Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Spinal Cord Injury, Depression - Major Depressive Disorder
Psilocybin to Treat Depression in Spinal Cord Injury
The main goal of this study is to determine if psilocybin is safe for use in people with SCI. The study will measure how people with SCI respond to three psilocybin doses: low (5mg), medium (10mg), and high (25mg).
- Conditions
- Spinal Cord Injury, Depression - Major Depressive Disorder, Veteran
- Trial name
- STOP (NCT07251491)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Cannabis Use Disorder, Depressive State
Substance Misuse To Psychiatric Disorders for Cannabis
With the recent availability of vortioxetine, and the surging phenomenon of cannabis misuses amongst young abusers, it is a timely opportunity to conduct an early pharmacotherapy intervention study to offer an evidence-based…
- Conditions
- Cannabis Use Disorder, Depressive State, Anxiety State, Depression
- Trial name
- NCT03485274
- Testing
- Vortioxetine, Treatment as Usual
- Where
- Hong Kong
- Volunteers
- 37 people
- Sponsor
- The University of Hong Kong
Major Depressive Disorder
Dupilumab in Major Depressive Disorder
This study aims primarily to test target engagement of dupilumab by assessing changes in peripheral immune markers following interleukin-4 receptor alpha (IL-4Rα) blockade in adults with major depressive disorder (MDD).
- Trial name
- NCT07908563
- Testing
- Dupilumab Injection
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Efficacy and Safety Study of BHV-7000 Monotherapy in Major Depression
The purpose of this study is to determine the efficacy and safety of BHV-7000 in participants with Major Depressive Disorder (MDD)
- Trial name
- NCT06419608
- Testing
- BHV-7000
- Where
- 62 sites in United States
- Volunteers
- 336 people
- Sponsor
- Biohaven Therapeutics Ltd.
Depression
A Safety and Efficacy Study of JNJ26489112 in Patients With Treatment-Resistant Major Depressive Disorder
The purpose of this study is to evaluate the effectiveness and safety of JNJ26489112 compared with an active control (Venlafaxine XR) and placebo in patients with Treatment-Resistant Major Depressive Disorder.
- Trial name
- NCT01114698
- Testing
- Venlafaxine XR, JNJ26489112
- Where
- 14 sites in United States
- Volunteers
- 12 people
- Sponsor
- Janssen Research & Development, LLC
Psychological Distress, Quality of Life
Bright IDEAS for Pediatric Palliative Care: A Problem-Solving Skills Intervention to Empower Parent Resilience
The goal of this or clinical trial is to test in the feasibility, acceptability and preliminary efficacy of the bright IDEAS problem solving skills training for parents of children in palliative care.
- Trial name
- NCT05899998
- Testing
- Bright IDEAS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Los Angeles
Depression, Treatment Resistant Depression
The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder
The primary goals of this proof of concept clinical trial are to determine the effectiveness, safety and tolerability of oral FMT in adults with Treatment Resistant Depression (TRD).
- Trial name
- NCT04805879
- Testing
- FMT oral Capsules
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Calgary
Depression, Postpartum
A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy
In this study, researchers will learn more about how zuranolone affects the symptoms of postpartum depression, also known as PPD. Zuranolone is a drug that healthcare professionals can prescribe for adults with PPD.
- Trial name
- NCT07047820
- Testing
- Zuranolone
- Where
- United States
- Volunteers
- 305 people
- Sponsor
- Biogen
Depression - Major Depressive Disorder, Generalized Anxiety Disorder
Ultra-brief Psychological Treatments for Emotional Symptoms and Disorders
The main objective of this randomized clinical trial is to study if various modalities of brief (eight sessions) and ultra-brief (four sessions) transdiagnostic cognitive-behavioral treatment work for decrease emotional symptoms…
- Conditions
- Depression - Major Depressive Disorder, Generalized Anxiety Disorder, Generalized Anxiety, Anxiety
- Trial name
- UltraPsyBrief (NCT06909669)
- Testing
- Group ultra-brief transdiagnostic cognitive-behavioral therapy, Group brief transdiagnostic cognitive-behavioral therapy, Individual ultra-brief transdiagnostic cognitive-behavioral therapy
- Where
- 2 sites in Spain
- Volunteers
- 184 people
- Sponsor
- Universidad de Córdoba
Depression, Anxiety
The Influence of Probiotic Supplementation on the Severity of Anxiety and Depressive Symptoms, as Well as the Function and Composition of Gut Microbiota, Metabolic, Inflammation, and Oxidative Stress Markers in Patients With Depression
The aim of this study is to gather empirical evidence which will enable to evaluate the impact of probiotic supplementation on the severity of anxiety and depressive symptoms, function, and composition of gut microbiota…
- Trial name
- NCT05717946
- Testing
- Probiotic composed of two bacteria strains: Lactobacillus helveticus Rosell and Bifidobacterium longum Rosell., control group
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Ischemic Stroke, Depression
Dose Milnacipran Prevent Depressive Symptoms in Patients With Acute Stroke?
Depression is one of the important psychiatric sequelae after stroke. The prevalence of post stroke depression (PSD) is approximately 20-40%.
- Trial name
- NCT00606203
- Testing
- milnacipran
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Behavior Problems, Oppositional Defiant Disorder
The Effectiveness of Parent-Child Interaction Therapy (PCIT)
The purpose of this study was to investigate whether a type of parent-based intervention, Parent-Child Interaction Therapy will lower symptoms of behavior problems in young children more than treatment as usual.
- Conditions
- Behavior Problems, Oppositional Defiant Disorder, Conduct Disorder
- Trial name
- NCT01085305
- Testing
- Parent-Child Interaction Therapy, TAU
- Where
- 2 sites in Norway
- Volunteers
- 63 people
- Sponsor
- Norwegian University of Science and Technology
Depressive Disorder, Major
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-911 in Healthy Subjects
This is a Phase 1, conventional, double-blind, placebo-controlled, single-center clinical study comprised of 2 segments (Segment 1 and Segment 2) in which single and multiple doses of SUVN-911 or placebo will be orally…
- Trial name
- SUVN-911 (NCT03155503)
- Testing
- SUVN-911
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Suven Life Sciences Limited
Obesity, Eating Disorders
Psychosocial Issues and Bariatric Surgery
Bariatric surgery is associated with long-term weight loss, as well as short-term improvements in obesity-related medical comorbidities.
- Conditions
- Obesity, Eating Disorders, Bariatric Surgery Candidate, Depressive Disorder
- Trial name
- LABS3 (NCT02495142)
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Neuropsychiatric Research Institute, Fargo, North Dakota
Major Depressive Disorder
AZD6765 Severe Major Depressive Disorder (MDD) IV
The purpose of this research study is to determine whether AZD6765 has an effect on the patient's depression when taken together with current depression medication.
- Trial name
- NCT00781742
- Testing
- AZD6765
- Where
- 27 sites in United States
- Volunteers
- 152 people
- Sponsor
- AstraZeneca
Esketamine, ECT
The Effectiveness and Safety of Esketamine in Modified Electroconvulsive Therapy
A multicenter, randomized, controlled, single blind clinical trial on the efficacy and safety of esmketamine injection in electroconvulsive therapy Objective to evaluate the efficacy and safety of esmketamine injection in the…
- Conditions
- Esketamine, ECT, Depression
- Trial name
- NCT04777110
- Testing
- Esketamine, Saline
- Volunteers
- 396 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Depressive Disorder, Major
Study to Evaluate Potential Predictors of Relapse in Participants With Major Depressive Disorder (MDD)
The purpose of this study is to identify if there are self-reported or objective measures related to mood parameters that can predict near-term relapse (within 1 month or at another identified time point before meeting the…
- Trial name
- NCT02489305
- Where
- 25 sites in United States
- Volunteers
- 330 people
- Sponsor
- Janssen Research & Development, LLC
Depressive Disorder, Major, Adult Attention Deficit Hyperactivity Disorder
Clinical and Suicidal Features of Urban, Turkish Middle Age Depressive Patients With Comorbid ADHD
In the presence of attention deficit hyperactivity disorder (ADHD) together with additional psychiatric diseases, the treatment process and prognosis of both ADHD and psychiatric comorbidity are adversely affected.
- Conditions
- Depressive Disorder, Major, Adult Attention Deficit Hyperactivity Disorder, Suicide
- Trial name
- NCT03721588
- Testing
- Clinical interviews, psychometric scales were applied.
- Volunteers
- 96 people
- Sponsor
- Bozyaka Training and Research Hospital
Artificial Intelligence (AI), Prolonged Grief Symptoms
AI-GF-GNW on Prolonged Grief Reactions
Prolonged Grief Disorder (PGD) is a severe, disabling condition characterized by intense yearning and difficulty accepting the reality of loss, which significantly impairs the academic and psychosocial functioning of bereaved…
- Conditions
- Artificial Intelligence (AI), Prolonged Grief Symptoms, Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT07589088
- Testing
- AI-Assisted Grief-Focused Guided Narrative Writing, No-Feedback Guided Narrative Writing, Free Writing
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Peking University
Depressive Disorder, Depressive Disorder, Major
The Efficacy of Acupressure Therapy on Patient With Depression
A new nursing intervention with non-invasive acupressure protocol for activation of parasympathetic nervous system to reduce stress related depression symptoms.
- Conditions
- Depressive Disorder, Depressive Disorder, Major, Depressive Symptoms
- Trial name
- Akupress (NCT05423405)
- Testing
- Acupressure
- Volunteers
- 150 people
- Sponsor
- University Psychiatric Clinics Basel