Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Major Depressive Disorder (MDD)
Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)
This will be a multicenter, randomized, double-blind study designed to assess the efficacy, safety and tolerability of an oral Aripiprazole/Escitalopram combination therapy in participants with MDD who have demonstrated an…
- Trial name
- NCT01111565
- Testing
- Escitalopram, Aripiprazole
- Where
- 53 sites in United States, Canada and 9 more
- Volunteers
- 137 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Major Depressive Disorder, Depression
Using Neuroimaging to Investigate Major Depressive Disorder
The purpose of this neuroimaging study is to investigate the brain correlates of Major Depressive Disorder with anxiety symptoms as well as potentially identify predictors of treatment outcome.
- Conditions
- Major Depressive Disorder, Depression, Anxiety
- Trial name
- NCT00781677
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Texas Southwestern Medical Center
Post-partum Depression
Mobile Application in the Management of Mild to Moderate Postpartum Depression (PPD)
Primary Objective: Evaluate the user experience with the Stella (TM) app for the management of Postpartum Depression in an observed population for 8 calendar weeks.
- Trial name
- NCT05077644
- Testing
- Stella (TM) Mobile Application
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Curio Digital Therapeutics, Inc.
Depressive Symptoms, Anxiety Symptoms
Efficacy of a Mobile Phone App for Depression and Anxiety in College Students
The goal of this clinical trial is to evaluate the efficacy of a mobile phone application for the early intervention of depression and anxiety among young university students in Chile.
- Trial name
- VamosJuntxs (NCT06628830)
- Testing
- VamosJuntxs App, Web Conciencia Saludable
- Where
- Chile
- Volunteers
- 200 people
- Sponsor
- University of Chile
Depressive Disorder, Major
A Study of Psilocybin for Major Depressive Disorder (MDD)
One hundred participants, ages 21 to 65, who meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for major depressive disorder (MDD) will be stratified by study site and randomized with a 1-to-1 allocation…
- Trial name
- NCT03866174
- Testing
- Psilocybin, Niacin, Set and Setting (SaS) Protocol
- Where
- 11 sites in United States
- Volunteers
- 347 people
- Sponsor
- Usona Institute
Sleep Deprivation, Sleep Hygiene
Breakthrough Anxiety and Sleep Evaluation Using Linked Devices and Smartphone Application Onar (BASEL)
Sleep is not simply the absence of wakefulness. Sleep is an active procedure, normally happening every night, and is absolutely vital. Good sleep is essential for our well-being.
- Conditions
- Sleep Deprivation, Sleep Hygiene, Sleepiness, Sleep Driving
- Trial name
- BASEL (NCT06027047)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Raivotech
Major Depressive Disorder
Analisis of Facors Involved in Antidepressant Treatment Response of Major Depressive Disorder
The purpose of this study is to predict and visualize sertraline treatment response in major depressive disorder with clinical symptoms, demographic and stress state, personality, eight genetic polymorphisms at baseline.
- Trial name
- AFADTRMDD (NCT01454635)
- Testing
- Sertraline
- Where
- Japan
- Volunteers
- 96 people
- Sponsor
- Showa University
Seasonal Affective Disorder
Study of Genes in Relation to Seasonal Affective Disorder and Major Depressive Disorder
The investigators are looking for volunteers who have a history of Major Depressive Disorder, the Winter Blues, or Seasonal Affective Disorder or healthy volunteers who do not have a history of these disorders for a research…
- Trial name
- Season605 (NCT01292889)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Depressive Disorder
Effectiveness of a Brief Psychological Mindfulness Based Intervention for the Treatment of Depression in Primary Care
The aim of this study is to assess and compare a mindfulness low-intensity (4 weeks) psychological intervention for the treatment of depression in Primary Care between different groups: a mindfulness intervention applied face to…
- Trial name
- NCT03034343
- Testing
- Mindfulness
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universitat Jaume I
Depression, Postpartum Depression
Effectiveness of a Web-based Prevention Program for Postpartum Depression
The original trial will evaluate the effectiveness of a Web-based program in preventing postpartum depression. The site has been modified to provide materials from both conditions.
- Trial name
- NCT00816725
- Testing
- Mothers and babies Internet course and PPD informational brochure
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depression - Major Depressive Disorder, Mindfulness Based Stress Reduction
Effect of Mindfulness-based Psychoeducation in Depression
Major depression is a mental illness that seriously threatens public health, leading to disability, reduced quality of life, economic burden, and premature death.
- Conditions
- Depression - Major Depressive Disorder, Mindfulness Based Stress Reduction, Psychiatric Nursing
- Trial name
- NCT07484789
- Testing
- Mindfulness-based psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- University of Gaziantep
Major Depressive Disorder, Dementia
Vortioxetine in Patients With Depression and Early Dementia
This study evaluates the effectiveness of vortioxetine on depressive symptoms in patients with depression and early dementia
- Trial name
- MEMORY (NCT04294654)
- Testing
- Vortioxetine
- Where
- 24 sites in Estonia, France and 4 more
- Volunteers
- 82 people
- Sponsor
- H. Lundbeck A/S
Major Depressive Disorder
Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression
The goal of this clinical trial is to learn how hormonal changes over the menstrual cycle affect mood symptoms in reproductive-aged women with depression that worsens during the premenstrual period.
- Trial name
- PEAR (NCT06610305)
- Testing
- Transdermal estradiol, Progesterone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of North Carolina, Chapel Hill
Pregnancy, Depression
The Staying Well Study: An Open Trial of Mindfulness-Based Cognitive Therapy for the Prevention of Perinatal Depression
Pregnant women with histories of depression are at high risk of depressive relapse during the perinatal period, and options for relapse prevention are limited.
- Conditions
- Pregnancy, Depression, Postpartum Depression
- Trial name
- NCT02391870
- Testing
- MBCT-PD
- Where
- 4 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of Colorado, Boulder
PICS, Anxiety
Behavioral Health Collaborative Care Model in an ICU Recovery Clinic
Survivors of critical illness are at high risk for mental health issues such as anxiety, depression, and PTSD. This single-site, randomized controlled trial at the Medical University of South Carolina will enroll 150 patients to…
- Conditions
- PICS, Anxiety, Depression - Major Depressive Disorder, Post-Traumatic Stress
- Trial name
- BeColM (NCT07372586)
- Testing
- Behavioral Health Collaborative Care Model
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Medical University of South Carolina
Depressive Disorder, Depressive Disorder, Major
A Study of the Effectiveness and Safety of Risperidone to Augment SSRI Therapy in Patients With Treatment-resistant Depression
The purpose of this study is to evaluate the effectiveness and safety of risperidone to augment SSRI therapy in patients with treatment-resistant depression and to demonstrate the long-term maintenance effect of risperidone as…
- Conditions
- Depressive Disorder, Depressive Disorder, Major, Depression
- Trial name
- NCT00044681
- Testing
- risperidone
- Volunteers
- 258 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Depression, Depressive Symptoms
Antidepressant Decision Aid for Major Depressive Disorder Patients
The purpose of this study is to determine whether Antidepressant Decision Aid for Major Depressive Disorder is feasible and effective in involving patients in the decision-making process when initiating pharmacotherapy.
- Conditions
- Depression, Depressive Symptoms, Depressive Disorder, Major, Mood Disorders
- Trial name
- ADAM (NCT04761757)
- Testing
- Booklet of Scripts of Doctors, Booklet of Scripts for Doctors and the Antidepressant Decision Aid for Major depressive disorder patients (ADAM)
- Where
- 17 sites in Malaysia
- Volunteers
- 752 people
- Sponsor
- University of Malaya
Gastrointestinal Neoplasms
Sleep Disturbance, Depressive Symptoms, and Subsequent Quality of Life During Adjuvant Chemotherapy for Gastrointestinal Cancer
This prospective, single-center, non-interventional observational cohort study evaluated longitudinal changes in sleep quality, depressive symptoms, and health-related quality of life among adults receiving fluoropyrimidine-based…
- Trial name
- TRACE-GI (NCT06996483)
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 198 people
- Sponsor
- Ankara Etlik City Hospital
Elderly People, Depressive Symptoms
Bibliotherapy-based Psychoeducation Program the Effect of Elderly Individuals on Depression and Hopelessness Levels
Bibliotherapy has been mainly focused on the social and emotional problems of children and young people, and studies with the elderly are very few.
- Conditions
- Elderly People, Depressive Symptoms, Despondency
- Trial name
- NCT05652803
- Testing
- bibliotherapy-based psychoeducation program, psychoeducation program
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Major Depression
Effect of Aerobic Exercise on Biomarkers in Depression
This study aims to investigate changes in the levels of biomarkers (IGF-1, FGF2, and EGF) involved in neuron development in patients diagnosed with major depression through the effects of breathing exercises and aerobic exercise…
- Trial name
- NCT07062783
- Testing
- Breathing exercise, Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kutahya Health Sciences University
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