Clinical trials: Depressive; Behavioral Disorder
Depression, Major Depressive Disorder
Effect of SSRIs on Response to Psilocybin Therapy
This study is an open-label, single-arm, within-subjects design in individuals with mild-moderate Major Depressive Disorder (MDD). All participants will receive a single dose of 25mg of psilocybin in a therapeutic setting.
- Conditions
- Depression, Major Depressive Disorder, Mild Depression, Moderate Depression
- Trial name
- NCT05594667
- Testing
- Psilocybin
- Where
- Canada
- Sponsor
- Cybin Therapeutics Inc.
Depression, Treatment Resistant Depression
Computational Psychiatric Approach to Depression
The purpose of this research is to investigate how the brain changes in patients undergoing electroconvulsive (ECT) treatment for depression.
- Trial name
- NCT04189939
- Testing
- clinical assessments
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Depressive Disorder, Major
The Effects of Exercise on Gut Bacteria, Mood and Cognition in Depression
This study aims to investigate the effects of a 12-week aerobic (cardio) exercise intervention in people with Major Depressive Disorder.
- Trial name
- Move4Mood (NCT06398496)
- Testing
- Aerobic Exercise
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- University College Cork
Child Behavior Disorders, Mother-child Relations
MOther-Child Interaction Assessment TRAINING for Pediatricians
The originality of the MOCITRAINING study lies in the integration of infant and maternal care during the pediatric consultation and the assessment of the impact of this type of care in the short and medium term on The…
- Conditions
- Child Behavior Disorders, Mother-child Relations, Depression, Postpartum
- Trial name
- MOCITRAINING (NCT03300713)
- Testing
- MOCITRAINING program, usual follow-up
- Where
- France
- Volunteers
- 3,504 people
- Sponsor
- University Hospital, Lille
Depressive Disorder
A Study Evaluating the Safety and Tolerability of Abrupt Discontinuation of Saredutant in Patients With Depression
The primary objective is to evaluate the safety and tolerability of abrupt discontinuation of saredutant over 1 week in outpatients with depression who completed 8 weeks of treatment with saredutant 100 mg once daily.
- Trial name
- NCT00429260
- Testing
- Saredutant
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Sanofi
Depression
Bikram Yoga and Aerobic Exercise for the Treatment of Major Depression
The primary goal of this project was to examine the antidepressant effects of yoga as an alternative treatment for depression as compared to no treatment and aerobic exercise.
- Trial name
- NCT04058080
- Testing
- Bikram Yoga, Aerobic Exercise
- Volunteers
- 53 people
- Sponsor
- Queen's University
Depressive Disorder, Major, Bipolar Depression
Triple Chronotherapy in Adolescents
Study Purpose This study is a randomized controlled trial examining the effectiveness of TCT in the acute treatment of depression and suicidality in adolescents compared to usual treatment care, which includes individual and…
- Conditions
- Depressive Disorder, Major, Bipolar Depression, Suicidal Ideation
- Trial name
- TCT-RCT (NCT03679962)
- Testing
- Triple Chronotherapy, Treatment as Usual
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Billings Clinic
Depressive Disorder
A 12-weeks Study to Evaluate Sulforaphane in the Treatment of Depression
Major depressive disorder is a serious, recurrent and disabling mental disorder, which is the second leading cause of years lost to disability worldwide.
- Trial name
- NCT04246905
- Testing
- sulforaphane, placedo, selective 5 - HT reuptake inhibitors (SSRI)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Central South University
Depression, Depressive Disorder
Behavioral Activation Teletherapy to Increase Physical Activity
This is a pilot study of acceptability, feasibility, and preliminary efficacy of a brief, 10-session Behavioral Activation intervention delivered via teletherapy to increase physical activity and treat depressive symptoms.
- Conditions
- Depression, Depressive Disorder, Depressive Symptoms, Depressive Episode
- Trial name
- BAT (NCT04990401)
- Testing
- Behavioral Activation Teletherapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Texas Southwestern Medical Center
Cocaine Dependence, Depressive Symptoms
Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans
To examine the clinical efficacy of sertraline (200 mg/day) alone or sertraline in combination with gabapentin. The purpose of this study is to examine whether the antidepressant sertraline alone or combined with gabapentin…
- Trial name
- NCT00654953
- Testing
- sertraline, gabapentin
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Arkansas
Major Depressive Disorder (MDD)
Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)
This will be a multicenter, randomized, double-blind study designed to assess the efficacy, safety and tolerability of an oral Aripiprazole/Escitalopram combination therapy in participants with MDD who have demonstrated an…
- Trial name
- NCT01111539
- Testing
- Escitalopram, Aripiprazole, Blinded capsule
- Where
- 62 sites in United States, Estonia and 7 more
- Volunteers
- 211 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Antenatal Depression, Major Depressive Disorder
Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)
The purpose of this study is to develop the safety, feasibility, and tolerability of a personalized transcranial alternating current stimulation (tACS) approach in antenatal depression.
- Conditions
- Antenatal Depression, Major Depressive Disorder, Major Depressive Disorder in Pregnancy, Healthy Controls
- Trial name
- PandA-tACS (NCT06979154)
- Testing
- tACS (aperiodic)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder
Efficacy of Trial-Based Cognitive Therapy and Behavioral Activation in Treatment of Depression
Major Depressive Disorder (MDD) is a mood disorder, highly prevalent in Brazil and in world. The treatments of choice are the psychotropic drugs of the class of antidepressants and Behavioral or Cognitive Behavior Therapy (CBT).
- Trial name
- NCT02624102
- Testing
- Trial based cognitive therapy, Behavioral Activation, Antidepressants
- Where
- Brazil
- Volunteers
- 76 people
- Sponsor
- Hemanny, Curt, M.D.
Major Depressive Disorder
Major Depressive Disorder With Mixed Features - Extension
Lurasidone HCl is a compound that is a candidate for the treatment of major depressive with mixed features.This clinical study is designed to test how well Lurasidone works to treat major depressive disorder with mixed features…
- Trial name
- RESOLVE3 (NCT01423253)
- Testing
- Lurasidone
- Where
- 17 sites in United States
- Volunteers
- 48 people
- Sponsor
- Sumitomo Pharma America, Inc.
Depressive Disorder in Mothers
Treatment of Maternal Depression in Home Visitation: Mother and Child Impacts
The purpose of this study is to determine the efficacy of In-Home Cognitive Behavioral Therapy (IH-CBT) in comparison to Present-Centered Therapy (PCT), a supportive therapeutic approach.
- Trial name
- MIDISII (NCT01212783)
- Testing
- In-Home Cognitive Behavioral Therapy, Present-Centered Therapy
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Conduct Problems, Anxiety Symptoms
Testing the Effectiveness of Supportive Parents - Coping Kids
The aim of this clinical trial is to test the effectiveness of the parent training intervention Supportive Parents - Coping Kids (SPARCK) for prevention of childhood mental health problems.
- Conditions
- Conduct Problems, Anxiety Symptoms, Depressive Symptoms
- Trial name
- SPARCK (NCT05800522)
- Testing
- Behavioral parent or child directed intervention, Supportive Parents - Coping Kids
- Where
- Norway
- Volunteers
- 252 people
- Sponsor
- Norwegian Center for Child Behavioral Development
PostPartum Depression
The Effect of Exercise on Preventing PostPartum Depression
The purpose of this study is to examine the feasibility and efficacy of an exercise intervention for the prevention of postpartum depression.
- Trial name
- NCT00961402
- Testing
- Wellness Control, Exercise Intervention
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Major Depression
Long-term Bilateral Theta Burst Stimulation for the Treatment of Major Depression
Repetitive transcranial magnetic stimulation has been shown to be moderately effective in the treatment of major depression. Theta burst stimulation (TBS) is a new form of rTMS that may exert larger effects.
- Trial name
- TheBuS_D (NCT01153139)
- Testing
- Repetitive Transcranial Magnetic Stimulation (Theta Burst Stimulation, TBS)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University Hospital Tuebingen
Treatment-resistant Depression
Olfactory and Brain Stimulations in Treatment-resistant Depression
This is a prospective, randomized, double-blind, parallel-group controlled trial. The aim of this research project is to compare the clinical benefits achieved in patients with major depressive disorder (MDD) following two types…
- Trial name
- COBRA (NCT05661383)
- Testing
- Non-invasive brain stimulation protocol (intermittent theta burst protocol (iTBS)) combined with pleasant odors delivered during the iTBS procol., Non-invasive brain stimulation protocol (intermittent theta burst protocol (iTBS)) delivered alone.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hôpital le Vinatier
Depressive Symptoms, Anxiety
Pilot Feasibility Trial of the Family Strengthening Intervention in Rwanda (FSI-R)
The research will examine the following Specific Aims: Specific Aim 1: To adapt a U.S.-developed family-focused and strengths-based prevention program to the context of HIV/AIDS-affected families in Rwanda (the…
- Conditions
- Depressive Symptoms, Anxiety, Parenting
- Trial name
- NCT01509573
- Testing
- Family Strengthening Intervention in Rwanda (FSI-R)
- Where
- Rwanda
- Volunteers
- 82 people
- Sponsor
- Harvard School of Public Health (HSPH)
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