Clinical trials: Depressive Disorder, Major Depressive Disorder
Major Depressive Disorder, Suicidal Ideation
MicroRNA Correlates of Childhood Maltreatment and Suicidality
This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g.
- Trial name
- NCT04923685
- Testing
- Trier Social Stress Test
- Where
- 2 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Major Depressive Disorder, Depression
HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2
This randomized two-arm intervention trial administers 8 weekly cognitive behavioral therapy (CBT) sessions and 4 bi-weekly active whole-body hyperthermia (active WBH) sessions or 4 bi-weekly sham WBH sessions to adults aged 18…
- Trial name
- HEATBED2 (NCT05708976)
- Testing
- Cognitive Behavioral Therapy (CBT), Active Whole-Body Hyperthermia (Active WBH)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Major Depressive Disorder
Targeting Cognitive Immunization in Depression
Research has shown that people suffering from MDD tend to maintain dysfunctional expectations despite experiences that disconfirm expectations.
- Trial name
- NCT03460574
- Testing
- INFORMATION, SALIENCE, ATTENTION
- Where
- Germany
- Volunteers
- 135 people
- Sponsor
- Philipps University Marburg
Depression / Major Depressive Disorder
Adjunctive Probiotic Therapy in Major Depressive Disorder (ProMOOD)
A double-blind, randomized controlled trial (RCT) aimed at evaluating the efficacy of probiotic supplementation in patients undergoing concurrent antidepressant therapy.
- Trial name
- ProMOOD (NCT07786285)
- Testing
- OMNi-BiOTiC® STRESS Repair
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Maribor
Schizophrenia, Schizoaffective Disorder
Get Moving and Get Well - Pilot Study
Individuals with serious mental illness have greater morbidity from physical illness and mortality than the general population, but tend not to initiate or sustain engagement in health promotion interventions.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- GMGWP (NCT01884025)
- Testing
- Get Moving and Get Well, Health and Humor Class
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Menopause, Depression
Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder
The purpose this study is to measure cortical gama-aminobutyric acid levels (GABA) levels in menopausal women with major depressive disorder and healthy subjects using nuclear magnetic resonance spectroscopy (MRS).
- Trial name
- NCT00626340
- Testing
- MDD diagnosis and Estrogen treatment, MDD diagnosis and Fluoxetine treatment, MDD diagnosis with both Estrogen and Fluoxetine treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Major Depressive Disorder (MDD)
The Effects of Aerobic Exercise and Mindful Breathing on Individuals With Major Depressive Disorder in Saudi Arabia
The goal of this Randomized Clinical Trial is to evaluate the effectiveness of aerobic exercise (AE) and mindful breathing (MB) on depressive symptom severity and quality of life (QoL), in adults with MDD.
- Trial name
- MDD/AE/MB (NCT07625163)
- Testing
- Aerobic exercise, Mindful Breathing
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- University of Pretoria
Major Depressive Disorder
Comparison of Tianeptine Versus Escitalopram Patients Major Depressive Disorder
The primary object of this study is to confirm the superiority of tianeptine compared to escitalopram on effects that improves subjective and objective cognitive impairments in patients suffering from major depressive disorder.
- Trial name
- CAMPION (NCT01309776)
- Testing
- Tianeptine, Escitalopram
- Where
- 6 sites in South Korea
- Volunteers
- 164 people
- Sponsor
- Samsung Medical Center
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Glutamate Probes in Adolescent Depression
The purpose of this study is to learn if measures of brain chemicals from a brain scan called Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) and brain activity (known as cortical excitability and inhibition) collected by…
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
- Trial name
- GPII (NCT02307617)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Major Depressive Disorder, MDD
Extended Reality Behavioral Activation: An Intervention for Major Depressive Disorder
The primary aims of this study are to assess the feasibility, acceptability, and tolerability of using an immersive extended reality (XR) headset to engage in behavioral activation (BA) for individuals diagnosed with major…
- Conditions
- Major Depressive Disorder, MDD, Depression
- Trial name
- NCT05525390
- Testing
- Extended Reality-Enhanced Behavioral Activation, Traditional Behavioral Activation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Stanford University
Generalized Anxiety, Stress Disorder, Posttraumatic
CBT for Anxiety Sensitivity vs. Disorder-specific CBT: An RCT
Adults with high anxiety sensitivity (AS) and a mental health diagnosis of anxiety, depression, or posttraumatic stress will be recruited and will be randomly assigned to either transdiagnostic cognitive behavioural therapy (CBT)…
- Conditions
- Generalized Anxiety, Stress Disorder, Posttraumatic, Social Anxiety, Major Depression
- Trial name
- NCT03015285
- Testing
- Cognitive Behavioural Therapy
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Major Depressive Disorder
A Study of JNJ-40411813 as Supplementary Treatment to an Antidepressant in Adults With Depression and Anxiety Symptoms
The purpose of this study is to evaluate the efficacy and overall safety and tolerability of treatment with adjunctive JNJ-40411813 compared to placebo in patients with MDD with anxiety symptoms being treated with an…
- Trial name
- NCT01582815
- Testing
- JNJ-40411813
- Where
- 26 sites in Bulgaria, Hungary and 4 more
- Volunteers
- 121 people
- Sponsor
- Janssen Research & Development, LLC
Major Depression
Impact of Immune Challenge on Triple Network Connectivity in Humans
Acquiring, processing and utilising "information" is crucial to any mental function -including seemingly simple daily functions.
- Trial name
- NCT02653235
- Testing
- Salmonella typhi vaccination
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Depression - Major Depressive Disorder
Designing and Pilot Testing a Just-in-time Adaptive Intervention (JITAI) for Adolescent Depression Treatment in Primary Care
The goal of this clinical trial is to learn if a tailored smartphone intervention called Sidekick can help improve sleep and physical activity for teenagers in depression treatment.
- Trial name
- NCT06875726
- Testing
- Sidekick
- Volunteers
- 30 people
- Sponsor
- University of Washington
Major Depressive Disorder
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33
The purpose of this research study is to determine if application of near infrared energy to the forehead can change blood flow in the brains of people with depression.
- Trial name
- TRIADE-R33 (NCT05573074)
- Testing
- Transcranial Photobiomodulator
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Depression, Depressive Disorders
A Study to Determine the Efficacy and Safety of 2 Doses of Org 34517 as Adjunctive Therapy in Subjects With Psychotic Major Depression (28130)(P05845)
The primary purpose of this study is to determine whether subjects with psychotic major depression benefit from adjunctive treatment with Org 34517.
- Conditions
- Depression, Depressive Disorders, Psychotic Disorders
- Trial name
- Hermes (NCT00212797)
- Testing
- Org 34517
- Volunteers
- 273 people
- Sponsor
- Merck Sharp & Dohme LLC
Major Depression
Secondary Prevention of Depression Applying an Experimental Attentional Bias Modification Procedure
Depression (Major Depressive Disorder; MDD) has been dubbed "the common cold among the mental illnesses" and it is also a highly recurrent disorder.
- Trial name
- NCT02658682
- Testing
- Attention Bias Modification
- Where
- 2 sites in Norway
- Volunteers
- 350 people
- Sponsor
- University of Oslo
Depression - Major Depressive Disorder, Resilience
Evaluating The Impact of A Mental Health App on Depression and Resilience Among Medical Students
This randomized controlled trial aims to determine whether access to a mental health app improves resilience and reduces depressive symptoms among medical students over a three-month period.
- Trial name
- NCT07397299
- Testing
- Full digital mental health intervention, Basic digital mental health intervention
- Where
- Malaysia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Major Depressive Disorder
Efficacy and Safety of S 47445 Versus Placebo as Adjunctive Treatment in Depressed Patients Not Fully Recovered From Depressive Symptoms With a Current Antidepressant Treatment
The purpose of this study is to assess the efficacy and safety of S47445 versus placebo as adjunctive treatment of Major Depressive Disorder in patients with an inadequate response to antidepressant therapy.
- Trial name
- NCT02805439
- Testing
- S47445 15mg, S47445 50mg
- Where
- 53 sites in Bulgaria, Czechia and 5 more
- Volunteers
- 400 people
- Sponsor
- Institut de Recherches Internationales Servier
Depression, Depressive Disorder, Major
Decentering and Relapse/Recurrence in MBCT for Depression in Adults
Objective: "Decentering" is defined as the ability to observe one's thoughts and feelings as temporary, objective events in the mind, and is increasingly regarded as a candidate mechanism in mindfulness-based interventions.
- Conditions
- Depression, Depressive Disorder, Major, Depression in Remission
- Trial name
- NCT05111665
- Testing
- Mindfulness-based Cognitive Therapy (MBCT), Relaxation Group Therapy (RGT), Treatment as usual (TAU)
- Where
- Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University of British Columbia