Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Treatment Resistant Depression (TRD)
Maintenance TMS in Treatment Resistant Depression
Electroconvulsive therapy (ECT) is one of the most efficacious treatments available for treatment-resistant depression (TRD). Although a maintenance ECT protocol exists, multiple barriers limit its use for long-term use.
- Trial name
- NCT06682299
- Testing
- Transmagnetic Stimulation, Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Austin Messner
Treatment Resistant Depression
Allogeneic Human Mesenchymal Stem Cells (hMSCs) Infusion in Patients With Treatment Resistant Depression
This study is intended to evaluate the safety and potential efficacy of Allogeneic Human Mesenchymal Stem Cell Infusion versus placebo in patients with Treatment Resistant Depression.
- Trial name
- ANU (NCT02675556)
- Testing
- Allo-hMSCs
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joshua M Hare
Carpal Tunnel Syndrome, Depressive Symptoms
The Relationship of Psychological Factors and Sleep Quality With the Severity of Carpal Tunnel Syndrome
The most common entrapment neuropathy symptoms, the diagnosis of CTS, is determined by examination findings and by means of the results of electro-diagnostic test.
- Conditions
- Carpal Tunnel Syndrome, Depressive Symptoms, Sleepiness, Anxiety
- Trial name
- NCT05047367
- Testing
- cross-sectional survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 149 people
- Sponsor
- Cumhuriyet University
Depression
Folic Acid and Omega -3 Fatty Acid Supplementation in Depressed Older Adults
Our specific aim is to determine the impact of folic acid and omega-3 supplementation on the severity of depressive symptoms among depressed adults aged 65 and above.
- Trial name
- NCT00480207
- Testing
- folic acid, omega-3, vit B12
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Prof. RH Belmaker
Suicide Prevention
Safety Planning and Cognitive Behavioral Therapy for Adolescent Suicide Prevention in Mozambique
This implementation research project aims to test the effectiveness and implementation outcomes of suicide safety planning along and a transdiagnostic cognitive behavioral intervention for suicide prevention on decreasing…
- Trial name
- NCT06465381
- Testing
- Safety Planning Intervention, Enhanced Usual Care, Transdiagnostic Cognitive Behavioral Therapy for Suicide Prevention
- Where
- 7 sites in Mozambique
- Volunteers
- 2,100 people
- Sponsor
- University of Washington
Depressive Disorder, Major
Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)
Multicenter, open-label, long-term extended access treatment protocol in adult patients with a primary diagnosis of MDD.
- Trial name
- NCT03668600
- Testing
- Rapastinel
- Where
- 74 sites in United States
- Volunteers
- 230 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Psoriasis, Metabolic Syndrome
Clinical Study of PET/CT and Association With Metabolic Syndrome/Depressive Symptoms in Psoriasis
Psoriasis is associated with increases in markers of inflammation in the skin and blood and increasingly is thought to be a systemic inflammatory disease and risk factor for incident diabetes mellitus, myocardial infarction…
- Conditions
- Psoriasis, Metabolic Syndrome, Depression
- Trial name
- NCT01661127
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Pusan National University Hospital
Major Depressive Disorder (MDD)
Efficacy, Safety and Tolerability of Agomelatine in the Treatment of Major Depressive Disorder
This study will assess efficacy, safety and tolerability of agomelatine (AGO178) 25 mg and 50 mg in patients with Major Depressive Disorder (MDD). This study includes an 8-week double-blind phase and a 52-week open-label phase.
- Trial name
- NCT00411242
- Testing
- agomelatine
- Where
- 51 sites in United States
- Volunteers
- 503 people
- Sponsor
- Novartis
Depression, Major Depressive Disorder
Novel Neural Circuit Biomarkers of Major Depression Response to CCBT
The purpose of the study is to learn more about computer-assisted cognitive behavioral therapy or "CCBT" and to examine connections in the brains of patients with depression.
- Conditions
- Depression, Major Depressive Disorder, Depressive Disorder, Depression, Unipolar
- Trial name
- NCT03096886
- Testing
- Computer-Augmented Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Depression, Depressive Disorder
Improving Retention of Hispanics Receiving Antidepressant Therapy
This study will develop an intervention that will increase the retention of Hispanics with major depression in antidepressant therapy.
- Trial name
- NCT00057642
- Testing
- Sertraline, Venlafaxine Extended Release
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Major Depression
Thyroid Medication and Antidepressants for Treating Major Depression
This study will evaluate the effectiveness of treatment with supplemental triiodothyronine (T3, Cytomel) and sertraline (Zoloft), a selective serotonin reuptake inhibitor (SSRI), in improving symptoms of major depressive disorder…
- Trial name
- NCT00208702
- Testing
- Triiodothyronine, Sertraline
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Emory University
Major Depressive Disorder
Study Evaluating the Effect of Desvenlafaxine on the Pharmacokinetics of Midazolam
The main purpose of this study is to evaluate the effect of desvenlafaxine administered as DVS SR on the pharmacokinetics of midazolam in healthy male and female subjects.
- Trial name
- NCT00952653
- Testing
- Desvenlafaxine Succinate Sustained Release, Midazolam
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cocaine Dependence, Depressive Symptoms
Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans
To examine the clinical efficacy of sertraline (200 mg/day) alone or sertraline in combination with gabapentin. The purpose of this study is to examine whether the antidepressant sertraline alone or combined with gabapentin…
- Trial name
- NCT00654953
- Testing
- sertraline, gabapentin
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Arkansas
Major Depressive Disorder
Dopaminergic Effects of Adjunctive Aripiprazole on the Brain in Treatment-Resistant Depression
Aripiprazole has been approved by the FDA for augmenting ineffective/partially effective oral antidepressant therapy in patients suffering from major depression. The mechanism by which this augmentation is achieved is not known.
- Trial name
- NCT00953745
- Testing
- Escitalopram, Aripiprazole
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Depression During Pregnancy, Depression, Postpartum
IMAGINE: Pilot Trial of a Digital Group Intervention to Prevent Perinatal Depression
The goal of this clinical trial is to evaluate if a digital group intervention (named IMAGINE) can prevent depression in perinatal populations.
- Trial name
- NCT06746337
- Testing
- IMAGINE
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Washington
Major Depressive Disorder, Depression
Testing a Transdiagnostic TMS Treatment Target
The goal of this clinical trial is to test a new brain stimulation treatment target for individuals with depression plus at least one additional psychiatric disorder.
- Conditions
- Major Depressive Disorder, Depression, Psychiatric Disorder, Mood Disorders
- Trial name
- T5 (NCT06282146)
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Late-life Depression, Major Depressive Disorder
Cognitive Behavioural Therapy for the Treatment of Late Life Depression
This study addresses the unmet medical problem of insufficient treatment of late life depression (LLD). Compared with depression in early adulthood, treatment options of LLD are limited.
- Conditions
- Late-life Depression, Major Depressive Disorder, Major Depressive Episode, Major Depressive Disorder, Recurrent
- Trial name
- CBTlate (NCT03735576)
- Testing
- Psychotherapy, Questionnaires, Magnetic Resonance Imaging
- Where
- 7 sites in Germany
- Volunteers
- 250 people
- Sponsor
- University of Cologne
Mood Disorder, Bipolar Disorder
A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Bipolar Depression
This is a pilot project to study if repetitive Transcranial Magnetic Stimulation (rTMS) will benefit patients with bipolar depression safely.
- Conditions
- Mood Disorder, Bipolar Disorder, Major Depression, Depression
- Trial name
- TMS-BD (NCT00699218)
- Testing
- Magnetic Stimulator Rapid2 made by Magstim Company Ltd. U.K.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Major Depressive Disorder, Cardiovascular Diseases
Emotion Regulation Training to Reduce Cardiovascular Disease Risk Among Depressed Young Adults in Southern Mississippi
The proposed study will investigate the utility of a single-session emotion regulation training to reduce CVD risk among young adults diagnosed with MDD living in Southern MS.
- Conditions
- Major Depressive Disorder, Cardiovascular Diseases, Inflammation, Blood Pressure
- Trial name
- NCT05425290
- Testing
- Single-session emotion regulation training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern Mississippi
Depression - Major Depressive Disorder
Dual Neuromodulation for Depression: Boosting TMS With tES
Major depressive disorder (MDD) is a common and disabling condition. Transcranial magnetic stimulation (TMS) is an established non-invasive neuromodulation treatment for depression, but clinical response varies considerably…
- Trial name
- DUAL MOD (NCT07879924)
- Testing
- Transcranial Magnetic Stimulation, Transcranial Alternating Current Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Mersey Care NHS Trust
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.