Clinical trials: Depressive; Behavioral Disorder
Depressive Disorder
Effect of Nicotine on Brain Reward Pathways
The investigators will determine whether an acute dose of nicotine, in the form of the nicotine lozenge, impacts brain and behavioral measures of mood and reward responsiveness in individuals with major depressive disorder.
- Trial name
- NCT02346539
- Testing
- Nicotine polacrilex
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Anxiety Disorders and Symptoms, Depressive Symptoms
Indicated Prevention Transdiagnostic Intervention for Adolescents At High Risk of Emotional Problems
Emotional disorders (anxiety and/or depression) are severely undiagnosed and untreated despite being among the most common mental disorders, particularly at a young age.
- Trial name
- PROCARE-I (NCT05252026)
- Testing
- PROCARE-I (UP-A for indicated purposes), Active control condition
- Where
- 3 sites in Spain
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Jaén
Substance-Related Disorders, Depressive Disorder
Outpatient Adolescent Treatment for Comorbid Substance Use and Internalizing Disorders
Adolescent substance abuse results in significant negative outcomes and extraordinary costs for youths, their families, communities, and society.
- Conditions
- Substance-Related Disorders, Depressive Disorder, Anxiety Disorder
- Trial name
- NCT00438685
- Testing
- Outpatient MST/OPTION-A, Usual Services
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Major Depressive Disorder, Schizo Affective Disorder
Getting Out of the House: Using Behavioral Activation to Increase Community Participation
The goal of this study is to evaluate the effectiveness of an behavioral activation intervention to increase meaningful activity and community participation for people with serious mental illness.
- Conditions
- Major Depressive Disorder, Schizo Affective Disorder, Schizophrenia, Bipolar Disorder
- Trial name
- NCT06336616
- Testing
- Behavior Activation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Temple University
Depressive Syndrome
Study of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer's Disease, Vascular Dementia, and Mixed Vascular and Alzheimer's Dementia
The goal of the present study is to compare the effectiveness of the active (S)-enantiomer of citalopram, escitalopram with placebo in the treatment of patients with depressive syndrome complicating Alzheimer's dementia (AD)…
- Trial name
- NCT00229333
- Testing
- Escitalopram
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Suicide, Depressive Disorders
Suicide Prevention by Lithium - the Lithium Intervention Study
The purpose of this study is to examine the proposed suicide preventive effects of lithium in a randomized controlled trial within a group of individuals with depressive disorders.
- Trial name
- SUPLI (NCT00520026)
- Testing
- lithium
- Where
- 5 sites in Germany
- Volunteers
- 167 people
- Sponsor
- University Hospital Schleswig-Holstein
Major Depressive Disorder
A Clinical Trial of PRAX-114 in Participants With Major Depressive Disorder
This is a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of PRAX-114 in participants with moderate to severe major depressive disorder (MDD).
- Trial name
- NCT04832425
- Testing
- PRAX-114
- Where
- 31 sites in United States, Australia
- Volunteers
- 216 people
- Sponsor
- Praxis Precision Medicines
Persistent Depressive Disorder, Treatment-resistant Depression
A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
The purpose of this study is to compare the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) conducted over 16 weeks (acute and continuation treatment) with Behavioral Activation (BA; same dose and duration) in…
- Trial name
- ChangePDD (NCT04996433)
- Testing
- inpatient CBASP individual therapy, inpatient CBASP group therapy, inpatient CBASP nurse contact
- Where
- 8 sites in Germany
- Volunteers
- 396 people
- Sponsor
- University of Greifswald
Depression
Understanding Brain Reward Responses in Individuals With Major Depressive Disorder
This study will examine brain responses associated with reinforcement and reward tasks in individuals with major depressive disorder (MDD).
- Trial name
- NCT00183755
- Where
- 3 sites in United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression - Major Depressive Disorder
Efficacy and Mechanisms of Escitalopram in Drug-Naïve First-Episode Major Depressive Disorder
The goal of this project is to quantify the effectiveness and safety of escitalopram oxalate oral solution in the treatment of first-episode, drug-naïve patients with major depressive disorder, and to explore the mechanisms…
- Trial name
- NCT07480525
- Testing
- Escitalopram (Oral antidepressant)
- Where
- 5 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University
Depression, Coronary Artery Disease (CAD)
A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease
The purpose of this study is to examine the relationship between depressive symptoms and markers of inflammation, two predictors of heart disease.
- Conditions
- Depression, Coronary Artery Disease (CAD), Acute Coronary Syndrome (ACS)
- Trial name
- CHIME (NCT00208117)
- Testing
- Sertraline (Zoloft), Simvastatin (Zocor)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Depression, Depressive Disorder
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women
Desvenlafaxine succinate (DVS) is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI). This study will investigate the safety, efficacy, and tolerability of DVS SR versus escitalopram in women with major…
- Conditions
- Depression, Depressive Disorder, Depressive Disorder, Major
- Trial name
- NCT00406640
- Testing
- Desvenlafaxine succinate sustained-release (DVS SR), Escitalopram
- Where
- 70 sites in United States, Argentina and 4 more
- Volunteers
- 595 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depression, Insomnia
Cognitive Behavioral Therapy for Insomnia with RTMS
Depression and insomnia occur together in a substantial number of patients. Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but does not help insomnia symptoms in depressed patients.
- Trial name
- NCT04258618
- Testing
- CBT-I (Cognitive Behavioral Therapy for Insomnia) with rTMS, Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Medical University of South Carolina
Depressive Symptoms, Depressive Disorder
Self-administered Acupressure for Depression
The goal of this clinical trial is to examine the effects of self-administered acupressure intervention for alleviating depressive symptoms among people with depression.
- Conditions
- Depressive Symptoms, Depressive Disorder, Depression
- Trial name
- SAAFD (NCT05631184)
- Testing
- Self-administered acupressure group, Mental health education group
- Where
- Hong Kong
- Volunteers
- 250 people
- Sponsor
- The Hong Kong Polytechnic University
Major Depressive Disorders
Efficacy and Safety of SR58611 Compared to Placebo and Paroxetine
Primary objective : To demonstrate the antidepressant efficacy on the Hamilton Depression Rating Scale of SR58611A 700mg/day compared with placebo in the treatment of patients with a recurrent major depressive episode.
- Trial name
- NCT00825058
- Testing
- amibegron (SR58611A), paroxetine
- Where
- 8 sites in Bulgaria, Croatia and 6 more
- Volunteers
- 317 people
- Sponsor
- Sanofi
Major Depressive Disorder, Social Anxiety Disorder
Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy Response
Many patients with Major Depressive Disorder (MDD) and generalized Social Anxiety Disorder (gSAD) are treated with cognitive behavioral therapy (CBT) but few have meaningful improvement.
- Trial name
- NCT03175068
- Testing
- CBT, ST
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Cannabis Use Disorder, Depressive State
Substance Misuse To Psychiatric Disorders for Cannabis
With the recent availability of vortioxetine, and the surging phenomenon of cannabis misuses amongst young abusers, it is a timely opportunity to conduct an early pharmacotherapy intervention study to offer an evidence-based…
- Conditions
- Cannabis Use Disorder, Depressive State, Anxiety State, Depression
- Trial name
- NCT03485274
- Testing
- Vortioxetine, Treatment as Usual
- Where
- Hong Kong
- Volunteers
- 37 people
- Sponsor
- The University of Hong Kong
Postpartum Depression (PPD), Self-Efficacy
NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)
The study's objective is to conduct a Phase II randomized controlled trial examining the preliminary efficacy of the VoiceLove app compared to usual care on maternal postpartum depression in mothers with infants admitted to the…
- Conditions
- Postpartum Depression (PPD), Self-Efficacy, Parental Anxiety, Engagement, Patient
- Trial name
- NURTURE (NCT07214597)
- Testing
- VoiceLove mobile phone application
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
PTSD, Suicidal Thoughts and Behaviors
Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study
This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD.
- Conditions
- PTSD, Suicidal Thoughts and Behaviors, PTSD Symptoms, Depressive Symptoms
- Trial name
- CNS (NCT07222306)
- Testing
- 1-(2-[+F]fluoroethyl)-L-tryptophan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wayne State University
PTSD, Anxiety
Exploring Medically Perceived Benefits, Use and Interest in Psychedelics and Cannabinoids
The primary objective of this study is to collect insights from first responders and military personnel on their need for, use of, and interest in physical and/or mental health medical marijuana or psychedelic-assisted therapy…
- Conditions
- PTSD, Anxiety, Anxiety Disorders, Depression
- Trial name
- EMPOWER (NCT04965740)
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Empower Research Inc