Clinical trials: Depression Chronic
COPD, Hypoxia
Automated Oxygen Administration -Rethinking Interventions Alleviating Dyspnea in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) is associated with high morbidity and mortality. The Danish Lung Association estimates that 320,000 Danes live with COPD, of which approximately 50,000 with severe COPD.
- Conditions
- COPD, Hypoxia, Closed-Loop Communication, Dyspnea
- Trial name
- NCT04370990
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Stroke, Intervention
The Effectiveness and Mechanism of Character Strengths-based STEP Programme on Rehabilitation of Stroke Patients
There is an urgent need for educational and psychological adjustment to stimulate the post-stroke patients' motivation to actively carry out rehabilitation.
- Conditions
- Stroke, Intervention, Rehabilitation, Depression
- Trial name
- STEP (NCT05738499)
- Testing
- Character strengths-based structured treatment and education programme (CSSTEP), Structured treatment and education programme (STEP)
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Peking University
Chronic Low Back Pain, Negative Affectivity
Treating Negative Affect in Low Back Pain Patients
This study will examine how the use of antidepressant, physical therapy, and combination of both affects pain, function, and depression outcomes in chronic low back pain patients.
- Trial name
- TNA-LBP (NCT04747314)
- Testing
- Antidepressant, Enhanced Fear Avoidance Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 308 people
- Sponsor
- Ajay Wasan, MD, Msc
Anxiety, Depression
Anxiety and Depression Perceived by Individuals With and Without Cancer During the COVID-19 Pandemic Period
The COVID-19 pandemic has negatively affected individuals not only physiologically but also psychologically. The aim of this study is to examine the anxiety and depression status of cancer patients, individuals with non-cancer…
- Conditions
- Anxiety, Depression, Covid19, Cancer
- Trial name
- NCT04698044
- Testing
- Hospital Anxiety Depression Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 1,107 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
COPD (Chronic Obstructive Pulmonary Disease)
Effectiveness of Active Cycle of Breathing Techniques in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial
This study aims to examine the effects of Active Cycle of Breathing Technique (ACBT) on pulmonary function, sleep quality, depressive symptoms, and dyspnea in patients with Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT07818187
- Testing
- ACBT+OPEP, Usual Care (Standard Medical Care)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Yang Ming Chiao Tung University Hospital
Post-Traumatic Stress Disorder, Chronic, Depressed Mood
An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma
The researchers are testing a single-group cognitive-behavioral intervention for treating traumatic stress related to interpersonal and developmental trauma in LGBTQ adults.
- Conditions
- Post-Traumatic Stress Disorder, Chronic, Depressed Mood, Depressive and Anxiety Disorders, Anxiety
- Trial name
- NCT07863817
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Treatment Resistant Depression, Chronic Pain
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)
Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects.
- Trial name
- TRANSCEND (NCT06518720)
- Testing
- Psilocybin 25 mg
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Addiction and Mental Health
Chronic Pain, Depressive Symptoms
Internet-delivered Cognitive Behavioral Therapy for Patients With Chronic Pain and Psychiatric Distress
This study is a randomized controlled trial studying the efficacy of an iCBT treatment for patients with chronic pain and comorbid psychiatric distress.
- Conditions
- Chronic Pain, Depressive Symptoms, Anxiety, Stress, Psychological
- Trial name
- TIPPS (NCT03316846)
- Testing
- Internet-Delivered Cognitive Behavioral Therapy
- Where
- Sweden
- Volunteers
- 187 people
- Sponsor
- Uppsala University
Depression, Hypertension
Strengthening Mental Health Care in Chronic Care Patients With Hypertension. A Cluster Randomised Control Trial
A pragmatic cluster randomized controlled trial (RCT) in 20 public sector primary care clinics in the Dr Kenneth Kaunda district of the North West Province of South Africa to assess mental health and health outcomes for depressed…
- Trial name
- NCT02425124
- Testing
- PC101+Mental Health
- Where
- South Africa
- Volunteers
- 1,052 people
- Sponsor
- University of KwaZulu
Depression, Multiple Chronic Conditions
An Approach to "Move a Little & Often" With Health Conditions
People with long term conditions such as diabetes and arthritis, and who also have depression spend a lot of time sedentary during the day. This is because they face many barriers to being active, such as pain and fatigue.
- Trial name
- NCT03537053
- Testing
- A plan to Move a Little and Often
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Manchester
Fatigue, Depression
Health Literacy Assessment and Intervention to Reduce Disparities: FLIGHT/VIDAS II
The purpose of this study will to be to evaluate the effects of a mobile intervention focused on improving the chronic disease self management skills of individuals with low health literacy.
- Conditions
- Fatigue, Depression, Pain, Sleep Wake Disorders
- Trial name
- FV2 (NCT02922439)
- Testing
- Tailored Intervention, Control Intervention
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Mild-to-moderate Depression, Neural Activity
Probiotics for Depressive Symptomatology and Neural Activity.
This study aims to investigate the acute and chronic effects of 16-week probiotic supplementation (Ecologic® Barrier) on depressive symptoms and neural activity in those with mild-to-moderate depression.
- Conditions
- Mild-to-moderate Depression, Neural Activity, Executive Function (Cognition)
- Trial name
- PRODAN (NCT07667530)
- Testing
- Ecologic® Barrier
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- University of Reading
Chronic Back Pain, Chronic Pain
Active Coping: Interdisciplinary Program for Chronic Pain, Physiotherapy Unit (Spain)
The goal of this observational intervention study is to evaluate the impact of a multidisciplinary active coping program for chronic back pain in adults referred from Primary Care to the Physiotherapy Unit of Teruel Ensanche.
- Conditions
- Chronic Back Pain, Chronic Pain, Back Pain, Low Back Pain, Chronic
- Trial name
- NCT07504094
- Testing
- Pain Neuroscience Education (PNE), Healthy Habits and Psychological Intervention, Therapeutic Exercise
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Universidad de Zaragoza
Cervical Myofascial Pain Syndrome, Chronic Neck Pain
Type D Personality, and Stigma in Myofascial Pain Syndrome
Cervical myofascial pain syndrome is a chronic musculoskeletal condition characterized by the presence of sensitive trigger points and taut muscle bands, resulting in localized or referred pain, muscle stiffness, and limited…
- Conditions
- Cervical Myofascial Pain Syndrome, Chronic Neck Pain, Type D Personality, Psychological Distress
- Trial name
- NCT07292155
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Chronic Obstructive Pulmonary Disease, Anxiety
Anxiety and Depression in Patients Hospitalizes for an Acute Exacerbation of COPD
This study will try to elucidate wheter the impact of a psychiatric intervention in patients hospitalized because an acute exacerbation of COPD and anxiety/depression and reconsulting at 1 and 6 month after discharge.
- Conditions
- Chronic Obstructive Pulmonary Disease, Anxiety, Depression
- Trial name
- ADPHA-EPOC (NCT01520376)
- Testing
- Counselling
- Where
- Spain
- Volunteers
- 169 people
- Sponsor
- Nestor Soler Porcar, MD, PhD
Kidney Failure, Chronic, Depression
Cognitive-behavioral (CBT) in ESRD Patients With Depression
Depression is common in end-stage renal disease (ESRD) patients and has a negative effect on the quality of life, functional ability, and mortality, with a prevalence rate as high as 20-25%.
- Conditions
- Kidney Failure, Chronic, Depression, Quality of Life
- Trial name
- NCT02011139
- Testing
- Cognitive-behavioral group therapy
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Seoul National University Boramae Hospital
Mood
Sub-chronic Effects of 5-hydroxytryptophan on Mood and Emotional Processing in Healthy Volunteers
5-hydroxytryptophan (5-HTP) is a nutritional supplement sold in many health food stores, and is taken in order to raise levels of serotonin in the brain. Serotonin is a neurotransmitter that is involved in the regulation of mood.
- Trial name
- NCT01514409
- Testing
- 5-Hydroxytryptophan, Pharmaceutical grade silica
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northumbria University
COPD, Quality of Life
Psychological Distress in Patients With COPD
Chronic obstructive pulmonary disease (COPD) can significantly impact a person's quality of life, not only physically but also mentally.
- Conditions
- COPD, Quality of Life, Mental Health, Psychological Distress
- Trial name
- NCT06395311
- Testing
- COPD psychological well-being assessment
- Where
- Romania
- Volunteers
- 98 people
- Sponsor
- Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara
Chronic Major Depression
Mindfulness-based Cognitive Therapy for Chronic Depression
The propose of the study is to investigate the efficacy of Mindfulness-based Cognitive Therapy (MBCT, Segal, Williams, \& Teasdale, 2002) for patients suffering from Chronic Major Depression.
- Trial name
- NCT01065311
- Testing
- Mindfulness-based Cognitive Therapy, The Cognitive Behavioral Analysis System of Psychotherapy, Standard psychiatric care
- Where
- Germany
- Volunteers
- 106 people
- Sponsor
- Johannes Michalak
Chronic Pancreatitis, Pain Syndrome
Personalized Education and Pain Response in Chronic Pancreatitis
Pain mechanisms in chronic pancreatitis (CP) are heterogeneous and includes nociception, pancreatic neuropathy and central neuropathy/neuroplasty.
- Conditions
- Chronic Pancreatitis, Pain Syndrome, Depression, Anxiety
- Trial name
- PEPCP (NCT04654377)
- Testing
- Personalised education
- Where
- India
- Volunteers
- 114 people
- Sponsor
- Asian Institute of Gastroenterology, India