Clinical trials: Depression NOS
Depression, Opioid-use Disorder
Ketamine for the Treatment of Opioid Use Disorder and Depression
The purpose of the study is to examine whether an investigational medication called ketamine is able to improve treatment outcomes for concurrent opioid addiction and depression when used in conjunction with buprenorphine…
- Conditions
- Depression, Opioid-use Disorder, Opioid Abuse
- Trial name
- NCT04177706
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Depression, Major Depressive Disorder
The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression
Many people with depression are treated with a serotonin-specific reuptake inhibitor anti-depressant (SSRI) and feel 'better'. Although many people feel 'better', they do not feel completely 'well'.
- Conditions
- Depression, Major Depressive Disorder, Unipolar Depression
- Trial name
- NCT00125957
- Testing
- Wellbutrin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mclean Hospital
Depression
Neurobiological Underpinnings of Placebo Response in Depression
In summary, the proposed research is novel with respect to design, technology, and its multi-level integration probing psychological and neurobiological constructs assumed to be crucially implicated in placebo response and has…
- Trial name
- NCT02562430
- Testing
- Welbutrin XL
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Massachusetts General Hospital
Self Harm, Depression
Computer Assisted Family Intervention to Treat Self-Harm Disparities in Latinas and Sexual/Gender Minority Youth
This study is designed to refine and test the efficacy of a computer assisted culturally informed and flexible/adaptive intervention for Latino adolescents for whom self-harm behaviors are a health disparity-specifically, Latinas…
- Conditions
- Self Harm, Depression, Emotion Dysregulation, Suicidal Ideation
- Trial name
- NCT03709472
- Testing
- Computer Assisted CIFFTA, Behavioral: Traditional face-to-face treatment-no technology
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depression
Managing Cancer and Living Meaningfully (CALM) Therapy in Individuals Diagnosed With a Primary Brain Tumor
Background: Psychological distress affects many people diagnosed with a primary central nervous system tumor (CNST). Distress can include negative feelings such as anger, fear, or sadness.
- Trial name
- NCT04852302
- Testing
- Cancer and Living Meaningfully (CALM) Therapy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Cancer Institute (NCI)
Dementia, Caregivers
VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers
The purpose of this study is to study the effects of an education and skill-building intervention on family caregivers of Veterans with dementia.
- Conditions
- Dementia, Caregivers, Neurodegenerative Diseases, Brain Diseases
- Trial name
- VACARES (NCT02106065)
- Testing
- Education and Skill-Building Rehabilitation (ESBR), Supplemental Education Materials
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder, Depression
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder
The purpose of this study is to determine if TC-5214 or placebo (a tablet that looks like medicine tablet or capsule, but contains no active medicine) is safe and effective when taken together with another antidepressant.
- Trial name
- NCT01180400
- Testing
- TC-5214
- Where
- 66 sites in Czechia, Estonia and 8 more
- Volunteers
- 295 people
- Sponsor
- AstraZeneca
Postpartum Depression
A Study To Assess The Safe-Use Conditions For Administration of ZULRESSO® in a Home Setting
The primary purpose of this study was to evaluate whether the safe-use conditions for administration of brexanolone (ZULRESSO®) can be implemented in a home setting.
- Trial name
- NCT05059600
- Testing
- ZULRESSO®
- Where
- 6 sites in United States
- Volunteers
- 52 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Psychosis, Substance Abuse
Effect Evaluation of Individual Placement and Support (IPS)
Roughly one third of disability pensions issued in Norway are classified as mental and behavioral disorders. The proposed study aims to evaluate the effect of an innovative intervention for returning people with moderate to…
- Conditions
- Psychosis, Substance Abuse, Depression, Anxiety
- Trial name
- NCT01964092
- Testing
- Individual Placement and Support, Ordinary employment schemes
- Where
- Norway
- Volunteers
- 410 people
- Sponsor
- NORCE Norwegian Research Centre AS
Respiratory Depression
Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Placebo.
The purpose of this study is to explore and compare VRH after administration of Belbuca, Oxycodone HCl and Placebo in recreational opioid users.
- Trial name
- NCT03996694
- Testing
- Belbuca 300 µg, Belbuca 600 µg, Belbuca 900 µg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- BioDelivery Sciences International
Depression, Adolescent Behavior
Adolescent Depression Screening and Treatment in Mozambican Primary Care
This is a cluster-randomized pilot trial of depression screening and treatment implementation at four Youth-friendly Health Services (YFHS) in primary care clinics, two in Maputo City and two in Maputo Province.
- Trial name
- NCT05476237
- Testing
- Group Interpersonal Therapy for Adolescents (IPT-AG), Treatment as Usual (TAU)
- Where
- 4 sites in Mozambique
- Volunteers
- 95 people
- Sponsor
- Columbia University
Perinatal Depression
"Mamma Mia" for Perinatal Health and Wellness
The purpose of this research study is to find out about ways to enhance well-being during pregnancy and the postpartum period (after the baby is born).
- Trial name
- NCT04300894
- Testing
- Mamma Mia, Mamma Mia Plus
- Where
- United States
- Volunteers
- 1,757 people
- Sponsor
- Virginia Commonwealth University
Major Depressive Disorder
Major Depressive Disorder With Mixed Features - Extension
Lurasidone HCl is a compound that is a candidate for the treatment of major depressive with mixed features.This clinical study is designed to test how well Lurasidone works to treat major depressive disorder with mixed features…
- Trial name
- RESOLVE3 (NCT01423253)
- Testing
- Lurasidone
- Where
- 17 sites in United States
- Volunteers
- 48 people
- Sponsor
- Sumitomo Pharma America, Inc.
Bipolar Depression
Multiple Treatment Study Using Low Field Magnetic Stimulation for Bipolar Depression
Objectives: To demonstrate the duration of the antidepressant effect of Low Field Magnetic Stimulation (LFMS)in subjects with bipolar depression.
- Trial name
- LFMS (NCT01929681)
- Testing
- Low Field Magnetic Stimulation
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Mclean Hospital
Depression, Fatigue
Programs To Support You During Chemotherapy
This randomized pilot trial studies how well two supportive programs work for improving fatigue and depressive symptoms in patients with GI undergoing chemotherapy.
- Conditions
- Depression, Fatigue, Stage IIA Colorectal Cancer, Stage IIB Colorectal Cancer
- Trial name
- PRO-YOU (NCT02489422)
- Testing
- Laboratory Biomarker Analysis, Questionnaire Administration, Daily Survey Administration
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Wake Forest University Health Sciences
Respiratory Depression
PRediction of Opioid-induced Respiratory Depression In Patients Monitored by capnoGraphY
PRODIGY is a prospective, multi-center, post-market, international cohort study. The primary objective of this study is to derive a score to identify subjects at risk to have respiratory depression (RD) episodes in patients…
- Trial name
- PRODIGY (NCT02811302)
- Testing
- Capnostream Monitor
- Where
- 16 sites in United States, France and 5 more
- Volunteers
- 1,495 people
- Sponsor
- Medtronic - MITG
Depression, Anxiety
Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part I
This pilot study is a precursor to a subsequent clinical trial that will test the impact of a set of automated motivational messages on patient engagement with a digital mental health intervention.
- Trial name
- NCT05360901
- Testing
- IntelliCare with automated motivational messaging
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Brigham and Women's Hospital
Major Depressive Disorder
Quantitative Electroencephalogram (QEEG) Predictors of Response to Psychotherapy Versus Antidepressant Treatment in Depression
The purpose of this research study is to find out if a test can predict whether someone with depression will get better with treatment.
- Trial name
- NCT00824044
- Testing
- Cognitive Behavioral Therapy (CBT), Escitalopram
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder
Decision-Making in Bipolar Disorder
Forty subjects with bipolar disorder who are not receiving a mood-stabilizing medication for the treatment of their illness will participate in this study.
- Trial name
- NCT01463111
- Testing
- Lithium, Valproate, Lamotrigine
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Emory University
Depression, Anxiety, Stress
A Trauma-Informed Intervention for Positive Youth Development and Teacher Wellness in Rural Montana
"A Trauma-Informed Intervention for Positive Youth Development and Teacher Wellness in Rural Montana" is intended to help mitigate stressors that may contribute to poor behavioral and mental health in rural Montana teachers.
- Trial name
- NCT05085392
- Testing
- Trauma-Informed Yoga
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Montana State University
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