Clinical trials: Depressive Disorder, completed
Major Depressive Disorder, Bipolar Depression
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
The investigators will test the hypothesis that inhaled xenon will produce a rapid improvement in depressive symptoms in patients suffering from treatment-resistant depression.
- Trial name
- NCT03748446
- Testing
- Xenon, Nitrogen gas
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Depressive Disorder, Major
Prediction of Antidepressant Effects of Electroconvulsive Therapy
Despite its successful use for more than 80 years, the mechanisms of action of electroconvulsive therapy (ECT) are still not fully understood.
- Trial name
- NCT05630469
- Testing
- Electroconvulsive therapy
- Where
- Austria
- Volunteers
- 23 people
- Sponsor
- Medical University of Vienna
Psoriasis (PsO), Psychological Distress
Online Therapist-guided Receptive Music Therapy in Adults With Psoriasis
This single-center, three-arm randomized controlled trial evaluated a four-week online therapist-guided receptive music therapy program as an adjunct to treatment as usual in adults with moderate-to-severe psoriasis and…
- Conditions
- Psoriasis (PsO), Psychological Distress, Depressive Symptom, Anxiety
- Trial name
- RePSO (NCT05894759)
- Testing
- Therapist-guided receptive music therapy, Audio-based active relaxation control
- Where
- Romania
- Volunteers
- 75 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Bipolar Disorder
Evaluation of the Genetics of Bipolar Disorder
This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.
- Trial name
- NCT00001174
- Where
- United States
- Volunteers
- 4,210 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Healthy Controls
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets
The study is investigating dysfunctions in neurocircuitry in regards to irritability with healthy controls (HC) and individuals with Major Depressive Disorder (MDD) by performing MRIs.
- Trial name
- UNIKET (NCT05046184)
- Testing
- Ketamine Hydrochloride, Midazolam injection
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Depressive Disorder, Treatment-Resistant
Brain Connectivity and Inflammatory Markers During Short-Term Psychotherapy for Treatment-Resistant Depression
Some adults continue to experience depression despite treatment with antidepressant medicines. This study aimed to explore relationships between depression symptoms, brain function, and blood markers of inflammation, and changes…
- Trial name
- NCT07847242
- Testing
- Short-Term Dynamic Psychotherapy, Mindfulness-Based Cognitive Therapy
- Where
- South Korea
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Korea University Ansan Hospital
Major Depressive Disorder
Closed-loop Optimized rTMS for Depression
Targeted and individualized treatments for mental health disorders are critically needed. Repetitive transcranial magnetic stimulation (rTMS) represents the front-line of new and innovative approaches to normalizing dysfunctional…
- Trial name
- NCT04142320
- Testing
- Neuronavigated rTMS
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stanford University
Major Depressive Disorder, Bipolar Depression
Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study
This study aims to compare the efficacy and safety profile of Magnetic Seizure Therapy and Electroconvulsive therapy.
- Trial name
- EMCODE (NCT05054699)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Major Depressive Disorder
Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neurofeedback
The purpose of this study is to develop a technique called real time fMRI neurofeedback. This technique uses a regular MRI scanner, except that special software allows the researchers to measure activity in participants brain…
- Trial name
- NCT06050070
- Testing
- FMRI with real time feedback
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Michigan
Depressive Disorder, Major
A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder
The purpose of this study is to evaluate how well JNJ-89495120 works (anti-depressant effects) and how well it is tolerated as compared to placebo on reducing the symptoms of depression in participants with major depressive…
- Trial name
- Moonlight-1 (NCT06785012)
- Testing
- JNJ-89495120
- Where
- 44 sites in United States
- Volunteers
- 105 people
- Sponsor
- Janssen Research & Development, LLC
Post-Traumatic Stress Disorder, Depressive Symptoms
Efficacy of EMDR Versus CBT for Post-Traumatic Stress and Comorbid Disorders in Pakistan: A Randomized Controlled Feasibility-Pilot Study
Post-Traumatic Stress Disorder (PTSD) is commonly accompanied by symptoms of depression and anxiety. Eye Movement Desensitization and Reprocessing (EMDR) and Cognitive Behavioral Therapy (CBT) are evidence-based psychological…
- Conditions
- Post-Traumatic Stress Disorder, Depressive Symptoms, Anxiety Symptoms
- Trial name
- NCT04021329
- Testing
- Eye Movement Desensitization and Reprocessing Therapy, Trauma-Focused Cognitive Behavioral Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 40 people
- Sponsor
- Khushal Khan Khattak Univeristy, Karak, Pakistan
Depression, Depressive Disorder
Near-infrared Transcranial Laser Therapy in Subjects With Major Depressive Disorder
Major depressive disorder (MDD) is a leading cause of disability worldwide, and many patients do not achieve adequate benefit from current treatments.
- Conditions
- Depression, Depressive Disorder, Depressive Disorder, Major
- Trial name
- ELATED-4 (NCT06934135)
- Testing
- Bilateral Near-Infrared Transcranial Photobiomodulation (tPBM)
- Where
- 2 sites in Peru
- Volunteers
- 50 people
- Sponsor
- NeuroThera DE
Depressive Symptoms, Depressive Disorder
Self-administered Acupressure for Depression
The goal of this clinical trial is to examine the effects of self-administered acupressure intervention for alleviating depressive symptoms among people with depression.
- Conditions
- Depressive Symptoms, Depressive Disorder, Depression
- Trial name
- SAAFD (NCT05631184)
- Testing
- Self-administered acupressure group, Mental health education group
- Where
- Hong Kong
- Volunteers
- 250 people
- Sponsor
- The Hong Kong Polytechnic University
Depressive, Symptoms Depressive Disorder, Depression
TCM Health Preservation for Depression
This study aims to evaluate the feasibility and preliminary effects of Traditional Chinese Medicine (TCM) health preservation for depression on depressive symptoms reduction and other health-related outcomes among Hong Kong…
- Trial name
- TCMHPFD (NCT05799586)
- Testing
- Traditional Chinese Medicine health preservation group, Waitlist control group
- Where
- Hong Kong
- Volunteers
- 31 people
- Sponsor
- The Hong Kong Polytechnic University
Major Depressive Disorder (MDD)
A Phase II Study to Evaluate NH102 for Depression
This study is a multicenter, randomized, double-blind, double-dummy, parallel-group, dose-finding Phase II clinical trial with placebo and active comparator duloxetine .
- Trial name
- NH102-21 (NCT06842992)
- Testing
- NH102, Duloxetine Hydrochloride Enteric-coated Capsule
- Where
- 24 sites in China
- Volunteers
- 243 people
- Sponsor
- Jiangsu Nhwa Pharmaceutical Co., Ltd.
Major Depressive Disorder
A Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 in Major Depressive Disorder
This is a multicenter, Phase 2, double-blind, randomized, parallel-arm, placebo-controlled clinical trial to evaluate the efficacy, safety, and tolerability of XEN1101 in subjects with Major Depressive Disorder.
- Trial name
- X-NOVA (NCT05376150)
- Testing
- XEN1101 10 mg, XEN1101 20 mg
- Where
- 20 sites in United States
- Volunteers
- 168 people
- Sponsor
- Xenon Pharmaceuticals Inc.
Depressive Disorder, Major, Inflammation
Treating Immuno-metabolic Depression With Anti-inflammatory Drugs
As the role of (neuro)inflammation in depression is emerging, augmentation of antidepressant treatments with anti-inflammatory drugs such as celecoxib has shown encouraging preliminary results.
- Trial name
- INFLAMED (NCT05415397)
- Testing
- Celecoxib 400mg
- Where
- Netherlands
- Volunteers
- 94 people
- Sponsor
- Amsterdam UMC, location VUmc
Major Depressive Disorder, Repetitive Transcranial Magnetic Stimulation
Individualized dlPFC-NAcc Modulation for Anhedonia in adMDD
This study evaluates a schedule of precise repetitive transcranial magnetic stimulation for depressive adolescent with anhedonia.
- Trial name
- NCT05544071
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Xijing Hospital
Depressive Disorder, Depression
Evaluation of the Naturalistic User Experience of the Website "Ich Bin Alles"
Using a multi-method approach, the aim of this study is to investigate the naturalistic user experience and acceptance of the German website "ich bin alles".
- Conditions
- Depressive Disorder, Depression, Depression in Children, Depression in Adolescence
- Trial name
- NCT06668701
- Testing
- "ich bin alles"
- Where
- Germany
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Depressive Disorder
Validity of the 3-item Patient Health Questionnaire (PHQ-3) for Identifying Moderate-to-Severe Depressive Symptoms Among Elderly Perioperative Patients: A Secondary Analysis of a National Prospective Cohort
This is a retrospective observational study based on our hospital's prospective peri-operative elderly patient database. We aim to evaluate the correlation between the 9-item Patient Health Questionnaire (PHQ-9) and the brief…
- Trial name
- NCT07818057
- Testing
- Retrospective data analysis
- Where
- China
- Volunteers
- 10,536 people
- Sponsor
- Chinese PLA General Hospital