Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Depressive Symptoms, Stress
Investigating Differential Effects of Online Mental Training Interventions on Mental Well-being and Social Cohesion
The SARS-CoV-2 pandemic, and the associated government-imposed isolationary lockdowns, has led to a mental health crisis on a global scale.
- Conditions
- Depressive Symptoms, Stress, Empathy, Compassion
- Trial name
- NCT04889508
- Testing
- Socio-emotional mental training, Mindfulness-based mental training
- Where
- Germany
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Max Planck Social Neuroscience Lab
Major Depressive Disorder
Behavioral Activation for Depression and Habitual Rumination
Depressive rumination, a negative thinking style characterized by repetitive and passive thoughts about the causes, meanings, and consequences of one's feelings and distress, is often described as being a habitual response…
- Trial name
- MoodHab (NCT06322420)
- Testing
- Behavioural Activation (BA)
- Where
- Iceland
- Volunteers
- 120 people
- Sponsor
- University of Iceland
Pregnancy, Depression
The Synchronized Trial on Expectant Mothers With Depressive Symptoms by Omega-3 PUFAs (SYNCHRO): Open Trial
The present study aims to examine the efficacy and safety of omega-3 polyunsaturated fatty acids for pregnant women with depressive symptoms.
- Trial name
- NCT01948596
- Testing
- Omega-3 polyunsaturated fatty acids
- Where
- 3 sites in Japan, Taiwan
- Volunteers
- 13 people
- Sponsor
- Tokyo Medical University
Current Major Depressive Disorder, Healthy
Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder
This study will evaluate emotional processing biases in the brain while viewing facial expressions in adults with current or remitted major depressive disorder and healthy volunteers.
- Conditions
- Current Major Depressive Disorder, Healthy, Remitted Major Depressive Disorder
- Trial name
- NCT00071123
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Mindbeacon Therapist Assisted Internet Delivered CBT for Depression
Utilization of therapist Assisted internet-delivered cognitive behavioural therapy (TAiCBT) for treating depression and anxiety disorders in stepped-care models, such as the UK's Improving Access to Psychological Therapies (IAPT)…
- Trial name
- NCT05134103
- Testing
- Mindbeacon Therapist Guided, Internet Cognitive Behavioral Therapy for Depression, Waitlist Control Group
- Sponsor
- Ontario Shores Centre for Mental Health Sciences
Treatment Resistant Depression, Electroconvulsive Therapy
ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)
The goal of the study is to conduct a comparative randomized trial of electroconvulsive therapy (ECT) vs. ketamine for patients with treatment resistant depression (TRD) in a real world setting with patient reported outcomes as…
- Conditions
- Treatment Resistant Depression, Electroconvulsive Therapy, ECT, Ketamine
- Trial name
- ELEKT-D (NCT03113968)
- Testing
- electroconvulsive therapy (ECT), Ketamine
- Where
- 5 sites in United States
- Volunteers
- 403 people
- Sponsor
- Bo Hu
Emotional Disturbances, Depression
Healthy Lifestyle Intervention for High-Risk Minority Pregnant Women
The overall purpose of this application is to evaluate the efficacy of an intervention designed to decrease health disparities in pregnant, emotionally distressed, minority women.
- Conditions
- Emotional Disturbances, Depression, Pregnancy Late, Post-Partum Depression
- Trial name
- A-RCT (NCT03416010)
- Testing
- COPE-P
- Where
- 3 sites in United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Ohio State University
IVF, In Vitro Fertilization
The Effect of a Four-Week Hatha Yoga Intervention to Improve Quality of Life, Anxiety, and Depressive Symptoms in Individuals Undergoing Assisted Reproductive Technology (ART) Treatment
The goal of this clinical trial is to learn if a four-week yoga program works to improve quality of life in people undergoing IVF (In Vitro Fertilization).
- Conditions
- IVF, In Vitro Fertilization, Quality of Life (QOL), Anxiety
- Trial name
- NCT07415850
- Testing
- Yoga
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Villanova University
Violence, Domestic, Stress Related Disorder
Applied Social Neuroscience: the Building Resilience Among Women Project
Intimate partner violence (IPV) is the most common and alarming form of violence against women, affecting up to 25% of all women in Catalonia.
- Conditions
- Violence, Domestic, Stress Related Disorder, Depressive Disorder
- Trial name
- BRAW (NCT03623555)
- Testing
- Trier Social Stress Test, Salivary cortisol
- Where
- Spain
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Ximena Goldberg
Depression, Depressive Disorder
Manual-based Art Therapy for Adolescents With Depression
There is a need to evaluate different interventions in order to meet young people's needs of treatment. The study's goal is to find out if manual-based art therapy is a useful method for young people with depression and thus…
- Trial name
- NCT04603235
- Testing
- Manual-based Art Therapy
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Vastra Gotaland Region
Depression, Major Depressive Disorder
The Treatment of Depression With Yoga and Walking
This randomized controlled trial is designed to test the Vagal-gamma amino-butyric acid (GABA) Hypothesis that one of the mechanisms by which yoga-based practices improve mood and decrease anxiety is by correcting an autonomic…
- Conditions
- Depression, Major Depressive Disorder, PTSD, Anxiety
- Trial name
- NCT02907476
- Testing
- Iyengar Yoga, Walking
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Boston University
Bipolar Disorder, Bipolar I Depression
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
- Conditions
- Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression
- Trial name
- NCT03336918
- Testing
- Lithium
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Major Depressive Disorder
MemFlex to Prevent Depressive Relapse
A wealth of research has demonstrated that they way in which the investigators recall our personal, autobiographical memories is influential in the course of depression.
- Trial name
- NCT02614326
- Testing
- Autobiographical Memory Flexibility (MemFlex) training, Psychoeducation
- Where
- 2 sites in United Kingdom
- Volunteers
- 70 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Major Depressive Disorder (MDD)
Improving Depression Outcome by Enhancing Memory for Cognitive Therapy
Existing drug and talking therapies for major depressive disorder (MDD) fail to produce complete recovery. This study will determine if substantial improvements to one of the most promising therapies, cognitive therapy (CT), can…
- Trial name
- NCT01790919
- Testing
- Cognitive therapy for depression
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of California, Berkeley
Major Depressive Disorder
Dupilumab in Major Depressive Disorder
This study aims primarily to test target engagement of dupilumab by assessing changes in peripheral immune markers following interleukin-4 receptor alpha (IL-4Rα) blockade in adults with major depressive disorder (MDD).
- Trial name
- NCT07908563
- Testing
- Dupilumab Injection
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Nursing Caries, Nurse's Role
Effects of Postpartum Nurse Navigation Program
The study was planned as a two-group parallel randomized controlled experimental study in order to determine the effects of the nurse navigation program developed for mothers in the postpartum period on mothers' self-care power…
- Conditions
- Nursing Caries, Nurse's Role, Postpartum Depression, Postpartum Anxiety
- Trial name
- NCT05225987
- Testing
- Postpartum Nurse Navigation Program based care
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Major Depressive Disorder, Anhedonia
Dopamine Neurotransmission in Major Depression
The overall aim of this study is to utilize an integrative research model in order to dynamically assess reward-related dopamine (DA) transmission in major depressive disorder (MDD) and test the role of dysfunctional DA release…
- Trial name
- NCT01659814
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Multiple Sclerosis (MS) - Relapsing-remitting, Anxiety
Psychological Interventions for Multiple Sclerosis: Effects on Anxiety, Depression, and Cognition.
This study evaluated the efficacy of two structured psychological interventions in individuals with relapsing-remitting multiple sclerosis (RRMS).
- Conditions
- Multiple Sclerosis (MS) - Relapsing-remitting, Anxiety, Depression, Cognitive Impairment
- Trial name
- MS-PSY (NCT07273604)
- Testing
- Cognitive Behavioral Therapy (CBT), Psychophysiological Regulation Therapy (PRT)
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Moisés Bermúdez Hernández
Postpartum Period, Maternal Mental Health
Brief Psycho-educational Intervention to Enhance Maternal Reflective Functioning in the Early Postpartum Among Primiparous: Pilot Study
This randomized pilot trial tests a brief psycho-educational group program designed to enhance maternal reflective functioning (RF)-the capacity to understand one's own and the baby's behavior in terms of thoughts and…
- Conditions
- Postpartum Period, Maternal Mental Health, Parenting / Maternal Behavior, Primiparity (First-Time Mothers)
- Trial name
- NCT07318168
- Testing
- Thinking Emotions - Postpartum RF Group
- Where
- Israel
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Depressive Symptoms, Diabetes
Vitamin D for Improving Metabolic Control and Depressive Symptoms
This study will examine whether weekly vitamin D supplementation in women with significant depressive symptoms and diabetes will exhibit improved mood and metabolic control.
- Trial name
- NCT01185574
- Testing
- Vitamin D supplementation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Loyola University
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