Clinical trials: Depressive; Behavioral Disorder
Postpartum Depression, Preterm Infant
The Impact of a Newborn Behavioral Intervention on the Mental Health of Mothers With Late Pre-Term Infants
Preterm birth is a serious public health issue, affecting 10% of all births in the US alone. Three quarters of these infants are born between 34 0/7 and 36 6⁄7 weeks' gestation or late-preterm (LP).
- Conditions
- Postpartum Depression, Preterm Infant, Infant Development
- Trial name
- BabyAMOR (NCT03836430)
- Testing
- Newborn Behavioral Observation-Family Wellness (NBO-FW)
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Brigham and Women's Hospital
Depression, Mild Cognitive Impairment
Combination Treatment Study for Memory Impairment and Depression
Patients presenting with depression (DEP) and cognitive impairment (CI), represent a unique, understudied population that is difficult to diagnose, treat and estimate prognosis.
- Trial name
- DEP-CI (NCT01658228)
- Testing
- Donepezil, Citalopram, Venlafaxine
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- New York State Psychiatric Institute
Depressive Disorder, Major
A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder
This is a 6-week, randomised, multicenter, double-blind, placebo controlled, fixed dose parallel group study to assess the efficacy and safety of orvepitant (30 and 60 mg/day) versus placebo in subjects with a diagnosis of a…
- Trial name
- orvepitant MDD (NCT00880399)
- Testing
- orvepitant
- Where
- 20 sites in United States, Canada
- Volunteers
- 328 people
- Sponsor
- GlaxoSmithKline
Depressive Symptoms, Anxiety Symptoms
Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency (VIP-RACE)
The aim of this study is to evaluate a novel cultural strengths parenting program - the Video-feedback Intervention to Promote Racial-Ethnic Socialization CompEtency (VIP-RACE) - which seeks to support Latine parents' motivation…
- Conditions
- Depressive Symptoms, Anxiety Symptoms, Conduct Problems
- Trial name
- VIP-RACE (NCT07055906)
- Testing
- Video-feedback Intervention to Promote Racial-Ethnic Socialization CompEtency (VIP-RACE)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Penn State University
Depression, HIV
Disposition Kinetics of Dolutegravir Among People Living With HIV With Major Depression in Nigeria
The goal of this clinical trial is to find out the usefulness and well-being of people when drugs for treating depression (fluoxetine) and HIV (dolutegravir) are used together.
- Trial name
- FLUDOPRESS (NCT07110831)
- Testing
- Fluoxetine, Cognitive-behavioral therapy
- Where
- Nigeria
- Volunteers
- 168 people
- Sponsor
- University of Ibadan
Major Depressive Disorder
A Safety and Effectiveness Study of JNJ-18038683 in Patients With Moderate to Severe Depression
The purpose of this study is to evaluate the safety and effectiveness of JNJ-18038683 compared to escitalopram and placebo in patients with moderate to severe depression.
- Trial name
- NCT00566202
- Testing
- Escitalopram, JNJ-18038683
- Where
- 26 sites in United States
- Volunteers
- 67 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Depression, Major Depressive Disorder
Relapse-Prevention Study With Levomilnacipran ER (F2695 SR) in Patients With Major Depressive Disorder
The purpose of this study is to evaluate the safety and efficacy of Levomilnacipran ER relative to placebo in the prevention of depression relapse in patients with major depressive disorder (MDD).
- Trial name
- NCT01085812
- Testing
- Levomilnacipran ER
- Where
- 35 sites in United States, Canada
- Volunteers
- 734 people
- Sponsor
- Forest Laboratories
Anxiety, Depression
CALM for Pregnant and Post-Partum Women
Anxiety and depression is common along pregnant mothers and has been found to increase risk for negative outcomes in both mothers and infants.
- Conditions
- Anxiety, Depression, Depression, Postpartum, Pregnancy Related
- Trial name
- NCT03351465
- Testing
- Coordinated Anxiety Learning and Management
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Depression, Unipolar, Fall
Integrated Tele-Behavioral Activation and Fall Prevention for Low-income Homebound Seniors With Depression
This study will test clinical and cost effectiveness of an integrated tele- and bachelor's-level counselor/coach delivered behavioral activation (BA) and fall prevention (FP) for low-income homebound older adults.
- Trial name
- TBF (NCT05011864)
- Testing
- Behavioral Activation, Fall Prevention, Telephone support
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- University of Texas at Austin
Major Depressive Disorder
Early Versus Delayed Switch in Medication in Patients With Major Depressive Disorder
This study investigates two different approaches to the change in antidepressant treatment when an initial treatment is not effective: early intervention or delayed intervention. Two hypothesis will be tested: 1.
- Trial name
- NCT00810069
- Testing
- Duloxetine Hydrochloride, Escitalopram
- Where
- 60 sites in Denmark, France and 9 more
- Volunteers
- 840 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
The objective of this study is to evaluate the safety, tolerability, and preliminary efficacy of the Motif eXternally powered Cortical Stimulation (XCS) System when used as indicated for treatment-resistant depression (TRD).
- Trial name
- RESONATE (NCT07594483)
- Testing
- Motif XCS System
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Motif Neurotech, Inc.
Major Depression
iCare4Depression: Effectiveness of a Blended Cognitive-Behavioral Therapy in Routine Practice
The main objective of this research project is to implement and evaluate the clinical effectiveness and cost-effectiveness of a Blended Cognitive-Behavioral Therapy (bCBT) in routine practice, comparing it with Treatment as Usual…
- Trial name
- iCare4Dep (NCT03623724)
- Testing
- blended Cognitive-behavioral Therapy, Treatment-As-Usual
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- University Institute of Maia
Major Depressive Disorder, Dysthymic Disorder
Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adults
The goal of this open-administration treatment study of citalopram (or duloxetine) is to evaluate the effect of antidepressant medication on treating the syndrome of "frailty" in older adults with depressive symptoms.
- Conditions
- Major Depressive Disorder, Dysthymic Disorder, Depressive Disorder, NOS
- Trial name
- NCT01973283
- Testing
- Antidepressant Medication
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder, Insomnia
Time to Remission of Depressive Symptoms With Combined SSRI and Ramelteon
Hypothesis I: Patients in the SSRI + ramelteon treatment group will achieve remission (defined as an IDS-C30 score of 11 or less) more quickly than those in the SSRI + placebo group.
- Trial name
- TAKEDA (NCT00642694)
- Testing
- Escitalopram, Ramelteon
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Texas Southwestern Medical Center
Healthy, Major Depressive Disorder
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
The core objective of this study is to enhance the translational potential of this electroencephalogram (EEG) biomarker by using ketamine(KET)-induced gamma potentiation as a prognostic marker of 4-week treatment outcome.
- Conditions
- Healthy, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- NCT06480201
- Testing
- Ketamine, Saline
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Premenstrual Dysphoric Disorder
Emotion Regulation-based Internet-delivered Cognitive Behavioural Therapy for Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is a debilitating cyclic mental disorder affecting about 2-5% of women of reproductive age.
- Trial name
- Premensis-s (NCT06496139)
- Testing
- Therapist-guided internet-delivered cognitive behavioural therapy
- Where
- Sweden
- Volunteers
- 164 people
- Sponsor
- Uppsala University
Parkinson Disease, Idiopathic, Freezing of Gait
Vortioxetine for Depressive Symptoms and Freezing of Gait in Parkinson Disease
The present study involves patients with Parkinson Disease (PD) suffering from freezing of gait (FOG) and depressive symptoms. The main aim of the study is evaluating the efficacy of vortioxetine in reducing moderate/severe FOG…
- Conditions
- Parkinson Disease, Idiopathic, Freezing of Gait, Depression Not Otherwise Specified
- Trial name
- NCT06805266
- Testing
- Vortioxetine (tablet)
- Volunteers
- 40 people
- Sponsor
- Marianna Amboni
Depression, Cost Benefit Analysis
Dysthymia: Associated Costs, Treatment and Change Process
The study evaluates cost and effect of inpatient versus outpatient treatment of dysthymia, as well as investigates the processes through which psychotherapy works in treating dysthymia.
- Conditions
- Depression, Cost Benefit Analysis, Psychotherapeutic Processes
- Trial name
- DFront (NCT04911829)
- Testing
- Psychotherapy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Modum Bad
Major Depression, End Stage Renal Disease
Bupropion for Depression in ESRD Patients on Hemodialysis
The proposed study will evaluate the response and remission rates for major depressive disorder (MDD) in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (HD) treated with bupropion or fluoxetine for 12…
- Trial name
- NCT02238977
- Testing
- Fluoxetine, Bupropion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Depression, Dysthymia
Medications for the Treatment of Dysthymic Disorder and Double Depression
The purpose of the study is to evaluate the efficacy and safety of flexible doses of escitalopram (Lexapro) compared to sertraline (Zoloft) for treatment of Dysthymic Disorder.
- Trial name
- NCT00234312
- Testing
- escitalopram and sertraline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
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