Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Major Depressive Disorder, Depression in Adolescence
Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
This is a single-site open-label clinical trial of fMRI-guided accelerated intermittent theta burst stimulation. The goal of this clinical trial is to learn if a new form of transcranial magnetic stimulation (TMS)-known generally…
- Conditions
- Major Depressive Disorder, Depression in Adolescence, Depression, Major Depressive Episode
- Trial name
- paiTBS-KID (NCT06523439)
- Testing
- MagPro X100 edition (MagVenture, Skovlunde, Denmark)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas at Austin
Postnatal Depression
Behavioural Activation (BA) for Postnatal Depression in Blackpool
Is Behavioural Activation feasible, acceptable and potentially effective for mothers experiencing post natal depression in Blackpool? Phase 1: A series of single case studies which aim to examine and refine a) the appropriateness…
- Trial name
- BA (NCT04183582)
- Testing
- Behavioural Activation
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- National Society for the Prevention of Cruelty to Children
DEPRESSION
Efficacy of Intermittent ThetaBurst Stimulation Compared to 10 Hz Stimulation on Dorsolateral Prefrontal Cortex in Treatment Resistant Major Depressive Disorder: a Double-blind Randomized Study
This trial will compare innovating stimulation parameters, intermittent Theta Burst Stimulation, to the standard high frequency stimulation protocol.
- Trial name
- THETA-DEP (NCT02376491)
- Testing
- Transcranial magnetic stimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Major Depressive Disorder
Treating Major Depressive Disorder With Music and Low-frequency Rhythmic Sensory Stimulation
Major depressive disorder (MDD) is a highly prevalent and disabling disorder associated with persistent low mood, loss of the capacity to experience pleasure (i.e.
- Trial name
- NCT02685982
- Testing
- Rhythmic Sensory Stimulation
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Schizophrenia Disorders, Personality Disorders
Recovery in Telling Life Stories
This project tests the Recovery In Telling Life Stories (RETELL) intervention, aimed at supporting personal recovery in people with severe mental illness (SMI).
- Conditions
- Schizophrenia Disorders, Personality Disorders, Obsessive - Compulsive Disorder, Anxiety Disorders
- Trial name
- RETELL (NCT07082777)
- Testing
- Narrative therapy
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Arthrogryposis, Craniofacial Abnormalities
Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions
Freeman-Sheldon syndrome (FSS) is a rare human neuromusculoskeletal disorder present before birth, involving primarily limb and craniofacial deformities.
- Conditions
- Arthrogryposis, Craniofacial Abnormalities, Posttraumatic Stress Disorder, Depressive Disorder
- Trial name
- FSS-QLS (NCT01307475)
- Testing
- PTSD Checklist-Specific, Modified Flanagan Quality of Life Scale, Center for Epidemiologic Studies Depression Scale
- Where
- 2 sites in United States, Guatemala
- Volunteers
- 6 people
- Sponsor
- Freeman-Sheldon Research Group, Inc.
Major Depressive Disorder
EffectsOfTranscranialPulseStimulationOnDepression-PilotRCT
The aim of this study is to evaluate the effects of transranial pulse stimulation (TPS) on young adults with symptoms of depression in Hong Kong.
- Trial name
- TPS (NCT05006365)
- Testing
- Transcranial Pulse Stimulation
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Depressive Symptoms, Coping Skills
Effects of Interpersonal Relational Role Analysis
Introduction: Interpersonal Relational Role Analysis (IRRA) is a psychosocial group intervention that allows individuals to see the problems they experience in interpersonal relationships and interactions in the group environment…
- Trial name
- NCT04832451
- Testing
- Interpersonal Relational Role Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Ankara University
Bipolar Depression
Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression
This study is an open-label, single-arm, proof-of-concept study, wherein treatment resistant bipolar depression (TRBD) participants will receive one 25 mg dose of oral psilocybin accompanied by preparatory, monitoring, and…
- Trial name
- Psilo-BD (NCT06506019)
- Testing
- Psilocybin, Functional MRI
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder
Effectiveness and Acceptability of MoodGYM in Treating Depressive Symptoms in Chinese Americans
This study aims to evaluate efficacy and acceptability of the Chinese language version of MoodGYM as a therapeutic intervention in treating symptoms of depression in community dwelling Chinese Americans in the Boston area.
- Trial name
- NCT01851967
- Testing
- MoodGYM
- Where
- 2 sites in United States, China
- Volunteers
- 112 people
- Sponsor
- Massachusetts General Hospital
Unipolar Depression
Bright Light Therapy for Depressed Geriatric Inpatients
Bright light therapy has been shown to be effective for the treatment of both seasonal and non-seasonal unipolar depression as well as bipolar depression, primarily in outpatients under the age of 60.
- Trial name
- NCT07002554
- Testing
- Bright light therapy, dim red light
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Major Depressive Disorder, Treatment Resistant Depression
Open-Label Safety Study of AXS-05 in Subjects With Depression
An open-label, long-term, safety study of AXS-05 in patients with major depressive disorder (MDD), including treatment resistant depression.
- Conditions
- Major Depressive Disorder, Treatment Resistant Depression, Depression
- Trial name
- NCT04039022
- Testing
- AXS-05 (dextromethorphan and bupropion) oral tablets
- Where
- 51 sites in United States
- Volunteers
- 876 people
- Sponsor
- Axsome Therapeutics, Inc.
Anxiety Disorders and Symptoms, Depressive Symptoms
Selective Prevention Transdiagnostic Intervention for At-risk Adolescents
Emotional disorders (anxiety and/or depression) are severely undiagnosed and untreated despite being among the most common mental disorders, particularly at a young age.
- Trial name
- PROCARE (NCT04851366)
- Testing
- PROCARE+ (with add-on modules), PROCARE (UP-A for selective purposes), Active control condition
- Where
- 3 sites in Spain
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Jaén
Depression
Safety and Antidepressant Effects of Rellidep in Major Depressive Disorder
The investigators hypothesize that Rellidep will be effective in improving the symptoms of major depression. The available evidence strongly suggests that Rellidep contains a mood altering ingredient or ingredients.
- Trial name
- NCT00446719
- Testing
- Rellidep
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Mount Sinai Hospital, Canada
Anxiety, Depression / Major Depressive Disorder
The Effectiveness of a One-stop Electronic Clinic for Psychological Service (eClinic) in Hong Kong
With an increasing need for effective and accessible mental health services, telepsychology can be one promising solution to narrowing the gap between demand and supply.
- Conditions
- Anxiety, Depression / Major Depressive Disorder, Common Mental Disorder
- Trial name
- NCT07597967
- Testing
- Internet-based Unified Protocol (UP) Intervention
- Where
- Hong Kong
- Volunteers
- 420 people
- Sponsor
- New Life Psychiatric Rehabilitation Association
Post-traumatic Stress Disorder, Major Depressive Disorder
Adjunctive Pregnenolone in Post-Traumatic Stress Disorder (PTSD) and Depression in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans
This study will be an 8-week randomized, placebo-controlled clinical trial of pregnenolone administered adjunctively to treatment as usual in PTSD and depression in OEF/OIF Veterans.
- Trial name
- NCT00993629
- Testing
- pregnenolone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Major Depressive Disorder
A Safety and Effectiveness Study of JNJ-18038683 in Patients With Moderate to Severe Depression
The purpose of this study is to evaluate the safety and effectiveness of JNJ-18038683 compared to escitalopram and placebo in patients with moderate to severe depression.
- Trial name
- NCT00566202
- Testing
- Escitalopram, JNJ-18038683
- Where
- 26 sites in United States
- Volunteers
- 67 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Pulmonary Disease, COPD
The Virtual Reality Therapy as a Pulmonary Rehabilitation Supporting Method
This study evaluates the effectiveness of virtual reality (VR) therapy in the treatment of depression and anxiety symptoms in patients undergoing the pulmonary rehabilitation.
- Conditions
- Pulmonary Disease, COPD, Anxiety State, Stress
- Trial name
- NCT04601545
- Testing
- Pulmonary rehabilitation, Virtual therapeutic support
- Where
- 2 sites in Poland
- Volunteers
- 50 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Parents, Children With Disabilities
ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics
The goal of this clinical trial is to evaluate the feasibility, usability, and preliminary benefits of implementing ACT Together for parents of children with disabilities in pediatric outpatient clinics.
- Conditions
- Parents, Children With Disabilities, Stress, Depression
- Trial name
- NCT07360600
- Testing
- ACT Together
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of South Florida
Multimorbidity, Comorbidity
A Study on the Effectiveness of Comprehensive Intervention Based on Specialized Physical Education Courses in the Prevention of Comorbidity Among Junior Middle School Students
Junior high school students are in a critical period of physical and mental development, currently facing two major health challenges: first, persistently high rates of myopia with a noticeable trend toward younger onset; second…
- Conditions
- Multimorbidity, Comorbidity, Common Diseases in Children and Adolescents, Myopia
- Trial name
- NCT07237698
- Testing
- The intervention group participated in specialized physical education courses.
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xiaoyan Wu
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