Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Depression Chronic, Depressed
Evaluation of Dalia Solution For Depressed Patient
The goal of this superiority clinical investigation, prospective, multicenter, controlled, randomized, open-label is to evaluate the clinical impact of the Dalia medical telemonitoring device on the management of depressive…
- Conditions
- Depression Chronic, Depressed, Depressed Mood, Depression and Quality of Life
- Trial name
- DaliaMonitorin (NCT07211984)
- Testing
- Dalia Monitoring, Conventional healthcare
- Where
- France
- Volunteers
- 644 people
- Sponsor
- Dalia Care
Major Depression, Irritable Bowel Syndrome
Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depression
This study will evaluate the efficacy of duloxetine in reducing depressive symptoms, abdominal pain, and other symptoms of Irritable Bowel Syndrome (IRS) in a population of outpatients with Major Depressive Disorder MDD and…
- Trial name
- IBS-MDD (NCT01754493)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder
Evaluation of a Mental Health Physician Support Program in Nova Scotia
The aim of this study is to test the program's effectiveness in a primary care setting in reducing stigma among medical personnel, increasing the comfort level of physicians and staff in providing care to those living with mental…
- Trial name
- NCT01975948
- Testing
- Mental Health Practice Support Program, Treatment as Usual
- Where
- Canada
- Volunteers
- 285 people
- Sponsor
- Nova Scotia Health Authority
Depression
The Effects of taVNS on Motivation in MDD With Anhedonia
Study of non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) intervention to improve the reward motivation and response inhibition of major depression disorder and its brain network mechanism.
- Trial name
- NCT06026904
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Depressive Disorder, Major, Borderline Personality Disorder
Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS
This study evaluates the antidepressant effects of an accelerated schedule of theta-burst stimulation, termed accelerated intermittent theta-burst stimulation (aiTBS), in individuals with borderline personality disorder (BPD) or…
- Trial name
- NCT04870255
- Testing
- Left Dorsolateral Prefrontal Cortex (L-DLPFC), Dorsomedial Prefrontal Cortex (DMPFC)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Depression
iTBS for Adolescent Depression: An Open Label Study Evaluating Safety and Efficacy of Treatment
This is an open label, pilot, feasibility study evaluating effects of Intermittent Theta Burst Transcranial Magnetic Stimulation (iTBS) on 5 eligible adolescents for the treatment of depression.
- Trial name
- NCT04485455
- Testing
- iTBS Device/Motor Threshold Coil, iTBS Device/Treatment Coil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Depression, Postpartum, Labor Pain
CSE v. Epidural for Postpartum Depression
The purpose of this pilot prospective randomized control trial is to compare the initiation of labor epidural analgesia by combined spinal epidural vs. epidural for the influence on risk for postpartum depression symptoms.
- Trial name
- COPE (NCT03022526)
- Testing
- CSE, Epidural, Bupivacaine / fentaNYL
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Major Depressive Disorder, Catatonia
Clonidine to Prevent Delirium After Electroconvulsive Therapy.
Electroconvulsive therapy (ECT) is a highly effective treatment for some psychiatric disorders like major depressive or bipolar disorder, but may lead to agitation and delirium after the procedure in up to 65% of patients.
- Conditions
- Major Depressive Disorder, Catatonia, Bipolar Disorder, Delirium Postseizure
- Trial name
- ECaTa (NCT04828226)
- Testing
- Clonidine
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Depression
PET-MRI F-DOPA Activity in the Mesocorticolimbic System and Depressive Symptoms in the Prediction of Treatment Compatibility
Main objectives: Comparing levels of F-DOPA reuptake rate as an indicator for Dopamine metabolism of un-medicated Depressed patients to healthy individuals in the Mesocorticolimbic System (VTA-NAc-PFC) and assessing structural…
- Trial name
- NCT03026309
- Testing
- no intervantion
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Bone Diseases, Metabolic, Depression, Involutional
Use of Bone Biopsy to Better Understand the Causes of Decreased Bone Mineral Density in Depression
In this study researchers would like to learn more about the low levels of bone mineral density seen in approximately half of women in their forties diagnosed as currently having or previously had depression.
- Conditions
- Bone Diseases, Metabolic, Depression, Involutional, Osteoporosis
- Trial name
- NCT00001916
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Mental Health (NIMH)
Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period
Ketamine and Postoperative Depressive Symptom-PASSION
Perioperative depression symptom (PDS) is one of the common mental comorbidity, and influences the clinical outcomes and prognosis. However, there is no rapid acting treatment to deal with it during the limited hospital stay.
- Trial name
- NCT03086148
- Testing
- Ketamine, Normal saline
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Beijing Tiantan Hospital
Treatment-resistant Depression
Action of Ketamine in Treatment-Resistant Depression
Depression carries the largest burden of all medical disorders in middle to high income countries, as determined by the World Health Organization.
- Trial name
- NCT01945047
- Testing
- Ketamine, Midazolam
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University of Ottawa
Suicidal Ideation, Major Depressive Disorder
Adaptation of Dialectical Behavior Therapy Skills-Groups for Individuals With Suicidal Ideation and Depression
Harley and colleagues demonstrated that adding Dialectical Behavior Therapy (DBT) skills-groups and therapist consultation to treatment as usual successfully reduced symptoms of depression.
- Trial name
- NCT01441258
- Testing
- Dialectical Behavior Therapy Skills (DBT-S) Groups, Wait List-Treatment as Usual, No intervention-treatment as usual
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Maurizio Fava, MD
Depression
Cognitive Bias Modification (CBM) and Internet Cognitive Behavioural Therapy (iCBT) for Depression- A Randomised Controlled Trial
Cognitive accounts of depression and anxiety emphasize the importance of cognitive biases in the maintenance of disorders. One specific bias is the interpretation of ambiguous information.
- Trial name
- NCT01488058
- Testing
- OxIGen + iCBT, Waitlist Control
- Where
- Australia
- Volunteers
- 69 people
- Sponsor
- Alishia Williams
Anxiety Symptoms, Depressive Symptoms
ICBT for Anxiety and Depressive Symptoms in Brazilian Young Adults
This study aims to investigate the effects of a selfguided internet-based cognitive behavioral therapy (ICBT) program on depressive and anxiety symptoms in young Brazilian adults.
- Trial name
- NCT06633679
- Testing
- Se Cuida Intervention
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Depression
Middle School Matters Study
This study aims to evaluate the short-term and long-term efficacy of two preventative intervention approaches designed to support middle school youth.
- Trial name
- MSM (NCT01220635)
- Testing
- Positive Thoughts and Actions Program, Individual Support Program
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Seattle Children's Hospital
Depression / Major Depressive Disorder, Mood
Intern Health Study 2026
The aim of this study is to evaluate the efficacy of using a reinforcement learning algorithm to determine the optimal content of a mobile health intervention (message delivered via smartphone) for improving the mood, physical…
- Conditions
- Depression / Major Depressive Disorder, Mood, Sleep, Physical Activity
- Trial name
- IHS 2026 (NCT07685925)
- Testing
- Intern Health Study behavioral change mobile notification
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Major Depressive Disorder, Depression
HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2
This randomized two-arm intervention trial administers 8 weekly cognitive behavioral therapy (CBT) sessions and 4 bi-weekly active whole-body hyperthermia (active WBH) sessions or 4 bi-weekly sham WBH sessions to adults aged 18…
- Trial name
- HEATBED2 (NCT05708976)
- Testing
- Cognitive Behavioral Therapy (CBT), Active Whole-Body Hyperthermia (Active WBH)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Depression - Major Depressive Disorder, Depression Disorders
Clinical Study of Compound Ciwujia Granules in the Treatment of Depression
The purpose of this clinical trial is to evaluate the therapeutic efficacy and safety of Compound Ciwujia Granules in treating depression disorder (heart-spleen deficiency syndrome).
- Trial name
- NCT07085143
- Testing
- Compound Ciwujia Granules
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Depressive Disorder, Major Depressive Disorder
Nitrous Oxide for Major Depressive Disorder
This study aims at investigating the persistence of antidepressant effect of Nitrous Oxide (N2O) for Treatment-Resistant Depression(TRD).
- Conditions
- Depressive Disorder, Major Depressive Disorder, Treatment Resistant Depression, Depressive Disorder, Major
- Trial name
- NCT03932825
- Testing
- Nitrous Oxide
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Lingjiang Li
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