Clinical trials: Depression NOS
Artificial Intelligence (AI), Depression - Major Depressive Disorder
Generated AI-informed Intervention (Emohaa) vs Group ACT vs WL on Emotional Distress
Emotional Distress, such as anxiety and depression, is an essential issue worldwide. There have been several evidence-based psychotherapies that are effective in improving emotional distress, such as Acceptance and Commitment…
- Conditions
- Artificial Intelligence (AI), Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT06735807
- Testing
- Generated AI-based intervention (Emohaa), group ACT, wailist (delayed intervenion)
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Central University of Finance and Economics, China
Postmenopause
Effects of Breathing Training on Psychosocial Functioning and Heart Rate Variability in Postmenopausal Women With Depressive Symptoms
The specific aims of this study are: 1. To develop a breathing training protocol specifically designed to improve HRV and psychosocial functioning for postmenopausal women with depressive symptoms, 2.
- Trial name
- NCT01044563
- Testing
- Breathing training, Stress management
- Where
- Taiwan
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- National Science and Technology Council, Taiwan
Perinatal Depression, Perinatal Anxiety
Cognitive Behavioral Couple Therapy for Perinatal Distress
The hypotheses of the study are There will be differences in perceived perinatal distress, dyadic coping strategies, social support, domains of quality of life, and well-being in couples at Pre- and Post-Test levels during the…
- Trial name
- NCT06001021
- Testing
- Psychopharmacological Intervention, Cognitive Behavioral Couple Therapy, Combination of Psychopharmacological Intervention and CBCT
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Sameera Shafiq
Depression
Dynamic Measures of Neurochemistry in Mood Disorders
The purpose of this study is to understand changes in brain chemical signals when people take antidepressants called sertraline (Zoloft®) and bupropion (Wellbutrin SR, Zyban ®).
- Trial name
- NCT00178828
- Testing
- sertraline, bupropion
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Depression, Depressive Disorder, Major
Decentering and Relapse/Recurrence in MBCT for Depression in Adults
Objective: "Decentering" is defined as the ability to observe one's thoughts and feelings as temporary, objective events in the mind, and is increasingly regarded as a candidate mechanism in mindfulness-based interventions.
- Conditions
- Depression, Depressive Disorder, Major, Depression in Remission
- Trial name
- NCT05111665
- Testing
- Mindfulness-based Cognitive Therapy (MBCT), Relaxation Group Therapy (RGT), Treatment as usual (TAU)
- Where
- Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Volunteers
Safety, Tolerability, and Efficacy of Sublingual Microdoses of 5-MeO-DMT for Depression and Anxiety
This Phase I/II clinical trial investigates the safety, tolerability, and potential therapeutic benefits of a novel sublingual formulation of 5-MeO-DMT.
- Trial name
- 5-MeO-DMT (NCT06816667)
- Testing
- BMND08, Brain electrical activity monitor, Pharmacokinetic Study of Sublingually Administered Psychoactive Substance
- Where
- Argentina
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Biomind Labs Inc.
Antenatal Depression
Enjoy Your Bump - Implementation Study
Enjoy Your Bump is an implementation study relating to antenatal maternal mental health in women who have mild to moderate feelings of depression and anxiety.
- Trial name
- NCT04700501
- Testing
- Enjoy Your Bump - CBT life skills learning programme
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Major Depressive Disorder, Suicidal Ideation
MicroRNA Correlates of Childhood Maltreatment and Suicidality
This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g.
- Trial name
- NCT04923685
- Testing
- Trier Social Stress Test
- Where
- 2 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Major Depressive Disorder, Bipolar Affective Disorder, Currently Depressed, Moderate
The Role of Negr1 In Modulating Neuroplasticity in Major Depression (RONIN)
Patients belonging to Group 1 (Major Depression) and 2 (Bipolar Disorder) will be tested with psychometric and functional scales at baseline (T0) and after 4 weeks of pharmacological therapy (T1), to evaluate clinical and…
- Trial name
- RONIN (NCT06131268)
- Testing
- Venlafaxine
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Molecular Mechanisms of Pharmacological Action, Depression
Effects of Seven Day Prucalopride Administration in Healthy Volunteers
This study will investigate whether seven days administration of the serotonin receptor subtype 4 (5-HT4) partial agonist prucalopride has effects on emotional processing and neural activity in healthy volunteers, compared to…
- Conditions
- Molecular Mechanisms of Pharmacological Action, Depression, Depressive Disorder, Mood Disorders
- Trial name
- NCT03572790
- Testing
- Prucalopride
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Bipolar Disorders
Escitalopram as a Mood Stabilizer for Bipolar II Disorder
This study will investigate the efficacy of Escitalopram, a Selective Serotonin Reuptake Inhibitor (SSRI) antidepressant, in the treatment of Bipolar II Disorder.
- Trial name
- NCT00156325
- Testing
- Escitalopram (Lexapro)
- Where
- Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Mild Depression
Using a Smartphone App to Reduce Cognitive Vulnerability and Mild Depressive Symptoms
Depression is one of the major challenges worldwide, with significant increasing personal, economic, and societal costs. Although empirically supported treatments have been developed, they are not always available for patients in…
- Trial name
- NCT02783118
- Testing
- Self administered online CBT
- Where
- Romania
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Angling, Supportive Therapeutic
Investigation of the Effects of Angling as Supportive Therapy in Schizophrenia Treatment on Serum Parameters, Anxiety, Depression, and Quality of Life
This study aims to evaluate the effects of recreational fishing (angling) as a supportive therapeutic intervention in individuals diagnosed with schizophrenia.
- Conditions
- Angling, Supportive Therapeutic, Schizophrenia
- Trial name
- NCT07682935
- Testing
- recreational fishing (angling)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Firat University
Tinnitus, Misophonia
Mindfulness Application Effects on Mental Health Symptoms in Children With Severe Tinnitus and Misophonia
Children with "bothersome" tinnitus and misophonia have elevated anxiety and depression symptoms. The mainstay therapy for adults and children with these disorders is cognitive behavioral therapy (CBT).
- Trial name
- NCT06493825
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Major Depressive Disorder
Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression
This study will apply a comprehensive tools that integrates neuroimaging, psychological evaluation, and sleep monitoring through 18F-MPPF PET/MR, neuropsychological tests, and polysomnography (PSG) to explore the neurobiological…
- Trial name
- NCT06211140
- Testing
- tACS, Control
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Major Depressive Disorder, Depression
Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescents
This study will examine if brain insulin resistance is a feature of depression in humans using magnetic resonance imaging (MRI) measures sensitive to brain insulin action.
- Trial name
- NCT05571878
- Testing
- Humalog, Saline nasal spray
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Epilepsy, Depression
fMRI Investigation of Depression in Patients With Epilepsy
Depression is very common in epilepsy. Depression is the strongest predictor of poor quality of life in patients with epilepsy. The biological basis for depression in epilepsy remains poorly understood.
- Trial name
- NCT00532376
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Major Depressive Disorder
A Study of LY2940094 in Major Depressive Disorder
The purpose of this study is to investigate the safety and tolerability of ascending single and multiple oral doses of LY2940094 in healthy male subjects.
- Trial name
- NCT01263236
- Testing
- LY2940094
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- BlackThorn Therapeutics, Inc.
Anxiety, Depressive Symptoms
The Effects of High-intensity Interval Training on Mental Health and Inflammation
The present study investigated the effects of high-intensity interval exercise training and placebo-exercise on mental health and inflammation using a randomized control trial.
- Conditions
- Anxiety, Depressive Symptoms, Inflammation
- Trial name
- NCT04118309
- Testing
- Exercise
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Major Depressive Disorder (MDD), Healthy Adult Volunteer
Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD.
- Trial name
- ENSURE (NCT05966532)
- Testing
- Hot Cognitive Task, Cold cognitive tasks, Structural magnetic resonance imaging (sMRI)
- Where
- 2 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center