Clinical trials: Depression Disorders
Depression Mild, Cognitive Impairment
Augmentation of Depression Treatment by Gamified Network Retraining
Major depressive disorder (MDD) is a highly prevalent and debilitating mental disorder with a high lifetime prevalence of 16-20%.
- Conditions
- Depression Mild, Cognitive Impairment, Cognitive Dysfunction, Depressive Disorder
- Trial name
- NCT04400162
- Testing
- Usability of the CCT, Changes in regards to the depressive disorder
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University Hospital Tuebingen
Mental Disorder, Depressive Symptoms
Module-Based Psychological (MBP) for Community Youths
This waitlist, randomised controlled trial (RCT) aims to examine the effectiveness of the Module-Based Psychological (MBP) intervention in reducing mental distress for youths aged 12-30 years in Hong Kong.
- Conditions
- Mental Disorder, Depressive Symptoms, Anxiety Symptoms
- Trial name
- MBP_RCT (NCT06005961)
- Testing
- Module-Based Psychological (MBP) Intervention
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- The University of Hong Kong
Treatment Resistant Depression
Rapid Acting Transcranial Magnetic Stimulation
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression.
- Trial name
- NCT04739969
- Testing
- Active TBS-DLPFC
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Major Depressive Disorder (MDD)
Investigating Functional Changes in the Frontotemporal Cortex of Patients With Major Depressive Disorder Following Electroconvulsive Therapy or Magnetic Seizure Therapy Using Functional Near-infrared Spectroscopy (fNIRS)
Against the clinical backdrop of the growing global burden of neuropsychiatric disorders, the rapid rise in depression prevalence, and the frequent association of these conditions with cognitive impairment, this study highlights…
- Trial name
- NCT07533773
- Testing
- Electroconvulsive Therapy, Magnetic Seizure Therapy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Anhui Medical University
Hyperhidrosis
Excessive Sweating Caused by Antidepressants: Measurement and Treatment With Terazosin
The study consists of measurement of antidepressant-induced excessive sweating and its treatment with an experimental medication, terazosin (approved for hypertension), that will be added to the antidepressant.
- Trial name
- ADIES (NCT00449683)
- Testing
- terazosin
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Insomnia, Major Depressive Disorder
The Exploratory Study to Investigate the Effect of Ramelteon for Insomnia Patients With Major Depressive Disorder by Using Actigraphy
The purpose of this study is to investigate exploratorily the effect of ramelteon 8 mg once daily for 8 weeks in the treatment of insomnia patients with depression by using actigraphy.
- Trial name
- NCT02669082
- Testing
- Ramelteon
- Where
- 7 sites in Japan
- Volunteers
- 26 people
- Sponsor
- Takeda
Multiple Sclerosis
Effects of Qigong Therapy in MS Patients
Chinese medical exercises (Qigong) are part of traditional Chinese medicine and martial arts, consisting of exercise sequences originating from China.
- Trial name
- NCT07473180
- Testing
- Conventional rehabilitation therapy, Qi gong Baduanjin Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Baskent University
Depression, Anxiety, Alcohol Abuse
Cognitive-Behavioral Therapy for Young Adult Lesbian, Gay and Bisexual: Transdiagnostic Minority Stress Approach
Background: LGB people experience a large number of anxiety and mood disorders, and risk behaviors than heterosexual (Marshall et al., 2011).
- Conditions
- Depression, Anxiety, Alcohol Abuse, Sexual Compulsivity, Unsafe Sex
- Trial name
- NCT03980873
- Testing
- ESTEEM (Effective Sikills to Empower Effective Men)
- Where
- Spain
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Major Depressive Disorder
SPL026 (DMT Fumarate) in Healthy Subjects and MDD Patients
SPL026 (N,N-dimethyltryptamine [DMT] fumarate) is a psychedelic tryptamine being developed as a therapy for patients with major depressive disorder (MDD).
- Trial name
- NCT04673383
- Testing
- SPL026
- Where
- 2 sites in United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Small Pharma Ltd
Burning Mouth Syndrome, Quality of Life
Effect to the Photobiomodulation in the Burning Mouth Syndrome
Introduction: Burning mouth syndrome (BMS) is a pathology with a low prevalence, affecting between 0.1% and 3.7% of the general population, the ratio between women and men is between 3 and 7:1.
- Conditions
- Burning Mouth Syndrome, Quality of Life, Anxiety Depression, Dry Mouth
- Trial name
- PBM-BMS (NCT05871580)
- Testing
- Low frequency laser activated photobiomodulation, Low frequency laser photobiomodulation inactive
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Suicidal Behaviors, Suicide Ideation
Examining the Efficacy of a Digital Therapeutic to Prevent Suicidal Behaviors
The primary aim of the project is to test the efficacy of BCBT delivered via a digital platform (i.e., smartphone) to Servicemembers with recent suicidal ideation and/or suicide attempts presenting to primary care clinics.
- Conditions
- Suicidal Behaviors, Suicide Ideation, Depression/Anxiety
- Trial name
- NCT06318962
- Testing
- Aviva
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Memphis
Physical Inactivity, Cognitive Decline
Developing and Assessing an Innovative Exergaming Technology for Older Adults Living in Long-term Care Homes
Residents living in long-term care (LTC) homes spend up to 75% of their day in sedentary, socially withdrawn situations which increases their risk for depression, dementia, decreased functional status and increased care costs.
- Conditions
- Physical Inactivity, Cognitive Decline, Aging, Social Isolation
- Trial name
- MouvMat (NCT05130203)
- Testing
- MouvMat Exergaming, Standard Recreational Programming
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Major Depressive Disorder
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and serious illness that can cause both emotional and physical symptoms such as…
- Trial name
- NCT07276997
- Testing
- Icalcaprant
- Where
- 33 sites in United States
- Volunteers
- 195 people
- Sponsor
- AbbVie
Respiration Disorders
Respiratory Monitoring System That Detects & Predicts OIRD
This study is being conducted to evaluate the ability of the Respiratory Monitoring System (RMS) to detect and predict opioid induced respiratory depression (OIRD) in post-operative surgical patients managed with opioid…
- Trial name
- RTM-NIH-SBIR-2 (NCT07217197)
- Testing
- Study to evaluate a Respiratory Monitoring System (RMS) with a Tracheal Sound Sensor (TSS) for detecting and predicting opioid induced respiratory Depression (OIRD).
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Thomas Jefferson University
Child Mental Disorder, Anxiety Disorders
Youth Metacognitive Therapy Feasibility Trial
One in eight children and young people (CYP) suffer mental health problems needing support or treatment and 5% have more than one such problem.
- Conditions
- Child Mental Disorder, Anxiety Disorders, Depression
- Trial name
- YoMETA (NCT05260060)
- Testing
- Treatment as usual: Control, Group Metacognitive Therapy (Group-MCT): Experimental
- Where
- United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Manchester
Major Depression
Secondary Prevention of Depression Applying an Experimental Attentional Bias Modification Procedure
Depression (Major Depressive Disorder; MDD) has been dubbed "the common cold among the mental illnesses" and it is also a highly recurrent disorder.
- Trial name
- NCT02658682
- Testing
- Attention Bias Modification
- Where
- 2 sites in Norway
- Volunteers
- 350 people
- Sponsor
- University of Oslo
Bipolar Disorder
rTMS for Treatment of Depressed Phase of Bipolar Disorder Type II
This research study evaluates an experimental device for the treatment of the depressed phase of Bipolar Disorder Type II. Repetitive Transcranial Magnetic Stimulation (rTMS) is an experimental procedure where a device delivers…
- Trial name
- rTMS (NCT00447096)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Bipolar Disorder
Understanding Treatment Adherence Among Individuals With Rapid Cycling Bipolar Disorder
This study will examine how various factors, such as psychiatric symptoms, gender, quality of life, and attitudes toward medication, affect treatment adherence in individuals with rapid cycling bipolar disorder.
- Trial name
- NCT00183703
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Case Western Reserve University
Major Depressive Disorder
Blended Care Versus Face-to-Face Therapy for Depression
Depression is a severe mental disorder that affects 5-7% of Belgians each year. Unfortunately, many individuals with depression do not seek professional help, and if they do seek professional help, waiting lists for psychotherapy…
- Trial name
- BLENDED (NCT04337242)
- Testing
- B-DIT, B-CBT, DIT
- Where
- 6 sites in Belgium
- Volunteers
- 504 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Eating Disorders (Excluding Anorexia Nervosa), Depression
Implementation of Evidence-based Treatments for On-campus Eating Disorders
The purpose of this study is to evaluate two training methods of IPT with mental health service providers in college counseling centers.
- Trial name
- NCT02079142
- Testing
- High Intensity Strategy: Train-the-trainer, Low Intensity Strategy: Expert Consultation
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- Washington University School of Medicine