Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Major Depressive Disorder, Parkinson's Disease
Psychosocial Treatment of Depression in Parkinson's Disease
The purpose of the study is to examine the effects of a form of talk therapy called cognitive behavior therapy (CBT) in the treatment of major depression in individuals with Parkinson's disease (PD).
- Trial name
- NCT00853346
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Amy Farabaugh, PhD
Premenstrual Dysphoric Disorder
Combined Effect of Tryptophan Rich Diet and Acupuncture on Depression Related to Premenstrual Dysphoric Disorder
Premenstrual Dysphoric Disorder (PMDD) is a severe form of premenstrual syndrome (PMS) affecting up to 8% of reproductive age women.
- Trial name
- NCT05813366
- Testing
- Acupuncture, Tryptophan-Rich Diet, Vitamin B6 Supplementation
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Cairo University
Stroke, Insomnia
Instant Message-delivered Cognitive Behavioural Therapy for Insomnia (CBT-I)Stroke Caregivers
The proposed trial aims to assess the effectiveness of Cognitive-behavioural therapy for insomnia (CBT-I) based ecological momentary intervention (EMI) for reducing insomnia symptoms among stroke caregivers.
- Conditions
- Stroke, Insomnia, Depressive Symptoms, Caregiver Burnout
- Trial name
- NCT05952245
- Testing
- iCBTI-based EMI, Education-based EMI
- Where
- 5 sites in Hong Kong
- Volunteers
- 138 people
- Sponsor
- The University of Hong Kong
Stress Management
Effect of a Cognitive Behavioral Stress Management Psychoeducation Program in Nursing Students
This study aimed to evaluate the effect of a cognitive-behavioral approach-based stress management psychoeducation program on the depression, anxiety, and stress levels of nursing students.
- Trial name
- SYPP (NCT07506694)
- Testing
- CBT-Based Stress Management Psychoeducation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Uşak University
Anxiety, Depressive Symptoms
Efficacy of Digital Problem Solving Application in Reduction of Anxiety, Depression and Substance Use Disorder Symptoms
The focus of this study is the impact of usage of a mobile application to support problem-solving therapy on symptoms of anxiety, depression and substance use.
- Conditions
- Anxiety, Depressive Symptoms, Substance Use Disorders
- Trial name
- Efficacy (NCT06346431)
- Testing
- DSPT - Digital Support for Problem-solving Therapy
- Volunteers
- 100 people
- Sponsor
- 7 Generation Games
Post-Traumatic Stress Disorder, Depression
Group Intervention for Interpersonal Trauma
This study will assess the acceptability and effectiveness of a six-session, modular, repeating group for low-income women who have symptoms of depression and/or post-traumatic stress disorder following interpersonal trauma…
- Trial name
- NCT00348036
- Testing
- Group Intervention for Interpersonal Trauma, Information only
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Georgetown University
Depressive Symptoms
Efficacy and Biological Targets of Response to rTMS Therapy in Youth Depression
Youth depression is a debilitating disorder that exacts enormous social, economic and personal cost. Unfortunately, treatments which are conventionally used to treat adult depression have often modest to no efficacy in youth and…
- Trial name
- NCT02472470
- Testing
- rTMS
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Healthy Volunteers, Depression
Neurobiology of Suicide
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies.
- Trial name
- NCT02543983
- Testing
- Magnetic Resonance Imaging scanner, 3T, NeurOptics PLRTM-3000 Pupillometer, Experimental Anxiety Devices
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
COVID-19 Pandemic, Pulmonary Disease, Chronic Obstructive
COVID-19, Patients' Evolution and the Influence of the Pandemic on Health Care and Outcomes in Chronic Diseases
Objectives: 1.- To evaluate the changes in health care and use of services in patients with chronic diseases such as chronic obstructive pulmonary disease (COPD), heart failure and major depression between 2017-2019 and the years…
- Conditions
- COVID-19 Pandemic, Pulmonary Disease, Chronic Obstructive, Heart Failure, Congestive, Depressive Symptoms
- Trial name
- NCT05168722
- Testing
- No interventions
- Where
- 5 sites in Spain
- Volunteers
- 2,220 people
- Sponsor
- Hospital Galdakao-Usansolo
Depressive Disorder
Research on the Biological Mechanism of the Efficacy of Psychotherapy for Depression Based on the fNIRS
In this project, the investigators will implement medication therapy, psychotherapy, and a combination of medication therapy with psychotherapy, specifically utilizing IPT, in patients with depression.
- Trial name
- NCT05927129
- Testing
- Antidepressant, Psychotherapy IPT, The combination of antidepressant and IPT
- Where
- China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Depression, Stroke
Electroacupuncture Combined With Antidepressants for Post-stroke Depression
This is a randomized, assessor-blind, placebo controlled study in post stroke depression patients. Subjects receiving antidepressant drug would be assigned to either active or placebo scalp electro-acupuncture treatment, on the…
- Trial name
- NCT01174394
- Testing
- DCEAS (Hwato®/ Dongbang®), Body electro-acupuncture (Hwato®/ Dongbang®), n-CEA (Strietberger®)
- Where
- 3 sites in Hong Kong
- Volunteers
- 43 people
- Sponsor
- The University of Hong Kong
Major Depressive Disorder
Oral Tyramine Pressor Response Study of CX157 Tablets in Healthy Male Volunteers
The objectives of this study were to examine the cardiovascular sensitivity to oral tyramine after establishment of steady state with CX157 Modified Release (MR) Tablets, 125 mg administered twice per day (BID) in healthy…
- Trial name
- CX157-112 (NCT01633437)
- Testing
- CX157
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- CeNeRx BioPharma Inc.
Depression, Anxiety
MT Combined With XKSA for Depressive Symptoms During COVID-19
Social isolation related mental health problems have raised many concerns during the COVID-19 outbreaks. Mental health care for people in quarantined hotels is in urgent need, but concrete program is rarely reported.
- Trial name
- NCT05631145
- Testing
- MT Combined With XKSA, MT
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Renrong Wu
Major Depressive Disorder (MDD)
Prescribing the Right Agent for Depression in Adults
Depression is a common mental health problem affecting almost 300 million people worldwide. Antidepressants are recommended as one of the first line treatments for people with moderate-to-severe symptoms of depression.
- Trial name
- PRADA (NCT07796295)
- Testing
- PRADA Tool, PETRUSHKA Tool
- Where
- 3 sites in Ethiopia, Pakistan and 1 more
- Volunteers
- 2,142 people
- Sponsor
- University of Oxford
Depressive Symptoms, Trauma, Psychological
Sharing HaRT in New Expanses
The goal of this parallel cluster randomized control (CRT) trial is to evaluate a group-based mind-body intervention (Move with HaRT) in survivors of human trafficking. The main study aims are: 1.
- Conditions
- Depressive Symptoms, Trauma, Psychological, Anxiety Generalized
- Trial name
- SHiNE (NCT06237439)
- Testing
- Move with HaRT
- Where
- Uganda
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Major Depressive Disorder
Movement for Depression - An RCT Assessing the Effects of Physical Activity Promotion for People With MDD
Randomized clinical trial that aims to increase physical activity levels in people with depression and to evaluate if the increase on PA levels has impact on clinical and biological measures.
- Trial name
- MOVEDEP (NCT03403881)
- Testing
- Physical activity promotion + TAU, Control
- Where
- Brazil
- Volunteers
- 130 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Depressive Symptoms, Loneliness
Online Mindfulness-Based College for Young Adults
MB-College (MBC) is an 9-week, 9 session program (i.e., the study intervention being tested in the RCT) providing systematic and intensive training in mindfulness meditation practices, applied to health behaviors relevant to…
- Conditions
- Depressive Symptoms, Loneliness, Sedentary Behavior, Mindfulness
- Trial name
- MBC (NCT04733300)
- Testing
- Mindfulness-Based College for Young Adults, Health Education for Young Adults
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Eric Loucks
Major Depression, Cancer
Omega 3 FA Supplements as Augmentation in the Treatment of Depression
To assess the efficacy of Omega 3 Fatty acid (Omega 3 FA) augmentation of desvenlafaxine (DVS) compared to placebo augmentation of DVS when used to treat depression and anxiety symptoms in patients with select medical conditions…
- Conditions
- Major Depression, Cancer, Diabetes, Cardiovascular Diseases
- Trial name
- NCT01803711
- Testing
- Desvenlafaxine, Omega 3 Fatty acids
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- UConn Health
Major Depressive Disorder, Depression
Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine
The Investigators are conducting a research study to learn about the safety and benefit of using a medication called buprenorphine for patient with difficult to treat depression .
- Trial name
- (IRLGREY-B) (NCT02263248)
- Testing
- venlafaxine, buprenorphine
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
6-week Study Treatment to Evaluate the Safety and Effectiveness of AZD2066 in Patients With Major Depressive Disorder
This is a 6-week study treatment to evaluate the safety and effectiveness of AZD2066 in patients with major depressive disorder.
- Trial name
- NCT01145755
- Testing
- AZD2066, Duloxetine
- Where
- 13 sites in United States
- Volunteers
- 131 people
- Sponsor
- AstraZeneca
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