Consecutive Repetitive Transcranial Magnetic Stimulation (rTMS) and Cognitive Bias Modification (CBM)
The goal of this study is to learn whether combining repetitive transcranial magnetic stimulation (rTMS) with a computerized behavioral intervention (imagery cognitive bias modification, CBM-I) reduces negative interpretation…
- Trial name
- TMS CBM (NCT07636694)
- Testing
- TMS, Cognitive Bias Modification
- Where
- Hong Kong
- Volunteers
- 180 people
- Sponsor
- The University of Hong Kong