Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Anxiety Depression, Placenta Previa
Anxiety and Depressive Symptoms in Placenta Previa / Accreta
placenta previa is an obstetric complication which is associated with depression and anxiety. As little is known about the emotional reaction to the diagnosis of placenta previa/accrete, a study is badly needed to estimate the…
- Trial name
- NCT05529381
- Where
- Egypt
- Volunteers
- 73 people
- Sponsor
- Assiut University
Major Depressive Disorder, Depression
The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density
PROTOCOL SYNOPSIS Title The effect of psilocybin on Major depressive disorder (MDD) symptom severity and synaptic density - a single dose randomized, double blind, placebo-controlled phase 2b positron emission tomography study…
- Trial name
- PSIPET (NCT04630964)
- Testing
- Psilocybin, Niacin
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Section for Affective Disorders; Northern Stockholm Psychiatry
Major Depressive Disorder, Unipolar Depression
Transcranial Direct Current Stimulation (tDCS) As Treatment for Major Depression
Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Treatment is often challenging; an estimated 20-40% of patients do not benefit sufficiently from existing antidepressant interventions…
- Conditions
- Major Depressive Disorder, Unipolar Depression, Depression
- Trial name
- DepressionDC (NCT02530164)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Depressive Disorder, Depression
Study of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Polaris Trial)
To compare the effect of OPC-34712 (brexpiprazole) to the effect of placebo (an inactive substance) as add on treatment to an assigned FDA approved antidepressant treatment (ADT) in patients with Major Depressive Disorder who…
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders
- Trial name
- Polaris (NCT01360632)
- Testing
- OPC-34712 + ADT
- Where
- 71 sites in United States, Canada and 5 more
- Volunteers
- 1,539 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Unipolar Depression, Major Depressive Disorder (MDD)
Validation of EmoDTx as a Digital Endpoint for Mood Monitoring in Adult Patients Suffering From Unipolar Depression
The aim of this study is to validate the EmoDTx as a digital tool for mood monitoring in adult patients with unipolar depression. The study is prospective, multicenter, and observational, with a single-arm approach.
- Conditions
- Unipolar Depression, Major Depressive Disorder (MDD), Depression
- Trial name
- EMC2FR (NCT06860165)
- Where
- 2 sites in France
- Volunteers
- 98 people
- Sponsor
- Emobot
Epilepsy, Epilepsy, Temporal Lobe
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression
Objective: To study the relative balance of GABA (A) binding potential and glutamate utilization in subjects with localization-related epilepsy with and without depression, subjects with major depressive disorder alone, and in…
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Depression, Depressive Disorder, Major
- Trial name
- NCT00931619
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Depression, Major Depressive Disorder
Nitrous Oxide for the Treatment of Major Depressive Disorder
The investigators are conducting a randomized controlled trial to evaluate the antidepressant effects of nitrous oxide in people with Major Depressive Disorder (MDD).
- Trial name
- NCT03869736
- Testing
- Nitrous Oxide
- Where
- 2 sites in United States, Australia
- Volunteers
- 81 people
- Sponsor
- Bayside Health
Major Depressive Disorder
Long-term Safety Study of BHV-7000 in Participants With Major Depressive Disorder (MDD)
The purpose of this study is to evaluate the long-term safety and tolerability of BHV-7000, in participants with Major Depressive Disorder (MDD).
- Trial name
- NCT06423781
- Testing
- BHV-7000
- Where
- 66 sites in United States
- Volunteers
- 233 people
- Sponsor
- Biohaven Therapeutics Ltd.
Major Depressive Disorder
Assessment in Work Productivity and the Relationship With Cognitive Symptoms in Patients With MDD Taking Vortioxetine
The purpose of the study is to describe the association/correlation between change in patient-reported cognitive symptoms and work productivity in gainfully employed patients receiving vortioxetine for a Major Depressive Episode…
- Trial name
- AtWoRC (NCT02332954)
- Testing
- vortioxetine
- Where
- 26 sites in Canada
- Volunteers
- 226 people
- Sponsor
- Lundbeck Canada Inc.
Depressive Symptoms, Anxiety
Mental Health Mobile Apps for Adults
In Hong Kong, the shortage of mental health professionals has been a public health concern for many decades. The World Health Organization (WHO) recommends self-care intervention as one of the most promising and exciting new…
- Conditions
- Depressive Symptoms, Anxiety, Well-Being, Psychological
- Trial name
- NCT06099301
- Testing
- Brief advice of a list of mobile apps
- Where
- Hong Kong
- Volunteers
- 234 people
- Sponsor
- Hong Kong Metropolitan University
Depressive Disorder, Major
Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)
Multicenter, open-label, long-term extended access treatment protocol in adult patients with a primary diagnosis of MDD.
- Trial name
- NCT03668600
- Testing
- Rapastinel
- Where
- 74 sites in United States
- Volunteers
- 230 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Depression / Major Depressive Disorder, Food Insecurity
The Medically Tailored Groceries and Mental Health Study
This randomized controlled trial will test whether providing medically tailored groceries for 6 months can improve depressive symptoms among adults with depression and food insecurity.
- Trial name
- MTG : RCT (NCT07779707)
- Testing
- Medically Tailored, Home-delivered Groceries, Active Comparison Group: Monthly Grocery Gift Card
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Massachusetts, Worcester
Major Depressive Disorder, MDD
Mechanism of Action of tACS for the Treatment of MDD
The purpose of this research study is to use a specific type of non-invasive brain stimulation known as transcranial alternating current stimulation (tACS) to determine its effects on brain activity (measured with EEG) and mood…
- Trial name
- GLADIATOR2 (NCT03994081)
- Testing
- tACS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Molecular Mechanisms of Pharmacological Action, Depression
Citalopram and Self Emotional Processing
This study is investigating the effect of an acute dose of citalopram on emotional processing about the self. Using a parallel-group double-blind design, participants will be randomised to receive either an acute dose of…
- Conditions
- Molecular Mechanisms of Pharmacological Action, Depression, Depressive Disorder, Mental Disorder
- Trial name
- NCT04169230
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Iron Deficiency Anemia of Pregnancy, Iron-deficiency
Non-invasive Detection of Iron Deficiency in Obstetrics
Validation of non-invasive measurement of zinc protoporphyrin for detection of iron deficiency in pregnancy. In addition, the impact of iron deficiency on the incidence of postpartum depression, restless legs syndrome, obstetric…
- Conditions
- Iron Deficiency Anemia of Pregnancy, Iron-deficiency, Restless Leg Syndrome in Pregnancy, Restless Leg Syndrome Due to Iron Deficiency Anaemia
- Trial name
- PICCOLINO (NCT07083492)
- Testing
- non-invasive measurement of zink protoporphyrin
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Anxiety Disorders, Depressive Disorders
Virtual Reality-Based Psychotherapeutic and Psychoeducational Intervention for Anxiety and Depression in Children, Adolescents, and Adults
This study is designed as a non-pharmacological, interventional clinical research project to evaluate the feasibility, safety, and implementation of virtual reality (VR)-based psychoeducational and psychotherapeutic interventions…
- Trial name
- VR-PAD (NCT07250971)
- Testing
- Virtual Reality-Based Psychotherapeutic Program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Aydın University
Depressive Symptoms, Trauma, Psychological
Sharing HaRT in New Expanses
The goal of this parallel cluster randomized control (CRT) trial is to evaluate a group-based mind-body intervention (Move with HaRT) in survivors of human trafficking. The main study aims are: 1.
- Conditions
- Depressive Symptoms, Trauma, Psychological, Anxiety Generalized
- Trial name
- SHiNE (NCT06237439)
- Testing
- Move with HaRT
- Where
- Uganda
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Depressive Symptoms, Expectations
Disentangling Pharmacological and Expectation Effects in Antidepressant Discontinuation
Antidepressant medication is established as an evidence-based, guideline-recommended treatment for Major Depressive Disorders. In the past decades, prescriptions of antidepressant medication have markedly increased, with a…
- Conditions
- Depressive Symptoms, Expectations, Antidepressants
- Trial name
- PHEA (NCT05191277)
- Testing
- Treatment 'discontinuation of antidepressant medication', Treatment 'continuation of antidepressant medication', Expectation 'high'
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Anxiety, Mental Disorders
Keeping Well:Online Cognitive Behavioral Therapy (CBT) for Pregnant Women With Depressive Symptoms
Most depression during pregnancy is undetected and untreated although it is known to be harmful both to the woman herself and her future child.
- Conditions
- Anxiety, Mental Disorders, Postpartum Depression, Depressive Symptoms
- Trial name
- OnCBTDep (NCT01909167)
- Testing
- Online Cognitive Behavioral Therapy (CBT), Treatment as usual
- Where
- United Kingdom
- Sponsor
- Imperial College London
Depression; Major Depressive Disorder
Sleep/Wake Cycle and Depression: An Imaging and Treatment Study
16.2 million American adults are affected by depression each year. The investigators are studying the relationship between sleep/wake cycle and depression.
- Trial name
- NCT04350567
- Testing
- Sleep Deprivation
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
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