Clinical trials: Depression Symptoms, active
Depression and/or Anxiety Symptoms, Problematic Phone Use Behavior
The Mindful Smartphone Use Study
The goal of this clinical trial is to understand the feasibility and acceptability on a mindfulness-based intervention to address co-existing smartphone addiction and psychological distress among adolescents ages 13-19…
- Trial name
- NCT07892807
- Testing
- Mindwire
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Depressive Symptoms, Allostatic Load
Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
American youth and young adults face persistent and chronic stressors, which have contributed to a mental health crisis in the United States.
- Conditions
- Depressive Symptoms, Allostatic Load, Metabolic Syndrome
- Trial name
- R&T (NCT07554326)
- Testing
- Rise Together: Community Engagement Intervention, Adulting 101: Life Skills
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
PTSD, Suicidal Thoughts and Behaviors
Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study
This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD.
- Conditions
- PTSD, Suicidal Thoughts and Behaviors, PTSD Symptoms, Depressive Symptoms
- Trial name
- CNS (NCT07222306)
- Testing
- 1-(2-[+F]fluoroethyl)-L-tryptophan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wayne State University
Aging, Depression
Cognitive Enhancement in Recurrent Depression (The COG-D-R Study)
The goal of this clinical trial is to learn if a combination of non-drug treatments works to benefit memory, thinking, and brain functioning in older individuals with recurrent depression.
- Conditions
- Aging, Depression, Cognitive Symptoms
- Trial name
- NCT07527273
- Testing
- Depression Cognitive Training, Non-Specific Cognitive Training, tDCS (active stimulation)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Vanderbilt University Medical Center
Depressive Symptoms, Anxiety Disorders and Symptoms
Family Spirit Strengths
This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities.
- Conditions
- Depressive Symptoms, Anxiety Disorders and Symptoms, Substance Use, Mental Health Issue
- Trial name
- FSS (NCT05836090)
- Testing
- Family Spirit Strengths (FSS), Family Spirit Nurture
- Where
- 3 sites in United States
- Volunteers
- 188 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Anxiety Symptoms, Post-traumatic Stress Symptoms
Improving Student Mental Health Through a Universal Trauma-Informed Intervention
The goal of this trial is to identify the most effective ways for schools to deliver RAP Club, a universal school-based mental health intervention.
- Conditions
- Anxiety Symptoms, Post-traumatic Stress Symptoms, Depressive Symptoms, Behavioral Problems
- Trial name
- PPP (NCT07842432)
- Testing
- RAP Club Delivered by a School Clinician, RAP Club Delivered by a Teacher, Standard Supervision
- Where
- 3 sites in United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Depression and Anxiety Symptoms, Multiple Sclerosis
An Online Tailored Cognitive Therapy-Based Intervention for Depression in Multiple Sclerosis: ACTION-MS Online
Individuals with MS experience significantly high levels of depression which are higher than in any other chronic illness or neurological disorder. Depression can occur at any point in the course of the disease.
- Trial name
- ACTION-MS onli (NCT07875309)
- Testing
- ACTION-MS website - an 8-week cognitive behavioural therapy intervention for depression., The 'Health and Wellbeing in MS' website
- Where
- 2 sites in Australia, Canada
- Volunteers
- 240 people
- Sponsor
- University of Melbourne
Post-traumatic Stress Symptoms, Anxiety
Psychological Prehabilitation for Complex Gastrointestinal Surgery
The goal of this clinical trial is to learn if a psychological program before surgery can help adults who have lasting stress from past medical experiences. The program is called PREPARE-GI.
- Conditions
- Post-traumatic Stress Symptoms, Anxiety, Depression Disorder, Gastrointestinal Disease
- Trial name
- PREPARE-GI (NCT07865052)
- Testing
- PREPARE-GI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Depression, Unipolar
FMRI-neurofeedback in Depression
Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction.
- Trial name
- NCT05640089
- Testing
- fMRI-based neurofeedback
- Where
- 3 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Maastricht University Medical Center
Mental Health, Parenting / Maternal Behavior
Healing Hearts: A Mindfulness App for Parents Navigating Divorce or Separation
This study examines online programs for parents navigating divorce or separation. Researchers will study whether a self-guided mindfulness app called Healing Hearts, followed by a self-guided online parenting program called the…
- Conditions
- Mental Health, Parenting / Maternal Behavior, Parenting Anxiety, Parenting Behavior
- Trial name
- NCT07871916
- Testing
- Healing Hearts, electronic New Beginnings Program, Curated internet resources
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Depression Symptoms, Depression - Major Depressive Disorder
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes
This study aims to evaluate the efficacy of a specially developed internet-based Cognitive Behavioural Therapy (CBT) programme with human interaction-referred to as the 3D programme-tailored specifically for women experiencing…
- Conditions
- Depression Symptoms, Depression - Major Depressive Disorder, Depressive Disorder
- Trial name
- 3D01 (NCT07060690)
- Testing
- iCBT with human interaction, Psychoeducational videos
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Francesc Colom, PsyD, PhD
Depression / Major Depressive Disorder, Mental Health (Depression)
Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms
Many Asian Americans with depression also struggle with physical symptoms-such as pain, fatigue, or other forms of bodily discomfort-that occur at the same time.
- Trial name
- NCT07610928
- Testing
- Stress Management and Resiliency Training with Qigong/Tai Chi, Healthy Living Program
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Functional Neurological Disorders, Multiple Sclerosis
Assessment of the Frequency of Functional Neurological Disorders in Multiple Sclerosis and Analysis of Clinical and Psychological Determinants
Multiple sclerosis (MS) and functional neurological disorders (FND) share clinical features, which may result in FND being overlooked in patients with MS.
- Trial name
- FTNF-SEP (NCT07849816)
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Suicide, Depressive Disorder, Treatment-Resistant
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
Background: Major depressive disorder (MDD) is a serious mental illness that can put people at risk of self-harm and death. Many drugs are used to treat MDD, but it can take a long time for them to be effective.
- Conditions
- Suicide, Depressive Disorder, Treatment-Resistant, Ketamine, Molecular Mechanisms of Pharmacological Action
- Trial name
- NCT06511908
- Testing
- (2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression - Major Depressive Disorder, Generalized Anxiety Disorder
Ultra-brief Psychological Treatments for Emotional Symptoms and Disorders
The main objective of this randomized clinical trial is to study if various modalities of brief (eight sessions) and ultra-brief (four sessions) transdiagnostic cognitive-behavioral treatment work for decrease emotional symptoms…
- Conditions
- Depression - Major Depressive Disorder, Generalized Anxiety Disorder, Generalized Anxiety, Anxiety
- Trial name
- UltraPsyBrief (NCT06909669)
- Testing
- Group ultra-brief transdiagnostic cognitive-behavioral therapy, Group brief transdiagnostic cognitive-behavioral therapy, Individual ultra-brief transdiagnostic cognitive-behavioral therapy
- Where
- 2 sites in Spain
- Volunteers
- 184 people
- Sponsor
- Universidad de Córdoba
Behavioral Symptoms, Suicide
Natural History of Depression, Bipolar Disorder and Suicide Risk
Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments.
- Conditions
- Behavioral Symptoms, Suicide, Self-Injurious Behavior, Sensory System Agents
- Trial name
- NCT06462196
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Mental Health (NIMH)
Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder
HBOT Effects on First Responders' Cognition and Well-Being
The goal of this study is to examine changes in cognitive functioning and post-concussive symptoms following hyperbaric oxygen therapy (HBOT) in current and former first responders with a history of traumatic brain injury.
- Conditions
- Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Anxiety, Depression
- Trial name
- NCT07852728
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Summit Hyperbarics and Wellness
Irritable Bowel Syndrome (IBS), Functional Dyspepsia
Interactive Effects of Early-Life Stress, Diet, and Metabolism on Gastrointestinal Dysfunction With Neuropsychiatric Symptoms
The goal of this observational case-control study is to learn how stressful experiences, dietary habits, and blood nutrient levels are associated with gastrointestinal symptoms and symptoms of depression and anxiety in adults…
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Dyspepsia, Inflammatory Bowel Disease (IBD), Gastroparesis
- Trial name
- NCT07852819
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Depressive Symptoms, Emotional Depression
Parenting-STAIR Modular for Military Fathers and OCONUS Families
The goal of this clinical trial is to learn if a family-based treatment called Parenting-STAIR-Modular (PSTAIR-M) can help military parents recover from trauma, strengthen emotion regulation skills, and improve parent-child…
- Conditions
- Depressive Symptoms, Emotional Depression, Depression, Parent Child Relationship
- Trial name
- NCT07843654
- Testing
- Parenting-STAIR Modular (PSTAIR-M), Treatment as Usual (TAU)
- Where
- 6 sites in United States, South Korea
- Volunteers
- 243 people
- Sponsor
- New York University
Depression, Depressive Disorder
The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study
The goal of this clinical trial is to see if a mobile phone app can deliver depression treatment to African Americans who are depressed.
- Conditions
- Depression, Depressive Disorder, Depressive Symptoms
- Trial name
- OHDC-DC (NCT06206226)
- Testing
- OHDC-DC
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Wisconsin, Madison