Clinical trials: Depression Symptom
Alzheimer's Disease, Dementia
Safety and Efficacy Study of Ladostigil in Mild to Moderate Probable Alzheimer's Disease
For many, Alzheimer's disease is the number one medical issue facing our aging society. It is a late onset neurodegenerative disease, frequently under diagnosed, that impairs memory and cognitive performance.
- Conditions
- Alzheimer's Disease, Dementia, Memory Loss, Cognitive Impairment
- Trial name
- NCT01354691
- Testing
- ladostigil hemitartrate
- Where
- 19 sites in Austria, Croatia and 3 more
- Volunteers
- 200 people
- Sponsor
- Avraham Pharmaceuticals Ltd
Alzheimers' Disease
Cognitive Behavioural Therapy for Persons With MCI or Mild Dementia
A total of 200 home dwelling participants, who fulfil the inclusion criteria, Alzheimer's disease, will be recruited from three hospitals in Norway.
- Trial name
- NCT02013518
- Testing
- Cognitive Behavioural Therapy
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Help-Seeking Behavior, Depression
Improving Help-seeking for Depression Care in Nepal
Depression is a serious public health concern worldwide due to its high prevalence rate and significant emotional and financial burden on individuals, their families, and society.
- Trial name
- NCT06574074
- Testing
- Gain-Life (Give informAtIoN to transform Life)
- Where
- Nepal
- Volunteers
- 286 people
- Sponsor
- Transcultural Psychosocial Organization Nepal
Insomnia Chronic, Insomnia
Effects of Insomnia Treatment on Metabolism in Patients With Depression
This project will examine changes in metabolism and depressive symptoms after receiving CBT-I in 30 subjects with insomnia disorder and MDD.
- Conditions
- Insomnia Chronic, Insomnia, Insomnia, Primary, Depression
- Trial name
- NCT04719143
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Depression, Anxiety
More Individualized Care: Assessment and Recovery Through Engagement
The MI-CARE trial tests 12 months of telephone-based nurse care management for patients with depressive symptoms who take or have taken opioids at some time.
- Conditions
- Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
- Trial name
- MI-CARE (NCT05122676)
- Testing
- More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
- Where
- 2 sites in United States
- Volunteers
- 805 people
- Sponsor
- Kaiser Permanente
Unipolar Depression
RCT of Psychoeducational Program of Depression
The purpose of the study is to test the efficacy of a psychoeducational group program on unipolar depression
- Trial name
- NCT00319540
- Testing
- Control with depression course (CWD)
- Where
- Norway
- Volunteers
- 155 people
- Sponsor
- Norwegian Institute of Public Health
Depressive Symptoms
A Pilot Investigation of Clinician-guided Internet-Delivered Cognitive Behavioural Therapy for Depressed Patients
This study aims to explore the efficacy and acceptability of a clinician-guided internet-based Cognitive Behavioural Therapy (iCBT) programme for patients with depression, in Singapore.
- Trial name
- iCBT (NCT04100785)
- Testing
- Internet-delivered Cognitive Behavioural Therapy
- Volunteers
- 55 people
- Sponsor
- Institute of Mental Health, Singapore
Major Depressive Disorder, Recurrent, Depressive Episode
Confirmation Bias Towards Treatments of Depressive Disorders in Social Tagging
The study examines whether people primarily want to confirm their prior attitudes in health-related information search, in an online environment using social tags for navigation.
- Conditions
- Major Depressive Disorder, Recurrent, Depressive Episode, Depressive Disorder, Major, Depression
- Trial name
- NCT03899168
- Testing
- Social Tag Popularity, Confidence in Prior Attitudes, Source Credibility
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Leibniz-Institut für Wissensmedien
Postpartum Recovery, Mother-infant Bonding
Labor Epidural Analgesia and Mother-Infant Bonding After Vaginal Delivery
This prospective observational cohort study aims to evaluate the association between postpartum recovery quality and mother-infant bonding in women undergoing vaginal delivery.
- Conditions
- Postpartum Recovery, Mother-infant Bonding, Labor Pain
- Trial name
- NCT07582289
- Testing
- Labor Epidural Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ataturk University
Depressive Symptoms, Metabolic Syndrome X
Reducing Disparities in Late Life Depression and Metabolic Syndrome
Linkages between depression and cardiovascular disease have been well documented. These appear to be more than associations, and may reflect causal relationships through a number of proposed pathways, including decreased physical…
- Conditions
- Depressive Symptoms, Metabolic Syndrome X, Overweight, Obesity
- Trial name
- BRIGHTEN-Heart (NCT01428791)
- Testing
- Generations older adult membership program, BRIGHTEN Heart Virtual Team intervention
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Anxiety Disorders
"Machine Learning Analysis of Lingual Colorimetry and MADRS Anxiety-Depression Score in Acupuncture Patients"
This observational study aims to assess the potential relationship between tongue colorimetry (using standardized photographic techniques) and anxiety-depression scores measured by the Montgomery-Åsberg Depression Rating Scale…
- Trial name
- ML_AcuTongue (NCT06899490)
- Where
- France
- Volunteers
- 466 people, healthy volunteers welcome
- Sponsor
- Dr Benoit Bataille
Substance Use Disorder (SUD), Anxiety
Effects of Qigong Exercise on Anxiety and Depression in Patients Receiving Inpatient Treatment for Substance Use Disorder
Patients receiving inpatient treatment for substance use disorder may experience anxiety and depressive symptoms. Qigong is a mind-body exercise that combines gentle movements, breathing techniques, and relaxation.
- Conditions
- Substance Use Disorder (SUD), Anxiety, Depression
- Trial name
- NCT07909447
- Testing
- Qigong Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Uskudar University
Stress, Psychological, Depression
The Efficacy of a Mobile Application for Treating Depression and Anxiety Symptoms
This was a 12-week, parallel randomised controlled trial, including a 6-week follow-up. The trial compared a group of university students (N = 84) receiving a mobile CBT application intervention ("Feel Stress Free") to a…
- Conditions
- Stress, Psychological, Depression, Anxiety
- Trial name
- NCT03032952
- Testing
- "Feel Stress Free" mobile application
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University College, London
Major Depressive Disorder
International Study to Predict Optimised Treatment - in Depression
The aim of this study is to identify genetic, physical (brain) and psychological (cognitive) markers (or combinations of them) that predict specific response to a range of antidepressants treatment (Escitalopram, Venlafaxine…
- Trial name
- iSPOT-D (NCT00693849)
- Testing
- Escitalopram, Sertraline, Venlafaxine-XR
- Where
- 20 sites in United States, Australia and 3 more
- Volunteers
- 2,688 people, healthy volunteers welcome
- Sponsor
- BRC Operations Pty. Ltd.
Anhedonia, Depression
Computational Cognitive Training To Boost Reward Responsiveness In Anhedonic Patients
Anhedonia, i.e., reduced positive mood and decreased sensitivity to rewards, is observed in many psychiatric illnesses, particularly depression and anxiety disorders.
- Trial name
- NCT05383248
- Testing
- High Reward - High Variance, High Reward - Low Variance
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Depression
Effect of Psychedelic VR-augmented Therapy on Patients With Clinical Depression
Research has demonstrated that psychedelic compounds possess significant therapeutic potential for a variety of disorders, including depression.
- Trial name
- NCT06174285
- Testing
- Therapeutic Intervention with Psychedelic Virtual Reality, Therapeutic Intervention with Non-Psychedelic Virtual Reality
- Where
- Estonia
- Volunteers
- 45 people
- Sponsor
- University of Tartu
Depressive Disorder
Study In Patients With Depression Not Responding to Selective Serotonin Re-uptake Inhibitors
This study is designed to evaluate the efficacy and safety in depressive patients who did not respond sufficiently to selective serotonin re-uptake inhibitors (SSRI).
- Trial name
- NCT00296517
- Testing
- 323U66 (Bupropion Hydrochloride Sustained Release)
- Where
- 62 sites in Japan
- Volunteers
- 325 people
- Sponsor
- GlaxoSmithKline
Depressive Symptoms
Feasibility and Effects of a Blended Baduanjin Exercise and Green Tea Consumption Program on Depressive Symptoms, Gut Microbiota and Quality of Life in Older Adults
Depression is a common mental health issue in older adults, often manifesting as insomnia, low mood, vague somatic complaints, cognitive decline, and recurrent thoughts of death or suicide.
- Trial name
- NCT07687940
- Testing
- blended Baduanjin and Green Tea consumption program, Non-treatment control
- Where
- Hong Kong
- Volunteers
- 48 people
- Sponsor
- Hong Kong Baptist University
Acquired Brain Injury, Depression
MAPLES Pilot Study for Low Mood in ABI
Low mood and depression are common following acquired brain injury (ABI). There is a lack evidence on effective treatments in ABI. Behavioural Activation (BA) is a potentially valuable option.
- Trial name
- MAPLES (NCT03874650)
- Testing
- Activity Planning Group, Activity Engagement Group, Waitlist Group
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Cambridge
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