Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Depressive and Anxiety Disorders
Evaluating the Effectiveness of Tion-Emo Therapy and Technique (TET)
The goal of this clinical trial is to explore the new therapy Cion-Emo therapy (TET) and to see if this technique is effective for treating depression and anxiety.
- Trial name
- TET (NCT06950970)
- Testing
- Tion-Emo therapy and technique for depression and anxiety Improvement
- Where
- Ecuador
- Volunteers
- 19 people
- Sponsor
- Rafael Navia
Major Depressive Disorder
Development of Pregnenolone as a Treatment for Depression
Pregnenolone, an over-the-counter supplement, is a naturally occurring neurosteroid made in the adrenal glands and brain. Preclinical research suggests pregnenolone has antidepressant, cognitive enhancing, and neuroprotective…
- Trial name
- NCT03645096
- Testing
- Pregnenolone 500 mg, Pregnenolone 800 mg
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Texas Southwestern Medical Center
Healthy
A Multiple Ascending Dose Study of BCI-838 in Healthy Volunteers
This study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of BCI-838 and its metabolite BCI-632 in healthy male and female subjects.
- Trial name
- NCT01548703
- Testing
- BCI-838
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- BrainCells Inc.
Depressive Disorder, Major
54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide
The purpose of this study is to evaluate the efficacy of intranasal esketamine 84 milligram (mg) compared with intranasal placebo in addition to comprehensive standard of care in reducing the symptoms of Major Depressive Disorder…
- Trial name
- Aspire II (NCT03097133)
- Testing
- Esketamine, Standard of Care
- Where
- 61 sites in United States, Argentina and 10 more
- Volunteers
- 230 people
- Sponsor
- Janssen Research & Development, LLC
Suicidal Ideation, Major Depressive Disorder
Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation
The purpose of this study is to gather information regarding the use of a new type of transcranial magnetic stimulation (TMS) called theta burst stimulation (TBS) for suicidal ideation in adolescents with Major Depressive…
- Trial name
- NCT04502758
- Testing
- MagVenture TMS Therapy System w/Theta Burst Stimulation
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Mayo Clinic
Depression, Anxiety
Clinical and Cost Effectiveness of Brief Cognitive-Behavioral Therapy (CBT) for Pediatric Internalizing Disorders
This project assesses the clinical and cost effectiveness of brief cognitive-behavioral therapy (CBT) for depressed (ages 11-17) and anxious (ages 8-17) youths seen for services in pediatric primary care.
- Trial name
- NCT00669526
- Testing
- BCBT, SMHC referral
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Robert Wood Johnson Foundation
Depression
Reducing Symptoms of Depression in Low-Income Mothers
This study will test the effectiveness of a short-term intervention in treating depressed young mothers with young children enrolled in Early Head Start Programs.
- Trial name
- NCT00074789
- Testing
- Modified Interpersonal Therapy, Attention control/usual care
- Where
- 6 sites in United States
- Volunteers
- 226 people
- Sponsor
- University of North Carolina, Chapel Hill
Major Depression
Inflammatory Markers and Cognitive Function in Major Depression
Major depression is accompanied by cognitive changes as well as alterations in multiple physical functions. The inflammatory system is altered generally toward a pro-inflammatory state.
- Trial name
- NCT01391221
- Testing
- Duloxetine
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
Psychological Stress, Depression - Major Depressive Disorder
The Effect of Mindfulness in Inflammation Markers (IL-6, TNF-A, CRP and Cortisol) Among Survivors of Tidal Flooding in Sayung Demak
Recurrent tidal flooding (rob) in the coastal areas of Sayung District, Demak Regency, poses a continuous environmental threat that inflicts housing damage, economic instability, and prolonged socioeconomic uncertainty on local…
- Conditions
- Psychological Stress, Depression - Major Depressive Disorder, Anxiety, Inflammation
- Trial name
- NCT07790055
- Testing
- Mindfulness Body Scan Training
- Where
- Indonesia
- Volunteers
- 75 people
- Sponsor
- Natalia Dewi Wardani, MD
Emotional Problem, Anxiety Disorder of Childhood
3-year Follow-up of the Mind My Mind RCT
This is a three-year follow up of a previously completed randomized clinical trial (RCT) of a transdiagnostic cognitive and behavioral (CBT) program ("Mind My Mind" [MMM]) compared to management as usual (MAU) in youth with…
- Conditions
- Emotional Problem, Anxiety Disorder of Childhood, Depressive Symptoms, Behavior Problem of Childhood and Adolescence
- Trial name
- MindMyMindFU (NCT04804917)
- Where
- Denmark
- Volunteers
- 396 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Post Partum Depression, Depression, Anxiety
Mandala Coloring and Postpartum Blues
One of the art therapy techniques that can provide psychological support and healing is mandala painting. Mandala is a Sanskrit word meaning 'circle'.
- Trial name
- NCT06637891
- Testing
- Mandala coloring
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
Major Depressive Disorder, Bipolar I Disorder
Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.
Depression and suicidal ideation/attempt/death are major causes of morbidity and mortality from psychiatric illnesses. In 2009, the World Health Organization listed depression as the leading cause of years lost due to disability…
- Conditions
- Major Depressive Disorder, Bipolar I Disorder, Bipolar II Disorder, Bipolar Depression
- Trial name
- NCT02593643
- Testing
- Ketamine, Midazolam, Treatment as usual (TAU)
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Sunnybrook Health Sciences Centre
Depression, Depressive Disorder
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)
This is a Phase 2, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy, safety, and tolerability of TNX-601 ER monotherapy versus placebo in patients with Major Depressive Disorder (MDD).
- Conditions
- Depression, Depressive Disorder, Depressive Symptoms, Depressive Disorder, Major
- Trial name
- UPLIFT (NCT05686408)
- Testing
- TNX-601 ER
- Where
- 27 sites in United States
- Volunteers
- 132 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Environmental Exposure, Winter Depression
Health Consequences of Wintering in the French Southern and Antarctic Territories
Polar stays expose people to extreme climate, isolation and confinement. The combination of these factors induces psychological disorders, sleep disorders, immune and endocrine disturbances, and deficiencies.
- Conditions
- Environmental Exposure, Winter Depression, Endocrine System Diseases, Sleep Disorder
- Trial name
- MediTAAF (NCT04768621)
- Testing
- Questionary
- Where
- Reunion
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Depressive Symptoms
Pilot Study Comparing Two Versions of Group Cognitive-behavioral Indicated Prevention Programs
The purpose of this study is to compare the effectiveness of two depression prevention programs and a control brochure for college students.
- Trial name
- NCT04111887
- Testing
- Group-based therapy
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Insomnia, Depression
Acupuncture for Persistent Insomnia Associated With Major Depressive Disorder
The purpose of this study is to evaluate the clinical effectiveness of acupuncture treatment on residual insomnia in major depressive patients.
- Trial name
- NCT01707706
- Testing
- Acupuncture
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- The University of Hong Kong
Major Depressive Disorder
Efficacy of Adjunctive Exercise for the Behavioral Treatment of Major Depression
Major depressive disorder (MDD) is the leading cause of disability in the developed world and is associated with lost productivity, increased health care utilization, and mortality.
- Trial name
- NCT02176408
- Testing
- Behavioral Activation, Exercise Intervention, Stretching Intervention
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Boston University Charles River Campus
Depression, Major Depressive Disorder
Stress Generation and Recurrent Depression: The Role of Differential Treatment Response
Depression affects over one million people in Canada, resulting in $14.4 billion per year in costs to Canadian society. In order to prevent this often lifelong disorder, it is critically important to identify risk factors for the…
- Trial name
- NCT00745017
- Testing
- Cognitive Behavioral Therapy, Interpersonal Therapy, Antidepressant medication
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Centre for Addiction and Mental Health
Premenstrual Syndrome
Progressive Muscle Relaxation and Kinesio Taping for Premenstrual Syndrome
This randomized controlled trial evaluated the effects of progressive muscle relaxation exercise, kinesio taping, and their combined application on premenstrual symptoms, perceived stress, severity of depressive symptoms, and…
- Trial name
- NCT07791121
- Testing
- Progressive Muscle Relaxation Exercise, Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 194 people
- Sponsor
- ASLI ER KORUCU
Stress, Psychological, Depression
The Efficacy of a Mobile Application for Treating Depression and Anxiety Symptoms
This was a 12-week, parallel randomised controlled trial, including a 6-week follow-up. The trial compared a group of university students (N = 84) receiving a mobile CBT application intervention ("Feel Stress Free") to a…
- Conditions
- Stress, Psychological, Depression, Anxiety
- Trial name
- NCT03032952
- Testing
- "Feel Stress Free" mobile application
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University College, London
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