Clinical trials: Depression in Schizophrenia
Schizophrenia, Schizoaffective Disorder
AIMHI NT Relapse Prevention Trial
A new treatment for indigenous people with mental illness in remote communities has been developed. The study hypothesis is that this new treatment will result in better outcomes for clients and carers than the outcomes of…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychoses, Substance Induced, Depression
- Trial name
- NCT00192582
- Testing
- Motivational Interview with care plan and education
- Where
- Australia
- Volunteers
- 90 people
- Sponsor
- Menzies School of Health Research
Bipolar Disorder, Schizophrenia
Community-based Mental Health Care for People With Severe and Enduring Mental III Health
A single-blinded hybrid effectiveness-implementation trial (Type II), that both evaluates the intervention outcomes (clinical and service use outcomes) through patient-randomization in the implementation sites, as well as…
- Conditions
- Bipolar Disorder, Schizophrenia, Severe Depression
- Trial name
- RECOVER-E (NCT03922425)
- Testing
- Community mental health team
- Where
- Bulgaria
- Volunteers
- 180 people
- Sponsor
- The National Center for Public Health and Analyzes, Bulgaria
Dementia, Depression
Pharmacovigilance in Gerontopsychiatric Patients
The purpose of this multicenter-study is to investigate safety of psychopharmacological treatment and rates of adverse drug reactions in gerontopsychiatric inpatients.
- Conditions
- Dementia, Depression, Schizophrenia, Psychosomatic Disorders
- Trial name
- GAP (NCT02374567)
- Testing
- Phenobarbital, Phenytoin, Carbamazepine
- Where
- 5 sites in Germany
- Volunteers
- 407 people
- Sponsor
- Hannover Medical School
Mental Illness, Schizophrenia
Walking for Health: an Intervention to Increase Physical Activity and Reduce Sedentary Behaviour in People With SMI
People who have a severe mental illness can have poorer physical health and higher mortality rates than the general population. Their medications combined with low levels of physical activity and increased sedentary behaviour can…
- Conditions
- Mental Illness, Schizophrenia, Bipolar Disorder, Major Depression
- Trial name
- WORtH (NCT04134871)
- Testing
- Group walk and one to one coaching
- Where
- 3 sites in Ireland, United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Ulster
Tobacco Use Disorder, Mental Illness
Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings
The study team will conduct a Multisite Randomized Controlled Trial to evaluate the advantages and disadvantages of two approaches for quitting smoking among people with serious mental illness (SMI).
- Conditions
- Tobacco Use Disorder, Mental Illness, Recurring Major Depressive Disorder, Bipolar Disorder
- Trial name
- MTQT (NCT05030272)
- Testing
- Quit on the Go App (formerly "Learn to Quit " App), Brief advice, Nicotine patch
- Where
- 3 sites in United States
- Volunteers
- 343 people
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia
Oral Versus Injectable Risperidone for Treating First-Episode Schizophrenia
This study will determine the effectiveness of oral risperidone versus long-acting injectable risperidone in treating people with first-episode schizophrenia.
- Trial name
- NCT00330551
- Testing
- Oral Risperidone, Risperidone in Long-Acting Injectable Form (Consta)
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Lithium Level Detection in Sweat
Indirect Evaluation of Lithium Level in Blood Using Non-invasive Sweat Biosensors
Indirect evaluation of the accuracy and the efficacy of biosensors developed for Li+ detection in sweat.
- Trial name
- NCT04186507
- Testing
- Smartwatch with integrated Li+ sensor (provided by Spectrophon LTD)
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Tirat Carmel Mental Health Center
Schizophrenia, Bipolar 1 Disorder
A Trial to Measure the Difference in All-cause Hospitalizations for Participants Who Are Using Abilify MyCite Versus Virtual Matched Controls in Adults With Schizophrenia, Bipolar 1 Disorder, and Major Depressive Disorder
The primary objective of this pragmatic clinical trial (Main Study) was to assess the difference between all-cause hospitalizations in participants using Abilify MyCite versus virtual matched controls.
- Conditions
- Schizophrenia, Bipolar 1 Disorder, Major Depressive Disorder
- Trial name
- NCT03643159
- Testing
- Abilify MyCite - Digital Medicine System, Aripiprazole or other oral antipsychotics
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Severe Mental Illness, Schizophrenia
Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness
This study evaluates a group-based intervention designed to improve romantic and social relationship skills in adults living with a severe mental illness (SMI), such as schizophrenia, bipolar disorder, or major depressive…
- Conditions
- Severe Mental Illness, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- A2C'estMieuxVE (NCT07316803)
- Testing
- À deux, c'est mieux (Better Together) Group Intervention
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre hospitalier de Ville-Evrard, France
Psychiatric Disorder, Schizophrenia
Improving Physical Health in Patients With Psychiatric Disorders in General Practice (SOFIA)
People with a severe mental illness (SMI) have an increased risk for premature mortality, predominantly due somatic health conditions.
- Conditions
- Psychiatric Disorder, Schizophrenia, Bipolar Disorder, Severe Depression
- Trial name
- SOFIA (NCT04618250)
- Testing
- SOFIA model
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- University of Copenhagen
Serious Mental Illness, Schizophrenia
Mindfulness-Based Therapy for Serious Mental Illness
Serious mental illness (SMI), encompassing schizophrenia-spectrum and major mood disorders, has been estimated to affect approximately 5.4% of the U.S. adult population each year.
- Conditions
- Serious Mental Illness, Schizophrenia, Major Depressive Disorder, Bipolar Disorder
- Trial name
- MBT (NCT06880796)
- Testing
- Mindfulness-based therapy, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Butler Hospital
Schizophrenia, Schizoaffective Disorder
Agomelatine Treatment of Depression in Schizophrenia (AGOPSYCH)
Major depressive episodes (MDEs) occur frequently during the course of psychotic disorders, and several antidepressive agents have been successfully applied.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Delusional Disorder
- Trial name
- AGOPSYCH (NCT01822418)
- Testing
- agomelatine
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Schizophrenia, Autism
Pediatric Open-Label Extension Study
This is an open-label, 104-week, multicenter, extension study designed to evaluate the long-term safety, tolerability and effectiveness of flexibly dosed lurasidone (20, 40, 60 or 80 mg/day) in pediatric subjects who have…
- Conditions
- Schizophrenia, Autism, Bipolar Depression
- Trial name
- NCT01914393
- Testing
- Lurasidone 20, 40, 60, 80 mg, flexibly dosed
- Where
- 88 sites in United States, Bulgaria and 13 more
- Volunteers
- 702 people
- Sponsor
- Sumitomo Pharma America, Inc.
Schizophrenia, Bipolar Disorder
Cognitive Training to Improve Work Outcomes in Severe Mental Illness
This study will compare the efficacy of two types of supportive treatments for a program called Individual Placement and Support, which helps people with severe mental illnesses find and keep jobs.
- Conditions
- Schizophrenia, Bipolar Disorder, Depression
- Trial name
- NCT00895258
- Testing
- Individual placement and support plus cognitive training (IPS-CT), Individual placement and support plus enhanced support (IPS-ES)
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of California, San Diego
Mental Health
Patient Generated Goals in Mental Health: Better Outcomes?
Researchers believe that clinical care can be improved by engaging patients and families directly in planning the care process. Engagement efforts have included asking patients/families to provide information about whether they…
- Trial name
- NCT03527914
- Testing
- Goal Based Outcomes, Treatment as Usual
- Where
- Canada
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Psychosis, Schizophrenia Disorder
Cognitive Strategies in Early Psychosis 2
The goal of this clinical trial is to learn more about decision making in psychosis spectrum disorders, like schizophrenia. Participants will be people who have had symptoms of a psychosis spectrum disorder start within the last…
- Conditions
- Psychosis, Schizophrenia Disorder, Schizoaffective Disorder, Major Depressive Disorder With Psychotic Features
- Trial name
- COSTEP 2 (NCT07263022)
- Testing
- Modafinil, D-serine solution
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Effectiveness of a Problem-solving Intervention for Common Adolescent Mental Health Problems in India
We will conduct a two-arm individually randomized controlled trial in six Government-run secondary schools in New Delhi. The targeted sample is 240 adolescents in grades 9-12 with persistent, elevated mental health difficulties…
- Trial name
- PRIDE (NCT03630471)
- Testing
- PRIDE 'Step 1' problem-solving intervention, Enhanced usual care
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Sangath
Schizophrenia, Schizoaffective Disorder
The Efficacy of Metacognitive Skills Training in the Context of Forensic Psychiatric Care
Deficiencies in social cognition are part of the core symptomatology of psychotic disorders. And deficiencies in social cognition, the closely related concept of metacognition, and, for example, paranoid attitudes are all…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychotic Disorders, Delusional Disorder
- Trial name
- NCT06005766
- Testing
- Metacognitive Skills Training (MCT), Treatment as usual
- Where
- Finland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Jyvaskyla
Schizophrenia
Pharmacodynamic/Pharmacokinetic Study of AQW051 in Schizophrenia
Part 1 of the study will assess the enhancement of task-related brain activation (BOLD response) in key brain areas in schizophrenia during the performance of working memory, episodic memory and visual activation tasks as…
- Trial name
- NCT00825539
- Testing
- AQW051
- Where
- 7 sites in United States
- Volunteers
- 68 people
- Sponsor
- Novartis Pharmaceuticals
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Psycho-social Support on Mental Health and Hope of Adolescents Affected by Earthquake in Nepal
Adolescents are prone to mental health problems such as post-traumatic stress disorder (PTSD) and depression which could become worse in the aftermath of disasters.
- Trial name
- NCT03387007
- Testing
- Psychosocial support training for school teachers
- Volunteers
- 1,912 people, healthy volunteers welcome
- Sponsor
- Tokyo University