Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Major Depressive Disorder
A Study of the Cost Effectiveness of Generalist Care Managers for Depression Treatment in Medicaid Recipients
This project will enable the investigators to conduct a randomized clinical trial to demonstrate the value of generalist care managers in the treatment of depression in Medicaid patients seen in primary health care practices.
- Trial name
- NCT00373477
- Testing
- Generalist Care Manager vs Usual Care
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of North Carolina
Depression
Predicting Effectiveness of Light Treatment for Winter Seasonal Affective Disorder
This study will evaluate a possible tool for predicting future effectiveness of bright light in treating seasonal affective disorder, winter subtype, and will examine secondary effects of bright light on cardiovascular risk…
- Trial name
- NCT00742365
- Testing
- Bright light
- Volunteers
- 41 people
- Sponsor
- University of Maryland, Baltimore
Depressive Symptoms, Anxiety Symptoms
Effects of Inserting Exercises During Physical Education Classes on Anxiety and Depression Symptoms in Adolescents
The main objective of this project will be to verify if the insertion of diaphragmatic, cardiorespiratory and strength breathing exercises and cooperative sports activities in Physical Education classes, during a period of 12…
- Trial name
- NCT05561192
- Testing
- Diaphragmatic breathing exercises, Cardiorespiratory and strength exercise, Cooperative sports activities group
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Depressive Disorder, Major
Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function
The purpose of this study is to assess the low-intensity focused ultrasound pulsation (LIFUP) neuromodulation on emotion processing in healthy individuals, and to assess the overall safety of the LIFUP to stimulate or inhibit…
- Trial name
- NCT05194332
- Testing
- LIFUP sonication to the amygdala
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Weight Gain
Exenatide for the Treatment of Weight Gain Associated With Olanzapine in Obese Adults
The purpose of this research study is to test the safety and efficacy (how well it works) of exenatide as a treatment for weight gain associated with olanzapine in obese adults with Bipolar Disorder, Major Depressive Disorder…
- Trial name
- NCT00845507
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Cincinnati
Bipolar Disorder, Anxiety Disorders
Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder
Pediatric Bipolar Disorder (BD) is uncommon in children. Its symptoms include periods of manic behavior (being overly happy or giddy, feeling grandiose, feeling a decreased need for sleep, having too much energy, moving more than…
- Conditions
- Bipolar Disorder, Anxiety Disorders, Bipolar Affective Disorder, Bipolar Depression
- Trial name
- NCT00805493
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Anxiety
Information Sources and Their Relationship to Depressive and Anxiety Symptoms During the COVID-19 Pandemic: A Network Study
This study aims to investigate the association between the use different information sources to obtain information about the COVID-19 pandemic and symptoms of psychopathology (i.e., depression and anxiety).
- Trial name
- NCT04444336
- Testing
- Cross-sectional study examining the impact of information sources to obtain information about COVID-19 on depression and anxiety symptoms
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Major Depressive Disorder
Safety Study of F2695 SR in Major Depressive Disorder
The purpose of this study is to evaluate the long- term safety of F2695-SR in the treatment of adults with major depressive disorder.
- Trial name
- LVM-MD-04 (NCT01034267)
- Testing
- F2695 SR
- Where
- 68 sites in United States
- Volunteers
- 828 people
- Sponsor
- Forest Laboratories
Depressive Symptoms
Cognitive Behavioral vs. Interpersonal Therapy (IPT) Prevention of Depression in Adolescents
The purpose of this study is to evaluate the efficacy of a cognitive-behavioral vs. an interpersonal therapy program for preventing depressive symptoms in adolescents.
- Trial name
- NCT00374439
- Testing
- Cognitive-behavioral, Interpersonal Therapy
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Depression, Anxiety
Retrospective Analysis of Outcomes With a Pharmacogenomic Algorithm
Antidepressants are among the most widely prescribed medications, yet only 35-45% of patients achieve remission following an initial antidepressant trial.
- Trial name
- UHS (NCT01632267)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Assurex Health Inc.
Depression
Care Manager - Coordinating Care for Person Centered Management of Depression in Primary Care
The aim of the project is to explore if a complementary addition of a care manager for depression treatment in the primary care setting has positive effects concerning reduction of the patients' depressive symptoms as well as…
- Trial name
- PRIM-CARE (NCT02378272)
- Testing
- care manager for depression
- Where
- Sweden
- Volunteers
- 376 people
- Sponsor
- Göteborg University
HIV, Stigma, Social
Efficacy Testing of a Culturally Relevant Stigma Intervention With WLWH in Tanzania
This study will test a stigma reduction intervention with women living with HIV in Tanzania.
- Conditions
- HIV, Stigma, Social, Self Efficacy, Self Esteem
- Trial name
- NCT05033002
- Testing
- Labda Siku Moja stigma reduction intervention
- Where
- Tanzania
- Volunteers
- 167 people
- Sponsor
- Duke University
Depression - Major Depressive Disorder, Depression Disorders
Clinical Study of Compound Ciwujia Granules in the Treatment of Depression
The purpose of this clinical trial is to evaluate the therapeutic efficacy and safety of Compound Ciwujia Granules in treating depression disorder (heart-spleen deficiency syndrome).
- Trial name
- NCT07085143
- Testing
- Compound Ciwujia Granules
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Depressive Disorder, Treatment-Resistant, Memory Deficits
SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression
The goal of this clinical trial is to learn whether Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT®), a type of transcranial magnetic stimulation (TMS), is safe and may improve memory and thinking in adults aged…
- Trial name
- NCT07876908
- Testing
- Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT®) with the Magnus Neuromodulation System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- BrainHealth Solutions, Inc.
Premenstrual Dysphoric Disorder, Premenstrual Syndrome
A Placebo-Controlled Study to Investigate the Onset of Action of Paroxetine in Premenstrual Dysphoria
The objective of this study is to explore the onset of action when serotonin reuptake inhibitors are used to treat premenstrual dysphoric disorder
- Trial name
- NCT00516113
- Testing
- paroxetine
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Karolinska Institutet
Stress, Anxiety
Effects of Coherent Breathing Breathwork on Health
The investigators are conducting a randomised-controlled trial comparing coherent breathing at ~5.5 breath cycles per minute-bcpm (with equal inhalation/exhalation durations of ~5.5secs each) to a well-designed placebo (paced…
- Conditions
- Stress, Anxiety, Depressive Symptoms, Wellbeing
- Trial name
- NCT05676658
- Testing
- Coherent breathing
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Sussex
Depressive Symptoms, Anxiety
Strategies for Coping With Negative Thoughts
The primary objective of this study is to assess the impact of two strategies for coping with negative automatic thoughts (positive thinking and cognitive restructuring) on one's belief in negative thoughts and one's affect.
- Conditions
- Depressive Symptoms, Anxiety, Negative Thinking
- Trial name
- NCT05566691
- Testing
- Positive thinking, Positive thinking + Mood induction, Thought reevaluation
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Bipolar Disorder
Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
A long-term study of current treatments for bipolar disorder, including medications and psychosocial therapies.
- Trial name
- NCT00012558
- Testing
- lithium, valproate, bupropion
- Where
- 11 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Inflammation
The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects With Depressive Disorder
Major depressive disorder (MDD) is a chronic mental illness, with 60% lifetime risk of recurrence after the first MDD episode. Despite available treatment options for MDD, only about half to two-thirds of patients respond to…
- Conditions
- Major Depressive Disorder, Inflammation, Cognitive Dysfunction, Endotoxemia
- Trial name
- NCT06203015
- Testing
- The Cambridge Neuropsychological Test Automated Battery., Venous blood samples, brain MRI
- Where
- 2 sites in Lithuania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Depression, Adolescent Behavior
Volunteering as an Intervention to Reduce Depression Among Adolescents
The purpose of the present study is to test in a preliminary manner an innovative strategy for treating depression among adolescents (alongside existing therapy) using community volunteerism.
- Conditions
- Depression, Adolescent Behavior, Depressive Symptoms
- Trial name
- NCT03816215
- Testing
- Volunteer experience
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Wake Forest University Health Sciences
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