Clinical trials: Depression NOS
Opioid-use Disorder, Anxiety Disorders
Digital Intervention to Treat Anxiety and Depression Among Persons Receiving Treatment for Opioid Use Disorder
The majority of opioid users meet criteria for anxiety and depressive disorders, but most substance use disorder treatment programs do not offer treatment for co-occurring mental health problems.
- Conditions
- Opioid-use Disorder, Anxiety Disorders, Depressive Disorder
- Trial name
- NCT05047627
- Testing
- Smartphone-Based Digital Intervention
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Trustees of Dartmouth College
Suicidal Ideation
Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality
This within-person, crossover, 3-condition, placebo-controlled study compares the impact of three perimenstrual conditions on severity of suicidal symptoms in females with past-month suicidality but minimal risk of imminent…
- Trial name
- CLEAR-2 (NCT03498313)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Anxiety Disorders, Depression
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms.
- Conditions
- Anxiety Disorders, Depression, Posttraumatic Stress Disorder
- Trial name
- NCT04912089
- Testing
- COGENT
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of California, San Diego
Depression
The Antidepressive Effect of rTMS as add-on to ECT
The aim of the present study is to investigate in which degree low frequency right prefrontal rTMS used ad add-on may potentiate the antidepressant effect of unilateral ECT and accelerate remission .
- Trial name
- TMS (NCT02123485)
- Testing
- Low frequency (1 hz) rTMS, as add-on to ECT
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- University of Aarhus
Major Depressive Disorder
Safety and Effectiveness of Omega 3-Fatty Acids, EPA Versus DHA, for the Treatment of Major Depression
This study examines the difference in the effectiveness of two natural compounds, eicosapentanoic (EPA) and docosahexanoic (DHA)omega-3 fatty acids, in treating major depressive disorder.
- Trial name
- NCT00361374
- Testing
- eicosapentaenoic acid, docosahexaenoic acid
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Massachusetts General Hospital
Depression
Examining the Impact of Sirolimus on Ketamine's Antidepressant Effects
The aim of the study is to provide insight into the impact of the immunosuppressant drug sirolimus, on the antidepressant effects of the prototypal rapid-acting antidepressant medication, ketamine.
- Trial name
- NCT02487485
- Testing
- Ketamine, sirolimus
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Yale University
Cardiovascular Disease, Depression
Internet-guided Cognitive Behavioural Therapy to Improve Depression Patients With Cardiovascular Disease
Purpose and aims Tailored internet-based cognitive behavioural therapy (I-CBT) is a new innovative and person-centred method that is promising that may be used to decrease depression in patients with cardiovascular disease (CVD).
- Trial name
- NCT02778074
- Testing
- Internet cognitive behavioural therapy, Moderated Discussion Forum
- Where
- Sweden
- Volunteers
- 144 people
- Sponsor
- University Hospital, Linkoeping
Depression, Parkinson's Disease
The Effects of Sertraline on Depression in Parkinson's Disease
The aim of this open-label, self-control study is to evaluate the efficacy of sertraline in treating depression in Patients with Parkinson's disease.
- Trial name
- PD (NCT01437189)
- Testing
- Sertraline
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Zhejiang University
Bipolar Disorder, Bipolar Depression
Treatment for Bipolar Depression: Acute & Prophylactic Efficacy With Citalopram
Bipolar depression is one of the least studied depressive illnesses. The standard practice for many doctors is to use antidepressant medicines, but there are few studies on the long-term results of these medicines.
- Trial name
- NCT00562861
- Testing
- citalopram + mood stabilizer
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Tufts Medical Center
Mechanical Ventilation, Airway Patency
The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency.
- Conditions
- Mechanical Ventilation, Airway Patency, Respiratory Depression
- Trial name
- NCT01969227
- Testing
- Subanesthetic ketamine
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Depression, Postpartum Depression
Personalized Integrated Chronotherapy for Perinatal Depression
Perinatal depression and anxiety are common, serious, and frequently overlapping disorders that increase morbidity and mortality in new mothers (including suicide) and result in poor infant/child outcomes.
- Conditions
- Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation
- Trial name
- NCT04364646
- Testing
- Personalized Integrated Chronotherapy
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Rhode Island Hospital
Depression
Advancing Personalized Antidepressant Treatment Using PET/MRI
Despite current medications, morbidity and mortality of Major Depressive Disorder (MDD) remain high. According to the World Health Organization, MDD affects 121 million people worldwide, and is projected to be the second leading…
- Trial name
- NCT02623205
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Stony Brook University
Depression
A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)
This is a multi-site, double-blind, placebo-controlled study of the acute efficacy of brexpiprazole or placebo in combination with intranasal ketamine added to ongoing, stable, and adequate antidepressant therapy (ADT) in the…
- Trial name
- NCT03149991
- Testing
- Brexpiprazole, Ketamine
- Where
- 6 sites in United States
- Volunteers
- 51 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Placebo Effects in the Treatment of Depression: Cognitive and Neural Mechanisms
Studies of the neural mechanisms underlying placebo effects in antidepressant clinical trials largely have been limited to demonstrating objective differences in brain activity between responders and non-responders to placebo.
- Trial name
- NCT01919216
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Caregivers
Mobile Technology and Data Analytics to Identify Real-time Predictors of Caregiver Well-Being
The purpose of this study is to test whether personalized messages from an easy-to-use mobile app improve mood and stress among care partners and to see if care partners like using the app.
- Trial name
- NCT04556591
- Testing
- Just-in-time adaptive intervention (JITAI), Control
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Depression
Imaging Biomarkers for TMS Treatment of Depression
The purpose of this research is to learn more about how rTMS works to reduce the symptoms of depression. This information can be used to improve the effectiveness of the treatment.
- Trial name
- NCT01900314
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Depression
Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression
The purpose of the study is to determine whether changing sleep patterns improves response to an antidepressant medication.
- Trial name
- NCT01545843
- Testing
- Sleep scheduling, Fluoxetine
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Michigan
Depression, Anhedonia
DTA (Dopaminergic Therapy for Anhedonia) Study
The purpose of this 6-week, double-blind, placebo-controlled, crossover study is to explore new treatment options for people with depression who have high inflammation and anhedonia.
- Trial name
- NCT04723147
- Testing
- Carbidopa Levodopa
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Emory University
Gulf War Veterans Illness, Neurobehavioral Manifestations
Scalp Application of LED Therapy to Improve Thinking and Memory in Veterans With Gulf War Illness
The purpose of this study is to learn if an experimental treatment can help thinking ability, and memory in Veterans with Gulf War Veterans Illnesses (GWVI).
- Conditions
- Gulf War Veterans Illness, Neurobehavioral Manifestations, Memory Disorders
- Trial name
- NCT01782378
- Testing
- Real LED Treatment
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- VA Office of Research and Development
Bipolar Depression
Minocycline for Bipolar Depression
The purpose of this study is to evaluate minocycline as a potential treatment for bipolar depression when added to a mood-stabilizing medication.
- Trial name
- NCT01514422
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.