Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Major Depressive Disorder, Depression
Nitrous Oxide- Suicidal Ideation
Most clinical major depression responds to standard treatments (medication and psychotherapy); however, a significant subset of depressed patients (15-20%) do not respond to these treatments and are referred to as…
- Conditions
- Major Depressive Disorder, Depression, Mood Disorders, Suicidal Ideation
- Trial name
- NCT03736538
- Testing
- Nitrous Oxide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Psychological Stress, Sleep Disturbance
Sleep More, Stress Less: 90-Day Trial of Neuralli Mood
This decentralized, single-arm study evaluates the effects of 90 days of daily Neuralli Mood supplementation on perceived stress, sleep disturbance, mood, anxiety, depressive symptoms, happiness, and occupational burnout in…
- Conditions
- Psychological Stress, Sleep Disturbance, Anxiety Symptoms, Depressive Symptoms
- Trial name
- NM90 (NCT07717385)
- Testing
- Neuralli Mood
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Efforia, Inc
Perimenopause, Major Depressive Episode (MDE)
The Immunobiological Mechanisms of Depression in Perimenopause
This project aims to identify immunobiological mechanisms underlying the development of depression during the perimenopause. During the perimenopause, the risk for recurrence of depression is increased 13-fold among women who…
- Trial name
- NCT07910552
- Where
- 4 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Van Andel Research Institute
Mental Health Wellness 1, Domestic Violence
Intervention for Abused Chinese Immigrant Women
The purpose of this study is to evaluate the efficacy of a purpose-built intervention in improving the mental health of abused Mainland Chinese immigrant women in a community in Hong Kong.
- Trial name
- NCT01503138
- Testing
- Purpose-built intervention
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Major Depressive Disorder, Suicide
Accelerated iTBS for Depression and Suicidality
The overall objective of this current study is to evaluate the feasibility, safety, and tolerability of "high dose" aiTBS in psychiatric inpatient and outpatients with treatment-refractory unipolar, non-psychotic major depressive…
- Trial name
- RAPID (NCT04441008)
- Testing
- Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT)
- Volunteers
- 50 people
- Sponsor
- University of Iowa
Major Depressive Disorder
VR-Moodboost; an Innovative Virtual Reality Treatment for Adolescents With Depression
Major depressive disorder (MDD) is a prevalent and disabling mental health condition. A recent meta-analysis shows that across all forms of psychotherapy, only 43% of all depressive patients fully recover from MDD and relapse…
- Trial name
- VR-Moodboost (NCT05486676)
- Testing
- VR-Moodboost; a Virtual Reality intervention for depression to enhance positive affect and reduce depressive symptoms.
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Claudi Bockting
Depressive Disorders, Depression
Acupuncture in the Treatment of Depression
The current large randomized placebo-controlled trial is testing the ability of acupuncture to treat major depression. The study is unique in that treatment effects will be from the perspective of both Western psychiatry and…
- Trial name
- NCT00010517
- Testing
- Acupuncture
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Depression
Examining the Link Between Depression and Seasonal Allergies
This study will examine whether spring and fall seasonal depression in individuals with high sensitivity to pollen is linked to seasonal increases in tree and ragweed pollen.
- Trial name
- NCT00770068
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Anxiety, Somatization
Effect of an ACT-based Intervention to Reduce Anxiety in Medical Students
Objective: To evaluate the association between ACT-process with negative psychological variables in a cross-sectional design, and to evaluate the effect of an ACT-based intervention to diminish anxiety in a sample of medical…
- Conditions
- Anxiety, Somatization, Depressive Symptom, Stress (Psychology)
- Trial name
- ACT (NCT07813520)
- Testing
- ACT_based intervention, Active Control group
- Where
- Mexico
- Volunteers
- 135 people
- Sponsor
- University of Guadalajara
Major Depressive Disorder, Anxiety Disorders
Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone Administration
The current study will test the causal relationship between elevated levels of cortisol and the serotonin transporter gene (5-HTTLPR) as these factors influence sensitivity to environmental threat.
- Trial name
- 5-HTTLPR (NCT01710202)
- Testing
- Hydrocortisone
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Unipolar Depression, Bipolar Disorder
Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression
Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat.
- Trial name
- NCT06363981
- Testing
- Active rTMS over the left DLPFC and over the left DMPFC, Active rTMS over the left DLPFC
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Jakub Antczak
Multimorbidity, Hypertension
Development and Validation of a Comprehensive Management Service Package for Older Adults With Multimorbidity
This study aims to test a new comprehensive management service package for older adults with two or more chronic conditions (multimorbidity).
- Conditions
- Multimorbidity, Hypertension, Diabetes Mellitus, Coronary Artery Disease
- Trial name
- COMPASS (NCT07151430)
- Testing
- Service Package Group
- Volunteers
- 358 people
- Sponsor
- Xuanwu Hospital, Beijing
Depression
PEER Interactive to Inform the Prescription of Medications
Improving the prescription accuracy of psychotropic medications for military personnel diagnosed with neuropsychiatric disorders is imperative to promote accelerated treatment response and recovery.
- Trial name
- NCT04620499
- Testing
- EEG
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- University of Ottawa
Depression, Depressive Disorder
Multifaceted Depression and Cardiovascular Program
1. Implement an evidence-based structured care approach that includes screening; acute treatment and relapse prevention follow-up tailored for public sector clinics and low-income and minority patients. 2.
- Conditions
- Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders
- Trial name
- MDCP (NCT02069912)
- Testing
- Collaborative depression care management
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Southern California
Depressive Disorder, Depression
Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Recruited in an Outpatient Setting
The POKAL-PSY project is a study that monitors participants for five years. The goal of the study is to identify distinguishable subtypes of depression on the basis of biomarkers and to gain insight into their prognostic…
- Conditions
- Depressive Disorder, Depression, Depressive Symptoms, Depressive Episode
- Trial name
- POKAL-PSY (NCT05547711)
- Testing
- drawing blood
- Where
- Germany
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Julia Eder
Chronic Pain, Depressive Disorder
Ketamine Treatment Plans for Chronic Conditions
A study aimed to assess the efficacy of the various approaches to prescribing Ketamine currently in use off-label. The focus will be to include ketamine within the study plan of those with chronic conditions who are receiving…
- Conditions
- Chronic Pain, Depressive Disorder, Anxiety Disorders, Chronic Disease
- Trial name
- NCT06038409
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- RIVER Foundation
Major Depressive Disorder
Sensory and Psychomotor Profile in Depression
Despite a possible psychomotor retardation during a depressive episode, standardized psychomotor assessment is rare. So, other possible psychomotor disorders or neurological "soft signs" are not known in depression.
- Trial name
- DEPCOR (NCT04031937)
- Testing
- Psychomotor assessment
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Esquirol
Psychological Stress, Depression - Major Depressive Disorder
The Effect of Mindfulness in Inflammation Markers (MLR, NLR, PLR), Stress, Anxiety, and Depression Rate Among Survivors of Tidal Flooding in Sayung Demak
Tidal flood disasters in coastal areas cause chronic psychological stress due to economic, social, and residential disruption. Psychological stress is closely linked to systemic inflammatory responses-marked by elevated…
- Conditions
- Psychological Stress, Depression - Major Depressive Disorder, Anxiety, Post-traumatic Stress Symptoms
- Trial name
- NCT07796919
- Testing
- Mindfulness Body Scan
- Where
- Indonesia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Natalia Dewi Wardani, MD
Major Depressive Disorders
Loneliness and Occurrence of Suicide Attempts and Suicidal Ideas
Suicide is a major health problem that causes annually a million death worldwide. Loneliness is known to be associated with suicidal ideation in minors and to be related with suicidal risk in elderly people.
- Trial name
- SOLSTIS (NCT02829671)
- Testing
- Clinical and biological assessment
- Volunteers
- 600 people
- Sponsor
- University Hospital, Montpellier
Depression - Major Depressive Disorder, Insomnia
Auditory Stimulation for Insomnia and Depression
The goal of this clinical trial is to determine if alpha phase-locked auditory stimulation can improve sleep in people with insomnia and depression.
- Trial name
- NCT07553364
- Testing
- Alpha phase-locked auditory stimulation
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
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