Clinical trials: Depression Mild
Mild Cognitive Impairment
Effects of Cognitive-motor Training on Cognition, Depression and Daily Functioning in Patients With Mild Cognitive Impairment (MCI)
This randomized controlled trial evaluated the effectiveness of an immersive virtual reality (IVR) application (focused on a daily activity) to train cognitive functions and its impact on depression and the ability to perform…
- Trial name
- NCT06313931
- Testing
- cognitive training via immersive virtual reality, cognitive training via paper and pencil, motor stimulation
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Universidad de Zaragoza
Posttraumatic Stress Disorder, Depression
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
The overarching goal of this UH2-UH3 proposal is to work with the NIH Health Care Systems Research Collaboratory to develop and implement a large scale, cluster randomized pragmatic clinical trial demonstration project that…
- Conditions
- Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation
- Trial name
- TSOS6 (NCT02655354)
- Testing
- Motivational Interviewing, Cognitive Behavioral Therapy Elements, Care Management
- Where
- 24 sites in United States
- Volunteers
- 635 people
- Sponsor
- University of Washington
Depression
Efficacy, Safety, and Acceptability of Internet-based Cognitive Behavioral Therapy
This is a prospective, randomized, multicenter, double-blind, placebo-controlled phase III trial evaluating the efficacy and safety of WL-iCBT - a smartphone-based digital therapeutic combining cognitive behavioral therapy and…
- Trial name
- NCT05554289
- Testing
- Depression Auxiliary Intervention Treatment Software (WL-iCBT)
- Where
- 11 sites in China
- Volunteers
- 315 people
- Sponsor
- Adai Technology (Beijing) Co., Ltd.
Anxiety Disorder; Mixed With Depression (Mild)
Pilot RCT to Test Effectiveness of the ACE4 (Activity Challenge- 4 Areas) for Depression and Anxiety
Behavioral activation (BA) is a low cost, evidence-based intervention that can be effective in treating depression and anxiety. We have developed a behavioural activation card game for clients receiving treatment through the…
- Trial name
- NCT02538549
- Testing
- ACE4
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Queen's University
Mild to Moderate Depression.
Cost-effectiveness of a Non-Pharmacological Treatment (Active Monitoring) vs. a Pharmacological Treatment for Major Depression in Primary Care.
Major Depression (MD) is highly prevalent and has associated a high burden and economic costs. Mild levels of MD could be treated without antidepressants at Primary Care (PC).
- Trial name
- NCT02245373
- Testing
- Antidepressants, Active Monitoring
- Volunteers
- 263 people
- Sponsor
- Fundació Sant Joan de Déu
Coronary Artery Disease, Non-significant Coronary Artery Disease
TweeSteden Mild Stenosis Study
Psychosocial factors have been found to be associated with an increased risk for coronary artery disease incidence, progression and worse clinical outcomes.
- Conditions
- Coronary Artery Disease, Non-significant Coronary Artery Disease, Mild Stenosis, Vascular Irregularities
- Trial name
- TWIST (NCT01788241)
- Where
- Netherlands
- Volunteers
- 547 people
- Sponsor
- Tilburg University
Depression Mild, Cognitive Impairment
Augmentation of Depression Treatment by Gamified Network Retraining
Major depressive disorder (MDD) is a highly prevalent and debilitating mental disorder with a high lifetime prevalence of 16-20%.
- Conditions
- Depression Mild, Cognitive Impairment, Cognitive Dysfunction, Depressive Disorder
- Trial name
- NCT04400162
- Testing
- Usability of the CCT, Changes in regards to the depressive disorder
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University Hospital Tuebingen
Depression
Hypericum vs Fluoxetine for Mild to Moderate Adolescent Depression
The study is a pilot study where adolescents 12 - 18 years of age with mild to moderate depression will be randomized to receive either hypericum 250mg twice daily or fluoxetine 10mg daily increased to 20mg daily after 1 week and…
- Trial name
- NCT00557427
- Testing
- hypericum, fluoxetine
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rafa Laboratories
Social Anxiety, Major Depression Mild
Transdiagnostic REBT Prevention Program for Adolescents
Anxiety and depressive disorders are common in adolescents, however they are often unrecognized. Rational emotive behavioral therapy (REBT), a form of cognitive behavioral therapy (CBT) is efficient for children and adolescents.
- Conditions
- Social Anxiety, Major Depression Mild, Panic Disorder, Specific Phobia
- Trial name
- NCT02756507
- Testing
- video-based transdiagnostic REBT, Wait list
- Where
- Romania
- Volunteers
- 381 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Depression - Major Depressive Disorder, Cognition Disorders in Old Age
Real-world Clinical Response to Trazodone in Italy, Poland, and Romania
TRACOMDD study is a study with the intention to describe the real-world use of trazodone and the clinical response in a sub-group of patients affected by Major Depressive Disorder and Mild Cognitive impairment, by collecting data…
- Trial name
- NCT07377682
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Multiple Sclerosis
Online Mindfulness-Based Cognitive Therapy for People With Multiple Sclerosis With Mild-Moderate Depression
This study will use a waiting list randomized controlled trial design with a mixed-methods research approach, including both quantitative and qualitative methods.
- Trial name
- NCT07742579
- Testing
- Mindfulness-Based Cognitive Therapy
- Volunteers
- 152 people
- Sponsor
- Robert Simpson
Anxiety, Depression - Major Depressive Disorder
Integrative Group Psychotherapy (Terebenin's Method) in Adults With Subclinical and Mild/Moderate Anxiety and Depression
Title Pilot Randomized Controlled Trial of an Integrative Group Psychotherapy (Terebenin's Method) in Adults with Subclinical and Mild/Moderate Anxiety and Depression Summary and Detailed Description (Single Text Block) Anxiety…
- Trial name
- NCT06863948
- Testing
- Teribenin method, Control Interventions
- Where
- Russia
- Volunteers
- 66 people
- Sponsor
- S.LAB (SOLOWAYS)
Early Onset Alzheimer Disease, Mild Cognitive Impairment
Reference Database & Longitudinal Registry of the Normal and Pathological Aging Brain
Establishment of a BNA reference database for the Adult and Elderly Population. Hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between clinical…
- Conditions
- Early Onset Alzheimer Disease, Mild Cognitive Impairment, Depression, Aging
- Trial name
- (BNA™) (NCT02875496)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Social Isolation or Loneliness, Anxiety
Health Surveillance at University of Applied Science Hamburg (HAW)
The aim of Health Surveillance 2025 is to analyze and describe the state of health of employees at University of Applied Science Hamburg, key influencing factors and individual resources.
- Conditions
- Social Isolation or Loneliness, Anxiety, Anxiety Acute, Anxiety Depression
- Trial name
- HAW_HS2025 (NCT07089914)
- Where
- Germany
- Volunteers
- 679 people, healthy volunteers welcome
- Sponsor
- Jacobs University Bremen gGmbH
Depression Moderate, Depression Mild
Cognitive Behavioral Therapy-Based Group Counseling
The university environment presents a valuable opportunity to reach the young population of society, which has a high risk of depression, and to provide protective mental-health services.
- Trial name
- CBTBGC (NCT04192721)
- Testing
- Cognitive Behavioral Therapy-Based Group Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Gazi University
Traumatic Brain Injury, Concussion, Mild
fMRI-neuronavigated rTMS Treatment for Symptoms of Depression Associated With Concussive TBI in the Military Population
This study aims to investigate the efficacy and tolerability of fMRI-targeted repetitive transcranial magnetic stimulation (rTMS) in the treatment of depressive symptoms in service members with a history of concussive traumatic…
- Conditions
- Traumatic Brain Injury, Concussion, Mild, Depressive Symptoms
- Trial name
- NCT03523507
- Testing
- Active: rTMS
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Mild Cognitive Impairment, Alzheimer's Disease
Effect of Cerefolin®/CerefolinNAC® on Biomarker Measurements
In a retrospective analysis of data from 1100 patients, disease-delaying effects of Cerefolin®/CerefolinNAC® were examined in terms of cognition.
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease Related Disorders
- Trial name
- NCT01745198
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Pamlab, Inc.
Depression, Multiple Sclerosis
The Efficacy and Safety of Escitalopram for Depression in Multiple Sclerosis
Emotionally labile, depressed participants with multiple sclerosis treated with escitalopram will have a greater reduction in emotional lability scores and in their psychological distress scores than those who are randomized to…
- Trial name
- NCT00151294
- Testing
- escitalopram oxalate antidepressant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Mild Cognitive Impairment, Alzheimer Disease
The China Longitudinal Aging Study of Cognitive Impairment
Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly. The burden of dementia is rising in China, with major medical, social and economic impacts.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia, Vascular, Dementia With Lewy Bodies
- Trial name
- NCT03672448
- Testing
- Naturalistic observation
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center