Clinical trials: Depression in Schizophrenia
Schizophrenia Disorders, Personality Disorders
Recovery in Telling Life Stories
This project tests the Recovery In Telling Life Stories (RETELL) intervention, aimed at supporting personal recovery in people with severe mental illness (SMI).
- Conditions
- Schizophrenia Disorders, Personality Disorders, Obsessive - Compulsive Disorder, Anxiety Disorders
- Trial name
- RETELL (NCT07082777)
- Testing
- Narrative therapy
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Autism Spectrum Disorder, Depression - Major Depressive Disorder
Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models
This study investigates whether AI-driven analysis of speech can accurately predict clinical diagnoses and assess risk for various mental or behavioral health conditions, including attention-deficit/hyperactivity disorder (ADHD)…
- Conditions
- Autism Spectrum Disorder, Depression - Major Depressive Disorder, Anxiety, Generalized, Bipolar Disorder (BD)
- Trial name
- MINDAIM (NCT06792175)
- Testing
- Solicue Machine Learning Models, Mercuria Machine Learning Models
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Psyrin Inc.
Major Depressive Disorder, Bipolar Disorder
Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT
This prospective, open-label clinical trial aims to compare a novel "Venous Tourniquet with Regional Low-Dose Sugammadex" method against the gold standard "Arterial Tourniquet" (Isolated Forearm Technique - IFT) for monitoring…
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT07534475
- Testing
- Device: Arterial Tourniquet, Device: Venous Tourniquet, Sugammadex
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Medipol University
Major Depressive Disorder, Bipolar Disorder
Decreasing the Use of Unmodified Electroconvulsive Therapy (ECT) in an Indian Hospital
In developing countries, electroconvulsive therapy (ECT) is typically delivered without the use of an anesthetic prior to the treatment, known as unmodified ECT.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT01526395
- Testing
- Propofol
- Where
- India
- Volunteers
- 99 people
- Sponsor
- Johns Hopkins University
Major Depressive Disorder, Psychotic Disorders
A United States Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depression
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress…
- Trial name
- NCT00128479
- Testing
- mifepristone, mifepristone 600 mg, mifepristone 1200 mg
- Where
- 44 sites in United States
- Volunteers
- 443 people
- Sponsor
- Corcept Therapeutics
Schizophrenia, Major Depressive Disorder
DIMES - DIgital MEdicine Study for Adults With Schizophrenia, Bipolar I Disorder, or Major Depression Currently Using Aripiprazole
This is a 12 month, pragmatic trial designed to assess the differences in a digital medicine system (DMS)- ABILIFY MYCITE (Aripiprazole tablets with sensor)- measuring adherence versus treatment as usual (TAU) for adult patients…
- Conditions
- Schizophrenia, Major Depressive Disorder, Bi-Polar Disorder, Schizo Affective Disorder
- Trial name
- DIMES (NCT03881449)
- Testing
- ABILIFY MYCITE
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Durham VA Medical Center
Bipolar Disorders, Mood Disorders
A Study of the Effectiveness and Safety of Topiramate in the Treatment of Patients With Bipolar Disorder
The primary purpose of this study is to evaluate the effectiveness and safety of topiramate compared with placebo in the treatment of acute manic or mixed episodes in patients with Bipolar I Disorder.
- Conditions
- Bipolar Disorders, Mood Disorders, Affective Disorders, Psychotic
- Trial name
- NCT00240721
- Testing
- topiramate
- Volunteers
- 363 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Bipolar Disorder, Schizophrenia
Comparison of Physical Fitness, Physical Activity Level in Patients With Bipolar Disorder and Schizophrenia
According to the World Health Organization; Bipolar disorder ranks in the top 20 causes of disability among all medical conditions and 6th among mental disorders worldwide.
- Trial name
- NCT05936983
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Yeditepe University
Schizophrenia, Schizoaffective Disorder
Improving Outcome in Schizophrenia Through Identification of Genetic Risk Factors
The goals of this study are to replicate previous findings of genetic predictors of response to clozapine and other antipsychotic drugs.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- NCT00178932
- Testing
- genetic analysis, genetic assay
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Weight Gain
Exenatide for the Treatment of Weight Gain Associated With Olanzapine in Obese Adults
The purpose of this research study is to test the safety and efficacy (how well it works) of exenatide as a treatment for weight gain associated with olanzapine in obese adults with Bipolar Disorder, Major Depressive Disorder…
- Trial name
- NCT00845507
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Cincinnati
Schizophrenia, Schizophreniform Disorder
Biomarkers in First Episode Schizophrenia
This study will identify and evaluate relevant biomarkers and structural brain imaging for understanding potential biological illness related mechanisms in medication-naïve subjects with early psychosis before and after…
- Conditions
- Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, Depressed Type
- Trial name
- NCT02033382
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Depression, Schizophrenia
Olanzapine Versus Active Comparator in the Treatment of Depression in Patients With Schizophrenia
This is a research study comparing the safety and efficacy of two active study medications
- Conditions
- Depression, Schizophrenia, Schizoaffective Disorder
- Trial name
- NCT00034801
- Testing
- olanzapine, ziprasidone
- Where
- 30 sites in United States
- Volunteers
- 378 people
- Sponsor
- Eli Lilly and Company
Mental Disorders, Severe
Measuring Development of Brain Responses to Vocal Sounds in Babies of Mums With Mental Illness
CAPRI-Voc examines the differences in how speech and environmental sounds are processed in the infant brain as they grow from 9 to 12 months.
- Trial name
- CAPRI-Voc (NCT04350294)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Stigmatization, Depression
Impact of Video Presentations on Medical Students' Attitudes Toward Mental Illness
This is a randomized controlled trial examining the impact of videos on medical students' implicit and explicit attitudes and knowledge related to mental illness in Nepal.
- Conditions
- Stigmatization, Depression, Psychosis
- Trial name
- NCT03231761
- Testing
- Service user testimonial videos, mhGAP didactic video
- Where
- 2 sites in Nepal
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- George Washington University
Schizophrenia, Psychosis
Minnesota Community-Based Cognitive Training in Early Psychosis
The purpose of this study is to determine whether cognitive training exercises can improve cognitive functioning in young patients with recent-onset psychosis who are being treated in community mental health settings using the…
- Conditions
- Schizophrenia, Psychosis, Schizoaffective Disorder, Schizophreniform Disorders
- Trial name
- Mini-COTES (NCT03079024)
- Testing
- Targeted Cognitive Training, General Cognitive Exercises, Coordinated Specialty Care for First Episode Psychosis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Schizophrenia (Recent-onset)
Oral Risperidone Versus Injectable Paliperidone Palmitate for Treating First-Episode Schizophrenia
This study will determine the efficacy of oral risperidone (Risperdal) versus long-acting injectable paliperidone palmitate (Invega Sustenna) in treating people with first-episode schizophrenia.
- Trial name
- NCT01451736
- Testing
- paliperidone palmitate, risperidone
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Schizophrenia, Major Depression
Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Schizophrenia or Major Depression
We investigate whether the add-on specific antitoxoplasmatic medication has positive effects in individuals with schizophrenia or major depression seropositive for Toxoplasma gondii (TG) infection.
- Trial name
- NCT00300404
- Testing
- daraprim, pyrimethamine, folinic acid
- Volunteers
- 40 people
- Sponsor
- Zentrum für Integrative Psychiatrie
Psychosis, Anxiety
Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis
The aim of this trial is to evaluate the feasibility and preliminary efficacy of using passive smartphone sensors to detect moments of heightened negative mood and inform the timing of brief mental health interventions, such as…
- Conditions
- Psychosis, Anxiety, Depression, Rumination
- Trial name
- NCT07503093
- Testing
- Smartphone-based Mindfulness Exercise, Smartphone-based Psychoeducation, Neutral Control Message
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mclean Hospital
Schizophrenia
The Efficacy of Escitalopram for Negative Symptoms in Schizophrenia
The aim of this study is to evaluate the therapeutic effect of escitalopram in the treatment of negative symptoms in schizophrenia patients in a double-blind placebo-controlled study.
- Trial name
- NCT00148447
- Testing
- escitalopram
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- BeerYaakov Mental Health Center
Family Members, Healthy
The Effect Of Logotherapy-Based Psychoeducatıon Applıed To Famıly Members Of Indıvıduals Dıagnosıs Of Schızophrenıa
Objective: This study aimed to determine the effects of logotherapy-based psychoeducation applied to family members of individuals diagnosed with schizophrenia on meaning in life, hope, and depression, and to examine experiences…
- Trial name
- NCT06859112
- Testing
- logotherapy focused psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- aslı zeynep sipahi