Clinical trials: Depressive; Episode, Major
Major Depressive Disorder, Bipolar 1 Disorder
Efficacy of the Mobile Application for Prediction and Prevention of Mood Episode Recurrence Based on Machine Learning
This study was designed to evaluate the efficacy of the mobile application named Circadian Rhythm for Mood (CRM), which was developed to prevent recurring episodes of mood disorders (major depressive disorders, bipolar disorders…
- Conditions
- Major Depressive Disorder, Bipolar 1 Disorder, Bipolar II Disorder
- Trial name
- NCT05400785
- Testing
- Circadian Rhythms for Mood (CRM) application - Active
- Where
- South Korea
- Volunteers
- 93 people
- Sponsor
- Hucircadian
Major Depressive Disorder, Major Depressive Episode
Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder (MDD) (DEPARRESTCLIN)
Predictive factors and biomarkers of response to antidepressants in major depressive disorder are scarce. Beta-arrestins are proteins which inhibit G Protein Coupled Receptors and desensitize serotonergic and dopaminergic…
- Trial name
- DEPARRESTCLIN (NCT02051413)
- Testing
- Venlafaxine extended release
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Bipolar Disorder, Depression
Antidepressant Therapy in Treating Bipolar Type II Major Depression
This study will compare the safety and effectiveness of antidepressant therapy versus mood stabilizing therapy in treating people with bipolar type II major depression.
- Trial name
- NCT00602537
- Testing
- Venlafaxine, Lithium Carbonate
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Pennsylvania
Major Depressive Episode
Major Depression and Messenger RNAs
Major Depressive Episode (MDE) affects nearly 15% of the general population. In a preliminary study, the investigators identified 12 genes whose expression was either altered between patient and control samples and/or between…
- Trial name
- NCT00998231
- Testing
- blood sample
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Psychotic Disorders
Treatment of MDEs During the Course of Psychotic Disorders With Duloxetine
We evaluate the efficacy and tolerability of duloxetine in the treatment of major depressive episodes during the course of psychotic disorders
- Trial name
- NCT00224302
- Testing
- Duloxetine
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Depression
RESIST : Administration of MAP4343 in Antidepressant Non-Responders Patients Experiencing a Major Depressive Episode
The study is a phase II, double-blind, randomized, placebo controlled, parallel, multicentric study in 110 patients with drug resistant depression.
- Trial name
- NCT03870776
- Testing
- MAP4343
- Where
- 10 sites in France
- Volunteers
- 126 people
- Sponsor
- Mapreg
Bipolar Disorder
A Study to Evaluate the Efficacy of FK949E in Bipolar Disorder Patients With Major Depressive Episodes
In period I, the treatment effect of FK949E was compared with that of placebo in a blind manner in bipolar disorder patients with major depressive episodes. In period II, the long-term safety and efficacy of FK949E was evaluated.
- Trial name
- NCT01725308
- Testing
- FK949E
- Where
- 98 sites in Japan
- Volunteers
- 431 people
- Sponsor
- Astellas Pharma Inc
Treatment-Resistant Depression
Study of Efficacy, Safety, Tolerability and Pharmacokinetics of MIJ821 in Participants With Treatment- Resistant Depression (TRD)
The main purpose of this study was to evaluate safety and efficacy of a single injection of MIJ821 in addition to standard of care (SoC) pharmacological anti-depressant treatment in participants with treatment-resistant…
- Trial name
- NCT05454410
- Testing
- MIJ821 Subcutaneous Injection 1 mg, MIJ821 Subcutaneous Injection 4 mg, MIJ821 Subcutaneous Injection 10 mg
- Where
- 16 sites in United States, Japan and 2 more
- Volunteers
- 60 people
- Sponsor
- Novartis Pharmaceuticals
Bipolar Disorder
FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder
This study will assess the effects of bipolar disorder on brain activity and will determine if medication changes the brain activity in people with bipolar disorder.
- Trial name
- NCT00596622
- Testing
- Lithium
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Indiana University
Depressive Episode, Depressive Disorder
Theta-Burst Stimulation in Major Depressive Episodes With Mixed Characteristics.
The investigators will perform a double-blind, randomized, sham-controlled clinical trial of theta-burst stimulation (TBS) in mixed depressive episodes of both bipolar and major depressive disorders.
- Conditions
- Depressive Episode, Depressive Disorder, Bipolar Disorder
- Trial name
- NCT04123301
- Testing
- Active Theta Burst Stimulation (TBS)
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo
Relapse Rate of a Major Depressive Episode, Safety of Olanzapine in Subjects With Major Depression
Optimal Duration of Olanzapine Add-on Therapy in Major Depression
Evaluation of olanzapine versus placebo in the continuation therapy of subjects with major depression who had a response with additional olanzapine to an antidepressant.
- Trial name
- OLA-D (NCT00568672)
- Testing
- Olanzapine
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Major Depressive Episode, ECT
Metabolomics During ElectroConvulsivoTherapy
Investigators will measure the variation of blood Metabolome through 1H NMR at several time points during the course of electroconvulsivetherapy in patients with a major depressive episode.
- Trial name
- METECT (NCT05973643)
- Testing
- Electroconvulsive therapy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hôpital le Vinatier
Depression, Major Depressive Disorder
Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression
Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD.
- Conditions
- Depression, Major Depressive Disorder, Cardiovascular Disease, Coronary Artery Disease
- Trial name
- NCT00818506
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Major Depressive Disorder
Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes
Background: Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. It stimulates the brain. Researchers want to see if using magnetic resonance imaging (MRI) scans helps locate the best area for rTMS…
- Trial name
- NCT03289923
- Testing
- Active TMS + Cognitive therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression
Promoting Enhanced Pharmacotherapy Choice Through Immunomarkers Evaluation in Depression
PRECISE-D is a single site, randomized, open label 8-week clinical trial that will enroll 70 participants to evaluate if the level of inflammation in our body can predict how we will respond to antidepressants.
- Trial name
- PRECISE-D (NCT03993457)
- Testing
- Escitalopram, Bupropion
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Texas Southwestern Medical Center
Major Depressive Episode
Personalized Ultrasonic Brain Stimulation for Depression
This study will evaluate a new form of non-invasive brain stimulation for individuals with depression. Personalized low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation…
- Trial name
- NCT05301036
- Testing
- Diadem prototype
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Utah
Depressive Disorder, Depression
Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Recruited in an Outpatient Setting
The POKAL-PSY project is a study that monitors participants for five years. The goal of the study is to identify distinguishable subtypes of depression on the basis of biomarkers and to gain insight into their prognostic…
- Conditions
- Depressive Disorder, Depression, Depressive Symptoms, Depressive Episode
- Trial name
- POKAL-PSY (NCT05547711)
- Testing
- drawing blood
- Where
- Germany
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Julia Eder
Major Depressive Disorder
Evaluation of the H-coil Transcranial Magnetic Stimulation TMS Device - Safety and Feasibility Study for Acute and Maintenance Treatment in Major Depressive Episode
This is a prospective open label study of acute and maintenance treatment of MDD. The acute phase consists of daily treatments for 4 weeks.
- Trial name
- NCT00807105
- Testing
- H-coil dTMS
- Where
- Israel
- Volunteers
- 29 people
- Sponsor
- Shalvata Mental Health Center
Major Depressive Disorder, Hepatitis C, Chronic
Efficacy and Safety of Escitalopram for Prevention of Depression Induced by Peg-Interferon in Hepatitis C Patients
The purpose of this study is to determine whether the use of an antidepressant (escitalopram) can prevent depressive episodes that appear during the treatment with peg-interferon and ribavirin in patients with chronic hepatitis C.
- Trial name
- NCT00166296
- Testing
- Escitalopram
- Where
- 15 sites in Spain
- Volunteers
- 133 people
- Sponsor
- Germans Trias i Pujol Hospital
Severe Mental Disorder, Schizophrenia
Development of a Model for Digital Monitoring of the Mental State of the Hospitalized Patient
This study presents the development and validation of a unique Digital Experience Sampling Method (ESM) questionnaire specifically adapted for monitoring changes in the mental state of patients during psychiatric hospitalization.
- Conditions
- Severe Mental Disorder, Schizophrenia, Personality Disorders, Mood Disorders
- Trial name
- NCT06182787
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center