Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Depressive Symptoms
Efficacy of Peer Counseling, Social Engagement, and Combination Interventions in Improving Depressive Symptoms of Filipino Senior Citizens
Poor mental health is getting more common in low- and middle-income countries than in high-income countries due to lack of available resources and access to health services.
- Trial name
- NCT03989284
- Testing
- Community-based depression interventions
- Where
- Philippines
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Tokyo University
Depressive Symptoms
Building Resiliency and Increasing Community Hope
The purpose of this study is to build a scientific evidence base for the training and delivery of a depressive symptoms education program, developed by local community members, called a Resiliency Class (RC).
- Trial name
- BRICH (NCT01698047)
- Testing
- Resiliency Class, Case Management
- Where
- 3 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Depressive/Anxiety Symptoms, Depressive Disorder
Lifestyle Intervention for Symptoms of Depression wIth App Support in General Practice
The goal of this clinical trial is to find out whether a smartphone app can help reduce symptoms of depression by supporting healthy lifestyle changes and encouraging self-monitoring in adults who visit their general practitioner…
- Trial name
- LIDIAS (NCT07022184)
- Testing
- Personalized Lifestyle Intervention
- Where
- 3 sites in Netherlands
- Volunteers
- 216 people
- Sponsor
- Radboud University Medical Center
Unipolar Depression, Bipolar Disorder
Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression
Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat.
- Trial name
- NCT06363981
- Testing
- Active rTMS over the left DLPFC and over the left DMPFC, Active rTMS over the left DLPFC
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Jakub Antczak
Major Depressive Disorder, Treatment Resistant Depression
Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression
We propose a clinical study of medial forebrain bundle DBS as a treatment in 20 patients with treatment refractory depression (TRD).
- Trial name
- NCT02046330
- Testing
- Deep Brain Stimulation Model 3387 Model 3389
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center, Houston
Depression
Combination Therapy of Different Antidepressants With Dietary Supplements
The aim of this clinical trial is to compare the effect of antidepressants in combination with different dietary supplements in patients with depression.
- Trial name
- NCT05931965
- Testing
- L-methylfolate, Vitamin B12, magnesium
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- Riphah International University
Depression, Depressive Disorder
Stimulation of Parieto-hippocampal Connectivity in Patients With Major Depressive Disorder
This study aims to investigate the effects of individualized repetitive transcranial magnetic stimulation (rTMS) of parieto-hippocampal functional connectivity in patients with major depressive disorder (MDD).
- Conditions
- Depression, Depressive Disorder, Depressive Episode, Depressive Disorder, Major
- Trial name
- NCT04081519
- Testing
- active rTMS over DLPFC, Add-on active rTMS over DLPFC, Add-on active rTMS over LPC
- Where
- Germany
- Volunteers
- 53 people
- Sponsor
- University Hospital, Bonn
Major Depressive Disorder
Creatine for Treatment of Depression Associated With Type 2 Diabetes
The investigators hypothesize that the administration of a widely available, naturally occurring dietary supplement, creatine monohydrate, will reduce the severity of depression in individuals with type 2 diabetes.
- Trial name
- NCT03202095
- Testing
- Creatine Monohydrate
- Where
- United States
- Sponsor
- University of Utah
Subclinical Depressive Symptoms
Preventing Depression of Chinese American Adolescents by RRE
The goal of this clinical trial is to test if a culturally sensitive mobile health application (Relax, Reflect, Empower-RRE) is feasible and effective in promoting psychological wellbeing and reducing depressive symptoms among…
- Trial name
- NCT05921201
- Testing
- Relax, Reflect, and Empower mobile application
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Dementia
Northern Manhattan Caregiver Intervention Project
Elderly Hispanics have a higher burden of dementia compared to Non-Hispanic Whites. Furthermore, Hispanic caregivers tend to have a higher burden of care for their relatives with dementia.
- Trial name
- NOCIP (NCT01306695)
- Testing
- New York University Caregiver Intervention (NYUCI), Community Health Worker (CHW) Case Management
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Columbia University
Major Depressive Disorder
Efficacy and Safety of S 47445 Versus Placebo as Adjunctive Treatment in Depressed Patients Not Fully Recovered From Depressive Symptoms With a Current Antidepressant Treatment
The purpose of this study is to assess the efficacy and safety of S47445 versus placebo as adjunctive treatment of Major Depressive Disorder in patients with an inadequate response to antidepressant therapy.
- Trial name
- NCT02805439
- Testing
- S47445 15mg, S47445 50mg
- Where
- 53 sites in Bulgaria, Czechia and 5 more
- Volunteers
- 400 people
- Sponsor
- Institut de Recherches Internationales Servier
Suicidal Ideation, Treatment-resistant Depression
Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI
This is a prospective clinical trial to confirm the effectiveness of bilateral accelerated theta burst stimulation (aTBS) on suicidal ideation (SI), while exploring cortical inhibition measures in this treatment paradigm.
- Trial name
- COMBAT-SI (NCT05377177)
- Testing
- Accelerated Theta Burst Stimulation
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of California, San Diego
Major Depressive Disorder
A Comparison of Cognitive and Dynamic Therapy for Depression in Community Settings
The goal of this study is to compare supportive-expressive therapy, a type of psychodynamic psychotherapy, with cognitive therapy for the treatment of depression in community mental health consumers.
- Trial name
- NCT01207271
- Testing
- Cognitive Therapy, Supportive-Expressive Psychodynamic Therapy
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder, Bipolar Disorder
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
Background: People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect memory and thinking. Researchers want to study a treatment called TEST that uses less electricity.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Unipolar Major Depression
- Trial name
- NCT05172271
- Testing
- MagPro TMS Stimulator and coil, Thymatron(R) System IV, Magnetic Resonance Imaging Scanner
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Major
Study of Genetic Differences in People With Depression
The purpose of this study is to identify genes involved in depression. Specifically, the investigators will analyze some genes that may be related to whether or not a person responds to antidepressant medication.
- Trial name
- Genetics (NCT00229463)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Major Depression, Mania
Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
The primary aims of this study are to assess: 1. The inter-rater and test-retest reliability of the MINI-KID 2. The validity of the standard MINI-KID interview in relation to the parent rated pencil/paper version (MINI-KID-P) and…
- Conditions
- Major Depression, Mania, Anxiety Disorders, Psychotic Disorder
- Trial name
- NCT00579267
- Testing
- MINI-KID
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Depression Disorder
Maintenance Individualized Neuromodulation and Depression-detection Via Sensors for Early Treatment
This proposal seeks to carry out a prospective, single-arm open label study aimed at sustaining treatment-resistant depression (TRD) response in patients with TRD who had responded to prior individualized resting-state functional…
- Trial name
- MINDSET (NCT07779330)
- Testing
- Individualized resting-state functional connectivity-guided iTBS, Symptom-titrated algorithm-based longitudinal ECT (STABLE) algorithm
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- National University Hospital, Singapore
Schizophrenia, Schizo Affective Disorder
Intervention Targeting Motivational Negative Symptoms
This study aims to investigate the effects of the Switch intervention on motivation and associated processes and explore the dynamics between the processes.
- Conditions
- Schizophrenia, Schizo Affective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- Switch (NCT04325100)
- Testing
- Switch - Individual sessions, Switch - Group programme
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University of Liege
Postpartum Depression, Parenting
Social Media Intervention for Postpartum Depression
This study is intended to compare the acceptability and feasibility and explore outcomes related to two different formats of a parenting program for mothers with postpartum depressive symptoms.
- Trial name
- NCT02355067
- Testing
- Social Media Intervention, Traditional In-Person Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Type 1 Diabetes Mellitus, Depressive Symptoms
Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms in Adolescents With Type 1 Diabetes Mellitus
This study evaluates the use of an established internet-based cognitive behavioral therapy intervention in a group of adolescents with type 1 diabetes and mild to moderate depressive symptoms.
- Trial name
- NCT03655067
- Testing
- CATCH-IT
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Texas Southwestern Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.