Clinical trials: Depression in Schizophrenia
Depression, Schizophrenia
Symptom Based Treatment Affects Brain Plasticity - Cognitive Training in Patients With Affective Symptoms
The aim of the study is the examination of brain plasticity on on affective symptoms after neuromodulation with fMRI (functional magnetic resonance imaging) neurofeedback.
- Trial name
- APIC-II (NCT03183947)
- Testing
- fMRI, Neurofeedback, PANAS
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Severe Mental Disorders, Schizophrenia
Community-based Mental Health Care for People With Severe and Enduring Mental Ill Health
A single-blinded hybrid effectiveness-implementation trial (Type II), that both evaluates the intervention outcomes (clinical and service use outcomes) through patient-randomization in the implementation sites, as well as…
- Conditions
- Severe Mental Disorders, Schizophrenia, Bipolar Disorder, Severe Depression
- Trial name
- RECOVER-E (NCT03837340)
- Testing
- CMHT, CAU
- Where
- Montenegro
- Volunteers
- 160 people
- Sponsor
- Special Psychiatric Hospital Kotor
Schizophrenia, Major Depressive Disorder
Effectiveness of Traditional Chinese Metacognitive Training (MCT) in Patients With Schizophrenia, Depression, or Bipolar Disorder Attending a Psychiatric Day Hospital in Taiwan
Schizophrenia is characterized by positive symptoms such as delusions and hallucinations, which significantly impact daily functioning.
- Conditions
- Schizophrenia, Major Depressive Disorder, Bipolar Disorder
- Trial name
- NCT07051746
- Testing
- Metacognitive Training (MCT), Traditional Chinese version
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- ZI-YU LIN
Schizophrenia Disorders, Bipolar Disorders
MonPsy&Moi: A Digital Platform for Collecting Patient-Reported Experience and Outcome Measures in Psychiatry
Mental health disorders, with a 30% annual prevalence rate, are a leading cause of disability and reduced life expectancy. Despite their impact, patient-reported experience measures (PREMs) and outcome measures (PROMs) are…
- Conditions
- Schizophrenia Disorders, Bipolar Disorders, Major Depression
- Trial name
- Mon Psy & Moi (NCT06818227)
- Where
- France
- Volunteers
- 23,660 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Psychotic Depression, Severe Major Depression With Psychotic Features
A Study of Mifepristone vs. Placebo in the Treatment of Patients With Major Depression With Psychotic Features
Approximately 450 patients will be randomized to receive mifepristone or placebo for 7 days followed by antidepressant. The purpose is to compare the efficacy of mifepristone followed by antidepressant versus placebo followed by…
- Conditions
- Psychotic Depression, Severe Major Depression With Psychotic Features, Psychosis
- Trial name
- NCT00637494
- Testing
- mifepristone
- Where
- 42 sites in United States
- Volunteers
- 292 people
- Sponsor
- Corcept Therapeutics
Bipolar Disorder, Depression
Effect of Immersive Virtual Reality-based Cognitive Remediation in Patients With Mood - or Psychosis Spectrum Disorders
The goal of this clinical trial is to investigate the effect of a four-weeks, intensive virtual reality (VR)-based cognitive remediation (training) programme involving simulated daily-life challenges on cognition and functional…
- Conditions
- Bipolar Disorder, Depression, Psychotic Disorders, Cognitive Impairment
- Trial name
- NCT06038955
- Testing
- Virtual reality Based Cognitive Remediation, Virtual reality control training
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Schizophrenia, Bipolar Disorder
Individualizing Incentives for Alcohol in the Severely Mentally Ill
The investigators will evaluate the efficacy of a 2 various contingency management (CM) interventions (High-Magnitude CM, Shaping CM) for treating heavy drinking among individuals with serious mental illness and alcohol…
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Alcohol Dependence
- Trial name
- NCT03481049
- Testing
- Usual CM, High-Magnitude CM, Shaping CM
- Where
- 2 sites in United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Washington State University
Schizophrenia
Efficacy and Safety of Quetiapine in Treating Affective Symptoms of Patients With First-episode psychosis-a Pilot Study
The purpose of this study is: To investigate whether a treatment with quetiapine for six months in patients with first-episode psychosis may be effective in treating depressive symptoms.
- Trial name
- NCT00511277
- Testing
- Seroquel®
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
Schizophrenia
Adjuvant Therapy With Pergolide in Treating Cognitive Deficits in Schizophrenia
The objective of this study is to compare the modulation of pergolide, a D1/D2 receptor agonist, to placebo in non-acute schizophrenic subjects under concomitant therapy with atypical antipsychotics on specific PFC functions.
- Trial name
- NCT01066403
- Testing
- Pergolide
- Where
- 4 sites in Germany
- Volunteers
- 28 people
- Sponsor
- Heidelberg University
Schizophrenia, Major Depression
A Double Blind Sham Controlled Trial of tDCS in Treating Schizophrenia and Depression
The project will investigate the use of a novel technique, transcranial direct current stimulation (tDCS) in the treatment of patients with schizophrenia and patients with depression.
- Trial name
- NCT00481026
- Testing
- transcranial direct current stimulation (tDCS), active tDCS
- Where
- Australia
- Volunteers
- 31 people
- Sponsor
- Bayside Health
Schizophrenia, Schizophrenia and Related Disorders
Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling
The goal of this randomized clinical trial is to be adequately powered to evaluate the effect of ketogenic metabolic therapy on the quality of life in serious mental illness, schizophrenia, bipolar disorder, major depressive…
- Conditions
- Schizophrenia, Schizophrenia and Related Disorders, Bipolar Disorder, Bipolar and Related Disorders
- Trial name
- NCT06748950
- Testing
- LCHF Ketogenic Diet, Diet-as-Usual (DAU)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stanford University
Schizophrenia, Bipolar Disorder
EMR Data to Assess Monitoring of Patients Treated With Quetiapine
A study to evaluate the effectiveness of an update of educational materials with respect to evaluation of monitoring of metabolic parameters
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT01793324
- Volunteers
- 6,153 people
- Sponsor
- AstraZeneca
Patients Diagnosed With Severe Mental Illness
From Compliance to Alliance: Engaging Psychiatric Patients in Illness Management
The purpose of this study is to determine the benefit and impact on relapse prevention,adherence to treatment and general health indices of participation in psycho-eduational group intervention among psychiatric patients with…
- Trial name
- NCT00192751
- Testing
- Psychoeducational group sessions
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rambam Health Care Campus
Schizophrenia, Bipolar Disorder
Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications
Previous and our studies have shown that cognitive impairments are core symptoms of three major psychiatric disorders-schizophrenia, bipolar disorder, and major depressive disorder, and are associated with underlying brain…
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder (MDD)
- Trial name
- NCT07444463
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Central South University
Psychosis, Schizophrenia
Cognitive Behavioral Therapy for Patients With an Early Psychosis
The purpose of the present study is to examine whether cognitive behavior therapy will reduce depressive symptoms and increase self-esteem for patients with a first episode psychosis.
- Conditions
- Psychosis, Schizophrenia, Depressive Symptoms, Self-esteem
- Trial name
- NCT01511406
- Testing
- cognitive behavioral therapy
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Alzheimer Disease
Home-based Transcranial Direct Current Stimulation (tDCS) for Behavioral Symptoms in Alzheimer's Disease and Related Dementias (ADRD)
The purpose of this study is to assess acceptability, and safety of providing tDCS to ADRD patients with behavioral symptoms and to assess the efficacy of tDCS for ADRD-related symptoms, mainly behavioral symptoms.
- Trial name
- NCT05478681
- Testing
- active tDCS
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Health Science Center, Houston
Suicidal Ideation, Major Depressive Disorder
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse …
- Conditions
- Suicidal Ideation, Major Depressive Disorder, Schizo Affective Disorder, Bipolar Disorder
- Trial name
- LAP-ST vs ECT (NCT06529029)
- Testing
- Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michigan State University
Type 2 Diabetes Mellitus, Schizophrenia
Lifestyle Intervention for Diabetes and Weight Management in Psychosis
The rate of type-2 diabetes mellitus (T2DM) is at least 2-3 times higher in persons with psychotic illnesses than in the general population.
- Conditions
- Type 2 Diabetes Mellitus, Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- Healthy_LIFE (NCT01828931)
- Testing
- Lifestyle Intervention, Usual Care
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder (MDD), SCHIZOPHRENIA 1 (Disorder)
Transcranial Direct Current Stimulation (tDCS) in Different Psychiatric Disorders
The goal of this clinical trial is to evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) in reducing core symptoms of different psychiatric disorders using validated clinical scales.
- Conditions
- Major Depressive Disorder (MDD), SCHIZOPHRENIA 1 (Disorder), Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
- Trial name
- Transcranial (NCT07452835)
- Testing
- tDCS Parameters
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Menoufia University
Stress Disorders, Post-Traumatic
Treatment of Post Traumatic Stress Disorder in Patients With Other Mental Illnesses
The purpose of this study is to develop an effective treatment for people with Post Traumatic Stress Disorder (PTSD) along with other mental illnesses.
- Trial name
- NCT00053690
- Testing
- Cognitive Behavior Treatment
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Dartmouth-Hitchcock Medical Center