Clinical trials: Depressive; Behavioral Disorder
Postpartum Depression
Behavioral Change in the Mother-Infant Dyad: Preventing Postpartum Depression
Postpartum depression (PPD) is undertreated and the consequences of this are substantial for women and children. Studies show that infant cry/fuss and sleep behavior are associated with PPD, and that parenting interventions can…
- Trial name
- NCT01379781
- Testing
- Behavioral Intervention for PPD
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder, Major Depression
Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group
Our goal is to study pharmacogenetics in Mexican-Americans, using depression treatments as a proof of the concept that pharmacogenetic approaches can be used to optimize treatment strategies for common and complex disorders in…
- Conditions
- Major Depressive Disorder, Major Depression, Unipolar Depression
- Trial name
- NCT00265291
- Testing
- fluoxetine or desipramine
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Prenatal Anxiety, Prenatal Depression
Effectiveness of an Online Biopsychosocial Intervention to Improve Well-being and Mental Health During Pregnancy
This study aims to develop and implement a preventive intervention through a mobile application to help pregnant women feel better emotionally and cope with the changes of pregnancy in a more positive way.
- Conditions
- Prenatal Anxiety, Prenatal Depression, Wellbeing, Obstetrical Complications
- Trial name
- BienGestar (NCT06871397)
- Testing
- Biopsychosocial Cognitive Behavioral Intervention
- Where
- Spain
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
HEART DISEASE, Liver Failure
Somatic Disease Among Alcohol Abusers in an Out-day Patients' Clinic
Alcohol abuse is associated with a variety of clinical diseases, but studies on prevalence of different somatic diseases among alcohol abusers are lacking. Studies on populations in an out-day patients' clinic are also lacking.
- Conditions
- HEART DISEASE, Liver Failure, DEPRESSIVE DISORDER, Alcoholic Neuropathy
- Trial name
- NCT01081197
- Testing
- Psychiatric and somatic examinations and ,if clinical indicated, treatment
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Helse Nord-Trøndelag HF
Depression - Major Depressive Disorder, Transcranial Magnetic Stimulation
Effects of Low-intensity Transcranial Magnetic Stimulation on Major Depressive Disorder, and on 5-hydroxyindoleacetic Acid and Brain-derived Neurotrophic Factor Levels
The goal of this randomised clinical trial is to evaluate the effects of transcranial magnetic stimulation (TMS) on major depressive disorder (MDD) and on the levels of 5-hydroxyindoleacetic acid (5-HIAA) and brain-derived…
- Conditions
- Depression - Major Depressive Disorder, Transcranial Magnetic Stimulation, Placebo
- Trial name
- NCT06667180
- Testing
- Low-intensity TMS
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Universidad de Guanajuato
Major Depressive Disorder (MDD), Depression in Adults
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD.
- Conditions
- Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder, Depression Disorders
- Trial name
- EMBRACE (NCT06793397)
- Testing
- CYB003, Psychological Support
- Where
- 79 sites in United States, Australia and 6 more
- Volunteers
- 330 people
- Sponsor
- Cybin IRL Limited
Osteoarthritis, Knee, Depressive Symptoms
Study on Brain Structure and Function of Pain-related Emotion Disorder
By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.
- Conditions
- Osteoarthritis, Knee, Depressive Symptoms, Anxiety State
- Trial name
- NCT03912610
- Testing
- Functional magnetic resonance examination
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Zhoujie
Treatment Resistant Depression (TRD)
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
This study is being conducted at Massachusetts General Hospital (MGH) to explore whether adding psychedelic coaching can enhance the effects of ketamine or esketamine maintenance treatment in individuals with treatment-resistant…
- Trial name
- NCT07563868
- Testing
- Psychedelic Integration Coaching
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder, Therapy Resistant Depression
Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine Spray
Pragmatic clinical trial of an add-on therapy regarding the use of edupression.com® - a licensed computer based self-help program - on patients with therapy-resistant depression receiving esketamine nasal spray
- Trial name
- Esketamin+ (NCT04843462)
- Testing
- edupression.com®, Esketamine nasal spray
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Lukas Pezawas
Pediatric Cancer
Psychoeducation Intervention for Caregivers of Children With Cancer
This randomized controlled trial aims to evaluate the effectiveness of the psychoeducation intervention on anxiety, depressive symptoms, coping, and HRQoL in caregivers of children with cancer.
- Trial name
- NCT05783310
- Testing
- Psychoeducation Intervention
- Where
- 2 sites in Malawi
- Volunteers
- 118 people
- Sponsor
- Chinese University of Hong Kong
Depressive Disorder, Anhedonia
Study to Treat Major Depressive Disorder With a New Medication
This project is designed to examine the neuronal KCNQ2/3 potassium (K+) channel subtype as a novel treatment target for mood disorders through the administration of the KCNQ-selective channel opener ezogabine (Potiga…
- Trial name
- NCT03043560
- Testing
- Ezogabine
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- James Murrough
Depressive Disorder
An Eight-week Study Evaluating the Efficacy of a 100mg Dose of Saredutant Once Daily, in Elderly Patients With Major Depressive Disorder
The purpose of the study is to evaluate the efficacy of saredutant in the treatment of Major Depressive Disorder in elderly patients.To evaluate the tolerability, safety and efficacy on disability and quality of life in patients…
- Trial name
- NCT00415142
- Testing
- saredutant (SR48968), escitalopram
- Where
- 8 sites in United States, Croatia and 6 more
- Volunteers
- 393 people
- Sponsor
- Sanofi
Breastfeeding, Postnatal Depression
Mother and Late Preterm Lactation Study
Breastfeeding has various benefits for the mother and infant. It has the capability of reducing the risk of short term and long term problems for the infant, such as gastroenteritis, respiratory infections, type II diabetes and…
- Conditions
- Breastfeeding, Postnatal Depression, Stress, Psychological, Preterm Infant
- Trial name
- MAPLeS (NCT03791749)
- Testing
- Breastfeeding Support
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University College, London
Stress Disorders, Post-Traumatic, Depressive Disorder
Whole Health in VA Mental Health: Omnis Salutis
Recent Veterans of the Afghanistan and Iraq conflicts are presenting in VA care with high rates of posttraumatic stress disorder (PTSD), depression, anxiety, and substance use disorders.
- Conditions
- Stress Disorders, Post-Traumatic, Depressive Disorder, Anxiety Disorders, Substance-Related Disorders
- Trial name
- OS RCT (NCT05400252)
- Testing
- Omnis Salutis, Health and Wellness
- Where
- 2 sites in United States
- Volunteers
- 238 people
- Sponsor
- VA Office of Research and Development
Guilt, Depressive Symptoms
Guilt Focused Psychological Intervention
Participants in the intervention study will be 120 caregivers with guilt feelings linked with care and high levels of emotional distress (anxiety and/or depression), randomly allocated to the intervention conditions: intervention…
- Conditions
- Guilt, Depressive Symptoms, Anxious Symptoms, Stress, Physiological
- Trial name
- LONG-CARE (NCT04656808)
- Testing
- Guilt Focused Intervention, Cognitive behavioral therapy
- Where
- Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
End Stage Renal Disease, Depression
Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life Outcomes
The objective of this study is to determine the effect of music therapy during dialysis on: depression, anxiety, quality of life, blood pressure, heart rate, medication compliance, compliance with dialysis treatment, number of…
- Conditions
- End Stage Renal Disease, Depression, Anxiety, Major Depressive Disorder
- Trial name
- NCT03925168
- Testing
- Music therapy
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Tulane University
Depressive Disorder, Major Depressive Disorder
Study Evaluating Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR) In The Treatment Of Child and Adolescent Outpatients With Major Depressive Disorder
The primary purpose of this study is to evaluate the long-term safety and tolerability of Desvenlafaxine Succinate Sustained-Release (DVS SR) in child and adolescent outpatients with major depressive disorder.
- Trial name
- NCT00669110
- Testing
- Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR)
- Where
- 9 sites in United States
- Volunteers
- 40 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Post-traumatic Stress Disorder (PTSD), Acute Stress Disorder
EMDR Flash Group Protocol for Earthquake Survivors
This pilot randomized controlled trial evaluated the preliminary effects of the online EMDR Flash Group Protocol among adults affected by the 2023 Kahramanmaraş earthquakes in Türkiye.
- Conditions
- Post-traumatic Stress Disorder (PTSD), Acute Stress Disorder, Anxiety, Depression
- Trial name
- FlashGP-EQ (NCT07672613)
- Testing
- EMDR Flash Group Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Istanbul Galata University
Depressive Symptoms, Mental Health Wellness 1
Mindfulness and Intercare Based Intervention for Medicine Students (MIIM)
The effects of Coronavirus Disease (COVID-19) pandemic on health, economy and social network has an impact on mental health, specially students.
- Conditions
- Depressive Symptoms, Mental Health Wellness 1, Anxiety
- Trial name
- MIIM (NCT05011955)
- Testing
- Mindfulness, compassion and intercare based Intervention, Psychoeducational based intervention, General curricular intervention
- Where
- Chile
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University Diego Portales
Depression / Major Depressive Disorder
Adjunctive Probiotic Therapy in Major Depressive Disorder (ProMOOD)
A double-blind, randomized controlled trial (RCT) aimed at evaluating the efficacy of probiotic supplementation in patients undergoing concurrent antidepressant therapy.
- Trial name
- ProMOOD (NCT07786285)
- Testing
- OMNi-BiOTiC® STRESS Repair
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Maribor
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