Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Anxiety Disorders, Depressive Disorder
Study on Mental Health Promoting Effects of Natural Psychotherapy for Adolescents
This randomized controlled trial aims to evaluate the efficacy of a universal intervention based on Natural Psychotherapy in reducing anxiety and depressive symptoms among primary and middle school students.
- Conditions
- Anxiety Disorders, Depressive Disorder, Mental Health
- Trial name
- NP-A-MHP (NCT07639476)
- Testing
- Multi-modal Nature-based Meditation, Intervention diary
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beijing HuiLongGuan Hospital
Depressive Disorder, Depressive Symptoms
Effectiveness of Traditional and Computerized Versions of Super Skills for Life in Children
Super Skills for Life (SSL) is a transdiagnostic cognitive-behavioral protocol developed for children aged 6 to 12 with anxiety and comorbid problems (e.g., depression, low self-esteem, and lack of social skills).
- Conditions
- Depressive Disorder, Depressive Symptoms, Anxiety Disorders, Anxiety Disorders and Symptoms
- Trial name
- NCT05574491
- Testing
- Super Skills for Life: traditional version, Super Skills for Life: computerized version
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Bipolar Disorder
Evaluation of the Genetics of Bipolar Disorder
This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.
- Trial name
- NCT00001174
- Where
- United States
- Volunteers
- 4,210 people
- Sponsor
- National Institute of Mental Health (NIMH)
Microbial Colonization
Comparing Impacts of Donor Human Milk to Formula Supplementation on the Gut Microbiome of Full-term Infants
The goal of this pilot randomized controlled trial (RCT) is to examine donor human milk (DHM) as a clinical intervention targeted at achieving beneficial microbiome signatures in full-term infants who are exposed to intrapartum…
- Trial name
- PPDHM (NCT05815433)
- Testing
- Donor Human Milk - Nutritional Replacement
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Major Depressive Disorder, Depression
Evaluation of Efficacy of Lycium Barbarum Polysaccharide in Patients With Major Depressive Disorder
Lycium barbarum, a traditional Chinese herbal medicine, is a commonly used herb in the traditional Chinese pharmacopoeia. Its main active ingredient, lycium barbarum polysaccharide (LBP), is reported to have neuroprotective…
- Conditions
- Major Depressive Disorder, Depression, Depressive Disorder
- Trial name
- NCT04124276
- Testing
- Lycium barbarum polysaccharide
- Where
- China
- Volunteers
- 284 people
- Sponsor
- Guangzhou Psychiatric Hospital
Major Depressive Disorder
Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder
Overall, the objective of this pilot study is to utilize the IL-6 receptor antagonist tocilizumab to prospectively evaluate the role of IL-6 in the antidepressant and immunological effects of whole body hyperthermia (WBH).
- Trial name
- NCT03787290
- Testing
- Tocilizumab, Whole-Body Hyperthermia
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Massachusetts General Hospital
Cancer, Health Behavior
Pilot Comparison of N-of-1 Trials of Light Therapy
This study compares the effect of two N-of-1 trials on study compliance with an N-of-1 protocol and on satisfaction with participation in an N-of-1 trial.
- Conditions
- Cancer, Health Behavior, Depression
- Trial name
- NCT03167372
- Testing
- Litebook® Advantage, Fitbit Flex2 TM
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Columbia University
Major Depressive Disorder, Dysthymia
Safety and Efficacy Study of Citalopram and Lithium for the Treatment of Depressive Mood Disorder Symptoms
The investigators hypothesize that patients receiving citalopram in combination with lithium will have a greater reduction in depressive symptoms than patients receiving citalopram in combination with placebo.
- Conditions
- Major Depressive Disorder, Dysthymia, Depression Not Otherwise Specified, Borderline Personality Disorder
- Trial name
- NCT01189812
- Testing
- Lithium Carbonate, Citalopram
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Columbia Northwest Pharmaceuticals
Major Depressive Disorder
Open Label Optimization Study
The goal of this observational study is to demonstrate effectiveness in the treatment of Major Depressive Disorder The primary objective is to assess the effectiveness in the treatment of Major Depressive Disorder using the CGI-I…
- Trial name
- OLO (NCT05819021)
- Testing
- SAINT® Neuromodulation System (NMS)
- Where
- 7 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Magnus Medical
Major Depressive Disorder
Effect of Intranasal Insulin on Depressive Symptoms in Major Depressive Disorder
The primary aim of the study is to determine whether adjunctive intranasal insulin will exert an antidepressant effect when compared to placebo in adults with major depressive disorder (MDD), insufficiently responsive…
- Trial name
- NCT00570050
- Testing
- Diluent / Insulin, Insulin / Diluent
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University Health Network, Toronto
Major Depression, Anxiety Disorder
Depression Agency-Based Collaboration
Seniors who receive supportive services face a variety of psychosocial vulnerabilities that put them at risk for depression. One group with very high risk is older adults receiving aging services through Medicaid waiver programs.
- Trial name
- NCT01566318
- Testing
- Problem-Solving Therapy
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Study of Mindfulness-Based Cognitive Therapy
Research aimed at assessing changes in depressogenic thinking and the ability to disengage from depressogenic thinking following Mindfulness-Based Cognitive Therapy
- Trial name
- MBCT (NCT00943033)
- Testing
- Mindfulness-Based Cognitive Therapy
- Volunteers
- 48 people
- Sponsor
- Binghamton University
Postpartum Anxiety, Postpartum Depression
Postpartum Screening for Anxiety and Comorbid Conditions
The goal of this project is to facilitate the design of individualized postpartum anxiety (PPA) screening strategies in British Columbia (BC), Canada.
- Conditions
- Postpartum Anxiety, Postpartum Depression, Postpartum Disorder, Postoperative Pain
- Trial name
- PPA (NCT06242717)
- Where
- Canada
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Depression - Major Depressive Disorder, Depression Disorders
Meditative Neurofeedback for Depression
The goal of this study is to test a meditative neurofeedback intervention for depressed mood.
- Trial name
- MediNF (NCT06675240)
- Testing
- MediNF
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Major Depressive Disorder
Internet-Based Depression Screening for College Students
This study aims to determine whether using telecommunication tools, specifically web pages containing online screening instruments and real-time video chat, will be an efficient way to implement Major Depressive Disorder…
- Trial name
- NCT01326793
- Testing
- Skype Consultation
- Where
- United States
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depressive Symptoms, Depression
Efficacy and Safety of Auricular Acupuncture in Depression During the Covid 19 Pandemic
Participants with moderate depressive symptoms measured by PHQ-9 will be randomized to receive auricular acupuncture. The triple blinded procedure will be conducted in 12 sessions (6 weeks).
- Conditions
- Depressive Symptoms, Depression, Anxiety, Insomnia
- Trial name
- NCT05855421
- Testing
- Auricular Acupuncture
- Where
- Brazil
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universidade do Sul de Santa Catarina
Stress, Anxiety
Comparing the Effects of Mindfulness-Based and Cognitive Behavioral-Based Stress Reduction in Medical Students
We aimed to compare the effects of the Mindfulness-Based Stress Reduction (MBSR) and the Cognitive Behavioural Stress Reduction (CBSR) group interventions on depression and anxiety symptoms and perceived stress of medical…
- Conditions
- Stress, Anxiety, Depressive Symptoms
- Trial name
- NCT06156852
- Testing
- Mindfulness-based stress reduction group, Cognitive behavioral-based stress reduction group
- Where
- Turkey (Türkiye)
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Gazi University
Perinatal Anxiety
Mindfulness for Perinatal Distress
This randomized controlled intervention study evaluated an 8-week group mindfulness intervention for pregnant women at 20 to 30 gestational weeks.
- Trial name
- NCT07757243
- Testing
- Group Mindfulness Intervention, Group Discussion, Routine Health Education
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Shenzhen Kangning Hospital
Major Depressive Disorder
Psychopharmacotherapy for Depressive Patients
The primary purpose of this study is to compare the short (12 week) and long-term (1-year) efficacy and the tolerability between stepwise psychopharmacotherapy and antidepressant monotherapy for 12 weeks in adult patients with…
- Trial name
- BMDD-2022 (NCT06054321)
- Testing
- stepwise pharmacotherapy, antidepressant monotherapy group
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Chonnam National University Hospital
Treatment Resistant Depression, MDD
Psilocybin rTMS for Treatment Resistant Depression
The purpose of this study is to determine the safety and feasibility of sequencing psilocybin therapy with a short-duration, aiTBS protocol (Stanford Accelerated Intelligent Neuromodulation Therapy, or SAINT) in individuals with…
- Conditions
- Treatment Resistant Depression, MDD, Major Depressive Disorder, Recurrent Depression
- Trial name
- PSILOBSD (NCT06132178)
- Testing
- Psilocybin, Accelerated intermittent theta burst (aiTBS) rTMS treatment, Low-dose psilocybin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Texas at Austin
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