Clinical trials: Depression in Adults
Depression
Applied Clinical Neuroscience Care for Self-reported Symptoms of Depression and Cerebellar Function in Adults
Pilot study design that operationalizes the multimodal manner of care while evaluating changes in depression symptoms, dysmetria, and balance for medication non-responders.
- Trial name
- DEP (NCT03997240)
- Testing
- Chiropractic Applied Clinical Neuroscience
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Life University
Sickle Cell Disease, Depression
Cognitive Behavioral Therapy and Real-time Self-management Intervention for SCD Via Mobile Applications
Patients with sickle cell disease (SCD) experience significant depressive symptoms that currently go unrecognized and under-treated.
- Conditions
- Sickle Cell Disease, Depression, Anxiety
- Trial name
- CaRISMA (NCT02384590)
- Testing
- Computerized cognitive behavioral therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Depression
Psycho-behavioral Intervention for Depression in Chronic Heart Failure
The study aims to explore the effectiveness of psycho-behavioral intervention on depressive symptoms among older adults with chronic heart failure.
- Trial name
- NCT03233451
- Testing
- Psycho-behavioral intervention
- Where
- 6 sites in China
- Volunteers
- 236 people
- Sponsor
- Peking University
Postpartum Depression
A Study of BRII-297 in Healthy Adult Subjects
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics of BRII-297 in healthy adult subjects.
- Trial name
- NCT05845840
- Testing
- BRII-297
- Where
- Australia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Brii Biosciences Limited
Depression
Collaborative Stepped-care Intervention for Adults With Subthreshold Depressive Symptoms in the Primary Care Setting
To ensure accessibility and availability of mental health services in the community and to reduce the burden associated with depression and related conditions, the study aim to evaluate the effectiveness of a collaborative…
- Trial name
- NCT06658041
- Testing
- Cognitive behavioural therapy (CBT)-based intervention with stepped-care, Care-as-usual
- Where
- Hong Kong
- Volunteers
- 352 people
- Sponsor
- The University of Hong Kong
Moderate Dementia, Severe Dementia
Can Virtual Reality Reduce Depression and Agitation in Older Adults With Moderate to Severe Dementia?
Dementia is a term used to describe a collection of symptoms including memory loss, problems with reasoning and communication, and a reduction in a person's ability to carry out daily activities.
- Trial name
- NCT04347668
- Testing
- Virtual Reality, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 266 people
- Sponsor
- Western University, Canada
Major Depressive Disorder, Dysthymia
A Study of L-DOPA for Depression and Slowing in Older Adults
Individuals with Late Life Depression (LLD) often have cognitive problems, particularly problems with memory, attention, and problem solving, all of which contribute to antidepressant non-response.
- Conditions
- Major Depressive Disorder, Dysthymia, Depression Not Otherwise Specified, Decreased Processing Speed
- Trial name
- NCT02744391
- Testing
- Levodopa
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- New York State Psychiatric Institute
Anxiety, Depression
Weighted Blankets for Dental Anxiety
The objective of this project is to determine the effectiveness of weighted blankets as an anxiety-reducing intervention for neurotypical adult patients with dental anxiety undergoing routine dental procedures at the University…
- Trial name
- NCT07879846
- Testing
- Blanket at visit 1., No blanket at visit 1, Blanket at visit 2.
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Postpartum Depression
A Study to Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression (547-PPD-202C)
The purpose of this study was to determine if SAGE-547 Injection infused intravenously at up to 90 μg/kg/h for 60 hours reduces depressive symptoms in participants with moderate postpartum depression (PPD) compared to placebo…
- Trial name
- NCT02942017
- Testing
- SAGE-547 90 μg/kg/h
- Where
- 32 sites in United States
- Volunteers
- 108 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
HIV/AIDS, Cognitive Impairment
A Randomized Pilot Trial Evaluating the Impact of a Yoga Intervention on Cognition in Older Adults Infected With HIV
Approximately 50% of people living with HIV (and as many as 80% over the age of 50) have difficulties with cognitive functions such as memory and thinking that can have a profound negative impact on activities of daily living and…
- Conditions
- HIV/AIDS, Cognitive Impairment, Aging, Mobility Limitation
- Trial name
- NCT03071562
- Testing
- Yoga-mindfulness
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Adria Quigley
Depression, Suicide
Antidepressant Drug Exposure and Risk of Suicide Attempt Resulting in Medical Intervention in US Adults
The primary objective of the study is to estimate the incidence of suicide attempts resulting in a medical encounter or hospitalization in seven propensity matched cohorts of subjects: patients treated with duloxetine for…
- Trial name
- NCT00763724
- Volunteers
- 254,432 people
- Sponsor
- Eli Lilly and Company
Depression, Fatigue
Individualized Exercise Programs for Patients Receiving Chemotherapy for Newly Diagnosed Acute or Relapsed Myeloid Leukemia or Lymphoblastic Leukemia
RATIONALE: An individualized exercise program may be effective in lessening fatigue and depression and improving quality of life in patients undergoing chemotherapy for leukemia.
- Conditions
- Depression, Fatigue, Leukemia, Musculoskeletal Complications
- Trial name
- NCT00499759
- Testing
- Resting vitals, Body Composition, Timed Get-up and Go test (TGUG).
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center