Clinical trials: Depression NOS
Maternal Depression, Child Development
Building Regulation in Dual Generations - Telehealth Model
Families who experience maternal mental illness and a variety of chronic stressors are currently underserved by the parenting programs.
- Conditions
- Maternal Depression, Child Development, Child Mental Health
- Trial name
- BRIDGE (NCT04639557)
- Testing
- BRIDGE Therapy Program
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Major Depression
Effects of ECT on Monoamine Oxidase A in Depression Investigated With PET
This study aims at evaluating the effect of electroconvulsive therapy in treatment-resistant depressed patients on the major serotonin degrading enzyme in the human brain using neuroimaging methods, the monoamine oxidase A.
- Trial name
- NCT02379767
- Testing
- Electroconvulsive therapy, Positron emission tomography of the brain using [11C]harmine, Structural magnetic resonance imaging
- Where
- Austria
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Depression, Sleep Disorders, Circadian Rhythm
Longitudinal Ecological Study on Sleep-Wake Patterns in MDD Using Actigraphy
The proposed study will include a longitudinal ecological study (Study 1) and a randomised controlled trial (Study 2). The aims will be to (1) identify the sleep-wake profiles in individuals with Major Depressive Disorder (MDD)…
- Trial name
- NCT06233422
- Testing
- No intervention involved
- Where
- Hong Kong
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Neurodegenerative Disease, Dementia
Cognition and Affective Research in China
This is a prospective cohort study of patients with cognitive impairment mood disorders and behavioral disorders. Comprehensive baseline and longitudinal follow-up assessments include clinical and epidemiological data, cognitive…
- Conditions
- Neurodegenerative Disease, Dementia, Alzheimer's Disease, Parkinson's Disease
- Trial name
- CARE (NCT07833267)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Post-traumatic Stress Disorder, Traumatic Brain Injury
Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop
In this proposal, the investigators extend their previous SPiRE feasibility and preliminary effectiveness study to examine STEP-Home efficacy in a RCT design.
- Conditions
- Post-traumatic Stress Disorder, Traumatic Brain Injury, Substance Related Disorders, Depression
- Trial name
- STEP-Home (NCT03868930)
- Testing
- STEP-Home, PCGT
- Where
- 2 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Negative Thoughts, Mild Depression
How Body Awareness Promotes Mental Health During Yoga and Physical Exercise
The integrity of interoceptive networks is linked to resilience against depressive symptoms, whereas degradation of these networks is linked to apathy and deficits in emotion processing.
- Conditions
- Negative Thoughts, Mild Depression, Stress
- Trial name
- NCT03553745
- Testing
- Gentle Yoga Intervention, Rigorous Yoga Intervention, Physical Exercise Intervention
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain
Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression
Volunteers will receive a weight-based opioid (remifentanil) infusion for 10 minutes. In the first run, serial pupillary measurements (pupillary unrest, pupil diameter) will be taken at baseline, and at 2.5-minute intervals…
- Conditions
- Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain, Overdose of Opiate, Respiratory Depression
- Trial name
- NCT04301895
- Testing
- Continuous conversational interaction, Remifentanil infusion
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depression, Sleep Apnea, Obstructive
Treatment Resistant Depression and Obstructive Sleep Apnea, Effect of Continuous Positive Airway Pressure (CPAP)
The purpose of the study is to determine the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD (treatment resistant depression) and associated OSA (obstructive sleep apnea).
- Trial name
- NCT00441636
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University
Heart Failure, Depression
Management of Depression and Anxiety in HF
Heart failure (HF) is a complex clinical syndrome characterized by inability of the heart to pump an adequate amount of blood. Heart failure affects patients' ability to carry out even simple activities of daily living and…
- Conditions
- Heart Failure, Depression, Anxiety
- Trial name
- NCT04636944
- Testing
- web-based COMPASS intervention
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- King's College London
Depression
Leucine for Depression Study (L-DEP)
Depression is very common and poses a huge disease burden. About 20% of the US population suffers from depression at lease once in their lifetime.
- Trial name
- NCT03557684
- Testing
- leucine, lipopolysaccharide (LPS)
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Depression
Learning Through Play (LTP) Plus Intervention for Depressed Fathers (LTP Plus Dads)
The aim of the study is to evaluate the clinical and cost effectiveness of culturally adapted group parenting intervention delivered by non-specialists and community health workers for depressed fathers.
- Trial name
- LTP+Dads (NCT03564847)
- Testing
- LTP Plus
- Where
- 2 sites in Pakistan
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Living and Learning
Hematopoietic/Lymphoid Cancer
Stress Management Intervention for Caregivers of Patients Undergoing Bone Marrow Transplant (BMT)
RATIONALE: A stress management intervention may be more effective than usual care in improving quality of life in caregivers of patients undergoing bone marrow transplant.
- Trial name
- NCT00833898
- Testing
- Paced respiration as part of PEPRR, PEPRR
- Where
- 2 sites in United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Depression, Mental Disorder in Adolescence
The PATHway Study: Primary Care Based Depression Prevention in Adolescents
Prevention of depressive disorders has become a key priority for the NIMH, but the investigators have no widely available public health strategy to reduce morbidity and mortality.
- Trial name
- PATHway (NCT05203198)
- Testing
- Competent Adulthood Transition with Cognitive-Behavioral, Humanistic and Interpersonal Training
- Where
- 6 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Perceived Stress, Depression
Online Yoga for Improving the Well-being of Desk-based Workers
The goal of this clinical trial is to evaluate the effectiveness of an 8-week online yoga intervention in improving the well-being and productivity of desk-based workers.
- Conditions
- Perceived Stress, Depression, Anxiety, Mindfulness
- Trial name
- NCT06289426
- Testing
- Yoga
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kingston University
Depression, Anxiety
Remotely Delivered Programs Targeting COVID-19 Stress-Related Depression and Substance Use
This 3-arm study compares the effectiveness of an (1) 8-week mindfulness-based intervention, MBCT-R (Mindfulness-Based Cognitive Therapy for Resilience During COVID-19)+CHA MindWell vs.
- Conditions
- Depression, Anxiety, Substance Use, Stress, Psychological
- Trial name
- NCT04595084
- Testing
- Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell, Internet Cognitive Behavioral Therapy plus CHAMindWell, CHAMindWell
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Parkinson's Disease, Depression
Validation of the Hebrew Version of the Montreal Affective Voices.
Today, no non-verbal auditory stimuli that assess mental processing are available in Israel. The goal of this study is to make available a validated set of auditory stimuli in Israel.
- Trial name
- NCT01512732
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chemotherapy Effect
Skin Sensitivity Acupuncture and Kinesiotherapy on Breast Cancer Patients Subject to Chemotherapy With Taxans
Objective: to compare different therapies employing acupuncture needles, silicon pellets and kinesiotherapy in breast cancer patients to taxane chemotherapy cycles.
- Trial name
- Acupuncture (NCT03373032)
- Testing
- Stiper, Acupuncture, Exercise
- Where
- Brazil
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Depression, Mood Disorders
Cold and Heat Investigation to Lower Levels of Depression
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body…
- Conditions
- Depression, Mood Disorders, Healthy (Controls)
- Trial name
- CHILL'D (NCT06263738)
- Testing
- Whole Body Hyperthermia, Cold Water Plunge
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Barry Sandler
Stress, Depression, Anxiety and Worry
The Veteran Caregiver Reducing Stress Time (VetCareReST) Study
Caring for a disabled adult, particularly those with long-lasting impairment, has been associated with elevated levels of stress, depression and anxiety among caregivers.Recent studies show that veteran caregivers experience…
- Trial name
- VetCareReST (NCT02852174)
- Testing
- Mindfulness meditation training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sandraluz Lara-Cinisomo
Fatigue Syndrome, Chronic, Healthy
Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression
Major depression represents a major public health problem worldwide and in the U.S. Fifteen percent of the U.S. population has depression at some point in life (40 million individuals).
- Conditions
- Fatigue Syndrome, Chronic, Healthy, Mood Disorders
- Trial name
- NCT00001479
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
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