Clinical trials: Depression NOS
Depression Disorder, fMRI Research
Modulatory Effects of Personalized Transcranial Magnetic Stimulation (TMS) on Heart-Brain Coupling in Individuals With Depressive Tendencies
This study focuses on individuals with depressive tendencies and investigates the regulatory effects of Transcranial Magnetic Stimulation (TMS)-guided by personalized functional connectivity mapping-on heart-brain coupling in…
- Conditions
- Depression Disorder, fMRI Research, Heart-Brain Coupling
- Trial name
- NCT07753473
- Testing
- DLPFC-insula TMS, DLPFC-sgACC TMS, 10-20 F3 TMS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xidian University
Anxiety, Depression Disorders
The Effectiveness of the REAL™, a School-based, Virtual Reality-integrated Social Emotional Learning Intervention to Promote Mental Health for Early Malaysian Adolescents
The REAL™ (Read Emotions and Learn to Regulate) module is a school-based social-emotional learning (SEL) intervention designed for early adolescents in Malaysia.
- Conditions
- Anxiety, Depression Disorders, Emotional Regulation
- Trial name
- REAL™ (NCT06849154)
- Testing
- REAL™ SEL Intervention Group
- Where
- Malaysia
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Depressed
Stress Sensitivity and Reward Responsivity in Depression
The goal of this project is to learn more about the different ways in which people process information that is stressful and rewarding, and how abnormalities in these two processes are related to depression.
- Trial name
- CAN-BIND-04 (NCT02798094)
- Where
- Canada
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Dr. Kate Harkness
Depression
Study of the Effects of an Antidepressant Medication and Placebo on the Brain Functioning of Normal Subjects
This study examines the effects of an antidepressant medication and placebo on the brain functioning of normal subjects. In this study, recordings of brain electrical activity are being used to detect and monitor the response to…
- Trial name
- NCT00634283
- Testing
- venlafaxine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Learning, Comprehensive Wellbeing
Future School of Comprehensive Well-Being
Good physical, mental and social health, particularly in childhood and early adolescence, are powerful predictors of positive life trajectories.
- Conditions
- Learning, Comprehensive Wellbeing, Social Wellbeing, Physical Wellbeing
- Trial name
- SchoolWell (NCT07906522)
- Testing
- Comprehensive well-being pedagogy intervention for primary and lower secondary school students
- Where
- 6 sites in Finland
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Major Depressive Disorder
Cognition in Mindfulness: Negativity and Depression
Mindfulness-Based Cognitive Therapy (MBCT) is effective in reducing relapse rates and (residual) symptoms in major depressive disorder (MDD). However, the mechanisms underlying those MBCT-induced effects are far from clear.
- Trial name
- CogMiND (NCT05802966)
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Telerehabilitation, Chair-based Yoga
The Effects of Telerehabilitation And Chair-based Yoga In The Elderly
The aim of the study is to investigate the effects of chair-based yoga with rehabilitation on quality of life is affected in elderly people.
- Conditions
- Telerehabilitation, Chair-based Yoga, Elderly People
- Trial name
- NCT05598554
- Testing
- Telerehabilitation, information
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sevval Kadriye Bakir
Post-traumatic Stress Disorder, Depression
Randomized Control Trial of Group Intervention With Former War-affected Boys in the Democratic Republic of Congo
The purpose of this study is to evaluate, in a randomised control trial (RCT), the effectiveness of group-based, trauma-focused Cognitive Behaviour Therapy (TF-CBT) in reducing psychological distress in former child soldiers and…
- Conditions
- Post-traumatic Stress Disorder, Depression, Conduct Disorder
- Trial name
- NCT01494831
- Testing
- TF-CBT
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Resilience, Anxiety
Music Breathing in Enhancing Resilience Among Elders at Risk of Mental Health Problems
The goal of this pilot randomised controlled trial is to examine the effects of a mindfulness-based music breathing intervention in enhancing resilience (primary outcome), and in reducing anxiety, depressive symptoms, loneliness…
- Conditions
- Resilience, Anxiety, Depressive Symptom, Loneliness
- Trial name
- NCT07631845
- Testing
- Mindfulness-based music breathing intervention, control group
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Depressive Disorder, Endogenous Depression
A Clinical Trial of Fluvoxamine for Melancholia
This study aims at investigating the special effectiveness of antidepressant effect of Fluvoxamine for endogenous depression. The investigators also aim to assess the effect of Fluvoxamine on the multimodal magnetic resonance…
- Conditions
- Depressive Disorder, Endogenous Depression, Melancholia
- Trial name
- NCT04160377
- Testing
- Fluvoxamine
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lingjiang Li
Melanoma, Cognitive Impairment
Cognitive Function in Melanoma Patients Treated With Adjuvant Immune Checkpoint Inhibitors
Immune checkpoint inhibitors (ICIs) are a group of novel immunotherapies that boost the body's own defense against the cancer by improving the immune system's ability to recognize and destroy cancer cells.
- Conditions
- Melanoma, Cognitive Impairment, Fatigue, Sleep
- Trial name
- NCT04565769
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Dementia, Mild Cognitive Impairment
Virtual Chair Yoga for Older Adults and Caregivers: Randomized Controlled Trial
Over 700,000 Canadians are affected by dementia costing the health care system approximately $10 billion/year. Due to COVID-19, the government has urged individuals over the age of 70 to stay home, putting this population at risk…
- Trial name
- NCT04884529
- Testing
- Chair-yoga program
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Depression, Stroke
Emotion-centered Problem-solving Intervention for Family Caregivers of Stroke Survivors (SoLVE)
Stroke is one of the leading causes of disability globally. Stroke survivors generally require lifelong support from family caregivers.
- Trial name
- SoLVE (NCT05448261)
- Testing
- Emotion-centered problem-solving intervention (EPi), stroke education
- Where
- China
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Bipolar Disorder, Involutional Depression
Study of the Psychological Development of Children of Parents With and Without Affective Disorders
This research study is the continuation of a study started more than 20 years ago. The study was designed to explore the effect that depressed parents have on their children and to better understand the factors that contribute to…
- Conditions
- Bipolar Disorder, Involutional Depression, Mood Disorder
- Trial name
- NCT00001170
- Where
- United States
- Volunteers
- 1,045 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Healthy Participants
A Study of the Neurobiology of Depression
Previous research studies have shown that depression is associated with changes in structure and activity in different parts of the brain and that antidepressant medication can affect brain activity in different parts of the…
- Trial name
- NCT01051466
- Testing
- Duloxetine
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy, Obesity
Open Label Randomized Clinical Study to Promote a Healthy Lifestyle in Medical Students
The main medical and social purpose of the project "It's trendy to be healthy!" is the promotion of healthy lifestyles and healthy eating among student youth.
- Conditions
- Healthy, Obesity, Nutrition, Healthy, Vitamin D Deficiency
- Trial name
- NCT05073029
- Testing
- nutrition program and modification of physical activity, synbiotic (Fructooligosaccharides+Lactobacillus rhamnosus GG ATCC 53103, 4.0х109 colony forming units - CFU), vitamin D3
- Where
- 2 sites in Ukraine
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bogomolets National Medical University
Depression, Inflammation
Stress and Inflammation in Late-Life Depression
Over 18% of Americans aged 65 years and older have depression. Recent evidence suggests that there is a link between depression and inflammatory disease.
- Trial name
- S&I (NCT02389465)
- Testing
- Escitalopram + Celecoxib
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Control Condition, Intervention
Effectiveness of AI Chatbots in Improving Students' General Wellbeing
The goal of this randomised controlled trial is to evaluate the effectiveness of an AI mental health chatbot in promoting emotional wellbeing and perceived empathy among university students in Singapore with mild or subclinical…
- Trial name
- NCT06965439
- Testing
- AI-delivered emotional wellbeing support, Neutral writing tasks
- Where
- Singapore
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Opiate Induced Respiratory Depression
Antagonism of Opioid-Induced Respiratory Depression by CX1739 With Preservation of Opioid Analgesia
The study is an investigation to assess the capacity of ascending doses of CX1739 to antagonize the respiratory depressive effect of remifentanil.
- Trial name
- NCT02735629
- Testing
- CX1739 - 300 mg, CX1739 - 600 mg, CX1739 - 900 mg
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- RespireRx
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