Clinical trials: Depressive Disorder
Sleep Disorder, Depressive Symptoms
Different Exercising Intensities and Frequencies of Exercise on Depressive Mood and Insomnia
Aerobic exercise intervention for depression was conventionally recommended three times weekly with moderate intensity in previous studies, but little is known about the training effect of aerobic exercise at low frequency and…
- Trial name
- NCT04354922
- Testing
- Exercise intervention
- Where
- Hong Kong
- Volunteers
- 75 people
- Sponsor
- The University of Hong Kong
Major Depressive Disorder
Mechanisms of Antidepressant Non-Response in Late-Life Depression
This project seeks to elucidate the mechanisms by which antidepressant medications have limited efficacy in Late Life Depression (LLD) in order to develop new treatment interventions for this prevalent and disabling illness.
- Trial name
- NCT01931202
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- New York State Psychiatric Institute
Suicide, Schizophrenia
Alexithymia Intervention for Suicide
Suicide rates among Veterans with Serious Mental Illness (SMI) are intractably high, representing a serious public health concern and a critical target for interventions.
- Conditions
- Suicide, Schizophrenia, Bipolar Disorder, Post Traumatic Stress Disorder
- Trial name
- ALEXIS (NCT05724953)
- Testing
- Affective Awareness
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- VA Office of Research and Development
Major Depression
A Randomized Control Trial of Enhanced Cognitive Behavioural Group Therapy for Older Adults with Depression: Efficacy Across Older Age-Groups
This study is on a type of psychotherapy to treat depression in older adults called Cognitive Behavioural Therapy (CBT-OA). CBT is based on the idea that changing thoughts and behaviours can improve mood.
- Trial name
- NCT06894641
- Testing
- Cognitive Behavior Therapy for Older Adults (CBT-OA)
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Depression
Improving Depression Management
Depression is disabling and affects one in five Veterans. VA's Primary Care-Mental health Integration (PC-MHI) enables specialists to support medication treatment in primary care, but timely and sufficient access to psychotherapy…
- Trial name
- IDMPC (NCT05050227)
- Testing
- cCBT Enhanced Collaborative Care, Usual Care
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- VA Office of Research and Development
Delirium, Postoperative Cognitive Dysfunction
Dexmedetomidine to Reduce the Incidence of POCD After Open Cardiac Surgery
Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated.
- Conditions
- Delirium, Postoperative Cognitive Dysfunction, Dexmedetomidine, Cognitive Impairment
- Trial name
- NCT03480061
- Testing
- Dexmedetomidine Hydrochloride Group
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Sunnybrook Health Sciences Centre
Depressive Disorder, Major
NeuroQore rTMS (Monophasic vs. Biphasic) for Major Depressive Disorder: A Randomized Controlled Pilot Trial
Major depressive disorder (MDD) is a debilitating illness that affects millions of individuals in North America and can result in clinical symptoms including loss of pleasure and feelings of worthlessness, in addition to…
- Trial name
- NCT02667041
- Testing
- NeuroQore rTMS Device
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Ottawa
Major Depression Disorder
Randomized，Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder
This is a Multicenter, open lable, parallel randomized controlled clinical trial. This study aimed to evaluate the treatment onset time, efficacy and safety in patients with major depressive disorders , accompanying anxiety…
- Trial name
- NCT02273154
- Testing
- Buspirone, Paroxetine
- Where
- 6 sites in China
- Volunteers
- 240 people
- Sponsor
- Si Tianmei
Depression, Obesity
Health At Every Size and Acceptance and Commitment Therapy vs. Behavioral Weight Loss for Obesity and Depression in Women
The primary aim of this project is to conduct a randomized controlled pilot study evaluating the feasibility and potential effectiveness of a newly developed combined Health At Every Size and Acceptance and Commitment Therapy…
- Trial name
- NCT02501239
- Testing
- Accept Yourself!, Weight Watchers
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Anxiety Depression (Mild or Not Persistent)
Clinical Trials to Evaluate Neurophysiological and Neuropsychological Effects of a Mindfulness-based Intervention
Depression and anxiety are conditions with a high prevalence in the world population and youth are no exception. In developing countries it is reported that given the conditions of social disadvantage, anxiety and depression are…
- Trial name
- PRESENTE-IA (NCT06618339)
- Testing
- Mindfulness-based intervention
- Where
- Mexico
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Depression, Anxiety Disorders
Engaging Pacific Islanders in Mental Health Treatment
This study will create and pilot test a culturally grounded intervention (Talking Story) to increase mental health treatment seeking among Pacific Islanders with mental disorders (e.g., major depressive disorder, generalized…
- Trial name
- NCT04890977
- Testing
- Talking Story
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Depression, Anxiety
Study of Dronabinol Treatment for Depression and/or Anxiety in Older Patients
This is an observational study evaluating the safety and efficacy of dronabinol for the treatment of anxiety and/or depression in older adults.
- Trial name
- NCT03369639
- Where
- United States
- Sponsor
- Mclean Hospital
Sleep, Pain
PROMIS Measures in Primary Care Practice
The purpose of this study is to determine the effectiveness of providing PROMIS Profile Scale scores (e.g., sleep, pain, anxiety, depression, energy/fatigue) to physicians on patients' symptoms.
- Conditions
- Sleep, Pain, Anxiety, Depression
- Trial name
- NCT02383862
- Testing
- Feedback Group
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Chronic Pain, Depressive Symptoms
Internet-delivered Cognitive Behavioral Therapy for Patients With Chronic Pain and Psychiatric Distress
This study is a randomized controlled trial studying the efficacy of an iCBT treatment for patients with chronic pain and comorbid psychiatric distress.
- Conditions
- Chronic Pain, Depressive Symptoms, Anxiety, Stress, Psychological
- Trial name
- TIPPS (NCT03316846)
- Testing
- Internet-Delivered Cognitive Behavioral Therapy
- Where
- Sweden
- Volunteers
- 187 people
- Sponsor
- Uppsala University
Inflammatory Bowel Diseases
Obsessive-compulsive Disorder, Depression and Anxiety Among Patients With Crohn's Disease
Introduction: Crohn's disease (CD) and obsessive-compulsive disorder (OCD) are two distinct medical conditions that affect millions of people worldwide.
- Trial name
- NCT06429488
- Testing
- no intervention, questionnaires were used
- Where
- Jordan
- Volunteers
- 293 people
- Sponsor
- University of Jordan
Psychological Distress, Anxiety
Effects of Acupressure on Nurses' Psychological Distress, Depression, Job Stress, Occupational Burnout, and Resilience
This measurement aims to understand the effect of self-acupressure on the Shenmen Point (神門) and (內關) points on the hand on emotional distress, anxiety, depression, stress, work fatigue and adaptability of clinical nurses.
- Conditions
- Psychological Distress, Anxiety, Depression, Nurses
- Trial name
- NCT06946888
- Testing
- Acupressure
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Depression
Behavioral Self-activation and Virtual Reality in Depression
Depression is a major handicap in daily life and is often treated by behavioral activation (CA), including the Brief Behavioral Activation Treatment for Depression (BATD).The CA principle is to set up activities, in keeping with…
- Trial name
- DEPREVACT (NCT03621488)
- Testing
- Efficacy of Behavioral Self-Activation with virtual reality, Efficacy of Behavioral Self-Activation without virtual reality
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Major Depressive Disorder
Contact: Developing New Clinical Management Strategies
The goal of this study is to develop new methods of administering antidepressant medications that will result in improved drug/placebo separation in randomized controlled trials (RCTs) for Major Depressive Disorder (MDD) and…
- Trial name
- NCT03812588
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- New York State Psychiatric Institute
Depression, Anhedonia
Dimensional Approach to Evaluate Reward Processing in Major Depressive Disorder Pre- and Post-Desvenlafaxine Treatment
Anhedonia (the lack of pleasure in normally pleasurable things) is a common symptom of major depressive disorder (MDD), and it may impact how patients with depression experience reward.
- Trial name
- NCT02859103
- Testing
- Desvenlafaxine
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Depression, Anxiety
Mechanisms of Mindfulness-based Interventions
Mindfulness-based Interventions (MBIs) are a family of standardized cognitive and behavioral therapies that focus on cultivating mindfulness-related skills for improving maladaptive cognitive, emotional, and behavioral processes.
- Conditions
- Depression, Anxiety, Stress
- Trial name
- MBI (NCT03571386)
- Testing
- Mindfulness-based Cognitive Therapy (MBCT), Mindfulness-based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Vanderbilt University Medical Center