Clinical trials: Depression NOS
Depressive Disorder
Effect of Nicotine on Brain Reward Pathways
The investigators will determine whether an acute dose of nicotine, in the form of the nicotine lozenge, impacts brain and behavioral measures of mood and reward responsiveness in individuals with major depressive disorder.
- Trial name
- NCT02346539
- Testing
- Nicotine polacrilex
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression, Treatment Resistant Depression
Computational Psychiatric Approach to Depression
The purpose of this research is to investigate how the brain changes in patients undergoing electroconvulsive (ECT) treatment for depression.
- Trial name
- NCT04189939
- Testing
- clinical assessments
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Psychological Distress, Secondary Trauma
Feasibility of SOLAR Group Program Among MHPSS Workers After the Earthquake
The goal of this intervention program is to provide the feasibility of a culturally adapted version of the SOLAR program among mental health and psychosocial support (MHPSS) workers who provide psychological or psychosocial…
- Conditions
- Psychological Distress, Secondary Trauma, Depression, Anxiety
- Trial name
- NCT06231927
- Testing
- The Skills for Life Adjustment and Resilience (SOLAR) program
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Koç University
Survivorship
A Study of Brief Behavioral Activation for the Treatment of Depression in Older Adult Cancer Survivors
The purpose of this study is to find out if a psychotherapy method called behavioral activation (BA) can be successfully delivered by telephone or videoconference (remotely) and can effectively treat depression in Older Adult…
- Trial name
- NCT05574127
- Testing
- Behavioral Activation, Supportive Psychotherapy
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Spina Bifida
Evaluation of Depression and Anxiety Levels of Parents of Children with Spina Bifida
Studies in the literature have measured the anxiety and depression levels of parents of children with spina bifida. Additionally, it has been reported that parents of children with non-neurogenic lower urinary tract dysfunction…
- Trial name
- NCT06802770
- Testing
- Anxiety, Depression levels
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University
Depressive Disorder, Mood Disorder
Progestin (Progesterone-Like Hormones) Induced Dysphoria (Depressed Mood, Irritability, Anxiety)
Often women are prescribed hormone replacement therapy (HRT) during the perimenopause or menopause. Hormone replacement therapy includes both estrogen and progesterone.
- Conditions
- Depressive Disorder, Mood Disorder, Psychomotor Agitation
- Trial name
- NCT00001770
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Empowerment, Domestic Violence
Men Engagement in Women Empowerment for Improving Maternal Mental Health Through Cash Transfer and Life Skills Building
This project aims to offer Life Skills Building (LSB) intervention to Benazir Income Support Program (BISP) Cash Transfer (CT) beneficiaries in couples in order to reduce domestic violence and depression and improve women…
- Conditions
- Empowerment, Domestic Violence, Depression, Self Efficacy
- Trial name
- MEWE (NCT04125251)
- Testing
- Life Skills Building Training
- Where
- Pakistan
- Volunteers
- 1,696 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Depression, Anxiety
Effect of Music Therapy in Mental Subhealth (EMTMS)
Mental health is increasingly at the forefront of concerns, especially since the start of COVID-19 pandemic. However, not all individuals under mental subhealth need pharmaceutical treatment.
- Trial name
- NCT05648539
- Testing
- The mini apps named "SOUL GYM" on the Wechat
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Alcohol Abuse, Criminalism
Survey of Adolescent Living in Vestmanland
The interaction of MAO-A genotype and psychosocial risk, in relation to male adolescent criminality The interaction of 5-HTTLPR genotype and psychosocial risk in relation to excessive adolescent alcohol consumption The…
- Conditions
- Alcohol Abuse, Criminalism, Depression
- Trial name
- SALVe (NCT01306812)
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Uppsala University
Suicidal Ideation, Depression
Digital Cognitive Behavior Therapy Program for Suicide Prevention
This study evaluates the efficacy of Thrive, a computerized cognitive behavior therapy program, to reduce depression and anxiety symptoms and to reduce suicidal thinking among adults.
- Conditions
- Suicidal Ideation, Depression, Anxiety
- Trial name
- TM2 (NCT03595254)
- Testing
- Thrive
- Where
- United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- Montana State University
Depression, Anxiety
The EARN-Health Trial of Financial Savings and Health
The current literature in social epidemiology and public health suggests that low financial savings has an unsurprising negative relationship with subjective well-being, and increases the odds of making visits to a healthcare…
- Conditions
- Depression, Anxiety, Alcohol Abuse, Tobacco Abuse
- Trial name
- EARN-Health (NCT02185612)
- Testing
- Savings program
- Where
- United States
- Volunteers
- 678 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cognitive Impairment, Covid19
The MentalPlus® for Assessment and Rehabilitation of Cognitive Function After Remission of the Symptoms of COVID-19
This study evaluates and rehabilitates the cognitive functions of attention, memory, visual perception, language, and executive by the mentalPlus® digital game of COVID-19 surviving patients after remission of symptoms.
- Conditions
- Cognitive Impairment, Covid19, Cognitive Dysfunction, Depression, Anxiety
- Trial name
- MP-COVID (NCT04632719)
- Testing
- The use of the MentalPlus® digital game for assessment and rehabilitation of cognitive function after remission of the symptoms of COVID-19
- Where
- 2 sites in Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Parent Child Abuse, Domestic Violence
Parenting for Lifelong Health - Thailand
Pilot design: The feasibility pilot of PLH for Young Children in Thailand has a single-site, pre-post design with no control group, with the aims of assessing programme implementation, cultural and contextual relevance, and study…
- Conditions
- Parent Child Abuse, Domestic Violence, Child Behavior Problem, Child Neglect
- Trial name
- NCT03539341
- Testing
- PLH-Thailand parenting programme, Control (care as usual)
- Where
- 4 sites in Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Diagnosis and Treatment of Depression
A Diagnosis and Treatment Optimization Study of Depression Based on the Neurological Mechanism of Reward System
Major depressive disorder (MDD) is a high-disabling disease. But its etiology and pathogenesis is not clear, and early recognition, diagnosis and treatment still has many challenges.
- Trial name
- NCT03148522
- Testing
- Escitalopram, Duloxetine, Mirtazapine
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University
Depression
An Evaluation of Safety and Feasibility Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression
The objective of this investigation is to examine the safety and feasibility of a series of repetitive transcranial magnetic stimulation (rTMS) treatments (10 Hertz [Hz]; Left Dorsolateral Prefrontal Cortex), with a Neuronetics…
- Trial name
- NCT00587639
- Testing
- rTMS Treatment
- Where
- 3 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Immune System Tolerance, Depression
ESAN II - Energy Sensing in Depression
The purpose of this study is to assess the effects of polyphenols from natural aronia juice on the immune system. Therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as…
- Conditions
- Immune System Tolerance, Depression, Obesity, Microbial Colonization
- Trial name
- NCT05432362
- Testing
- Aronia Juice
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Suicidal Ideation, Depression Disorders
Acceptability and Feasibility of Reframe-IT+U for Suicidality in University Students.
Mental health in university students is a growing concern worldwide. In Chile, previous studies have shown high rates of depressive symptoms, anxiety, and suicidal risk in this population.
- Conditions
- Suicidal Ideation, Depression Disorders, Anxiety
- Trial name
- Reframe-IT+U (NCT07001202)
- Testing
- Indicated Prevention for suicidality
- Where
- Chile
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Depressive Disorder, Major
Study of Genetic Differences in People With Depression
The purpose of this study is to identify genes involved in depression. Specifically, the investigators will analyze some genes that may be related to whether or not a person responds to antidepressant medication.
- Trial name
- Genetics (NCT00229463)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Sleep and Circadian Problems
Effect of Stellate Ganglion Block on Sleep Quality in Patients With Depression
# Brief Summary This clinical research study looks at whether stellate ganglion block (SGB) can improve sleep quality for people with depression. Poor sleep often goes together with depression.
- Trial name
- NCT07836738
- Testing
- Stellate Ganglion Block
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Li Juan
Depression, Mood
Intern Health Study 2024
The aim of this trial is to evaluate the efficacy of an intervention (delivered through a smartphone) for improving the mood, physical activity, and sleep of medical interns.
- Conditions
- Depression, Mood, Sleep, Physical Activity
- Trial name
- IHS (NCT06465680)
- Testing
- Intern Health Study behavioral change mobile notification
- Where
- United States
- Volunteers
- 1,047 people, healthy volunteers welcome
- Sponsor
- University of Michigan
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