Clinical trials: Depression and Quality of Life
Depressive Disorder, Treatment-Resistant
Brain Connectivity and Inflammatory Markers During Short-Term Psychotherapy for Treatment-Resistant Depression
Some adults continue to experience depression despite treatment with antidepressant medicines. This study aimed to explore relationships between depression symptoms, brain function, and blood markers of inflammation, and changes…
- Trial name
- NCT07847242
- Testing
- Short-Term Dynamic Psychotherapy, Mindfulness-Based Cognitive Therapy
- Where
- South Korea
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Korea University Ansan Hospital
Insomnia Chronic, Anxiety
Effectiveness of a Psychological Intervention on Mental Health and Sleep.
Background: The COVID-19 pandemic represented a global public health problem that brought considerable consequences to the physical and mental health of the entire population.
- Conditions
- Insomnia Chronic, Anxiety, Depression, Sleep Quality
- Trial name
- NCT05951803
- Testing
- Brief Behavioral Intervention in Insomnia
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Hospital General de Mexico
Bereavement, Cancer
Support for Bereaved Cancer Caregivers
Friend and family caregivers of recently deceased cancer patients experience acute bereavement following the death. Post death bereavement is an intense period of mourning that includes an unfolding of the grief process and is…
- Conditions
- Bereavement, Cancer, Caregiver, Grief
- Trial name
- NCT06662409
- Testing
- Nature-based healing meditation (NBHM) intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Cancer, Anxiety
My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life
The purpose of this study is to examine the implementation and effectiveness of the psychosocial eHealth intervention, My Wellbeing Guide, on the proposed primary outcome, depressive symptoms, in patients diagnosed with cancer…
- Conditions
- Cancer, Anxiety, Depressive Symptoms
- Trial name
- R37 (NCT05369429)
- Testing
- My Wellbeing Guide
- Where
- United States
- Volunteers
- 6,516 people
- Sponsor
- Northwestern University
Breast Cancer, Depressive Symptoms
Mindful-life: Mindfulness Based Intervention vs Cognitive Behavioral Therapy in Patients With Breast Cancer
Breast cancer is the most common cancer pathology among women worldwide and represents a complex psychological challenge for those affected.
- Trial name
- NCT03972020
- Testing
- Mindfulness Based Intervention, Cognitive Behavioral Therapy
- Volunteers
- 100 people
- Sponsor
- University of Turin, Italy
Major Depressive Disorder, Remission
Quality of Life in Chinese Working and School Age Population With MDD
Major depressive disorder (MDD) is a common mental illness with high prevalence and global burden. Previous studies revealed that over 70% patients in remission still had decreased quality of life, severe function impairment, low…
- Trial name
- NCT04986124
- Testing
- treatment as usual
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Mental Health Center
Dementia, Alzheimer Disease
Effectiveness of a 3-month Individual Reminiscence Therapy Program in Older Adults With Alzheimer's Disease
This research aims to evaluate the effectiveness of individual Reminiscence Therapy (RT) program, using a simple reminiscence format, to improve the overall cognitive function, mood, and quality of life (QoL) of older adults with…
- Conditions
- Dementia, Alzheimer Disease, Cognitive Impairment
- Trial name
- NCT06812442
- Testing
- Reminiscence therapy
- Where
- 4 sites in Portugal
- Volunteers
- 40 people
- Sponsor
- Rsocialform - Geriatria, Lda
Mental Health, Physical Health
Parental Well-being After Childbirth in Switzerland
Improving maternal and child health is a global priority, with increasing emphasis on ensuring women and their families not only survive but also thrive after childbirth.
- Conditions
- Mental Health, Physical Health, Postpartum, Parents
- Trial name
- SOCRATES (NCT06886841)
- Where
- 2 sites in Switzerland
- Volunteers
- 4,200 people
- Sponsor
- Laurent Gaucher
Pregnancy, Mother
A Feasibility Study of AMOR; ADHD, Mothers Online Resources
The primary aim of this study is to investigate the feasibility of the program AMOR for pregnant women and new mothers with Attention Deficit Hyperactivity Disorder (ADHD), by examining adherence, credibility, treatment…
- Conditions
- Pregnancy, Mother, Women, Attention Deficit Disorder With Hyperactivity
- Trial name
- AMOR (NCT06679010)
- Testing
- Online group counseling
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- University of Southern Denmark
Myasthenia Gravis, Adverse Childhood Experience
Psychological Health and Adverse Childhood Experiences in Myasthenia Gravis: Online Mental Health BMI Learning Program
This study evaluated psychological health in patients with myasthenia gravis (MG) using an online behavioral program called the "Positive Mental Health BMI Learning Program." The program consisted of four short video units…
- Conditions
- Myasthenia Gravis, Adverse Childhood Experience, Psychological Well-being, Mental Well-being
- Trial name
- NCT07291713
- Testing
- Positive Mental Health BMI Learning Program
- Where
- Taiwan
- Volunteers
- 77 people
- Sponsor
- Jiann-Horng Yeh
Major Depressive Disorder
Duloxetine for Major Depression in Peri-/Postmenopausal Women
The main objective of this study is to characterize a range of brain activation symptoms associated with major depression in peri- and post-menopausal women.
- Trial name
- NCT00889369
- Testing
- Duloxetine
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Healthy, Major Depressive Disorder (MDD)
Neurobiological and Genomic Predictors of Relapse in Depression
The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters.
- Trial name
- MDD (NCT07328373)
- Testing
- Antidepressant Medications
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Mehmet Kemal Arikan
Chronic Pain, Depression, Anxiety
Axon - Brain Train for Pain
A mixed methods proof of concept study to ascertain the effectiveness of a home-based self-administered neurofeedback intervention to treat the primary and secondary symptoms of chronic pain.
- Conditions
- Chronic Pain, Depression, Anxiety, Sleep, Quality of Life
- Trial name
- NCT04418362
- Testing
- Neurofeedback training
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Exsurgo Rehab Limited
Liver Cancer
Cross-sectional Study of Chinese Liver Cancer Patients
The goal of this cross-sectional study is to investigate the prevalence and risk factors of anxiety and depression and their relationships with immune functions and quality of life among liver cancer patients in the COVID-19…
- Trial name
- NCT05872828
- Testing
- No intervention
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Nethersole School of Nursing
Severe Mobility Impairment, Spinal Cord Injuries (Complete and Incomplete)
The Impact of 'Digital Strolling' on Depression and Quality of Life of People With Severe Mobility Impairment
This intervention aims to develop and test the feasibility, acceptability, and preliminary effects of a "Digital Strolling" intervention among people with SMI.
- Conditions
- Severe Mobility Impairment, Spinal Cord Injuries (Complete and Incomplete), Poliomyelitis
- Trial name
- NCT07073144
- Testing
- Virtual walking, Passive observing walking
- Where
- Hong Kong
- Volunteers
- 24 people
- Sponsor
- The Hong Kong Polytechnic University
Intensive Care Unit Syndrome, Relatives
The Effectiveness of a Post-ICU Recovery Program on Relatives
Relatives of intensive care patients are at risk of developing symptoms of anxiety, depression and post-traumatic stress disorder resulting in impaired health-related quality of life (HRQOL).
- Trial name
- RAPIT-II (NCT03264365)
- Testing
- Intervention
- Where
- Denmark
- Volunteers
- 181 people
- Sponsor
- Holbaek Sygehus
Lung Cancer, Depression
Exercise Program Among Lung Cancer Dyads
Pilot study of an exercise program among patients with all stages of lung cancer examining feasibility and acceptability. Preliminary outcomes include objective measures of physical function, depression, adherence to lung cancer…
- Conditions
- Lung Cancer, Depression, Physical Activity, Quality of Life
- Trial name
- PEP-LC (NCT03649737)
- Testing
- Exercise Intervention, Survey Administration, Quality-of-Life Assessment
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- OHSU Knight Cancer Institute
Type 2 Diabetes Mellitus
Effects of Progressive Muscle Relaxation on Anxiety, Depression, and Quality of Life in Adults With Type 2 Diabetes
This randomized controlled study evaluated the effects of an eight-week progressive muscle relaxation program on anxiety, depression, and quality of life in 80 adults with type 2 diabetes mellitus.
- Trial name
- NCT07876401
- Testing
- Progressive Muscle Relaxation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gul Dural
Stroke, Depression
The Sunlight Exposure Therapy on the Improvement of Depression and Quality of Life in Post-stroke Patients
Chronic diseases has been the leading causes of death in 2015 to 2017 based on the National database. In particular, cerebrovascular disease was the third in 2015, the fourth in 2016 and 2017.
- Trial name
- NCT04036565
- Testing
- sunlight therapy
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Idiopathic Pulmonary Fibrosis, Dyspnoea
Modelling of Quality Life, Clinical and Physiological Measures in Idiopathic Pulmonary Fibrosis
As there are no validated tools for assessing patient reported outcomes or health related quality of life in idiopathic pulmonary fibrosis (IPF), different studies have utilised different methods.
- Conditions
- Idiopathic Pulmonary Fibrosis, Dyspnoea, Anxiety, Depression
- Trial name
- NCT02176707
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of East Anglia