Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Depressive Disorder, Major
Study on the Influence of Electroconvulsive Therapy (ECT) on Homocysteine Levels
Elevated homocysteine levels are associated with depression and cognitive impairment. When depression ameliorates due to treatment, homocysteine serum levels often normalize.
- Trial name
- NCT00370058
- Testing
- ECT treatment
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Unipolar Depression, Bipolar Depression
The Antidepressant Efficacy of the Anticholinergic Scopolamine
A previous study showed that the intravenous administration of scopolamine produces antidepressant effects. This study is designed to determine if other routes of administration of scopolamine produce antidepressant effects.
- Trial name
- NCT00369915
- Testing
- Scopolamine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Symptoms, Aging
Twelve Weeks of Resistance Training is Equally As Effective At Improving Cardiovascular Risk Factors in Older Women with and Without Depression: a Non-randomized Cross-over Trial
Background: the purporse was to evaluate and compare the effects of 12 weeks of resistance training (RT) on cardiovascular disease (CVD) risk factors in older women with and without depressive disorders Methods: We included 79…
- Conditions
- Depressive Symptoms, Aging, Resistance Training, Cardiovascular Risk Factor
- Trial name
- NCT06591325
- Testing
- exercise, Control
- Where
- Brazil
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Depression, Depressive Disorder
A Treatment for Depression Via a Gamified Mobile Phone Application Based on a New Cognitive Model
The study is a randomized controlled treatment study comparing changes in depressive symptoms over 8 weeks between individuals with Major Depressive Disorder (MDD) who have access to an FTP-based mobile phone application and a…
- Conditions
- Depression, Depressive Disorder, Clinical Depression, Major Depressive Disorder
- Trial name
- FTP (NCT05685758)
- Testing
- FTP-based therapeutic mobile-app
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Hedonia Ltd
Treatment Resistant Depression, Major Depressive Disorder
Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression
The purpose of this study is to assess the effects of simultaneous administration of oral aspirin and oral ketamine as a therapeutic for those with Treatment Resistant Depression.
- Conditions
- Treatment Resistant Depression, Major Depressive Disorder, Analgesia, Ketamine
- Trial name
- NCT05615948
- Testing
- VTS-K
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Theresa Jacob, PhD, MPH
Postpartum Depression, Postnatal Depression
Phase 2 Clinical Trial of GH001 in Postpartum Depression
This study is a multicenter, open-label, single-arm Phase 2 clinical trial. Approximately 15 female participants with clinically diagnosed postpartum depression (PPD) will be included in this study.
- Trial name
- NCT05804708
- Testing
- GH001
- Where
- 4 sites in Netherlands, United Kingdom
- Volunteers
- 10 people
- Sponsor
- GH Research Ireland Limited
Pain, Depressive Symptoms
Depression and Pain Perseverance Through Empowered Recovery Intervention
African American women who are 50 years of age and older with depressive symptoms, pain and difficulty with mobility will participate in the DAPPER intervention study that includes 8 nurse visits in participants' homes to help…
- Conditions
- Pain, Depressive Symptoms, Frailty, Aging
- Trial name
- DAPPER (NCT04091347)
- Testing
- DAPPER
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Johns Hopkins University
Complicated Grief, Prolonged Grief Disorder
Pilot Study of Behavioral Activation for Prolonged Grief
The Institute of Medicine identifies Prolonged Grief (PG) as a critical under-addressed public health problem for which are no empirically supported treatments.
- Conditions
- Complicated Grief, Prolonged Grief Disorder, Major Depressive Disorder, Posttraumatic Stress Disorder
- Trial name
- NCT01556048
- Testing
- Behavioral Activation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Anthony Papa
Major Depressive Disorder
A 6-Month Extension Study To The B2061032 Study To Evaluate The Safety, Tolerability, And Efficacy Of DVS SR In The Treatment Of Child And Adolescent Outpatients With MDD
This is a 6-month, open-label, flexible-dose study evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) in the Treatment of Child and Adolescent Outpatients with Major Depressive Disorder (MDD).
- Trial name
- NCT01371708
- Testing
- DVS SR
- Where
- 36 sites in United States, Chile
- Volunteers
- 283 people
- Sponsor
- Pfizer
Ptsd, Depressive Symptoms
Transcendental Meditation and PTSD
This paper describes the rationale and design of a Phase 3 RCT comparing Transcendental Meditation to Present Centered Therapy for posttraumatic stress disorder (PTSD), suicidal ideation, alcohol use, and depressive symptoms in…
- Conditions
- Ptsd, Depressive Symptoms, Suicidal Ideation, Alcohol Use, Unspecified
- Trial name
- NCT04856033
- Testing
- TM, PCT
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- David Lynch Foundation
Major Depressive Disorder
Deficits in Emotion Regulation Skills as a Maintaining Factor in Major Depressive Disorder
The primary aim of the study is to evaluate the efficacy of a systematic training of general affect regulation skills (ART) on the reduction of depressive symptom in individuals meeting criteria for major depressive disorder…
- Trial name
- NCT01330485
- Testing
- Affect Regulation Training, Common Factor Control Condition
- Where
- 3 sites in Germany
- Volunteers
- 218 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Depression, Postpartum, Anxiety Disorders and Symptoms
Feasibility of M-health Version of "What Were We Thinking" Intervention to Promote Maternal Postpartum Mental Health
The purpose of this study is to assess the feasibility, acceptability and preliminary effectiveness of "What Were We Thinking" (WWWT) a psychoeducational intervention -delivered remotely via communication technologies- to prevent…
- Conditions
- Depression, Postpartum, Anxiety Disorders and Symptoms, Maternal Behavior
- Trial name
- NCT04847076
- Testing
- m-health version of WWWT intervention, Treatment as usual
- Where
- 2 sites in Chile
- Volunteers
- 128 people
- Sponsor
- Universidad del Desarrollo
Post-Traumatic Stress Disorders, Healthy
Effects of Hydrocortisone in Patients With Post-Traumatic Stress Disorder
The purpose of this study is to determine whether people who develop Post-Traumatic Stress Disorder (PTSD) after a trauma have increased sensitivity to the effects of a stress hormone.
- Trial name
- NCT00039715
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Symptoms, Allostatic Load
Our Voices Matter: Intervention for Depression in Youth
Over 15 million people participated in racial justice protests nationwide during 2020-2021 spotlighting activism as a collective tool against structural racism and discrimination (SRD).
- Conditions
- Depressive Symptoms, Allostatic Load, Metabolic Syndrome
- Trial name
- OVM (NCT07216326)
- Testing
- Racial Justice Activism Intervention ARM, Adulting 101- Control Arm
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Postpartum Depression
Translating Research Into Practice for Postpartum Depression
This is a study to assess the impact of introducing screening and planned follow up for postpartum depression. All women ages 18 to 45 who speak English or Spanish who come to the enrolled community family medicine offices will…
- Trial name
- TRIPPD (NCT00548743)
- Testing
- Screening and follow up, Usual care
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Olmsted Medical Center
Anxiety, Anxiety Disorders
A Feasibility Study of Nature-based Health Interventions for People With Mild to Moderate Anxiety, Depression and Stress
Background and aimThe increased burden on mental health both globally and nationally is a serious challenge that requires attention and action from healthcare professionals, politicians, and decision-makers.
- Conditions
- Anxiety, Anxiety Disorders, Depression - Major Depressive Disorder, Depressive Disorder
- Trial name
- NCT06981000
- Testing
- Locally adapted nature-based health intervention
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Copenhagen
Major Depressive Disorder
Spinal Cord Stimulation for the Treatment of Major Depressive Disorder
This pilot clinical trial will evaluate the efficacy and safety of transcutaneous direct current stimulation (tsDCS) in major depressive disorder.
- Trial name
- SPIDEP (NCT03433339)
- Testing
- Active transcutaneous spinal direct current stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Depression
A Clinical Trial to Evaluate the Efficacy and Safety of Generic Escitalopram in Depression
The primary objective of this study is to evaluate the efficacy and safety of Generic Escitalopram in the treatment of Chinese patients with depression compared with Innovator Escitalopram(Lexapro®) by evaluating the change of…
- Trial name
- NCT00866593
- Testing
- Generic Escitalopram, Innovator Escitalopram
- Where
- 6 sites in China
- Volunteers
- 260 people
- Sponsor
- Shanghai Mental Health Center
Depression
Neural, Genetic, and Peripheral Correlates of SSRI Pharmaco-Response
The aim of this pharmaco-MRI study is to investigate neural correlates of variable antidepressant treatment response driven by genetic variation in multiple genes involved in depression.
- Trial name
- NCT01251471
- Testing
- Escitalopram
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Medical University of Vienna
Major Depressive Disorder (MDD), Treatment-resistant Depression (TRD)
Cannabidiol Oil for Treatment-Resistant Major Depression
Major depressive disorder is one of the leading causes of disability worldwide, and a substantial proportion of patients do not achieve adequate improvement with conventional antidepressant treatments.
- Trial name
- ANANDA (NCT07696871)
- Testing
- Full-spectrum CBD oil 100 mg/mL
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade do Sul de Santa Catarina